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The scattered radiation protector for mobile x-ray systems, Creative Valuable Protector-2, has been recently developed. However, there have been no studies investigating the effects of this device. We aim to investigate the effects of the scattered radiation protector on the equivalent doses from scattered radiation delivered to radiosensitive organs while simulating spine surgery using a C-arm fluoroscope. Chest and rando phantoms were used to simulate a patient and a surgeon in this study. The equivalent dose from scattered radiation to radiosensitive organs was measured in four different situations according to the use of the scattered radiation protector and the C-arm configuration. To compare the quality of the images with and without the scattered radiation protector, an acryl step phantom with five steps was used, and the contrast resolution of each step was calculated. The equivalent dose from the scattered radiation to the surgeon’s eye, thyroid, and gonad decreased significantly by using the scattered radiation protector for both the Posteroanterior (PA) (p  <  0.001) and Anteroposterior (AP) (p  <  0.001) C-arm configurations. The installation of the scattered radiation protector also reduced the direct radiation dose to the chest phantom. A scattered map showed that scattered radiation doses decreased by approximately 50% for the PA configuration and 75% for the AP configuration by using the scattered radiation protector. Before and after installation of the scattered radiation protector, the contrast resolution of each adjacent step area was 0.025–0.404 and 0.216–0.421. The scattered radiation protector was effective in reducing not only the equivalent dose from scattered radiation to the surgeon’s radiosensitive organs, but also the direct radiation dose to the patient. This was all achieved without decreasing the quality of the C-arm fluoroscopic images. [ABSTRACT FROM AUTHOR]

Abstract Scrambler therapy is a noninvasive electroanalgesia technique designed to remodulate the pain system. Despite growing evidence of its efficacy in patients with neuropathic pain, little is known about the clinical factors associated with treatment outcome. We conducted a prospective, open-label, single-arm trial to assess the efficacy and safety of scrambler therapy in patients with chronic neuropathic pain of various etiologies. A post-hoc analysis was performed to investigate whether cluster analysis of the Neuropathic Pain Symptom Inventory (NPSI) profiles could identify a subgroup of patients regarding neuropathic pain phenotype and treatment outcome. Scrambler therapy resulted in a significant decrease in the pain numerical rating scale (NRS) score over 2 weeks of treatment (least squares mean of percentage change from baseline, − 15%; 95% CI − 28% to − 2.4%; p

Purpose This study evaluated the rates and annual trends of pediatric CT scans in South Korea using a nationwide population-based database. Materials and Methods Data regarding pediatric CT scan usage between 2012 and 2017 were retrieved from the health insurance review and assessment service. Data on the age, sex, diagnosis, and the anatomical area of involved patients were also extracted. Results A total of 576376 CT examinations were performed among 58527528 children aged below 18 years (9.8 scans/1000 children), and the number of CT examinations per 1000 children was noted to have increased by 23.2% from 9.0 in 2012 to 11.0 in 2017. Specifically, the number of CT examinations increased by 32.9% for the 6–12 years of age group (7.4/1000 to 9.8/1000) and by 34.0% for the 13–18 years of age group (11.4/1000 to 15.3/1000). Moreover, majority of the CT scans were limited to the head (39.1%), followed by the extremities (32.5%) and the abdomen (13.7%). Notably, the number of extremity CT scans increased by 83.6% (2.3/1000 to 4.2/1000), and its proportion as compared to other scans increased from 25.3% to 37.7%. Conclusion CT scans in the pediatric population increased continuously from 2012 to 2017 at an annual rate of 4.4%. Therefore, physicians should balance the benefits of CT with its potential harms from associated radiation exposure in pediatric patients. [ABSTRACT FROM AUTHOR]

Our perception of the body's metric is influenced by bias according to the axis, called the systematic metric bias in body representation. Systematic metric bias was first reported as Weber's illusion and observed in several parts of the body in various patterns. However, the systematic metric bias was not observed with a fake hand under the influence of the body ownership illusion during the line length judgment task. The lack of metric bias observed during the line length judgment task with a fake hand implies that the tactile modality occupies a relatively less dominant position than perception occurring through the real body. The change in weight between visual and tactile modalities during the body ownership illusion has not been adequately investigated yet, despite being a factor that influences the perception through body ownership illusion. Therefore, this study aimed to investigate whether the dominance of vision over tactile modality is prominent, regardless of the task type. To investigate whether visual dominance persists during the process of inducing body ownership illusion regardless of task type, we introduced spatial visuotactile incongruence (2 cm, 3 cm) in the longitudinal and transverse axes during the visuotactile localization tasks and measured the intensity of the body ownership illusion using a questionnaire. The results indicated that participants perceived smaller visuotactile incongruence when the discrepancy occurred in the transverse axis rather than in the longitudinal axis. The anisotropy in the tolerance of visuotactile incongruence implies the persistence of metric biases in body representation. The results suggest the need for further research regarding the factors influencing the weight of visual and tactile modalities.

Background: Idiopathic pes planovalgus is one of the most common foot deformities in children and adolescents. However, there is a discrepancy between subjective symptoms and radiographic severity in idiopathic planovalgus deformity, and very few studies have investigated this aspect. Further, the assessment of subjective symptoms in patients with pes planovalgus requires a quantitative scoring system for making meaningful comparisons, such as the Oxford Ankle Foot Questionnaire for Children (OxAFQ-c) and that for parents (OxAFQ-p). Therefore, the purpose of this study was to evaluate the factors affecting the symptoms of idiopathic planovalgus using the OxAFQ.Methods: All patients who were ≤18 years of age, had visited our clinic for the evaluation of pes planovalgus deformity, and had completed the OxAFQ were included in this study. The anteroposterior talo-first metatarsal, lateral talo-first metatarsal, and hallux valgus angles were measured on weight-bearing radiographs. The data were analyzed using a multiple regression model, with age, sex, and radiographic indices as explanatory variables.Results: Overall, 123 patients were enrolled in this study, and 246 standing foot radiographs were evaluated along with scores in each domain of the OxAFQ. The factors affecting physical domain scores in the OxAFQ-c were female sex (p = 0.047) and the anteroposterior talo-first metatarsal angle (p = 0.033). Age of ≥10 years was a significant factor (p < 0.05) affecting all domains in both the OxAFQ-c and OxAFQ-p other than the physical domain score.Conclusions: Although pes planovalgus deformity is 3-dimensional, the forefoot abduction component of the deformity should be carefully assessed as it is closely related to subjective symptoms. Further, in female patients with a more severe anteroposterior talo-first metatarsal angle, an aggravation of symptoms with aging should be expected when managing pes planovalgus deformity.Level Of Evidence: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence. [ABSTRACT FROM AUTHOR]

The frontal eye fields (FEF) in rhesus monkeys have been implicated in visual short-term memory (VSTM) as well as control of visual attention. Here we examined the importance of the area in the VSTM capacity and the relationship between VSTM and attention, using the chemical inactivation technique and multi-target saccade tasks with or without the need of target-location memory. During FEF inactivation, serial saccades to targets defined by color contrast were unaffected, but saccades relying on short-term memory were impaired when the target count was at the capacity limit of VSTM. The memory impairment was specific to the FEF-coded retinotopic locations, and subject to competition among targets distributed across visual fields. These results together suggest that the FEF plays a crucial role during the entry of information into VSTM, by enabling attention deployment on targets to be remembered. In this view, the memory capacity results from the limited availability of attentional resources provided by FEF: The FEF can concurrently maintain only a limited number of activations to register the targets into memory. When lesions render part of the area unavailable for activation, the number would decrease, further reducing the capacity of VSTM.

Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) has been widely used to quantify relative gene expression because of the specificity, sensitivity, and accuracy of this technique. In order to obtain reliable gene expression data from RT-qPCR experiments, it is important to utilize optimal reference genes for the normalization of target gene expression under varied experimental conditions. Previously, we developed and validated a novel icv-STZ cynomolgus monkey model for Alzheimer's disease (AD) research. However, in order to enhance the reliability of this disease model, appropriate reference genes must be selected to allow meaningful analysis of the gene expression levels in the icv-STZ cynomolgus monkey brain. In this study, we assessed the expression stability of 9 candidate reference genes in 2 matched-pair brain samples (5 regions) of control cynomolgus monkeys and those who had received intracerebroventricular injection of streptozotocin (icv-STZ). Three well-known analytical programs geNorm, NormFinder, and BestKeeper were used to choose the suitable reference genes from the total sample group, control group, and icv-STZ group. Combination analysis of the 3 different programs clearly indicated that the ideal reference genes are RPS19 and YWHAZ in the total sample group, GAPDH and RPS19 in the control group, and ACTB and GAPDH in the icv-STZ group. Additionally, we validated the normalization accuracy of the most appropriate reference genes (RPS19 and YWHAZ) by comparison with the least stable gene (TBP) using quantification of the APP and MAPT genes in the total sample group. To the best of our knowledge, this research is the first study to identify and validate the appropriate reference genes in cynomolgus monkey brains. These findings provide useful information for future studies involving the expression of target genes in the cynomolgus monkey.

The interaction between neural activity driven by inputs through the two eyes were examined using visual evoked-potentials (VEP) in normal human subjects. VEP recordings were obtained at the occipital electrodes using binocularly asynchronous pattern-reversal checkerboard stimuli: The patter-reversal times for the two eyes differed by 0, ±50, ±150, or ±350 ms, with the positive stimulus-onset asynchrony (SOA) meaning that the right-eye reversal occurred first. For comparison, monocular VEPs were also obtained using trial conditions where the checkerboard pattern-reversals were shown to only one eye, while a blank field to the other. The VEPs of the various trial conditions were analyzed using both temporal and frequency analysis methods. Three observations were made: First, the N75 amplitude was significantly reduced in the ±50 ms SOA conditions. Second, on ±150 ms and ± ms SOA conditions, a negative potential was observed over the period when the stimuli were binocularly incongruent. Third, the alpha-band power was reduced and the beta-band power increased on asynchronous conditions, compared to the synchronous patter-reversal. These findings show that activities of binocular neurons in the visual cortices get modulated by binocular incongruity in the asynchronous pattern-reversal stimuli. Our stimuli may prove valuable in elucidating neural mechanisms of integration of binocular visual inputs, especially when combined with brain source-localization techniques and compared between normal subjects and patients with dysfunction in binocular vision.

Tiny eye movements, such as micro-saccades, ocular tremor, and drifts, occur involuntarily during fixation. We found evidence that involvement of body action and anticipation of visual stimuli modulates them. While eye movements were monitored, subjects performed the working memory task with a touch-screen display in two different conditions. In the passive condition, each number was shown for 400-ms and spaced in time by 500-ms automatically. In the active condition, touching action was required to trigger the appearance of each number. The delay between the touch and stimulus onset was constant within a block as 200, 500, or 800-ms. Subjects were prompted to type in the number sequence after five numbers were shown. As a measure of fixation instability, deviation of eye position was analyzed by comparing eye positions with those during the reference interval (0∼50ms time period after the number onset). We observed two results: first, the deviation was smaller in pre-reference time than in post-reference time. Second, the deviation was smaller in the active condition. These results show that micro eye movements are influenced by attentive anticipation of upcoming events, which becomes more pronounced with bodily interactions. These findings suggest a cross-modal interaction among visual, motor, and oculomotor systems.