401. Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions.
- Author
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Shafaghi A, Mansour-Ghanaei F, Joukar F, Sharafkhah M, Mesbah A, Askari K, Geranmayeh S, Mehrvarz A, Souti F, Sokhanvar H, Fakhrieh S, Aminian K, Yousefi-Mashhour M, Khosh-Sorur M, and Rasoulian J
- Subjects
- Aged, Aged, 80 and over, Biomarkers analysis, Cross-Sectional Studies, Female, Follow-Up Studies, Gastric Mucosa pathology, Gastritis, Atrophic blood, Gastritis, Atrophic diagnosis, Gastritis, Atrophic pathology, Humans, Iran, Male, Metaplasia blood, Metaplasia diagnosis, Metaplasia pathology, Middle Aged, Neoplasm Staging, Precancerous Conditions blood, Precancerous Conditions pathology, Prognosis, ROC Curve, Stomach Neoplasms blood, Stomach Neoplasms pathology, Biomarkers, Tumor blood, Gastrins blood, Pepsinogen A blood, Pepsinogen C blood, Precancerous Conditions diagnosis, Stomach Neoplasms diagnosis
- Abstract
Background: Iran is a country with very high incidences of stomach cancer, especially in Northern parts. Here we assessed prognostic value of serum screening biomarkers among people >50 years old for early detection of precancerous lesions in a hot spot for gastric carcinoma in Guilan Province, North Iran., Methods: A cross- sectional population-based survey was conducted on 1,390 residents of Lashtenasha city with the mean age (SD) of 61.8 (9.02) years old (50.8% females) to assess the association of gastrin and the pepsinogen (PG) I/II ratio with premalignant gastric lesions. Blood samples were taken for CBC, blood group, and serologic exams (PGI, PGII, and gastrin 17) from each subject. Expert gastroenterologists performed upper GI endoscopy and ROC curves were generated to determine appropriate cutoff points., Results: Mean values of PGI, PGII, PGI/PGII and gastrin were significantly different between patients with and without atrophy or metaplasia (P<0.05). To diagnose atrophy and intestinal metaplasia, a significantly higher AUC was observed for the PGI/PGII ratio (70 and 72%, respectively) compared to the PGI (56, 55%), PGII (63, 64%) and gastrin (59, 61%) (all p<0.001)., Conclusions: Biomarker tests such as the PGI/II ratio can be used in the screening and diagnosis of subjects at high gastric cancer risk in our region.
- Published
- 2013
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