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Selection of high-quality sperm is critical to the success of assisted reproductive technologies. Clinical screening for top sperm has long focused on sperm swimming ability when following boundaries or when fully free of constraints. In this work, we demonstrate a sperm selection approach with parallel 2 μm tall confined selection channels that prohibit rotation of the sperm head and require planar swimming. We demonstrate that a planar swimming subpopulation of sperm capable of entering and navigating these channels has DNA integrity superior to the freely-swimming motile or raw sperm populations over a wide range of semen sample qualities. The DNA integrity of the selected sperm was significantly higher than that of the corresponding raw samples for donor samples and clinical patient samples, respectively. In side-by-side testing, this method outperforms current clinical selection methods, density gradient centrifugation and swim-up, as well as sperm selected via general motility. Planar swimming represents a viable sperm selection mechanism with the potential to improve outcomes for couples and offspring. [ABSTRACT FROM AUTHOR]

Accurately calibrated and characterised x-ray diagnostics are a key requirement in the fielding of experiments on the Orion laser where absolute measurements of x-ray emission are used to underpin the validity of models of emissivity and opacity. Diffraction crystals are used in spectrometers on Orion to record the dispersed spectral features emitted by the laser produced plasma to obtain a measurement of the plasma conditions. The ability to undertake diffraction crystal calibrations supports the successful outcome of these Orion experiments. This paper details the design and commissioning of a system to undertake these calibrations in the energy range 2.0 keV to approximately 8.5 keV. Improvements to the design are detailed which will extend the commissioned range of energies to below 1 keV. [ABSTRACT FROM AUTHOR]

Accurate simulation of multiphase flow in fractured porous media remains a challenge. An important problem is the representation of the discontinuous or near discontinuous behaviour of saturation in real geological formations. In the classical continuum approach, a refined mesh is required at the interface between fracture and porous media to capture the steep gradients in saturation and saturation-dependent transport properties. This dramatically increases the computational load when large numbers of fractures are present in the numerical model. A discontinuous finite element method is reported here to model flow in fractured porous media. The governing multiphase porous media flow equations are solved in the adaptive mesh computational fluid dynamics code IC- FERST on unstructured meshes. The method is based on a mixed control volume - discontinuous finite element formulation. This is combined with the P N+1 DG- P N DG element pair, which has discontinuous (order N+1) representation for velocity and discontinuous (order N) representation for pressure. A number of test cases are used to evaluate the method's ability to model fracture flow. The first is used to verify the performance of the element pair on structured and unstructured meshes of different resolution. Multiphase flow is then modelled in a range of idealised and simple fracture patterns. Solutions with sharp saturation fronts and computational economy in terms of mesh size are illustrated. [ABSTRACT FROM AUTHOR]

Purpose – This paper aims to present the quantitative results based on a comparison and evaluation of older people's experiences, needs and wants from their current kitchens, combining and comparing the results obtained from two studies conducted in 2000 and 2010 to see what progress has been made. Design/methodology/approach – A study in 2010 investigated the life-long and contemporary experiences of kitchens of 48 people aged over 60 years of age. The research included detailed questionnaire interviews asking people about their experiences of living in their current kitchen. A previous study, conducted in 2000, asked many of the same questions of 22 people in the same age group. Findings – By combining and comparing the two sets of data it seems that only limited progress has been made in terms of kitchen design meeting the needs of older people between 2000 and 2010. Research limitations/implications – Owing to the small sizes of the samples it is not possible to compare the figures statistically or present them as fully representative of the British older population but while the two samples are limited both had similar characteristics of age and gender, so differences do show potential trends over time. Practical implications – The research refers to guidance and a computer based design tool and identifies a number of practical implications for design. Social implications – As people age their abilities and needs can change and their kitchen may no longer be as accessible or appropriate to their needs. Originality/value – This paper adds to the relevant guidance for designers, developers and managers of buildings where the continued personal use of a kitchen is important for continuing independence of older people. [ABSTRACT FROM AUTHOR]

We report the serendipitous discovery of the Sloan Digital Sky Survey (SDSS) star SDSS J160043.6+074802.9 to be a very rapid pulsator. The variation is dominated by a frequency near 8380 μHz (period = 119.33 s) with a large amplitude (0.04 mag) and its first harmonic at 16760 μHz (59.66 s; 0.005 mag). In between these frequencies, we find at least another eight variations with periods between 62 and 118 s and amplitudes between about 0.007 and 0.003 mag; weaker oscillations might also be present. Preliminary spectrograms from the performance verification phase of the Southern African Large Telescope indicate that SDSS J160043.6+074802.9 is a spectroscopic binary consisting of an sdO star and a late-type main-sequence companion. This makes it the first unambiguous detection of such an sdO star to pulsate, and certainly the first found to exhibit multifrequency variations. [ABSTRACT FROM AUTHOR]

New field work, U–Pb ages, geochemical data, and Sm–Nd isotopic analyses have established the timing and determined the nature of volcanism, deformation, and tectonic assembly of the Pickle Lake greenstone belt in the Uchi subprovince of the western Superior Province of the Canadian Shield. The >2860 Ma Pickle Crow assemblage has been redefined to include the former Northern Pickle assemblage on the basis of stratigraphic continuity and similar volcanic geochemistry between the two units across a previously inferred fault contact. The Pickle Crow assemblage consists of tholeiitic basalt with thin, but laterally extensive, oxide-facies iron formation overlain by alkalic basalts and minor calc-alkaline andesites to dacites with primitive Nd isotopic compositions (εNd2.89 Ga = +2.1 to +2.4) suggestive of deposition in a sediment-starved oceanic basin. The ~2 km thick ~2836 Ma Kaminiskag assemblage (former Woman assemblage) consists of tholeiitic basalt interbedded with intermediate and rare felsic pyroclastic flows with primitive Nd isotopic compositions (εNd2.836 Ga = +2.4). Two samples of intermediate volcanic rocks interbedded with southeast-younging pillowed basalt, previously inferred to be part of the Pickle Crow assemblage, yielded U–Pb zircon ages of 2744 Ma and 2729 ± 3 Ma. These rocks are thus part of the younger Confederation assemblage, which consists of intercalated basalt and dacite (εNd2.74 Ga = +0.1 to +0.8) exhibiting diverse compositions probably reflecting eruption in a continental margin arc to back-arc setting. The contact between the Confederation and Kaminiskag assemblages is assumed to be a fault. The greenstone belt is intruded by late syn- to posttectonic plutons including the composite quartz dioritic to gabbroic July Falls stock with a new U–Pb zircon age of 2749 Ma, and the ~2741 to 2740 Ma trondhjemitic to granodioritic Ochig Lake pluton and Pickle Lake stock, as well as the ~2697 to 2716 Ma Hooker–Burkoski stock. The earliest recognized deformation (D1) is recorded by a local bedding-parallel foliation in the Pickle Crow assemblage. This foliation is truncated by the ~2735 Ma Albany quartz–feldspar porphyry dyke and is not recognized in the volcanic rocks of the Confederation assemblage. The early deformation event is attributed to overturning of the Pickle Crow assemblage prior to deposition of the ~2744 to 2729 Ma Confederation assemblage. Subsequent deformation and development of a regionally penetrative planar fabric (S2) postdates ~2729 Ma volcanism, pre-dates the intrusion of the ca. <2716 Ma Hooker–Burkoski stock and is host to gold mineralization. [ABSTRACT FROM AUTHOR]