Search

In this paper, a compact six-channel diplexer with low insertion loss and high isolation level is presented. The diplexer consists of two tri-band bandpass filters (BPFs), two meander transmission lines and hookshaped feeding lines. The BPFs are designed based on stub-loaded stepped impedance resonators (SLSIRs). Based on even- and odd-mode (EOM) analysis of the resonator, there are two resonant modes that operate at the same frequency. For splitting the two modes, stubstub coupling is employed here. The combination of the two BPFs is implemented by utilizing two meander transmission lines as the impedance matching network. Finally the proposed diplexer operating at 1.46/1.74/2.96 GHz (for Load 1) and 0.89/1.15/2.40 GHz (for Load 2) is fabricated and measured. A good agreement between simulated and measured results evidently validates the proposed diplexer. [ABSTRACT FROM AUTHOR]

As new generations of targeted therapies emerge and tumor genome sequencing discovers increasingly comprehensive mutation repertoires, the functional relationships of mutations to tumor phenotypes remain largely unknown. Here, we measured ex vivo sensitivity of 246 blood cancers to 63 drugs alongside genome, transcriptome, and DNA methylome analysis to understand determinants of drug response. We assembled a primary blood cancer cell encyclopedia data set that revealed disease-specific sensitivities for each cancer. Within chronic lymphocytic leukemia (CLL), responses to 62% of drugs were associated with 2 or more mutations, and linked the B cell receptor (BCR) pathway to trisomy 12, an important driver of CLL. Based on drug responses, the disease could be organized into phenotypic subgroups characterized by exploitable dependencies on BCR, mTOR, or MEK signaling and associated with mutations, gene expression, and DNA methylation. Fourteen percent of CLLs were driven by mTOR signaling in a non-BCR-dependent manner. Multivariate modeling revealed immunoglobulin heavy chain variable gene (IGHV) mutation status and trisomy 12 as the most important modulators of response to kinase inhibitors in CLL. Ex vivo drug responses were associated with outcome. This study overcomes the perception that most mutations do not influence drug response of cancer, and points to an updated approach to understanding tumor biology, with implications for biomarker discovery and cancer care. [ABSTRACT FROM AUTHOR]

Hairy cell leukemia (HCL) is marked by near 100% mutational frequency of BRAFV600E mutations. Recurrent cooperating genetic events that may contribute to HCL pathogenesis or affect the clinical course of HCL are currently not described. Therefore, we performed whole exome sequencing to explore the mutational landscape of purine analog refractory HCL. In addition to the disease-defining BRAFV600E mutations, we identified mutations in EZH2, ARID1A, and recurrent inactivating mutations of the cell cycle inhibitor CDKN1B (p27). Targeted deep sequencing of CDKN1B in a larger cohort of HCL patients identify deleterious CDKN1B mutations in 16% of patients with HCL (n = 13 of 81). In 11 of 13 patients the CDKN1B mutation was clonal, implying an early role of CDKN1B mutations in the pathogenesis of HCL. CDKN1B mutations were not found to impact clinical characteristics or outcome in this cohort. These data identify HCL as having the highest frequency of CDKN1B mutations among cancers and identify CDNK1B as the second most common mutated gene in HCL. Moreover, given the known function of CDNK1B, these data suggest a novel role for alterations in regulation of cell cycle and senescence in HCL with CDKN1B mutations. [ABSTRACT FROM AUTHOR]

• A near-infrared of 2.3 μm based in-situ, real-time and continuous carbon monoxide (CO) sensor. • The laser absorption spectroscopy-based equipment is proposed for the exhaust pipeline of furnace. • The CO content measured by this equipment can next be used to achieve high-efficiency combustion control with close to theoretical ratios. • The near-infrared based sensor for CO showed great applicability and potential for exhaust pipeline and combustion control systems. Carbon monoxide (CO) is a ubiquitous atmospheric trace gas produced by natural and anthropogenic sources. It can be used as a quantitative marker to help us understand the different production processes. A near-infrared laser absorption spectroscopy of 2.3 μm based in-situ, real-time and continuous CO sensor equipment is developed for the exhaust pipeline of furnace. High sensitivity is accomplished utilizing the ratio between the second and first harmonic signals detection (WMS-2f/1f). The analyzer is housed in an explosion-proof enclosure and installed at both sides of the pipeline with a diameter of 2.1 m. The measured gas temperature inside the pipeline reaches around 400 K. The results primarily show a more linear response and less error, the measurement precision and the minimum detection limit are 0.42 ppm and 1.29 ppm (1σ), simultaneously. Evaluation of the data suggested a dynamic range from 3.87 ppm to 1.3% based on the 3σ rule and maximum absorbance of one. An operator can analyze the industrial production process clearly, that is, the measured CO concentration is negatively correlated with excess oxygen (O 2) by observing the measurement results within 10 h. Meanwhile, the measurements of the real targets show that the sensor has great applicability and potential for exhaust pipeline and combustion control systems. [ABSTRACT FROM AUTHOR]

We demonstrate experimentally the existence of magic wavelengths and determine the ratio of oscillator strengths for a single trapped ion. For the first time, two magic wavelengths near 396 nm for the ^{40}Ca^{+} clock transition are measured simultaneously with high precision. By tuning the applied laser to an intermediate wavelength between transitions 4s_{1/2}→4p_{1/2} and 4s_{1/2}→4p_{3/2}, the sensitivity of the clock transition Stark shift to the oscillator strengths is greatly enhanced. Furthermore, with the measured magic wavelengths, we determine the ratio of the oscillator strengths with a deviation of less than 0.5%. Our experimental method may be applied to measure magic wavelengths for other ion clock transitions. Promisingly, the measurement of these magic wavelengths paves the way to building all-optical trapped ion clocks.