601. Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials.
- Author
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Zhang XW, Hou WS, Li M, and Tang ZY
- Subjects
- Aged, Humans, Intelligence Tests, Randomized Controlled Trials as Topic, Risk Factors, Treatment Outcome, Cognition Disorders diagnosis, Cognition Disorders metabolism, Cognition Disorders prevention & control, Fatty Acids, Omega-3 metabolism, Fatty Acids, Omega-3 pharmacology
- Abstract
Evidence has demonstrated that omega-3 fatty acids intake may be associated with age-related cognitive decline. However, randomized controlled trials (RCTs) have drawn inconsistent conclusions. We performed a meta-analysis to assess the association between omega-3 fatty acids and risk of cognitive decline in the elderly. A strategic literature search of PubMed, EMBASE, and Cochrane Library (updated to December 2014) was performed. We retrieved six randomized controlled studies as eligible for our meta-analysis. Among these six studies, the duration time ranged from 3 to 40 months. The dose of omega-3 fatty acids (DHA + EPA) ranged from 400 to 1800 mg. The result of our meta-analysis expressed that omega-3 fatty acids statistically decrease the rate of cognitive decline in MMSE score (WMD = 0.15, [0.05, 0.25]; p = 0.003). In conclusion, our meta-analysis indicated that omega-3 fatty acids may help to prevent cognitive decline in the elderly.
- Published
- 2016
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