451. In vitro antiplasmodial activity of crude extracts from Togolese medicinal plants.
- Author
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Koudouvo K, Karou SD, Ilboudo DP, Kokou K, Essien K, Aklikokou K, de Souza C, Simpore J, and Gbéassor M
- Subjects
- Animals, Antimalarials isolation & purification, Complex Mixtures isolation & purification, Humans, Inhibitory Concentration 50, Malaria, Falciparum parasitology, Parasitic Sensitivity Tests, Plasmodium falciparum isolation & purification, Togo, Antimalarials pharmacology, Complex Mixtures pharmacology, Ferns chemistry, Plant Extracts chemistry, Plants, Medicinal chemistry, Plasmodium falciparum drug effects
- Abstract
Objective: To investigate the antimalarial effect of a few plants in Togo folk medicine., Methods: After ethnobotanical survey, Opilia celtidifolia, Pavetta corymbosa (P. corymbosa) and Tamarindus indica (T. indica) were selected for screening. In vitro antimalarial tests were performed on crude extracts against fresh clinical isolates of Plasmodium falciparum using the semi microtest., Results: Different IC(50) values of the extracts ranged from 2.042 to 100.000 μg/mL. According to the results, the methanol extract of aerial part of P. corymbosa followed by aqueous extract of fruit of T. indica were the most active (IC(50) of 2.042 and 4.786 μg/mL, respectively). Qualitative test revealed the presence of alkaloids in the leaves of P. corymbosa that may be responsible for the activity of the plant., Conclusions: Our study provides scientific evidence for usage of plant in the folk medicine, and further studies are needed for identification and purification of the active principles., (Copyright © 2011 Hainan Medical College. Published by Elsevier B.V. All rights reserved.)
- Published
- 2011
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