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• TS-1 with mesoporous structure are used as the carrier of perovskite firstly. • The hollow structure of TS-1 isolates the inner from the external environment. • TS-1 is one of the few materials with hydrophobic in molecular sieves. • The PLQYs of CsPbX 3 -TS-1 is excellent (up to 74%). • The matched WLEDs show luminous efficiency of 95 lm/W. CsPbX 3 (X = Br, I) quantum dots (QDs) have gradually become the star materials in light-emitting diodes (LED), but its stability has a big impact on development. Here, a variety of novel CsPbX 3 -TS-1 nanocomposites have been fabricated and the luminescence wavelength can be tunable by varying the halide nanocomposites (Br, I). What's particularly nice is that the original photoluminescence quantum yield (PLQY) of CsPbBr 1 l 2 QDs approaches 82% and it still has close to 74% after being combined with TS-1. Besides, the nanocomposites enhance stability resisting moisture, thermal stressing and light. In addition, a 460 nm InGaN blue chip, YAG:Ce3+ and CsPbBr 1 I 2 -TS-1 were equipped with white light emitting diodes (WLEDs), with a luminous effect of 95 lm/W, a color rendering index of 80, and a color temperature of 5144 K. Meanwhile, wide color gamut (116% of the National Television Standards Committee, 86.3% of the ITU-R Recommendation BT. 2020) and great chromaticity coordinate (0.3425, 0.3408) are realized. This is a very important step to open up the awkward situation of the practical application of perovskite QDs materials in LED. [ABSTRACT FROM AUTHOR]

• Cs 4 PbBr 6 @EVA composite film were successfully prepared. • Cs 4 PbBr 6 NCs possess superior optical performance after EVA coating. • The thermal and water resistance of Cs 4 PbBr 6 @EVA composite film are excellent. • The color gamut is as wide as 124.7% based on the Cs 4 PbBr 6 @EVA composite film device, reaching 92.8% of Rec. 2020. • The Cs 4 PbBr 6 @EVA composite film has a low threshold, stable stimulated emission, and amplified spontaneous emission (ASE). In recent years, perovskite nanocrystals (NCs) have been considered novel and potentially valuable optical gain materials that can generate relatively low thresholds and stable stimulated emissions in various external environments. Here, for the first time, an ethylene vinyl acetate copolymer (EVA) film-protected metal halide perovskite (Cs 4 PbBr 6) solid powder was successfully synthesized, and its photoluminescence quantum yield (PLQY) value was as high as 61%. In addition, because the Cs 4 PbBr 6 @EVA composite film has excellent optical gain performance, this work explored the optical gain of the Cs 4 PbBr 6 @EVA composite film under 800 nm femtosecond (fs) laser excitation. The experimental results show that the Cs 4 PbBr 6 @EVA composite film has a low threshold (0.89 mJ/cm2) and stable stimulated emission and generates amplified spontaneous emissions (ASEs) at 544 nm. In addition, the application of Cs 4 PbBr 6 @EVA composite film in the field of white light-emitting diodes (WLEDs) has also been studied. The color gamut of this Cs 4 PbBr 6 @EVA composite film is as high as 124.7% of the National Television Standards Committee (NTSC) 1953 standard color gamut and covers 92.8% of the Rec. 2020 standard color gamut. This work proposes a simple method to solve the problem of the poor stability of perovskite solid powder, and the prepared Cs 4 PbBr 6 @EVA composite film shows significant promise in WLED and laser applications. [ABSTRACT FROM AUTHOR]

[Display omitted] • Using OA to etch surface smooth original α-Al 2 O 3 wafer to make the surface appear pore structure. • The PL intensity of CsPbBr 3 @α-Al 2 O 3 composite material exposure to the air after 28 days can maintain over 50%. • The PLQY of CsPbBrI 2 @α-Al 2 O 3 composite material can reach 58%. • The colour purity of CsPbBr 3 @α-Al 2 O 3 and CsPbBrI 2 @α-Al 2 O 3 achieve 97.1% and 99.8%, respectively. • The prepared blue, green, red composites possess a wide color gamut of 114%. Recently, perovskite has received extensive attention due to their excellent photoelectric properties, while the instability of perovskite quantum dots (PQDs) has always troubled us. Herein, we proposed a simple coating mechanism to protect PQDs. Using oleic acid (OA) for etching α-Al 2 O 3 wafer to make the surface appear pore structure, and the PQDs was coated within the modified α-Al 2 O 3 wafer, thereby improving the stability of PQDs. The CsPbX 3 @α-Al 2 O 3 composite material can achieve the emission of blue-green–red (436 nm to 636 nm) through adjustable luminescence wavelength. The photoluminescence (PL) intensity of CsPbBr 3 @α-Al 2 O 3 composite material exposure to the air after 28 days can maintain over 50%. It is worth noticing that the photoluminescent quantum yield (PLQY) of CsPbBrI 2 @α-Al 2 O 3 composite material can reach 58%, the colour purity of CsPbBr 3 @α-Al 2 O 3 and CsPbBrI 2 @α-Al 2 O 3 achieve 97.1% and 99.8%, respectively. It was due to the high colour purity of the composite materials can the selected CIE colour coordinate monochromatic light encompassed 114% of NTSC colour gamut. Moreover, the warm white light-emitting diode (WLED) yielded bright natural white light and showed the luminous efficiency (LE) of 86.58 lm/W, colour rendering index (CRI) of 86.9, correlated colour temperature (CCT) of 4602 K. The LE and CRI reaches a relatively balanced value, which showed that this composite material has a certain development prospect in the WLED field. [ABSTRACT FROM AUTHOR]

All inorganic CsPbX 3 (X = Cl, Br, I) perovskite quantum dots (QDs) have been widely reported. However, the poor stability of CsPbX 3 QDs limits their application in the field of optoelectronics. In this work, CsPbX 3 QDs were prepared by the hot injection strategy. We compounded CsPbX 3 QDs with mica to improve stability. A series of novel CsPbX 3 @mica composites with high thermal stability and light radiation stability were successfully fabricated and the narrow full width at half maximum (FWHM) of blue, green and red emissions are ~17 nm, ~21 nm and ~37 nm, respectively. What's more, the photoluminescence quantum yield (PLQY) of CsPbBr 3 @mica composite is 38.5%. Notably, the white light-emitting diodes (wLED) device can be manufactured by coupling the red-emitting CsPbBr 1 I 2 @mica composite material and commercial phosphor YAG: Ce3+ with the InGaN chip to produce bright natural white light. Meanwhile, CsPbX 3 @mica composites can be used as color conversion materials to construct a LED device, which exhibits a wide color gamut covering up 115.7% of National Television System Committee (NTSC). This present work provided novel CsPbX 3 @mica composites and could bring the potential inspiration in backlit display and lighting applications. [Display omitted] • The novel CsPbX 3 @mica composites with tunable emission in 468–630 nm were successfully fabricated. • The CsPbBr 3 @mica composite has excellent thermal and light irradiation stability. • The wLED can be manufactured by coupling CsPbBr 1 I 2 @mica and YAG:Ce3+ with InGaN chip to produce bright natural white light. • The CsPbX 3 @mica composites show a wide color gamut (115.7% NTSC). [ABSTRACT FROM AUTHOR]

• The prepared multi-color PiGs has a high internal quantum efficiency approaching 90% of original phosphors. • The luminous efficacy of YAG:Ce-PiG reaches 239.3 lm/W, which is almost the best result in WLDs so far. • Kinds of cyan/green/yellow/red phosphors can be composited into an entire PiG frame and full-color emissions from 470 to 700 nm is realized in WLDs. • The ideal white light with a high color rendering index of 94 is obtained in WLDs. Phosphor-in-glass (PiGs) is one of the most important strategies to overcome thermal influence in high-power white light-emitting diodes and laser diodes. By carefully designing the glass composition of Na 2 O-CaO-B 2 O 3 -SiO 2 , the multi-color PiGs are successfully fabricated by a single-step co-sintering strategy at a relative low temperature (850 °C), most of PiGs maintain a high internal quantum efficiency approaching 90% of original phosphors. Under the 450 nm blue laser diodes (LDs) excitation, the luminous efficacy of YAG:Ce-PiG reaches 239.3 lm/W, which is almost the best result in white laser diodes (WLDs) so far. Outstandingly, the designed glass overcomes the oxidation, corrosion and decomposition of commercial nitride red phosphors, and realizes broadband emission from 500 to 700 nm by compositing red/yellow/green phosphors in an entire glass. Correspondingly, this work paves the way to achieve ideal white light with a high color rendering index of 94 in WLDs. [ABSTRACT FROM AUTHOR]

• Gd-doped CsPbBrI 2 NCs were successfully prepared in borosilicate glass matrix. • CsPbBrI 2 NCs@glasses possess superior optical performance through Gd3+ doping. • The water / thermal / light stability of Gd-doped CsPbBrI 2 NCs@glasses are excellent. • High-performance WLEDs was assembled successfully by Gd-doped CsPbBrI 2 NCs@glasses. Here, Gd-doped CsPbBrI 2 nanocrystals (NCs) in borosilicate glass (B 2 O 3 -SiO 2 -ZnO) were successfully synthesized by the traditional melting quenching method. The optical properties of CsPbBrI 2 NCs@glasses at different heat treatment temperatures and the content of Gd3+ were studied. It is found that CsPbBrI 2 NCs@glasses have greatly improved photoluminescence quantum yields (PLQYs) after doping (form 15.3% to 37%) and excellent hydrothermal and light stability. In addition, a white light emitting diode (WLED) was successfully prepared by combining Gd-doped CsPbBrI 2 NCs@glass and Ce3+: YAG phosphors with the blue light emitting diode (LED). After a series of adjustments, the high performance WLED device with a chromaticity coordinate (CIE) of (0.3340, 0.3386), luminous efficiency (LE) of 90.09 lm/W, correlated color temperature (CCT) of 5430 K and the color rendering index (CRI) of 81.4 was fabricated. This work provides a new strategy in the field of metal ion doped perovskite NCs for future reference and has potential applications in LEDs. [ABSTRACT FROM AUTHOR]

• High quality CaAlSiN 3 :Eu2+ PiGs have been successfully synthesized. • CaAlSiN 3 :Eu2+ PiGs presented a higher EQE of 53% and better thermal stability. • The wLEDs with high CRI/LE were assembled successfully based on CaAlSiN 3 :Eu2+ PiGs. • The LDs based on CaAlSiN 3 :Eu2+ PiGs realized enhanced laser saturation threshold. CaAlSiN 3 :0.2%Eu2+ (CASN:Eu2+), an excellent red phosphor, plays a leading part in wide color gamut and high color rendition white light-emitting diodes (wLEDs). However, this phosphor or silicone resin mixture possesses a fatal defect of an intrinsic low thermal performance, which makes it hardly useful in high-power laser lighting and displays. Here, to improve the thermal performance of the CASN:Eu2+ phosphor, a series of red-emitting phosphor-in-glass materials (R-PiGs) with different CASN:Eu2+ concentrations (5–50 wt%) and sintering temperatures (750–850 °C) were successfully synthesized by dispersing the CASN:Eu2+ phosphor into a B 2 O 3 -Na 2 O-SiO 2 -CaO glass matrix. Surprisingly, the prepared R-PiGs showed a high external quantum efficiency (EQE) of 53%, and still maintained 82% efficiency compared with the CASN:Eu2+ phosphor (65%). The R-PiGs are superior to red ceramics for low cost and rapid batch preparation. Considering the densification of the R-PiGs, a systematic study was conducted on 10 wt% R-PiG sample. A facile chromaticity tuning for the configured wLEDs was obtained within the color range change from cool white to warm white when using the R-PiGs with different CASN:Eu2+ concentrations. Besides, we have successfully assembled a warm wLED with high luminous efficacy (90.3 lm/W) and color rendering (Ra = 94.2 and CCT = 5053 K). When irradiated by a blue laser, an optimized R-PiG can show enhanced luminous flux (49.27 lm) at a high laser incident power of 1.90 W/mm2. Therefore, with their excellent performances, R-PiGs are highly promising for use as red color converters for potential applications in tunable wLEDs and high-power laser lighting. [ABSTRACT FROM AUTHOR]

CsPbX 3 (X=Cl, Br or I) has been studied due to its outstanding optical properties. However, it is difficult to use in practical applications due to its poor stability. Currently, there are interesting examples of CsPbX 3 compounded with glass substrates. The quantum efficiencies of CsPbX 3 NC glasses are relatively low. In this work, we propose a simple method for fabricating Yb3+-doped CsPbI 3 quantum dots in glass via a conventional melt quenching technique. It was found that the CsPbI 3 NC glasses had blue-shifted emission with increasing amounts of the Yb3+ dopant. The photoluminescence quantum yield (PLQY) of CsPbI 3 : Yb3+ NC glass reached from 20% to 66.7%. And the CsPbI 3 : Yb3+ NC glass exhibited good thermal stability. Moreover, the experimental results showed th*at the CsPbI 3 : Yb3+ glass could match the properties of a commercial fluorescent powder used to make white LEDs (WLEDs). [ABSTRACT FROM AUTHOR]

Cd2+ doped CsPbBr 3 perovskite quantum dots were synthesized in borosilicate glass for the first time by traditional melting method. By X-Ray Diffraction (XRD) and high resolution electron microscopy analysis, it was proved that Cd2+ successfully entered the perovskite lattice structure. The samples have good optical properties, high photostability, chemical stability, thermal stability and water stability. On this basis, CsPb 0.7 Cd 0.3 Br 3 QDs glass, commercial red phosphor (CaAlSiN 3 :Eu2+) and blue light chip were coupled to produce white LED devices. This discovery opens up a new way for the application of metal ion-doped perovskite QDs glass in optoelectronic devices. • A series of Cd2+ doped CsPbBr 3 QDs glasses with high PL intensity, quantum efficiency and excellent stability were prepared. • The WLEDs made by CsPb x Cd 1-x Br 3 QDs glass produce high quality white light, adjustable from cold to warm white light. • Compared with the original CsPbBr 3 QDs glass, the quantum efficiency of Cd2+ doped glass has been improved greatly. [ABSTRACT FROM AUTHOR]

[Display omitted] • CsPbBr 3 :xZn2+ nanocrystalline glass was prepared by high temperature melting technology. • The Zn2+ doped CsPbBr 3 nanocrystalline glass was firstly used as photocatalysts to produce hydrogen via splitting water. • The hydrogen production performance of CsPbBr 3 : xZn2+ nanocrystalline glass with different concentrations was studied. • The mechanism of hydrogen production of CsPbBr 3 :xZn2+ nanocrystalline glass was studied simply. Zn2+-doped perovskite nanocrystals (NCs) are accepted as photoelectronic materials for used in LED, solar energy and photovoltaic devices but are not yet used in photochemical conversion. To the best of our knowledge, this is the first report of use of Zn2+-doped CsPbBr 3 NCs borosilicate glass powder in water for hydrogen production. The research results show that the doped nanocrystals perovskite decomposition hydrogen water effect is better than that of pure perovskite nanocrystals, and its hydrogen generation rate reached 127 μmol/g. In addition, Zn2+ -doped CsPbBr 3 perovskite NCs glass also greatly solves the problems of water, light and chemical instability, including rapid deactivation. The photocatalytic hydrogen production rule of with different Zn2+ doping amounts and the photocatalytic hydrogen production effect with different nanocrystalline concentrations were also investigated. [ABSTRACT FROM AUTHOR]

• A series of Ni2+ doped CsPbBr 3 NCs glass was prepared. • The principle of surface modification of perovskite was discussed. • The fluorescence intensity and quantum efficiency of NCs glass are greatly improved. • NCs glass has excellent thermal and water stability compared to NCs solutions. • Density functional theory reveals the formation of surface defects in perovskites. All-inorganic perovskite nanocrystals (NCs) have become a new generation of low-cost semiconductor luminescent materials for optoelectronic applications due to their excellent optical properties. Prepared perovskite NCs undergo different ion doping and surface modification, which makes the NCs photo-luminescence quantum yield (PLQY) basically uniform. However, stability of perovskite NCs solution in the environment has always been an important factor restricting its practical application. Here, we used melt-quenching method to prepare a series of different Ni2+ doped CsPbBr 3 NCs glass. Through experimental characterization and DFT calculation it is found that the entry of Ni2+ into the NCs lattice can eliminate the structural defects of NCs and improve the order of the perovskite lattice. Ni2+ doped perovskite NCs have strong band edge emission and high quantum yield (up to 84.3%). [ABSTRACT FROM AUTHOR]

• Ti-doped CsPbI 3 QDs were successfully prepared in borosilicate glass matrix. • Ti-doped CsPbI 3 QDs@glasses possess superior optical performance. • The water/thermal stability of Ti-doped CsPbI 3 QDs@glasses are excellent. • The wLED based on CsPb 1− x Ti x I 3 QDs@glasses realized outstanding LE and CRI. • LED devices based on CsPb 1− x Ti x I 3 QDs@glasses well satisfy plant growth. Currently, the application of all-inorganic cesium lead halide perovskite (CsPbX 3 , X = Cl, Br, I) quantum dots (QDs) is limited due to toxicity of lead and poor ambient stability. In our work, a series of Ti-doped CsPbI 3 QDs were successfully prepared in borosilicate glass (SiO 2 -B 2 O 3 -ZnO) by the melt quenching and in situ crystallization technique. The samples showed excellent water/thermal stability, and the tunable emission (650–695 nm) was controlled by different Ti contents and heat treatment temperatures. In particular, the optical properties of CsPb 1− x Ti x I 3 QDs@glasses (x ≤ 0.5) are superior to those of pristine CsPbI 3 QDs@glass. As a result, the wLED was assembled using red-emitting CsPb 1− x Ti x I 3 QDs@glasses and yellow-emitting Ce3+:YAG phosphor under excitation of InGaN blue chip, which demonstrated an outstanding luminous efficiency of 102.44 lm/W, a high color rendering index of 80.6. Particularly, Ti-doped CsPbI 3 QDs@glasses with red and far-red light are combined with a blue-chip to assemble an LED device, which exactly satisfies the lighting conditions of plant growth. [ABSTRACT FROM AUTHOR]

• K x Cs 1−x PbBr 3 NCs glasses and KPbBr 3 NCs glass have been successfully synthesized. • K 0.6 Cs 0.4 PbBr 3 NCs glass presented a higher PLQY of 62% and better stability. • Optical third-order nonlinearity of K 0.6 Cs 0.4 PbBr 3 NCs glass was researched. • High-performance WLEDs was assembled successfully by K 0.6 Cs 0.4 PbBr 3 NCs glass. CsPbX 3 (X = Cl, Br, I) nanocrystals (NCs) glasses formed utilizing conventional melt-quenching with a subsequent heat-treatment method demonstrate excellent performance and can resist temperature and light irradiation; further, CsPbX 3 NCs glasses have improved stability in air and water when compared to traditional way. Nevertheless, one of the fatal disadvantages of CsPbX 3 NCs glasses are their low photoluminescence quantum yields (PLQY). Here, we demonstrate a new avenue that K+ ions doped CsPbBr 3 NCs glasses (K-CPB NCs glasses) systems utilizing K x Cs 1−x PbBr 3 (x = 0, 0.2, 0.4, 0.6, 0.8, 1) NCs glasses, and we surprisingly find that K 0.6 Cs 0.4 PbBr 3 NCs glass reaches the highest PLQY of 62% when the molar ratio of K+/Cs+ = 0.6/0.4. Meanwhile, in comparative experiments, we have noticed that K 0.6 Cs 0.4 PbBr 3 NCs glass has better water resistance and thermal stability than CsPbBr 3 NCs glasses what we had before. K-CPB NCs glasses has a significantly improved applications scope for cesium lead halide perovskite in the field of photoelectricity, such as solar cells and perovskite light-emitting diodes (PeLEDs). In addition, we have successfully fabricated the pure phase of KPbBr 3 NCs glass and its existence has been proven via a series of representational means, consequently, this research opens the door for the further study of perovskite materials. Fortunately, K-CPB NCs glasses perform better in optical third-order nonlinearity, and we believe these findings will promote its applications in nonlinear optoelectronic devices. Ultimately, white LEDs (WLEDs) has been successfully equipped with K 0.6 Cs 0.4 PbBr 3 NCs glass, which presents excellent optical parameters. [ABSTRACT FROM AUTHOR]

Abstract: A novel biomolecule-assisted method has been successfully developed to prepare pyrargyrite (Ag3SbS3) nanorods via the reactions between AgNO3 and SbCl3 with l-cystine in ethylene glycol at 200°C for 15h, in which l-cystine was used as the sulfide source and complexing agent. The crystal phase, morphology, grain size, and chemical composition of the as-prepared products were characterized in detail by X-ray powder diffraction (XRD), energy dispersion spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and high-resolution transmission electron microscopy (HRTEM). Results revealed that the as-synthesized Ag3SbS3 nanorods had diameters range from 150 to 200nm and lengths up to several micrometers. The experimental results showed that the reaction time played an important role in the formation of Ag3SbS3 nanocrystalline. A possible formation mechanism for Ag3SbS3 nanorods was discussed. [Copyright &y& Elsevier]

The use of multiparametric magnetic resonance imaging (mpMRI) has become a common technique used in guiding biopsy and developing treatment plans for prostate lesions. While this technique is effective, non-invasive methods such as radiomics have gained popularity for extracting imaging features to develop predictive models for clinical tasks. The aim is to minimize invasive processes for improved management of prostate cancer (PCa). This study reviews recent research progress in MRI-based radiomics for PCa, including the radiomics pipeline and potential factors affecting personalized diagnosis. The integration of artificial intelligence (AI) with medical imaging is also discussed, in line with the development trend of radiogenomics and multi-omics. The survey highlights the need for more data from multiple institutions to avoid bias and generalize the predictive model. The AI-based radiomics model is considered a promising clinical tool with good prospects for application.

Objectives: RNF20 is recognized as a main E3 ligase for monoubiquitination of histone H2B at lysine 120 (H2Bub). The critical role of RNF20 and H2Bub in various molecular events, such as DNA replication, RNA transcription, and DNA damage response, has been widely investigated and documented. However, its role in porcine adipogenesis remains unknown. In this study, we aimed to clarify the effect of RNF20 on porcine preadipocyte differentiation., Materials and Methods: Backfat tissues from fat-type pigs (Bama and Meishan) and lean-type pigs (Yorkshire and Landrace) were collected to detect the expression level of RNF20. Preadipocytes were isolated from Bama piglets and induced to differentiation. Small interfering RNAs were applied to deplete RNF20. Oil Red O staining, quantitative real-time PCR, RNA-seq, Western blot analysis, and EdU assays were performed to study the regulatory mechanism of RNF20 during adipogenesis., Results: We found that the expression levels of RNF20 and H2Bub were significantly higher in backfat tissues from fat-type pigs than in those from lean-type pigs. Consistently, the significantly induced expression of RNF20 and H2Bub was also observed in porcine differentiated adipocytes. In addition, knockdown of RNF20 greatly inhibited porcine adipogenesis, as evidenced by dramatically decreased lipid droplet formation and lower expression levels of adipogenic transcription masters in RNF20 knockdown cells. Mechanistically, the depletion of RNF20 decreases the cell proliferation and the level of p-C/EBPβ via the Ras-Raf-MEK1/2-ERK1/2 cascade pathway at the mitotic clonal expansion phase and therefore suppresses cell differentiation., Conclusions: Our results demonstrate that RNF20 is required for porcine preadipocyte differentiation., (© 2021 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.)

RNF20, an E3 ligase critical for monoubiquitination of histone H2B at lysine 120 (H2Bub), has been implicated in the regulation of various cellar processes; however, its physiological roles in adipocytes remain poorly characterized. Here, we report that the adipocyte-specific knockout of Rnf20 (ASKO) in mice led to progressive fat loss, organomegaly and hyperinsulinemia. Despite signs of hyperinsulinemia, normal insulin sensitivity and improved glucose tolerance were observed in the young and aged CD-fed ASKO mice. In addition, high-fat diet-fed ASKO mice developed severe liver steatosis. Moreover, we observed that the ASKO mice were extremely sensitive to a cold environment due to decreased expression levels of brown adipose tissue (BAT) selective genes, including uncoupling protein 1 (Ucp1), and impaired mitochondrial functions. Significantly decreased levels of peroxisome proliferator-activated receptor gamma (Pparγ) were observed in the gonadal white adipose tissues (gWAT) from the ASKO mice, suggesting that Rnf20 regulates adipogenesis, at least in part, through Pparγ. Rosiglitazone-treated ASKO mice exhibited increased fat mass compared to that of the non-treated ASKO mice. Collectively, our results illustrate the critical role of RNF20 in control of white and brown adipose tissue development and physiological function.

All-inorganic halide perovskite (CsPb 2 Br 5 ) nanocrystals (NCs) have received widespread attention owing to their unique photoelectric properties. This work reports a novel strategy to control the phase transition from CsPbBr 3 to CsPb 2 Br 5 and investigates the effects of different treatment times and treatment temperatures on perovskite NCs formation. By controlling the volume of tetraethoxysilane (TEOS) added, the formation of different phases of perovskite powder can be well controlled. In addition, a white light-emitting diode (WLED) device is designed by coupling the CsPbBr 3 /CsPbBr 3 -CsPb 2 Br 5 NCs@TEOS nanocomposite and CaAlSiN 3 :Eu 2+ commercial phosphor with a 460 nm InGaN blue chip, exhibiting a high luminous efficiency of 57.65 lm/W, color rendering index (CRI) of 91, and a low CCT of 5334 K. The CIE chromaticity coordinates are (0.3363, 0.3419). This work provides a new strategy for the synthesis of CsPbBr 3 /CsPbBr 3 -CsPb 2 Br 5 NCs@TEOS nanocomposite, which can be applied to the field of WLEDs and display devices.

Fat deposition, which influences pork production, meat quality and growth efficiency, is an economically important trait in pigs. Numerous studies have demonstrated that stearoyl-CoA desaturase (SCD), a key enzyme that catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, is associated with fatty acid composition in pigs. As SCD was observed to be significantly induced in 3T3-L1 preadipocytes differentiation, we hypothesized that it plays a role in porcine adipocyte differentiation and fat deposition. In this study, we revealed that SCD is highly expressed in adipose tissues from seven-day-old piglets, compared to its expression in tissues from four-month-old adult pigs. Moreover, we found that SCD and lipogenesis-related genes were induced significantly in differentiated porcine adipocytes. Using CRISPR/Cas9 technology, we generated SCD -/- porcine embryonic fibroblasts (PEFs) and found that the loss of SCD led to dramatically decreased transdifferentiation efficiency, as evidenced by the decreased expression of known lipid synthesis-related genes, lower levels of oil red O staining and significantly lower levels of triglyceride content. Our study demonstrates the critical role of SCD expression in porcine adipocyte differentiation and paves the way for identifying it as the promising candidate gene for less fat deposition in pigs., Competing Interests: The authors declare no conflict of interest.

By increasing the heat treatment temperature, the average size of CsPbBr 3 quantum dots (QDs) in the glass matrix was increased, which contributed to a 5.5 fold increase of the optical gain coefficients. And the corresponding lasing threshold decreased from 0.752 mJ cm -2 to 0.138 mJ cm -2 .

Aims/hypothesis: ATPase copper transporting α (ATP7A), also known as Menkes disease protein, is a P-type ATPase that transports copper across cell membranes. The critical role of ATP7A-mediated copper homeostasis has been well recognised in various organs, such as the intestine, macrophages and the nervous system. However, the importance of adipocyte ATP7A-mediated copper homeostasis on fat metabolism is not well understood. Here, we sought to reveal the contribution of adipose ATP7A to whole-body fat metabolism in mice., Methods: We generated adipocyte-specific Atp7a-knockout (ASKO) mice using the Cre/loxP system, with Cre expression driven by the adiponectin promoter. ASKO mice and littermate control mice were aged on a chow diet or fed with a high-fat diet (HFD); body weight, fat mass, and glucose and insulin metabolism were analysed. Histological analysis, transmission electron microscopy and RNA-sequencing (RNA-Seq) analysis of white adipose tissue (WAT) were used to understand the physiological and molecular changes associated with loss of copper homeostasis in adipocytes., Results: Significantly increased copper concentrations were observed in adipose tissues of ASKO mice compared with control mice. Aged or HFD-fed ASKO mice manifested a lipoatrophic phenotype characterised by a progressive generalised loss of WAT. Dysfunction of adipose tissues in these ASKO mice was confirmed by decreased levels of both serum leptin and adiponectin and increased levels of triacylglycerol and insulin. Systemic metabolism was also impaired in these mice, as evidenced by a pronounced glucose intolerance, insulin resistance and hepatic steatosis. Moreover, we demonstrate a significant induction of lipolysis and DNA-damage signalling pathways in gonadal WAT from aged and HFD-fed ASKO mice. In vitro studies suggest that copper overload is responsible for increased lipolysis and DNA damage., Conclusions/interpretation: Our results show a previously unappreciated role of adipocyte Atp7a in the regulation of ageing-related metabolic disease and identify new metallophysiologies in whole-body fat metabolism., Data Availability: The datasets generated during the current study are available in the Genome Sequence Archive in BIG Data Center, Beijing Institute of Genomics (BIG), Chinese Academy of Sciences, under accession number CRA001769 (http://bigd.big.ac.cn/gsa).

All-inorganic perovskite (CsPbX3) quantum dots (QDs) have achieved unprecedented success in various applications due to their outstanding performance. Nevertheless, the inherent instability of these QDs severely limits their practical applications. Here, ultra-stable full visible spectrum CsPbX3 (X = Cl, Br, I) QD glasses are prepared successfully. For the first time, the full spectrum tunable up-conversion (UC) emission of CsPbX3 QD glasses ranging from 420 nm to 711 nm under excitation with an 800 nm femtosecond (fs) laser was achieved. Importantly, the two-photon absorption properties, the exciton binding energy and the UC full width at half maximum (FWHM) of CsPbCl1.5Br1.5 (blue), CsPbBr3 (green), and CsPbBr1.5I1.5 (red) QD glasses were studied in depth. Furthermore, CsPbCl1.5Br1.5 showed the highest exciton binding energy (∼87.5 meV), allowing the CsPbCl1.5Br1.5 QD glass to act as a good optical gain material that could more easily achieve amplified spontaneous emission (ASE).

Beige adipose tissue has been considered to have potential applications in combating obesity and its related metabolic diseases. However, the mechanisms of acute cold-stimulated beige formation still remain largely unknown. Here, transcriptional analysis of acute cold-stimulated (4 °C for 4 h) subcutaneous white adipose tissue (sWAT) was conducted to determine the molecular signatures that might be involved in beige formation. Histological analysis confirmed the appearance of beige adipocytes in acute cold-treated sWAT. The RNA-sequencing data revealed that 714 genes were differentially expressed ( p -value < 0.05 and fold change > 2), in which 221 genes were upregulated and 493 genes were downregulated. Gene Ontology (GO) analyses showed that the upregulated genes were enriched in the GO terms related to lipid metabolic process, fatty acid metabolic process, lipid oxidation, fatty acid oxidation, etc. In contrast, downregulated genes were assigned the GO terms of regulation of immune response, regulation of response to stimulus, defense response, etc. The expressions of some browning candidate genes were validated in cold-treated sWAT and 3T3-L1 cell browning differentiation. In summary, our results illustrated the transcriptional response of sWAT to acute cold exposure and identified the genes, including Acad11 , Cyp2e1 , Plin5 , and Pdk2 , involved in beige adipocyte formation in mice.

A series of CsPbBrxI3-x NC glasses, showing tunable emission (523-693 nm) controlled by different ratios of Br- and I-, were successfully prepared. The CsPbBrxI3-x NC glasses exhibited excellent optical properties and outstanding stability towards ambient conditions, water and heat.

Herein, we have introduced rare-earth cations Tb 3+ and Eu 3+ into CsPbBr 3 QDs glass by conventional melt-quenching. Rare-earth cations like Tb 3+ emit green light, causing the main peak of bromide lead cesium to exhibit some redshift, owing to the energy transfer between CsPbBr 3 and Tb 3+ . To achieve adjustable light, Eu 3+ emits red light, which was doped in this glass with different proportions to solve the problem of red deficiency. More importantly, Tb 3+ and Eu 3+ co-doped CsPbBr 3 QDs glass shows a series of desirable characteristics due to the energy transfer between Tb 3+ and Eu 3+ . Interestingly, the blue light radiated by blue chip can excite Tb 3+ , Eu 3+ , and CsPbBr 3 perovskite effectively. We acquired high-performance white light-emitting diodes with color-rendering index, color coordinate transformation, and luminous efficiency of 85.7, 4945 K, and 63.21 lm/W under the current of 20 mA. This acquired Tb 3+ , Eu 3+ co-doped CsPbBr 3 QDs glass proved the significant feasibility of luminescent materials in solid warm light source.

Since nonlinear optical materials used in the ultrafast all-optical switching is an important part for the modern optical technology, cuprates have been widely investigated for their specific Cu-O chain structure and intriguing optical properties. We present a new preparation method of microcrystalline Sr 2 CuO 3 glass films on glass substrates combining spin-coating and co-sintering techniques. Then, the as-prepared samples were polished for different times to obtain microcrystalline Sr 2 CuO 3 glass films with varying thickness. The influence of polishing time on the structure, the valence state and the nonlinear optical response were discussed, respectively. The purity of the Sr 2 CuO 3 phase, surface morphology and the chemical composites of these synthesized glass films were given with scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). Importantly, optical absorption spectroscopy and Z-scan technique were used to measure linear absorption and third-order optical nonlinearity of the films. The experiments showed that third-order nonlinear susceptibility of the 140 min polished film sample with a thickness of 18 μm was up to 1.23 × 10 -12  esu, indicating its potential application in the nonlinear field.

Eu3+ ions were introduced into the lattices of CsPbBr3 perovskite QDs and a tunable multicolour emission from CsPbBr3:xEu3+ perovskite QD glass was successfully obtained. Multicolour LEDs that were fabricated by combining the as-prepared CsPbBr3:xEu3+ QD glasses with a UV chip were also researched in this study.

The first use of the combination of ammonium citrate (AC) and ethylenediamine tetraacetic acid (EDTA) as coordinating precursors for the synthesis of highly fluorescent (quantum yield = 67%) multicolour nitrogen-doped carbon dots (CDs) is reported. Under UV light, these CDs emitted outstanding luminescence in colours from dark blue to red. Interestingly, a single component white-light CD point with high fluorescence efficiency was obtained by surface control. Alterations of the photoluminescence (PL) emission of these full-colour CDs were tentatively proposed to benefit from surface functional groups, such as C[double bond, length as m-dash]O and C[double bond, length as m-dash]N. An energy-level model was proposed to explain the continuously adjustable full-colour emission. The white light may be attributed to the overlap of diverse light emission induced by electron transitions between the energy levels. Subsequently, to avoid aggregation-induced solid-state fluorescence quenching, multicolour CD-based sandwich glasses with various colour emission was fabricated, which is anticipated to be compatible with the all-optical light-emitting diodes (LEDs). The facile preparation and outstanding optical features are believed to provide an alternative synthesis route and inspire more research into applications and CD-based materials of multicolour CDs.

We report the synthesis of CsPbBr 3 QDs with great stability and high quantum yield in phospho-silicate glass, which was fabricated by using a heat-treatment approach, for white light emitting devices. QD glasses exhibited excellent photo- and thermal stability, and significantly prolonged the lifetime of light emitters under ambient air conditions.

Copper (Cu) and iron (Fe), the enzymatic cofactors required for various biochemical processes, have been recently linked to lipid metabolism. Adipose tissues play central roles in energy balance and whether copper and iron homeostasis is involved in cold-stimulated energy metabolism remains unknown. In this study, the Cu and Fe contents in interscapular brown adipose tissue (BAT) and subcutaneous white adipose tissue (subWAT) from mice at different developmental stages were measured. Our results revealed the dynamic changes of Cu and Fe levels during development, suggesting their potential roles in energy homeostasis. Furthermore, the significantly increased Cu and Fe contents and the markedly up-regulated CTR1 and ATP7A expression in acute cold-stimulated BAT indicates the involvement of both Cu and Fe in the BAT-mediated thermogenesis. Comparably, no change in the Cu and Fe levels in cold-stimulated subWAT was observed at the indicated time points, suggesting that both metals are not involved in the cellular process of cold-induced WAT browning. Taken together, these data demonstrate the induction of Cu and Fe in acute cold-stimulated BAT activation, thus providing the direct evidences of the involvement of copper and iron homeostasis in BAT-mediated non-shivering energy metabolism., (Copyright © 2017 Elsevier Inc. All rights reserved.)

To elucidate the key miRNAs and the signalling pathways that are involved in porcine oocyte maturation, we performed a deep sequencing analysis of the miRNAs of pig germinal vesicle (GV) oocytes and metaphase II (MII) oocytes. Seven differentially expressed (DE) miRNAs were identified and the expression levels of miR-21 and miR-27b-3p were further confirmed by QPCR analysis. The target genes of 7 DE miRNAs were predicted and subjected to pathway analysis. Interestingly, fatty acid metabolism and fatty acid biosynthesis were the top two significantly enriched molecular functions during oocyte maturation. Heat map, which was built with 7 DE miRNAs and the enriched the molecular functions, revealed that miR-21, miR-27b-3p, miR-10a-5p and miR-10b-5p were involved in fatty acid metabolism. In particular, the regulatory role of miR-27b-3p on peroxisome proliferator-activated receptor-γ (PPARγ) was confirmed by their inversed expression patterns in GV and MII oocytes and luciferase report assays. In addition, we observed that PPARγ agonist (rosiglitazone) treatment significantly enhanced porcine oocyte maturation rate and early embryo developmental competent. Taken together, our results demonstrated that miR-27b and its target, PPARγ, play the vital roles in pig oocyte maturation through regulating the fatty acid metabolism. These data increased our understanding of the regulatory gene networks in porcine oocyte maturation and development., (Copyright © 2016 Elsevier Inc. All rights reserved.)

The integrated and transparent sodium borosilicate glasses that contain copper exhibiting different colors, that is, red, green, and blue were synthesized by combining the sol-gel process and heat treatment in H2 gas. To reveal substantially the cause of different colors in the glass, X-ray diffraction (XRD), transmission electron microscopy (TEM) and high resolution TEM (HRTEM) were systematically applied to investigate and determine the microstructure of the doped matter. The results showed three different crystals had formed in the red, green and blue glass, and the sizes of these crystals were range from 9 to 34, 1 to 6, and 1 to 5 nm, respectively. The valence state of copper was further analyzed by X-ray photoelectron spectroscopy (XPS) and electron energy loss spectroscopy (EELS). The third-order nonlinear optical properties of the glasses were investigated by using Z-scan technique at the wavelength of 800 nm. Interestingly, the third-order nonlinear absorption of the red, green, and blue glass can be successfully controlled from reverse saturable absorption, no absorption to saturable absorption and the optical nonlinear susceptibility χ((3)) of the red, green and blue glass were estimated to be 6.4 × 10(-14), 1.6 × 10(-14), and 2.6 × 10(-14) esu in the single-pulse energy of 0.36 μJ, respectively.

The 2-DE/MS-based proteomics approach was used to investigate the differences of porcine skeletal muscle, and ATP5B was identified as one differential expression protein. In the present study, ATP5B gene was further cloned by RT-PCR, the sequence was analyzed using the bioinformatics method, and the mRNA expression was detected by qRT-PCR. Sequence analysis showed that the porcine ATP5B gene contains an ORF encoding 528-amino-acid residues with 49 and 166 nucleotides in the 5' and 3' UTRs, respectively. The mRNA of ATP5B was widely expressed in all 14 tissues tested, but especially highly expressed in parorchis and fat. The expression pattern of ATP5B was similar in Large White and Meishan breeds, showing that the expression was upregulated by 3 days after birth and downregulated during postnatal development of skeletal muscle. Comparing the two breeds, the mRNA abundance of ATP5B in Large White was more highly expressed than in Meishan at all developmental stages (P < 0.05). Moreover, a synonymous mutation, G75A in exon 8, was identified and association analysis with the traits of meat quality showed that it was significantly associated with the RLF, FMP, IFR, IMF, and IMW (P < 0.05). These results suggested that ATP5B probably plays a key role in porcine skeletal muscle development and may provide further insight into the molecular mechanisms responsible for breed-specific differences in meat quality.