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A triple‐microstructure hydro‐mechanical constitutive damage model was proposed to describe the hydro‐mechanical behaviour of MX80 bentonite pellet/powder mixture, based on the results from a series of suction‐controlled oedometer tests and microstructure observations. Emphasis was put on the pellet damage behaviour. The model parameters were determined essentially based on these results. The model response was firstly verified with the obtained oedometer tests. Then, the results of Molinero‐Guerra et al. and Darde who carried out suction‐controlled oedometer tests and swelling pressure tests on similar bentonite pellet/powder mixture were employed to validate the proposed model. It appeared that the global volume behaviour and the development of swelling pressure with suction of the bentonite mixture could be well reproduced. The model allowed gaining insights into the microstructural evolutions under oedometer loading. The global compression behaviour was governed by the filling of inter‐grain pores at unsaturated state, but by the compression of grains themselves at saturated state. Conversely, when wetted under constant‐volume condition, inter‐grain pores and intra‐grain macro‐pores were closed, by the swelling of intra‐grain micro‐pores. Examination of the water‐retention property showed that water saturated the intra‐grain micro‐pores at suction 19 MPa, and then started filling intra‐grain macro‐pores. When inter‐grain pores and intra‐grain macro‐pores were all closed at suction 0.1 MPa, water finally came back to intra‐grain micro‐pores. On the whole, the hydro‐mechanical behaviour of the bentonite pellet/powder mixture can be well described by the proposed model. [ABSTRACT FROM AUTHOR]

Health technology assessment (HTA) is a multidisciplinary process that determines the value of health technology at different points in its lifecycle. Safety issues have become more important since regulatory authorities are increasingly adopting flexible standards, processes, and evidentiary requirements for drug approval. In this article, we compared the different role of regulatory authorities and HTA agencies. Additionally, the experience of regulatory-HTA collaboration for assessment and/or decision-making on safety issues in the lifecycle of a health technology is illustrated, including olmesartan (angiotensin II receptor antagonist) and the direct-acting hepatitis C virus (HCV) antiviral agents. Post-licensing data can be derived from various sources such as electronic health records, medical claims, drug and disease registries, post-authorization safety studies (PASS) or post-authorization safety efficacy studies (PAES), periodic benefit–risk assessment reports, as well as HTA reassessment reports, which incorporate utilization information from patients in a real-world setting and provide crucial evidence for various purposes. With the ongoing accumulation of safety and efficacy information during post-regulatory approval, a standardized process for continuous data collection and active reassessment of risk and benefit becomes crucial for managing the lifecycle of health technologies. In order to define evidence requirements clearly, reduce uncertainty, and minimize delays in HTA approval, early engagement and collaboration of HTA agencies in the regulatory review processes have become more common. However, there is currently limited interaction and collaboration between regulatory authorities and HTA agencies. This article aims to identify the challenges faced by regulators and HTA agencies today, emphasizing the significance of conducting regulatory reviews and health technology assessments throughout a technology's lifecycle, underlining the value of utilizing real-world data and evidence, and emphasizing the necessity of enhancing collaboration between regulatory authorities and HTA agencies, all within the overarching context of drug safety. [ABSTRACT FROM AUTHOR]

The importance of early science, technology, engineering, and math (STEM) learning opportunities for all young children has become increasingly documented by research and recommended practices. In addition, high quality inclusive settings where all children can access and benefit from learning activities continues to demonstrate optimal outcomes for all children. This manuscript reports findings from a survey broadly disseminated related to early childhood practitioners' and directors' perceptions related to STEM and inclusion and explores what practices related to STEM and inclusion are currently being used by early childhood practitioners and directors. While the majority of respondents supported the importance of both STEM and inclusion, there were varied responses related to relevance for infants and toddlers and inconsistent reports of specific practices being used. The findings suggest the need to emphasize and provide professional development opportunities focused on STEM and inclusion for our early childhood workforce more explicitly. Additional implications for research and practice are discussed. [ABSTRACT FROM AUTHOR]

Oral submucous fibrosis (OSF) is a precancerous lesion in the oral cavity, commonly results from the Areca nut chewing habit. Arecoline, the main component of Areca nut, is known to stimulate the activation of myofibroblasts, which can lead to abnormal collagen I deposition. Meanwhile, Resveratrol is a non-flavonoid phenolic substance that can be naturally obtained from various berries and foods. Given that resveratrol has significant anti-fibrosis traits in other organs, but little is known about its effect on OSF, this study aimed to investigate the therapeutic impact of resveratrol on OSF and its underlying mechanism. The cytotoxicity of resveratrol was tested using normal buccal mucosal fibroblasts (BMFs). Myofibroblast phenotypes such as collagen contractile, enhanced migration, and wound healing capacities in dose-dependently resveratrol-treated fBMFs were examined. Current results showed that arecoline induced cell migration and contractile activity in BMFs as well as upregulated the expressions of α-SMA, type I collagen, and ZEB1 markers. Resveratrol intervention, on the other hand, was shown to inhibit arecoline-induced myofibroblast activation and reduce myofibroblast hallmarks and EMT markers. Additionally, resveratrol was also demonstrated to restore the downregulated miR-200a in the arecoline-stimulated cells. In a nutshell, these findings implicate that resveratrol may have an inhibitory influence on arecoline-induced fibrosis via the regulation of miR-200a. Hence, resveratrol may be used as a therapeutic strategy for OSF intervention. [ABSTRACT FROM AUTHOR]

Objective: Olfactory disturbance is one of the main symptoms of coronavirus disease‐2019 (COVID‐19). Various olfactory disorders caused by viral infections are treated with nasal corticosteroids. This study aimed to evaluate the safety and efficacy of nasal corticosteroids in the treatment of olfactory disorders caused by the severe acute respiratory syndrome coronavirus 2. Data Sources: We searched the Web of Science, Embase, PubMed, and Cochrane Library databases for clinical trials of nasal corticosteroids for treating COVID‐19 olfactory dysfunction. Review Methods: We assessed the effect of nasal corticosteroids on olfactory function in COVID‐19‐affected individuals using a Meta‐analysis of published studies, considering the number of patients who fully recovered from olfactory dysfunction, olfactory scores following treatment, and olfactory recovery time. Results: Seven studies involving 930 patients were analyzed. The Meta‐analysis results revealed that the olfactory score of the experimental group was 1.40 points higher than that of the control group (standardized mean difference [MD]: 1.40, 95% confidence interval [95% CI]: 0.34‐2.47, P <.00001). However, the differences in the outcomes of cure rate (risk ratio: 1.18, 95% CI: 0.89‐1.69, P =.21) and recovery time (MD: −1.78, 95% CI: −7.36 to 3.81, P =.53) were not statistically significant. Only 1 study reported adverse effects of nasal steroid treatment, namely tension, anger, and stomach irritation. Conclusion: Although nasal steroid therapy does not result in significant adverse effects, it proves ineffective in the treatment of COVID‐19 olfactory dysfunction. [ABSTRACT FROM AUTHOR]

Emulsion polymerization is an effective means of synthesizing high-molecular-weight polymers in order to reduce the consumption of fossil energy. This paper adopts isoamyl octanoate to replace white oil as the continuous phase of emulsion polymerization to synthesize the high molecular weight polyacrylamide emulsion RSE. S-80 and T-80 were chosen as the emulsifiers, and the test results showed that the HLB value is 5.72 when S-80/T-80 is 6.5. When S-80/T-80 is 6.5, the HLB value is 5.72. Water and isoamyl octanoate can produce ultra-low interfacial tension and stable arrangement in the interfacial membrane to form a stable emulsion, and the particle size is uniformly distributed in a normal manner. The test of the exothermic process of polymerization shows that the emulsion can be stabilized into nuclei, and polyacrylamide polymers with a molar mass of more than 18 million are obtained. The microstructure test observes that RSE molecules are in an aggregated state in the aqueous solution. A three-dimensional spatial network structure is formed, and the polymerization can be stabilized in a three-dimensional network structure after 120 °C, 170 s−1 shear, which still has good stability. After the variable shear performance test proved that the aqueous solution of RSE belongs to the typical non-Newtonian fluids, to shock test the viscoelasticity of different concentrations of RSE polymer, G′ > G″, the RSE solution to elasticity is dominant. In this paper, the capacity to form stable emulsions of isoamyl octanoate in the emulsion polymerization process is investigated to provide a basis for seeking the selection of a continuous phase with little environmental pollution and high functionality. [ABSTRACT FROM AUTHOR]

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Open-set learning deals with the testing distribution where there exist samples from the classes that are unseen during training. They aim to classify the seen classes and recognize the unseen classes. Previous studies typically assume that the marginal distribution of the seen classes is fixed across the training and testing distributions. In many real-world applications, however, there may exist covariate shift between them, i.e., the marginal distribution of seen classes may shift. We call this kind of problem as open-set learning under covariate shift, aim to robustly classify the seen classes under covariate shift and be aware of the unseen classes.We present a new open-set learning framework with covariate generalization based on supervised contrastive learning, called SC–OSG, inspired by the latent connection between contrastive learning and representation invariance. Specifically, we theoretically justify supervised contrastive learning that could promote the conditional invariance of representations, a critical condition for covariate generalization. SC–OSG generates multi-source samples to promote the representation invariance and improve the covariate generalization. Based on this, we propose a detection score that is specific to the proposed training scheme. We evaluate the effectiveness of our method on several real-world datasets, on all of which we achieve competitive results with state-of-the-art methods. [ABSTRACT FROM AUTHOR]

The large-sized Tarangaole uranium deposit and its neighboring Daying and Nalinggou deposits, located in the northeastern margin of the Ordos Basin, constitutes a major uranium resource base in northern China. In order to further clarify the sedimentary material source, uranium source and regional sediment–tectonic setting of the uranium-fed clastic rocks (i.e., Zhiluo Formation(J2z)) in the district, this paper carried out whole-rock geochemistry, heavy minerals composition and in situ U-Pb dating of detrital zircons for sandstones from the lower section of the Zhiluo Formation. The results have shown that the average chemical differentiation index (CIA) for the host rocks is 73.16 and the chemical weathering degree is moderate. Heavy minerals are mainly composed of ilmenite, garnet, chlorpyrite, zircon, pyrite, apatite, hematite, etc. The U-Pb dating of detrital zircon generally indicates three age peaks, i.e., 260~Ma, 1850~Ma and 2450~Ma, respectively. In conclusion, the source rocks may have been formed at active continental margins, e.g., in a continental margin arc environment. The sedimentary materials mainly come from khondalite series, TTGs, granulite, and mafic–ultramafic intrusive rocks distributed among the Daqing–Ula Mountains and adjacent areas, etc. The Late Paleozoic U-rich intermediate and acidic magmatic rocks spreading over the eastern part of the Ula–Daqing and Wolf mountains have provided the main uranium sources for the formation of major U deposits in the northern Ordos Basin. [ABSTRACT FROM AUTHOR]

Efficient electrochemical CO2 reduction reaction (ECO2RR) to multi‐electron reductive products remains a great challenge. Herein, molecular engineering of copper phthalocyanines (CuPc) was explored by modifying electron‐withdrawing groups (EWGs) (cyano, sulfonate anion) and electron‐donating groups (EDGs) (methoxy, amino) to CuPc, then supporting onto carbon paper or carbon cloth by means of droplet coating, loading with carbon nanotubes and coating in polypyrrole (PPy). The results showed that the PPy‐coated CuPc effectively catalysed ECO2RR to CH4. Interestingly, experimental results and DFT calculations indicated EWGs markedly improved the selectivity of methane for the reason that the introduction of EWGs reduces electron density of catalytic active center, resulting in a positive move to initial reduction potential. Otherwise, the modification of EDGs significantly reduces the selectivity towards methane. This electronic effect and heterogenization of CuPc are facile and effective molecular engineering, benefitting the preparation of electrocatalysts for further reduction of CO2. [ABSTRACT FROM AUTHOR]

Impatiens beipanjiangensis Jian Xu & H. F. Hu (Balsaminaceae), a new species of Impatiens subg. Clavicarpa discovered in Guizhou, China, is described and illustrated in this study along with its molecular phylogenetic analysis. I. beipanjiangensis is similar to I. liboensis, I. chishuiensis and I. clavigera in morphology, but I. tubulosa has the closest relationship to it. However, there are various ways in which the new species can be easily distinguished from these four species: Inferior nodes swollen rhizoid, pale green and with hooked outer sepals, longer lateral united petals, subovate auricle, deeper lower sepal and shorter spur that is reflexed towards the lower sepal. Furthermore, I. beipanjiangensis is distinguished from other Impatiens species, based on morphological, micromorphological and palynological evidence and molecular data (PP 0.967). [ABSTRACT FROM AUTHOR]

To understand cultural intelligence's (CQ) role in expatriates' work outcomes, we examine the mediation mechanism of psychological availability in the associations between CQ with work engagement and CQ with job satisfaction, along with the moderated mediation effect of job autonomy. We examined data obtained from 546 Taiwanese expatriates. An online survey was established to collect from overseas Taiwanese expatriates. Data were analyzed using the SPSS macro-PROCESS models (Hayes, 2017). The Cronbach's alphas coefficients were acceptable, ranging from.80 to.94. Our results show that psychological availability positively mediated both the pathway between CQ and work engagement (β =.576***, LLCI =.439, ULCI =.717) and that between CQ and job satisfaction (β =.575***, LLCI =.428, ULCI =.744). Moreover, job autonomy helped expatriates utilize CQ more effectively to generate more resources for work engagement (β =.075, SE =.029, [.010,.125]) and job satisfaction (β =.075, SE =.028, [.011,.025]) through psychological availability. This study confirms that psychological availability serves as an important mediating mechanism in CQ's effects on expatriates' satisfaction with their jobs and engagement at work. This study presents two moderated mediation models between CQ and work engagement or job satisfaction (via job autonomy). The findings align with the conservation of resources theory and contribute new empirical evidence to the literature. Furthermore, this study provides suggestions for individuals, human resource departments, and organizations to help achieve better working outcomes and practical management in culturally diverse business environments. [ABSTRACT FROM AUTHOR]

Visible-light-induced EDA complex-promoted ring-opening of cycloketone oxime esters to synthesise various cyanoalkylated products with N-methacryloyl benzamides was developed. Various radical receptors were compatible with the current reaction system to furnish diverse heterocyclic compounds. Mechanistic analysis shows that the formation of an EDA complex was crucial to the photocatalytic strategy. Importantly, 4-cyanoalkyl isoquinoline-1,3-diones were obtained in high yields by using a catalytic amount of 1,4-diazabicyclo[2.2.2]octane (DABCO) through prolonging the reaction time, which provided a practical approach to give a variety of isoquinoline-1,3-dione derivatives. [ABSTRACT FROM AUTHOR]

With intentional adult guidance, all children have opportunities to learn new skills across developmental domains during motor play. We collected and analyzed 501 written responses from 16 preschool teachers regarding their perceptions of intervention outcomes across domains, based on their observations during the CHildren in Action: Motor Program for PreschoolerS (CHAMPPS) intervention. This 21-week class-wide, semi-structured motor program was implemented in eight inclusive preschool classrooms. The findings reveal that teachers noticed many positive changes in children's social, communication, and pre-academic skills as well as their approaches to learning during the months when they implemented the CHAMPPS program. In addition to sharing data from this qualitative analysis, we discuss (a) the value of motor interventions and purposefully embedding learning opportunities across developmental domains for young children with and without disabilities, and (b) the benefits of gathering end-users' perspectives as we collaborate with them to implement new interventions. [ABSTRACT FROM AUTHOR]