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We diagnosed sebaceous gland carcinoma of the right lower eyelid in an 82-year-old man. Computed tomography showed the lesion extending from the eyelids anteriorly to the optic foramen posteriorly. With this orbital neoplasm, was an occlusion of the central retinal artery in his right eye. The right orbit was removed surgically and biopsy of the optic foramen region indicated malignant cells. Localized radiation to the right orbit was then initiated postoperatively.

A 12-month trial of a community television series entitled Physiotherapy and Your Health has been completed. The evolution and philosophy of the series are described. Mechanics of production, limitations, and potential scope for other television series on physiotherapy, in areas served by community television outlets, are presented.

Phacoanaphylaxis (lens-induced uveitis) is a potentially curable ocular inflammation secondary to lens truma. Recently we have seen three clinically undiagnosed enucleation specimens in our eye pathology laboratory with this entity. Our observations add an argument to the recent concept that early lens removal in cases of traumatic cataract with lens capsule rupture would ultimately lead to better visual results.

The Saccomanno technique of sputum preparation is widely used. This study evaluates the role of this preparation in conjunction with fresh smears in the diagnosis of lung cancer. All sputum samples from September 1973 to July 1975 showing atypia were randomized and negative controls added. The Saccomanno and fresh smears were evaluated independently and blindly and classified as negative, atypical, suspicious, or cancer. When each preparation was compared with the original diagnosis, the diagnostic accuracy for 55 squamous carcinomas was similar (fresh 95%, Saccomanno 86%) but significantly less in the Saccomanno preparations of 22 small cell carcinomas (fresh 100%, Saccomanno 24%) and 26 adenocarcinomas (fresh 96%, Saccomanno 52%). Four cases negative on fresh smears were suspicious or diagnostic of cancer on the Saccomanno slides. There were no cases of small cell carcinoma in which the Saccomanno preparations added information not available on the fresh smears. The authors conclude that in conjunction with fresh smears, the Saccomanno preparation may contribute to the diagnosis of non-small cell carcinomas but does not appear to aid in the diagnosis of small cell carcinoma.

A quantitative study of the serological cross-reactions of the somatic antigens of Types I, III, and I-III Shigella paradysenteriae has been made. From the results obtained it has been concluded that the somatic antigens of Shigella paradysenteriae (Flexner) Types I, III, and I-III are single chemical substances. The specificity and serological cross-reactions exhibited by these antigens are dependent upon similarities in their chemical constitutions.

1. Volunteers have been immunized with the purified specific antigen of Type V Shigella paradysenteriae (Flexner). The subjects developed a high titer of bacterial agglutinins and mouse-protective antibodies. The agglutinin titer fell moderately after a period of 6 months. The subjects responded fairly well to a small recall dose of the antigen. 2. Two individuals from a group of 10 injected with the specific polysaccharide obtained from Type V organisms responded with an increase in bacterial agglutinins. Mouse-protective antibodies were demonstrable in the one serum tested.

1. Studies of the precipitation reaction of C polysaccharide with C protein, and of C polysaccharide with C antibody are reported. The similarity between these two systems in this respect is demonstrated. 2. The differences between C protein and C antibody are emphasized. The differences between this protein and antibodies in general have been reported previously by others. 3. Electrophoretic studies show that C antibody is in the gamma globulin fraction of serum whereas C protein migrates with the alpha(1) globulin fraction of acute phase protein.

The chemical and enzymatic dissociation of the specific antigen of Type Z Shigella paradysenteriae has been studied. The chemical, toxic, and serological properties of the products of degradation have been investigated. The nature of the toxic component has been discussed.

It has been shown that phase variation of Sh. sonnei is accompanied by changes in morphology and antigenic structure. Two mutants of the Phase I organism (II(S) and II(R)), which were studied, elaborate somatic antigens which are immunologically identical. The purified lipocarbohydrate-protein antigens of the Phase I and II(S) microorganisms are chemically similar yet immunologically distinct and specific. By inference the same should hold true of the antigen of II(R), but it has not yet been investigated in this relation. It is suggested that when Sh. sonnei undergoes variation from Phase I to II(S) the immunological changes occurring are dependent upon a change in the enzyme systems responsible for the synthesis of the lipocarbohydrate-protein constituent.

1. The toxicity of killed dysentery bacilli can be ascribed to the somatic antigen. Antibodies to intact dysentery bacilli apparently contain no toxin-neutralizing antibodies other than those which precipitate the purified somatic antigen. 2. The serological properties of dysentery bacilli are determined by the specific somatic antigen. The specificity and cross-reactivity of the somatic antigen are dependent upon the carbohydrate moiety of the molecular complex.

1. Methods for the isolation of the specific antigens of Types V, W, Z, and Newcastle Shigella paradysenteriae are given. 2. The physical, chemical, toxic, and immunological properties of these substances are described.