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Ciplukan (Physalis angulata L.) empirically has been used to treat sore throat, inflammatory of the airways, gingivitis, and other diseases. This research was to determine the inflammatory activity of water herb extract of P. angulata L. on white male rats edema Wistar strain induced carragenan. P. angulata L. herbs were extracted using infundation method and were dried with frezee drying. Parameter that would be observed of this research was the inhibition foot edema of rat after induction of 0.1 mL of λ-carragenan 2% for 360 minutes. Measurement of edema volume was using pletismometer. The results of this research showed water herb extract of P. angulata L. in dose 100, 200, and 400 mg/kgBW has potensial as an antiinflammatory drug by percent respectively were 20.13; 28.93; and 34.70%. The three doses hasn’t showed any significant difference (p>0.05) with the positive control of diclofenac sodium dose 4.5 mg/kgBW was 33.90%. Conclusion of this research states water herb extract of P. angulata L. has antiinflammatory activity with effective dose of 400 mg/kgBW.

Lantana camara L. is a widely distributed plant on tropics region belonging to the Family Verbenaceae. In Indonesia, the plant is used in traditional medicines of edema and rheumatisms. The aims of this research were to compare saponins, flavonoids, and essential oils constituents among the roots, the leaves, and the fruits and to know about anti-inflammatory effects of ethanolic extracts of L. camara on white male rats. The framework of the research was that the saponins, flavonoids, and essential oils constituents of L. camara have an anti-inflammatory effect. Organs with the highest constituents of saponins, flavonoids and essential oils would expect giving optimal anti-inflammatory effects. Complete Randomized Design with five treatment groups, each of the treatment had five repetitions, was used in this study. Each group have been treated: Group I CMC 0.5% control (placebo), Group II positive control (Na-diclofenac), Group III, IV and V giving ethanolic extracts of L. camara dose 720, 1080 and 1440 mg/kg BW, respectively. The inflammation was produced by sub plantar injection of carrageenan suspension in the right hind paw of the rats. The quantitative data of Area under Curve of edema percentage were analyzed statistically with SPSS program using One-Way ANOVA followed by LSD test. The results showed that the highest constituents of saponins, flavonoids, and essential oils were found in the leaves. Ethanolic extracts of L. camara’s leaves dose 720 mg/kg BW had given the highest anti- inflammatory effects (38.1%).

The thiazolidin-4-one derivatives and the corresponding spiro compounds were synthesized from sulphanilamide and were evaluated for anti-inflammatory and analgesic activity in acute and sub acute models. Compounds were also evaluated for antipyretic and cyclooxygenase enzyme inhibitory activity. All the compounds showed significant antiinflammatory, analgesic and antipyretic activity at 100 mg/kg in all the models. The compounds B1, B2, B5, B6, and B8 showed maximum inhibition of COX-2 activity without inhibiting the COX-1 activity. The nimesulide was used as standard drug for comparison. The substitution at R, R(1) and R(2) with the functional groups Cl, OCH(3), NO(2) and OH in the aromatic ring resulted in increased activity as compared to unsubstituted thiazolidin-4-ones. However the substitution at R(3) with spiro group did not improve the activity. The study suggests that COX-2 binding site may not be a rigid structure but might adopt to various related molecules.

Inflammation is the human body's response to a tissue damage as indicated by an increase of vascular permeability. One of the natural substances that can be used to treat inflammation is clove oil (MABC). This study aimed to evaluate the physical properties and MABC emulgel irritation test ( S yzygium aromaticum ). This experimental study was initiated by the emulgel formulation with three kinds of formula, with each formula contains MABC levels of 10% (F1), 12.5% (F2), and 15% (F3). The physical tests for emulgel was done including pH, spreading test and adhesive test and irritation test in guinea pigs using Draize test method. Statistical analysis by t test with a level of confidence 95% was conducted to detect a significant differences between the treatment groups. The emulgel formula with a concentration of 10%, 12.5% and 15% were physically stable, moreover the dispersive power test for each formula showed normal distribution data (p>0.05) and homogeneous (p>0.05), ANOVA test results obtained significantly different results in each formula (p

Hladkykh F. V. Studying of antiinflammatory and analgesic effect of ibuprofen and its combination with vinboron on the model adjuvant arthritis in rats. Тези доповідей 84-ої науково-практичної конференції студентів та молодих вчених із міжнародною участю «Інновації в медицині»: тези доп. (12–13 березня 2015 р.). Івано-Франківськ, 2015. С. 160–161. It is known that non-steroidal antiinflammatory drugs (NSAIDs) have antiinflammatory effects of a wide spectrum - they are able to reduce the expression of inflammatory reaction of any etiology, location and nature of any leakage, inhibiting both processes exudation in acute inflammation and proliferative activity of fibroblasts in chronic inflammation. However, all members of this class of drugs are common so-called class-specific side effects. Therefore, one of the pressing problems of NSAID drug therapy is to increase their safety. PURPOSE: to provide a comparative assessment of anti-inflammatory and analgesic action of ibuprofen and its combination with vinboron in adjuvant arthritis in rats. MATERIALS AND METHODS The study was conducted on 28 mature male rats, divided into 4 groups: I - intact rats (n=7), II - rats with simulated adjuvant arthritis (AA) untreated (control), III - rats with AA (n=7), treated with ibuprofen (218 mg/kg), IV- rats with AA (n=7) treated with ibuprofen (218 mg/kg) in combination with vinboron (11 mg/kg). RESULTS AND DISCUSSION Treatment of AA combination with ibuprofen and vinboron led to a distinct anti-inflammatory effect of ibuprofen through potentiation of the pharmacological effect of both drugs. This is evidenced by statistically significant reduction of inflammatory reaction in damaged limbs of animals in the study group compared with the 14 day of experiment, and even more expressive suppression of the inflammatory response compared with monotherapy ibuprofen. Thus, combination therapy ibuprofen and vinboron resulted in statistically significant inhibition of the inflammatory response by 35.9% compared to day 14 of the experiment, which is 6% higher than the same indicator monotherapy ibuprofen. Also found that the most pronounced changes in pain threshold were recorded in the group of animals treated with a combination of ibuprofen and vinboron 14 days of the experiment. The increase pain threshold by 28 days of the experiment group combination with ibuprofen and vinboron statistically significantly higher than the corresponding figures twice as monotherapy ibuprofen and accounted for 15.9% and 39.2%. This shows the ability vinboron potentiate the analgesic effect of ibuprofen by the presence of his anti-inflammatory, analgesic and antispasmodic activity. CONCLUSIONS In assessing the results of the survey, it concludes that the combination of ibuprofen and vinboron inherent larger in size inflammatory and analgesic action in adjuvant arthritis in rats than monotherapy specified NSAID. This is evident increase in anti-inflammatory action of ibuprofen in the area of the damaged joint and increase pain threshold, through potentiation of the pharmacological effects of both drugs. Also mentioned combination improves safety of ibuprofen.

Objectives: The purpose of this study was to identify the possible effects of Hypericum Perforatum (HP) on the prevention of experimentally induced myringosclerosis (MS). Methods: Twenty eight Wistar Albino rats were used and they were divided into four groups. Tympanic membranes of all animals were perforated and then group I had no treatment as a control group, group II had treated with olive oil only, group III had treated with HP orally and group IV had treated with HP topically. Results: Groups I and II showed extensive myringosclerosis in contrast to those of Groups III and IV which had significantly less changes (p

Cocoa powder has twice more antioxidants than red wine and three times more than green tea. Ten prcent of its weight is made up of flavonoids. Cocoa has antioxidant and antiinflamatory effects by downregulating cyclooxigenase-2 receptors expression in the endothelium and enhancing nitric oxide bioavailability. There are evidences that while polyphenols ingestion have cardioprotective effects in the adult, it may have deleterious effect on the fetus if ingested by the mother on the third trimester of pregnancy, causing intrauterine fetal ductus arteriosus constriction.Polyphenols present in many foods and their anti-inflammatory and antinociceptive activities have been shown to be as or more powerful than those of indomethacin. These effects are dependent on the inhibition of modulation of the arachidonic acid and the synthesis of prostaglandins, especially E-2, which is responsible for fetal ductus arteriosus patency. So, we hypothesized that this same mechanism is responsible for the harmful effect of polyphenol-rich foods, such as cocoa, upon the fetal ductus arteriosus after maternal intake of such substances in the third trimester of pregnancy, thereby rising the perspective of a note of caution for pregnant women diet.

Os AINH (Antiinflamatórios não hormonais) são agentes utilizados na prática clínica que interferem no processo inflamatório pela inibição da síntese de prostaglandinas e tromboxanos. Alguns trabalhos experimentais investigaram sua ação no processo de consolidação de fraturas, por meio de estudos clínicos e histológicos, sendo escassas as análises biomecânicas. Nesse estudo foram utilizados 20 ratos da linhagem Wistar, divididos aleatoriamente em dois grupos iguais: grupo A (controle) e grupo B (tratado com diclofenaco sódico). Em ambos os grupos foram realizadas fraturas abertas, após perfuração, na tíbia direita. A administração da droga foi via intramuscular, dose única diária, por 28 dias. Os animais foram pesados semanalmente. Após o sacrifício as tíbias foram dissecadas, pesadas e submetidas a ensaio biomecânico de flexão analisando-se carga máxima, deformação e coeficiente de rigidez. Observou-se que no grupo tratado com AINH não houve aumento do peso corpóreo a partir da segunda semana e as tíbias fraturadas foram mais pesadas. Neste grupo o calo ósseo suportou menor carga máxima, apresentando maior deformação e menor coeficiente de rigidez. Nos animais tratados, o osso não fraturado também se mostrou menos rígido. Concluiu-se, nas condições estudadas, que o DS alterou o processo de consolidação e o metabolismo ósseo, levando a retardo na maturação do calo e menor rigidez do osso intacto, respectivamente.The antinflammatories are agents utilized on clinical practice that interfere on inflammatory process by synthesis inhibition of prostaglandin and tromboxanes. Some experimental studies investigated their action on the fractures consolidation process, through clinical and histological studies, as the biomechanical analyses are scarce. In this study, 20 (twenty) Wistar pedigree rats were used, aleatory divided into two groups: A group (control) and B group (treated with diclofenac). In both groups open fractures were made through perforation on right tibia. The drug administration was done intramuscularly in a single daily dose, during 28 (twenty-eight) days. The animals were weekly weighed. After the sacrifice the tibias were dissected, weighed and submitted to a biomechanical analysis of flexion and the maximum load, deformation and rigidity coefficient were measured. It was remarkable that the treated group with antinflammatory did not present body weight gain after the second week and the broken tibias were heavier. In this group the osseous callous supported less maximum load, presenting larger deformation and smaller rigidity coefficient. In the treated group, the non-fractured bone was also less rigid. Concluding, at this studied conditions, the diclofenac can interfere on the consolidation process and on the osseous metabolism, promoting a delay on the callous maturation and a smaller rigidity of the intact bone, respectively.

9-Chloro-2,4-(un)substituted acridines (1) on condensation with sulpha- diazine, sulphathiazole, and sulphaacetamide gave condensation products 3a-h. 3-Aryl-4-phenyl-2-imino-4-thiazolines (4) on condensation with 9-chloro-2,4-(un)substituted acridines (1) gave condensation products 5a–5o. Both 3a–3h and 5a–5o were purified by crystallization or by chromatography. Structures assigned to 3a–3h and 5a–5o are supported by correct spectral data. Antiinflammatory and analgesic activity screening of 3a, 3e, 3f and 5a–5c, 5e, 5g, 5i, 5m, 5n were carried out using carrageenin induced paw oedema and phenyl quinone writhing assay. Some of the compounds exhibited interesting antiinflammatory or analgesic activities.

Este trabalho investigou a margem de segurança do inibidor COX-2, meloxicam, em cães, enfocando seus efeitos deletérios nas células sangüíneas e no trato gastrintestinal. Para tanto, após uma avaliação clínico-laboratorial, os cães foram distribuídos nos seguintes grupos: I (placebo; n= 3), II (piroxicam; 1,0mg kg-1; n= 5), III (meloxicam; 0,2mg kg-1; n= 5), IV (meloxicam;1,0mg kg-1; n= 5) e V (meloxicam; 2,0mg kg-1; n= 5). Os fármacos foram usados, por via oral, por 16 dias. No 17º dia, repetiu-se o hemograma completo e, então, procedeu-se a eutanásia seguida pela necrópsia. No grupo I, não houve alterações dignas de nota. No grupo II, todos os cães apresentaram episódios moderados de vômito e diarréia. O perfil celular sangüíneo não foi significativamente modificado. Em dois cães, houve redução no hematócrito e na hemoglobina. Na necropsia, observaram-se focos hemorrágicos e lesões gastriduodenais moderadas. A análise microscópica revelou a presença de gastrite e enterite ulcerativa. No grupo III, quatro cães (80%) apresentaram vômito e diarréia, sem alteração no perfil celular sangüíneo. Na análise macroscópica, observaram-se lesões brandas na mucosa gástrica e focos hemorrágicos no duodeno em quatro cães. Na histopatologia, observaram-se lesões sugestivas de discreta gastroenterite. No grupo IV, os cinco cães tiveram vômito e diarréia sanguinolenta. Quatro deles (80%) apresentaram anemia (p < 0,05). Quatro e cinco cães apresentaram redução no hematócrito e hemoglobina, respectivamente. Ocorreram, ainda, leucocitose, neutrofilia e linfopenia significantes (p < 0,05), em 60% dos cães. Na necrópsia, evidenciaram-se hiperemia, hemorragia e úlceras gástricas severas em 100% dos animais. Verificou-se na microscopia um quadro de gastroenterite ulcerativa nos cinco cães. No grupo V, todos os cães apresentaram sérios episódios de vômito, diarréia e melena. Os quatro (80%) cães que suportaram o tratamento apresentaram anemia e leucocitose com neutrofilia e linfopenia significativas (p< 0,05). Houve, ainda, uma redução no hematócrito e hemoglobina desses cães. Na necropsia, foram visualizadas hemorragias e graves ulcerações gastroduodenais. À histopatologia, evidenciou-se severa gastroenterite. Conclui-se que o meloxicam, mesmo sendo COX-2 seletivo, induz efeitos deletérios no trato gastrintestinal e células sangüíneas de cães, quando administrado em concentrações cinco e dez vezes a dose terapêutica, que demonstram sua estreita margem de segurança nesta espécie.This study investigated the margin of safety of the COX-2e inhibitor, meloxicam on blood cells and gastrointestinal tract of dogs. After a clinical and laboratorial examination, the dogs were distributed in the following groups: I (placebo; n=3), II (piroxicam: 1.0mg kg-1; n=5), III (meloxicam: 0.2mg kg-1; n=5), IV (meloxican: 1.0mg kg-1; n=5) and V (meloxican: 2.0mg kg-1; n=5). The drugs were given orally for 16 days. On the 17th day the complete hemogram was repeated and the euthanasia and necropsy were then accomplished. In group I there were no significative alterations. In group II, all the dogs showed moderate episodes of vomit and diarrhea. The blood-cell profile was not modified. Two dogs had hematocrit and hemoglobin reduction. In the necropsy, hemorrhagic spots and moderate gastroduodenal lesions were seen. The microscopic analysis revealed the presence of gastritis and ulcerative enteritis. In group III, four dogs (80%) showed vomit and diarrhea, without alteration in blood-cell profile. The microscopic analysis showed mild lesions in the gastric mucosa and hemorrhagic spots in the duodenum of four dogs. Histology showed lesions suggesting mild gastroenteritis. In group IV, all the dogs (n=5) showed vomit and blood diarrhea. Four of them showed anemia (p

Submitted by Boris Flegr (boris@uerj.br) on 2021-01-07T15:06:04Z No. of bitstreams: 1 DISSERTACAO_FINAL_DIEGO_JUNIOR_SILVA_SANTOS.pdf: 909459 bytes, checksum: 5a3671188bf53eea8e4c5714a2078e33 (MD5) Made available in DSpace on 2021-01-07T15:06:04Z (GMT). No. of bitstreams: 1 DISSERTACAO_FINAL_DIEGO_JUNIOR_SILVA_SANTOS.pdf: 909459 bytes, checksum: 5a3671188bf53eea8e4c5714a2078e33 (MD5) Previous issue date: 2014-01-28 Conselho Nacional de Desenvolvimento Científico e Tecnológico The aim of this study was to evaluate the pain perception after orthodontics adjustment by visual analogue scale questionaires. Thus, were compared the analgesic effect of ibuprofen, acetaminophen, placebo and chewing gum. The initial hypothesis was that ibuprofen, acetaminophen, and chewing gum would be more effective than placebo in controlling orthodontic pain and that chewing gum could be an effective alternative to the use of ibuprofen and acetaminophen in the management of dental pain of orthodontic origin. Patients were randomly assigned to one of five groups: placebo, acetaminophen 500 milligrams, ibuprofen 400 mg, chewing gum and control. All subjects had brackets with slots .022 bonded to their teeth and banded molars in one of the arches. The placebo, ibuprofen and acetaminophen groups were instructed to take 1 capsule of the respective compound shortly after the insertion of the initial .014" nickel-titanium arch and every 6 hours for a week if the pain persisted, the chewing gum group was instructed to chew a stick of gum for 5 minutes immediately after insertion of the initial arch of nickel-titanium .014 dimension and every 6 hours for 5 minutes for a week if the pain persisted and the control group received no method of pain control. The subjects were instructed to mark the visual analogue scales in the first 24 hours, at 9am, 1pm, 5 pm and 9 pm their perception of spontaneous pain and pain during chewing. From the third to the twenty-first day the markings were made only at two times: 9:00 and 21:00. According to the descriptive statistics analysis, placebo was more effective than ibuprofen, acetaminophen and chewing gum in the control of orthodontic pain in both spontaneous pain and in pain during masticatory function. Chewing gum was as effective as acetaminophen in the control of spontaneous pain 24 hours after initial arch insertion. For pain relief during masticatory function, the chewing gum can be an alternative to ibuprofen and acetaminophen in the control of orthodontic pain. O objetivo deste trabalho foi avaliar através de questionários de escalas visuais analógicas a percepção da dor após a inserção do primeiro arco ortodôntico, comparando-se o efeito analgésico de ibuprofeno, acetaminofeno, placebo e goma de mascar. Este trabalho também partiu da hipótese de que ibuprofeno, acetaminofeno e gomas de mascar seriam mais eficazes que placebo no controle da dor de origem ortodôntica e que gomas de mascar poderiam ser uma alternativa ao uso de ibuprofeno e acetaminofeno no manejo da dor dentária de origem ortodôntica. Neste estudo, tomaram parte 41 pacientes da Clínica de Ortodontia da Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro. Os pacientes foram aleatoriamente distribuídos em cinco diferentes grupos: placebo, acetaminofeno 500 miligramas, ibuprofeno 400 miligramas, goma de mascar e controle. Todos os indivíduos tiveram bráquetes com slots .022" colados em seus dentes e molares bandados em uma das arcadas. Os grupos placebo, ibuprofeno e acetaminofeno foram orientados a tomar 01 cápsula do respectivo composto logo após a inserção do arco inicial de liga de níquel-titânio de dimensão .014 e, se a dor persistisse, a cada 6 horas por uma semana.O grupo goma de mascar foi orientado a mascar um tablete de goma por 5 minutos imediatamente após a inserção do arco inicial de liga de níquel-titânio de dimensão .014 e a cada 6 horas por 5 minutos durante uma semana, caso a dor persistisse. O grupo controle recebeu nenhum método de controle da dor. Os indivíduos foram orientados a marcar nas escalas visuais analógicas nas primeiras 24 horas, às 09:00, 13:00, 17:00, 21:00 a percepção de dor espontânea e durante a mastigação. Do terceiro até o vigésimo primeiro dia as marcações foram feitas somente em dois tempos às 09:00 e 21:00. Através da análise estatística descritiva, concluiu-se que o placebo foi mais eficiente que ibuprofeno, acetaminofeno e goma de mascar no controle da dor ortodôntica, tanto em dor espontânea quanto em dor durante a mastigação. O grupo goma de mascar foi tão eficiente quanto o acetaminofeno no controle da dor espontânea 24 horas após a inserção do arco inicial. Para alívio da dor durante a mastigação, a goma de mascar pode ser uma alternativa à atuação medicamentosa no controle da dor ortodôntica.

Ethnopharmacological relevance Vast numbers of plant species from northeastern Brazil have not yet been phytochemically or biologically evaluated. Aim of the study The goal of this work was to obtain, characterize and show the antimicrobial, analgesic and anti-inflammatory activities of aqueous and acetone–water extracts of Libidibia ferrea, Parapiptadenia rigida and Psidium guajava. Materials and methods The plant material (100 g) was dried, and the crude extracts were obtained by using turbo-extraction (10%; w/v) with water or acetone:water (7:3, v/v) as the extraction solvent. High-performance liquid chromatography (HPLC) methods were used to screen the crude extracts for hydrolysable tannins (gallic acid) and condensed tannins (catechins). The antibacterial activity was evaluated by agar-diffusion and microdilution methods against Gram-positive strains (Staphylococcus aureus ATCC 25923, Staphylococcus epidermidis INCQS 00016, Enterococcus faecalis ATCC 29212 and a clinical isolate of methicillin-resistant Staphylococcus aureus) as well as Gram-negative strains (Escherichia coli ATCC 25922, Salmonella enteritidis INCQS 00258, Shigella flexneri and Klebsiella pneumoniae). To evaluate the anti-inflammatory activity, a leukocyte migration model was used. Analgesic activity was determined by the hot plate test and the acetic acid-induced abdominal writhing test. Data were analyzed by analysis of variance (ANOVA) at a significance level of 5%. Results Parapiptadenia rigida presented the highest amount of total polyphenols (35.82±0.20%), while the greatest catechin content was found in the acetone–water extract of Psidium guajava (EAWPg; 1.04 μg/g). The largest amounts of catechins were found in the aqueous extract of Libidibia ferrea (EALf; 1.07 μg/g) and the acetone–water extract of Parapiptadenia rigida (EAWPr; 1.0 μg/g). All extracts showed activity against Gram-positive bacteria. The aqueous and acetone–water extracts of Psidium guajava showed the greatest inhibition zones in the agar diffusion tests. In the evaluation of the minimum inhibitory concentration (MIC), the most susceptible Gram-positive bacterium was Staphylococcus epidermidis and the most susceptible Gram-negative bacterium was Shigella flexneri. EAPg and EAWPg showed the greatest MIC values. All extracts were significant inhibitors of leukocyte migration (p

No abstract available. Article truncated at 150 words. As we enter the influenza season, Ivan et al. (1) are reporting in Chest that oseltamivir-clarithromycin-naproxen combination for treatment of serious influenza results in reduced mortality, less frequent ICU admission, and shorter hospital-stay compared to oseltamivir alone. From February to April 2015, the authors conducted a prospective open-label randomized-controlled trial. Adult patients hospitalized for A(H3N2) influenza were randomly assigned to a 2-day combination of clarithromycin 500mg, naproxen 200mg and oseltamivir 75mg twice daily, followed by 3 days of oseltamivir; or oseltamivir 75mg twice daily for 5 days as control (1:1). Among the 217 influenza A(H3N2) patients enrolled, 107 were randomly assigned to the combination treatment. Ten patients succumbed during the 30-day follow-up. The combination treatment was associated with lower 30-day mortality (p=0.01), less frequent ICU/HDU admission (p

The antiinflammatory activity of the polyherbal formulation Entox(®) was investigated in rats for acute and sub acute models of inflammation using carrageenan-induced rat paw edema and cotton pellet granuloma methods respectively at a dose of 300 mg/kg and 600 mg/kg administered orally. The formulation in doses of 300 mg/kg and 600 mg/kg showed 51.61% and 54.84% inhibition of paw edema, respectively at the end of 3 h. The percent inhibition of granuloma by cotton pellet method was 27.92% and 53.17%, respectively. The formulation showed a significant antiinflammatory activity in both the experimental models and the activity was comparable to that of the standard drug, indomethacin.

Cinnamon bark (Cinnamomum zeylanicum Syn C. verum, family: Lauraceae) is one of the oldest traditional medicines for inflammatory- and pain-related disorders. The objective of the present study was to evaluate the efficacy of the polyphenol fraction from Cinnamomum zeylanicum bark (CPP) in animal models of inflammation and rheumatoid arthritis. Dose-response studies of CPP (50, 100, and 200 mg/kg) used in a separate set of in vivo experiments were conducted in acute (carrageenan-induced rat paw edema), subacute (cotton pellet-induced granuloma), and sub-chronic (AIA, adjuvant-induced established polyarthrtis) models of inflammation in rats and the acetic acid-induced writhing model of pain in mice. Effects of CPP on cytokine (IL-2, IL-4, and IFNγ) release from Concanavalin (ConA)-stimulated lymphocytes were also evaluated in vitro. CPP showed a strong and dose-dependent reduction in paw volume, weight loss reversal effects against carrageenan-induced paw edema, and cotton pellet-induced granuloma models in rats. CPP (200 mg/kg p.o. for 10 days) showed a significant reduction in elevated serum TNF-α concentration without causing gastric ulcerogenicity in the AIA model in rats. CPP also demonstrated mild analgesic effects during acute treatment as evidenced by the reduction in the writhing and paw withdrawal threshold of the inflamed rat paw during the acetic acid-induced writhing model and Randall-Selitto test. CPP was found to inhibit cytokine (IL-2, IL-4, and IFNγ) release from ConA-stimulated lymphocytes in vitro. In conclusion, CPP demonstrated prominent action in animal models of inflammation and arthritis and therefore can be considered as a potential anti-rheumatic agent with disease-modifying action.

Lichens produce variety of secondary metabolites including depsides, depsidones and dibenzofurans having multifunctional activity in response to external environmental condition. Present study provides evidence for in vitro antibacterial and in vivo antiinflammatory activity of acetone and ethanol extracts of Parmotrema reticulatum. In vitro antibacterial activity was investigated against gram positive and gram negative bacteria. Cotton pellet-induced granuloma, xylene-induced ear swelling, carragennan-induced edema, histamine-induced and carboxymethylcellulose sodium-induced leukocyte emigration in mice models were used to quantify the antiinflammatory activity. Acetone and ethanol extracts were showed antibacterial activity against Bacillus subtilis (minimal inhibitory concentration: 100 and 150 μg/ml) and Staphylococcus aureus (minimal inhibitory concentration: 100 and 200 μg/ml), Escherichia coli (minimal inhibitory concentration: 200 and 250 μg/ml), and Pseudomonasa eruginosa (minimal inhibitory concentration: 200 and 300 μg/ml). Acetone extract was inhibited edema significantly at 200 mg/kg with xylene, cotton pellet, carragennan and histamine induced edema in vivo models. Ethanol extract was found effective at dose of 300 mg/kg with all in vivo antiinflammatory models. The results showed significant (P

We investigated the in vitro anti-inflammatory activity of 1(10),4-furanodien-6-one, one the most active compounds of the hexane extract of Commiphora erythraea (Ehrenb.) Engl., by exposing microglial BV-2 cells to lipopolysaccharide. We showed that furanodien-6-one pre-treatment restored cell viability and ROS to control levels while halving NO generation. Production of pro-inflammatory IL-6, IL-23, IL-17, TGF-β, and INF-γ, significantly induced by LPS, was also markedly reduced by furanodien-6-one treatment. We further showed that furanodien-6-one protects primary neuronal cultures against the inflammatory/toxic insults of LPS-treated BV-2 conditioned media, indicating that furanodien-6-one exerts anti-inflammatory/cytoprotective effects in neuronal cells. We then investigated whether furanodien-6-one exerts anti-inflammatory properties in an in vivo model of microglial activation. In adult mice ip-injected with LPS we found that furanodien-6-one had strong cerebral anti-inflammatory properties by inhibiting liver and brain TNFα as well as IL-1β expression. Results were not unexpected since FTIR-metabolomic analyses showed that furanodien-6-one-treated mice had a reduced dissimilarity to control animals and that the response to LPS treatment was markedly modified by furanodien-6-one. In conclusion our data provide strong evidence of the anti-inflammatory properties of furanodien-6-one that could be exploited to counteract degenerative pathologies based on neuroinflammation.

Background: Ginger (Zingiber officinale Rosc.) belongs to the family Zingiberaceae. The health-promoting perspective of ginger is attributed to its rich phytochemistry. This study aimed to review the current evidence on ginger effects as an anti-inflammatory and anti-oxidative. Methods: We searched MEDLINE for related publications using “ginger” and “anti-oxidative” and “ginger” and “anti-inflammatory” as keywords. This search had considered Papers that had been published between 2000 and 2010 without any filter. Conclusions: The anticancer potential of ginger is well documented and its functional ingredients like gingerols, shogaol, and paradols are the valuable ingredients which can prevent various cancers. This review concludes to favor ginger but some ambiguities necessitate further research before claiming its efficacy.

New series of N-[3-(1H-6-nitroindazol-1-yl)-propyl]-2-(substituted phenyl)-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine-carboxamide, compounds 5(a-j) have been synthesized from 6-nitroindazole. Structures of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass. All the synthesized compounds were screened for their antibacterial, antifungal, antitubercular and antiinflammatory activities.

Made available in DSpace on 2017-07-24T19:22:20Z (GMT). No. of bitstreams: 1 Ligia Nadal Zardo.pdf: 1622548 bytes, checksum: c53861afcded6ded4873acf4121bba9f (MD5) Previous issue date: 2012-02-28 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior The aim of this study was to compare the use of etoricoxib and dexamethasone for the prevention and control of postoperative pain in mucogingival surgery. Fifty-eight patients took part in this randomized parallel double- blind clinical trial. Patients who had at least one area with indication for mucogingival surgery, such as narrow width and thickness of keratinized tissue, labial frenum with an insertion close to the gingival margin, shallow depth of the vestibule and Miller`s Class I and II gingival recession with aesthetic complain were included in the study and were randomly divided into 3 groups (G): G1 – placebo 1h before surgery; G2 – 8mg dexamethasone 1h before surgery; G3 – 90mg etoricoxib 1h before surgery. Pain intensity was assessed in the donor and receptor area separately using the numerical rating scale NRS – 101, every hour for the first 8 hours after surgery and three times a day within 3 days. Rescue medication (paracetamol 750mg) was provided to be used in case of pain. The results showed that there was a statistically significant difference in the intensity of postoperative pain in the donor region between G1 and G3 after 1 hour (h), 2h, 3h, 7h, 8h and in the second day evening; between G1 and G2 after 2h and 3h, and between G2 e G3 only after the first hour. Pain intensity in the receptor area was statistically significantly between G1 and G3 after 1 and 2 hours (Kruskall-Wallys and LSD pos-test ; p