501. Effects of pentobarbital and ketamine on brain injury-induced anti-ischemic activity.
- Author
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Shimoji K, Takahata Y, Fujiwara N, Endoh H, Taga K, and Ohama E
- Subjects
- Anesthesia, Animals, Brain Injuries complications, Brain Ischemia complications, Male, Mice, Time Factors, Brain Injuries physiopathology, Brain Ischemia physiopathology, Cerebrovascular Circulation drug effects, Ketamine pharmacology, Pentobarbital pharmacology
- Abstract
Survival rates following incomplete brain ischemia induced during pentobarbital anesthesia were significantly higher in mice with a minor brain injury, inflicted one week before, than in those given a sham operation. Improvement of the survival rates in mice with brain injury, however, became insignificant when brain ischemia was imposed during ketamine anesthesia, suggesting that the actions of certain factors or protective mechanisms against brain ischemia, developed by brain injury, are antagonized by ketamine and/or potentiated by barbiturate anesthesia.
- Published
- 1987
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