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664 results on '"Michael Butler"'

652. Frisch: Andorra

Author

Calvin N. Jones and Michael Butler

Published
1987

654. Dear Lois

Author

Jones, Michael Butler

Published
1978

655. Extracting Symbolic Transitions from $TLA+$ Specifications

Author

Jure Kukovec, Thanh-Hai Tran, Igor Konnov, Vienna University of Technology (TU Wien), Modeling and Verification of Distributed Algorithms and Systems (VERIDIS), Max-Planck-Institut für Informatik (MPII), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft-Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Formal Methods (LORIA - FM), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Proof-oriented development of computer-based systems (MOSEL), Department of Formal Methods (LORIA - FM), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria), Supported by the Vienna Science and Technology Fund (WWTF) through project APALACHE (ICT15-103) and the Austrian Science Fund (FWF) through Doctoral College LogiCS (W1255-N23)., Michael Butler, Alexander Raschke, Thai Son Hoang, Klaus Reichl, Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Discrete mathematics, Model checking, Successor cardinal, Programming language, Computer science, Contrast (statistics), [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], 020207 software engineering, System requirements specification, 02 engineering and technology, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], 16. Peace & justice, computer.software_genre, Satisfiability, model checking, Variable (computer science), TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, TLA+, 020204 information systems, 0202 electrical engineering, electronic engineering, information engineering, State (computer science), computer, Software, Logical formula
Abstract

In , a system specification is written as a logical formula that restricts the system behavior. As a logic, does not have assignments and other imperative statements that are used by model checkers to compute the successor states of a system state. Model checkers compute successors either explicitly — by evaluating program statements — or symbolically — by translating program statements to an SMT formula and checking its satisfiability. To efficiently enumerate the successors, TLA's model checker TLC introduces side effects. For instance, an equality x ′ = e is interpreted as an assignment of e to the yet unbound variable x. Inspired by TLC , we introduce an automatic technique for discovering expressions in formulas such as x ′ = e and x ′ ∈ { e 1 , … , e k } that can be provably used as assignments. In contrast to TLC , our technique does not explicitly evaluate expressions, but it reduces the problem of finding assignments to the satisfiability of an SMT formula. Hence, we give a way to slice a formula in symbolic transitions, which can be used as an input to a symbolic model checker. Our prototype implementation successfully extracts symbolic transitions from a few benchmarks.

Published
2018

656. Agriculture and agro-Industrial wastes, byproducts, and wastewaters: origin, characteristics, and potential in bio-based-compounds production

Author

PETRUCCIOLI M., RAVIV M., DI SILVESTRO, RAFFAELLA, DINELLI, GIOVANNI, MURRAY MOO-YOUNG, MICHAEL BUTLER, COLIN WEBB, ANTONIO MOREIRA, BERNARD GRODZINSKI, Z F CUI & SPIROS AGATHOS, PETRUCCIOLI M., RAVIV M., DI SILVESTRO R., and DINELLI G.

Subjects
biorefinery, green chemistry, biofuel, white biotechnology, multifunctional food ingredient, fine chemical, valorization, bio-based compound
Abstract

A survey of the origin, characteristics and possible re-uses of various agriculture and agro-industrial wastes and wastewaters is given. By-products and effluents often contain substances of high-added value that can be directly recovered or can represent a zero- or low-cost substrate for fermentation processes aimed at producing bio-fuels or bio-molecules of actual or potential commercial interest. At first, focus has been put on the general upgrading criteria and strategies. Then, a number of examples have been reported and examined concerning wastes and wastewaters such as residual agricultural and agro-industrial biomasses, relevant effluents (i.e., slaughterhouse, winery and starch industry wastewaters and whey) and by-products of the olive-oil extraction industry.

Published
2011

657. Quest for novel muscle pathway biomarkers by proteomics in beef production

Author

Brigitte Picard, Nicolas Guillemin, Muriel Bonnet, Isabelle Cassar-Malek, Unité de Recherches sur les Herbivores (URH), Institut National de la Recherche Agronomique (INRA), Murray Moo-Young, Michael Butler, Colin Webb, Antonio Moreira, Bernard Grodzinski, Z.F. Cui, and Spiros Agathos

Subjects
[SDV.BIO]Life Sciences [q-bio]/Biotechnology, Antibody microarray, Computational biology, Biology, Bioinformatics, Proteomics, beef quality, Muscle hypertrophy, 03 medical and health sciences, proteomics, medicine, 030304 developmental biology, 0303 health sciences, tendreté, Myogenesis, 0402 animal and dairy science, Skeletal muscle, biomarkers, 04 agricultural and veterinary sciences, 040201 dairy & animal science, 3. Good health, Tenderness, medicine.anatomical_structure, tenderness, Identification (biology), myogenesis, medicine.symptom
Abstract

International audience; Proteomics constitutes a useful tool for the study of protein from cells or tissues. The main techniques are based on the separation of proteins by electrophoresis or chromatography and their identification by mass spectrometry. This approach, combined with the use of bioinformatics tools, allows the construction of functional interactomes. During the last few years, proteomics was in a phase of expansion in medicine, pharmacology, and agronomy. In this article, we will focus on proteomics as applied to beef production. Protein maps of cattle skeletal muscle have been constructed, and comparative proteomics has provided new insights into the knowledge of muscle development and its regulation. New pathways involved in the origin of muscle hypertrophy have been identified. Proteomics also allowed to providing a list of markers of beef tenderness, which will be used in the conception of immunological tools such as antibody microarray, applied in the evaluation of the tenderness potential of cattle. The use of bioinformatics tools allowed a better knowledge of the functional mechanisms at the origin of beef tenderness.

Published
2011

658. A Rodin plugin for quantitative timed models

Author

Rehm, Joris, Proof-oriented development of computer-based systems (MOSEL), INRIA Lorraine, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Michael Butler and Stefan Hallerstede and Laurent Voisin, and ANR-06-SETI-0015,RIMEL,Raffinement Incrémental de Modèles EvènementieLs(2006)

Subjects
[INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO]
Abstract

International audience; We propose to develop a Rodin plug-in that experiments a systematic use of a refinement pattern. The goal of this pattern is to help in modeling of timed system in Event-B. By timed system we mean system with quantitative temporal constraints and properties.

Published
2009

659. Combining Scenario- and Model-Based Testing to ensure POSIX Compliance

Author

Frédéric Dadeau, Adrien de Kermadec, Régis Tissot, Combination of approaches to the security of infinite states systems (CASSIS), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Formal Methods (LORIA - FM), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Egon Börger, Michael Butler, Jonathan P. Bowen and Paul Boca, Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
File system, symbolic animation, Model-based testing, Java, business.industry, Process (engineering), Computer science, Model-Based Testing, Functional testing, scenarios, POSIX challenge, 020207 software engineering, 02 engineering and technology, computer.software_genre, B machine, POSIX, 020204 information systems, Non-regression testing, Chaining, 0202 electrical engineering, electronic engineering, information engineering, Operating system, Software engineering, business, computer, computer.programming_language
Abstract

International audience; We present in this paper a way to produce test suites for the POSIX mini-challenge, based on a formal model of a file system manager, written using a B machine. By this case study, we illustrate the limitations of a fully-automated testing process, which justifies the use of scenarios that complements the classical functional testing approach. Scenarios are expressed through schemas, focusing only on operation chaining. They are played on the model using a symbolic animation engine in order to automatically compute pertinent operation parameter values, based on model coverage criteria such as behavioral or data coverage. We concretize our experimentation by testing the POSIX conformance of two different file systems: a recent Linux distribution, and a customized Java implementation of POSIX used to evaluate the relevance of our approach.

Published
2008

660. A Verifiable Conformance Relationship between Smart Card Applets and B security Models

Author

Thierry Moutet, Julien Lamboley, Frédéric Dadeau, Marie-Laure Potet, Combination of approaches to the security of infinite states systems (CASSIS), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Formal Methods (LORIA - FM), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), VERIMAG (VERIMAG - IMAG), Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Joseph Fourier - Grenoble 1 (UJF), Egon Börger, Michael Butler, Jonathan P. Bowen and Paul Boca, Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)

Subjects
021110 strategic, defence & security studies, OpenPGP card, Engineering, Cloud computing security, business.industry, 0211 other engineering and technologies, 020207 software engineering, 02 engineering and technology, Computer security model, Computer security, computer.software_genre, Logical security, Smart card application protocol data unit, MULTOS, 0202 electrical engineering, electronic engineering, information engineering, Open Smart Card Development Platform, Smart card, business, computer
Abstract

International audience; We propose a formal framework based on the B method, that supports the development of secured smart card applications. Accordingly to the Common Criteria methodology, we start from a formal definition and modelling of security policies, as access control policies. At the end of the development process, smart card applications are implemented in a standardized way, based on both the life cycle of smart card applets and the APDU protocol. In this paper, we define a conformance relationship that aims at establishing how smart card applications can be related to security requirement models. This embraces both the notions of security conformance as well as traceability allowing to relate basic events appearing at the level of applications with abstract security policies. This approach has been developed in the RNTL POS´E project1, involving a smart card issuer, Gemalto.

Published
2008

661. Ranging behaviours across ecological and anthropogenic disturbance gradients: a pan-African perspective of giraffe ( Giraffa spp . ) space use.

Author

Brown MB, Fennessy JT, Crego RD, Fleming CH, Alves J, Brandlová K, Fennessy S, Ferguson S, Hauptfleisch M, Hejcmanova P, Hoffman R, Leimgruber P, Masiaine S, McQualter K, Mueller T, Muller B, Muneza A, O'Connor D, Olivier AJ, Rabeil T, Seager S, Stacy-Dawes J, van Schalkwyk L, and Stabach J

Subjects
Humans, Animals, Anthropogenic Effects, Movement, Africa, Ecosystem, Giraffes
Abstract

Animal movement behaviours are shaped by diverse factors, including resource availability and human impacts on the landscape. We generated home range estimates and daily movement rate estimates for 149 giraffe ( Giraffa spp . ) from all four species across Africa to evaluate the effects of environmental productivity and anthropogenic disturbance on space use. Using the continuous time movement modelling framework and a novel application of mixed effects meta-regression, we summarized overall giraffe space use and tested for the effects of resource availability and human impact on 95% autocorrelated kernel density estimate (AKDE) size and daily movement. The mean 95% AKDE was 359.9 km 2 and the mean daily movement was 14.2 km, both with marginally significant differences across species. We found significant negative effects of resource availability, and significant positive effects of resource heterogeneity and protected area overlap on 95% AKDE size. There were significant negative effects of overall anthropogenic disturbance and positive effects of the heterogeneity of anthropogenic disturbance on daily movements and 95% AKDE size. Our results provide unique insights into the interactive effects of resource availability and anthropogenic development on the movements of a large-bodied browser and highlight the potential impacts of rapidly changing landscapes on animal space-use patterns.

Published
2023
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662. Skeletal dysplasia-like syndromes in wild giraffe.

Author

Brown MB and Wells E

Subjects
Animals, Namibia, Ruminants, Syndrome, Uganda, Giraffes
Abstract

Objective: Skeletal dysplasias, cartilaginous or skeletal disorders that sometimes result in abnormal bone development, are seldom reported in free-ranging wild animals. Here, we use photogrammetry and comparative morphometric analyses to describe cases of abnormal appendicular skeletal proportions of free-ranging giraffe in two geographically distinct taxa: a Nubian giraffe (Giraffa camelopardalis camelopardalis) in Murchison Falls National Park, Uganda and an Angolan giraffe (Giraffa giraffa angolensis) on a private farm in central Namibia., Results: These giraffe exhibited extremely shortened radius and metacarpal bones relative to other similarly aged giraffe. Both giraffe survived to at least subadult life stage. This report documents rare occurrences of these apparent skeletal dysplasias in free-ranging wild animals and the first records in giraffe.

Published
2020
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663. Lomitapide and mipomersen: novel lipid-lowering agents for the management of familial hypercholesterolemia.

Author

Dixon DL, Sisson EM, Butler M, Higbea A, Muoio B, and Turner B

Subjects
Anticholesteremic Agents economics, Anticholesteremic Agents pharmacokinetics, Anticholesteremic Agents pharmacology, Benzimidazoles economics, Benzimidazoles pharmacokinetics, Benzimidazoles pharmacology, Humans, Hyperlipoproteinemia Type II economics, Liver drug effects, Oligonucleotides economics, Oligonucleotides pharmacokinetics, Oligonucleotides pharmacology, Risk Assessment, Treatment Outcome, Anticholesteremic Agents therapeutic use, Benzimidazoles therapeutic use, Hyperlipoproteinemia Type II drug therapy, Oligonucleotides therapeutic use
Abstract

Background: Familial hypercholesterolemia (FH) is an autosomal dominant disorder caused primarily by mutations in the low-density lipoprotein receptor gene. Familial hypercholesterolemia is characterized by exceedingly high levels of low-density lipoprotein cholesterol (LDL-C) and subsequent premature coronary heart disease. Homozygous FH (HoFH) is less prevalent, but more severe, than heterozygous FH. Current treatment options include dietary therapy, lipid-lowering agents (eg, statins), and/or LDL-C apheresis., Purpose: Despite the available treatment options, patients with FH rarely attain treatment goals. This review will focus on 2 novel agents, lomitapide and mipomersen, with recently approved US Food and Drug Administration (FDA) labeling for use in patients with HoFH., Conclusions: Lomitapide and mipomersen are 2 agents with novel mechanisms of action and the ability to significantly lower LDL-C, apolipoprotein B, and non-high-density lipoprotein cholesterol levels. A black box warning exists for lomitapide and mipomersen regarding the risk for transaminase elevations and hepatic steatosis. Furthermore, these agents are currently restricted for use only in patients with HoFH and have been required by the FDA to participate in a Risk Evaluation and Mitigation Strategy., Clinical Implications: These new agents offer additional treatment options for clinicians managing patients with HoFH, but it remains uncertain whether lomitapide and mipomersen will gain FDA approval for use in patients with heterozygous FH or in the general population. Cost and concern for the risk for hepatotoxicity will remain limiting factors to these agents being more widely used.

Published
2014
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664. South Florida home prices fall, but key issue remains

Abstract

MIAMI (AP) ” Housing prices fell again last month in Miami-Dade County and dipped for the first time in months in neighboring Broward County, an uplifting sign for aspiring home buyers.Miami-Dade™s median sale price dwindled to $551,250 for a single-family home in August, down from $570,000 the prior month, according to the monthly sales report released Wednesday by the Miami Association of Realtors. Condominium prices also dropped to a $375,000 midpoint from $380,000 in July. [ABSTRACT FROM PUBLISHER]

Published
2022

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