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Objective. While high-quality learning environments are increasingly recognized as vital for health professions education programs and student success, no tools to assess such environments have been validated for use within the pharmacy education context. This study seeks to assess whether the six-factor structure of the Health Education Learning Environment Survey (HELES) will replicate in a sample of pharmacy students. Methods. The study was conducted in a Doctor of Pharmacy program offered at a Western Canadian university. Across two years of data collection, a sample of 288 pharmacy students completed the 35-item HELES as an anonymous and online survey. Results. While the six-factor model of the HELES did not replicate through confirmatory factor analysis, a follow-up examination of unidimensionality for the individual subscales of the HELES showed that five of the six subscales met this requirement. One subscale, the work-life balance subscale, was better represented by the dimensions of time management and emotional well-being. Conclusion. These results provide preliminary support for the use of the HELES among pharmacy students, with additional research being needed to explore the work-life balance subscale and its appropriateness for this student group. In Canada, the HELES has the potential to fill an existing local and national gap in program evaluation tools, which are needed to gather evidence on pharmacy programs' quality, strengths, and weaknesses and to inform continuous quality improvement efforts and accreditation standards., (© 2022 American Association of Colleges of Pharmacy.)

The desire to support student learning and professional development, in combination with accreditation requirements, necessitates the need to evaluate the learning environment of educational programs. The Health Education Learning Environment Survey (HELES) is a recently-developed global measure of the learning environment for health professions programs. This paper provides evidence of the applicability of the HELES for evaluating the learning environment across four health professions programs: medicine, nursing, occupational therapy and pharmaceutical sciences. Two consecutive years of HELES data were collected from each program at a single university (year 1 = 552 students; year 2 = 745 students) using an anonymous online survey. Reliability analyses across programs and administration years supported the reliability of the tool. Two-way factorial ANOVAs with program and administration year as the independent variables indicated statistically- and practically-significant differences across programs for four of the seven scales. Overall, these results support the use of the HELES to evaluate student perceptions of the learning environment multiple of health professions programs., (© The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021.)

Competing Interests: Competing interests: None declared.

Preconception carrier screening offers couples the possibility to receive information about the risk of having a child with a recessive disorder. Since 2016, an expanded carrier screening (ECS) test for 50 severe autosomal recessive disorders has been available at Amsterdam Medical Center, a Dutch university hospital. This mixed-methods study evaluated the experiences of couples that participated in the carrier screening offer, including high-risk participants, as well as participants with a general population risk. All participants received genetic counselling, and pre- (n = 132) and post-test (n = 86) questionnaires and semi-structured interviews (n = 16) were administered. The most important reason to have ECS was to spare a future child a life with a severe disorder (47%). The majority of survey respondents made an informed decision (86%), as assessed by the Multidimensional Measure of Informed Choice. Among the 86 respondents, 27 individual carriers and no new carrier couples were identified. Turn-around time of the test results was considered too long and costs were perceived as too high. Overall, mean levels of anxiety were not clinically elevated. High-risk respondents (n = 89) and pregnant respondents (n = 13) experienced higher levels of anxiety before testing, which decreased after receiving the test result. Although not clinically significant, distress was on average higher for carriers compared to non-carriers (p < 0.0001). All respondents would opt for the test again, and 80.2% would recommend it to others. The results suggest that ECS should ideally be offered before pregnancy, to minimise anxiety. This study could inform current and future implementation initiatives of preconception ECS., (© 2021. The Author(s).)

The learning environment can be broadly conceptualized as the physical, social, and psychological context in which learning and socialization takes place. While there is now an expectation that health professions education programs should monitor the quality of their learning environment, existing measures have been criticized for lacking a theoretical foundation and sufficient validity evidence. Guided by Moos's learning environment framework, this study developed and preliminarily validated a global measure of the learning environment. Three pilot tests, conducted on 1,040 undergraduate medical students, refined the measure into the 35-item Health Education Learning Environment Survey (HELES), which consists of six subscales: peer relationships, faculty relationships, work-life balance, clinical skills development, expectations, and educational setting and resources. A final validation study conducted on another sample of 347 medical students confirmed its factor structure and examined its reliability and relation of the HELES to the Medical School Learning Environment Survey (MSLES). Subscale reliabilities ranged from .78 to .89. The HELES correlated with the MSLES at .79. These results indicate that the HELES can provide a valid and reliable assessment of the learning environment of medical students and, as such, can be used to inform accreditation and program planning in health professions programs.

Background & Aims: Low muscle mass and -quality on ICU admission, as assessed by muscle area and -density on CT-scanning at lumbar level 3 (L3), are associated with increased mortality. However, CT-scan analysis is not feasible for standard care. Bioelectrical impedance analysis (BIA) assesses body composition by incorporating the raw measurements resistance, reactance, and phase angle in equations. Our purpose was to compare BIA- and CT-derived muscle mass, to determine whether BIA identified the patients with low skeletal muscle area on CT-scan, and to determine the relation between raw BIA and raw CT measurements., Methods: This prospective observational study included adult intensive care patients with an abdominal CT-scan. CT-scans were analysed at L3 level for skeletal muscle area (cm 2 ) and skeletal muscle density (Hounsfield Units). Muscle area was converted to muscle mass (kg) using the Shen equation (MM CT ). BIA was performed within 72 h of the CT-scan. BIA-derived muscle mass was calculated by three equations: Talluri (MM Talluri ), Janssen (MM Janssen ), and Kyle (MM Kyle ). To compare BIA- and CT-derived muscle mass correlations, bias, and limits of agreement were calculated. To test whether BIA identifies low skeletal muscle area on CT-scan, ROC-curves were constructed. Furthermore, raw BIA and CT measurements, were correlated and raw CT-measurements were compared between groups with normal and low phase angle., Results: 110 patients were included. Mean age 59 ± 17 years, mean APACHE II score 17 (11-25); 68% male. MM Talluri and MM Janssen were significantly higher (36.0 ± 9.9 kg and 31.5 ± 7.8 kg, respectively) and MM Kyle significantly lower (25.2 ± 5.6 kg) than MM CT (29.2 ± 6.7 kg). For all BIA-derived muscle mass equations, a proportional bias was apparent with increasing disagreement at higher muscle mass. MM Talluri correlated strongest with CT-derived muscle mass (r = 0.834, p < 0.001) and had good discriminative capacity to identify patients with low skeletal muscle area on CT-scan (AUC: 0.919 for males; 0.912 for females). Of the raw measurements, phase angle and skeletal muscle density correlated best (r = 0.701, p < 0.001). CT-derived skeletal muscle area and -density were significantly lower in patients with low compared to normal phase angle., Conclusions: Although correlated, absolute values of BIA- and CT-derived muscle mass disagree, especially in the high muscle mass range. However, BIA and CT identified the same critically ill population with low skeletal muscle area on CT-scan. Furthermore, low phase angle corresponded to low skeletal muscle area and -density., Trial Registration: ClinicalTrials.gov (NCT02555670)., (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Purpose: The importance of confidence for learning and performance makes learners' perceptions of readiness for the next level of training valuable indicators of curricular success. The "Readiness for Clerkship" (RfC) and "Readiness for Residency" (RfR) surveys have been shown to provide reliable ratings of the relative effectiveness of various aspects of training. This study examines the generalizability of those results., Method: Surveys were administered at four medical schools approximately four months after the start of clerkship and eight months after the start of residency during 2013-2015. Collected data were anonymized. A total of 647 medical students and 483 residents participated., Results: Reliabilities of G = 0.8 could be obtained with only 6 to 12 medical students and 8 to 15 residents. Within MD programs, no meaningful differences in item ratings were observed across cohorts. Residents in each school consistently rated themselves higher than clerks on the majority of Medical Expert and Communicator competencies common to both surveys. Similar strengths and weaknesses were identified across programs, but differences were observed on five clerkship items and one residency item., Conclusions: Across four MD programs, the RfC and RfR surveys provided reliable ratings of the relative effectiveness of aspects of training with small numbers of respondents. The capacity of these surveys to efficiently identify perceived strengths and weaknesses held by cohorts of learners may, thereby, facilitate program improvement.

Educators often seek to demonstrate the equivalence of groups, such as whether or not students achieve comparable success regardless of the site at which they trained. A methodological consideration that is often underappreciated is how to operationalize equivalence. This study examined whether a distribution-based approach, based on effect size, can identify an appropriate equivalence threshold for medical education data. Thirty-nine individuals rated program site equivalence on a series of simulated pairwise bar graphs representing one of four measures with which they had prior experience: (1) undergraduate academic achievement, (2) a student experience survey, (3) an Objective Structured Clinical Exam global rating scale, or (4) a licensing exam. Descriptive statistics and repeated measures ANOVA examined the effects on equivalence ratings of (a) the difference between means, (b) variability in scores, and (c) which program site (the larger or smaller) scored higher. The equivalence threshold was defined as the point at which 50 % of participants rated the sites as non-equivalent. Across the four measures, the equivalence thresholds converged to average effect size of Cohen's d = 0.57 (range of 0.50-0.63). This corresponded to an average mean difference of 10 % (range of 3-13 %). These results are discussed in reference to findings from the health-related quality of life field that has demonstrated that d = 0.50 represents a consistent threshold for perceived change. This study provides preliminary empirically-based guidance for defining an equivalence threshold for researchers and evaluators conducting equivalence tests.

Background: Health professions programs continue to search for meaningful and efficient ways to evaluate the quality of education they provide and support ongoing program improvement. Despite flaws inherent in self-assessment, recent research suggests that aggregated self-assessments reliably rank aspects of competence attained during preclerkship MD training. Given the novelty of those observations, the purpose of this study was to test their generalizability by evaluating an MD program as a whole., Method: The Readiness for Residency Survey (RfR) was developed and aligned with the published Readiness for Clerkship Survey (RfC), but focused on the competencies expected to be achieved at graduation. The RfC and RfR were administered electronically four months after the start of clerkship and six months after the start of residency, respectively. Generalizability and decision studies examined the extent to which specific competencies were achieved relative to one another., Results: The reliability of scores assigned by a single resident was G = 0.32. However, a reliability of G = 0.80 could be obtained by averaging over as few as nine residents. Whereas highly rated competencies in the RfC resided within the CanMEDS domains of professional, communicator, and collaborator, five additional medical expert competencies emerged as strengths when the program was evaluated after completion by residents., Conclusions: Aggregated resident self-assessments obtained using the RfR reliably differentiate aspects of competence attained over four years of undergraduate training. The RfR and RfC together can be used as evaluation tools to identify areas of strength and weakness in an undergraduate medical education program.

Purpose: Accreditation standards require medical schools to use comparable assessment methods to ensure students in rotation-based clerkships and longitudinal integrated clerkships (LICs) achieve the same learning objectives. The National Board of Medical Examiners (NBME) Clinical Science Subject Examinations (subject exams) are commonly used, but an integrated examination like the NBME Comprehensive Clinical Science Examination (CCSE) may be better suited for LICs. This study examined the comparability of the CCSE and five commonly required subject exams., Method: In 2009-2010, third-year medical students in rotation-based clerkships at the University of British Columbia Faculty of Medicine completed subject exams in medicine, obstetrics-gynecology, pediatrics, psychiatry, and surgery for summative purposes following each rotation and a year-end CCSE for formative purposes. Data for 205 students were analyzed to determine the relationship between scores on the CCSE (and its five discipline subscales) and the five subject exams and the impact of clerkship rotation order., Results: The correlation between the CCSE score and the average score on the five subject exams was high (0.80-0.93). Four subject exam scores were significant predictors of the CCSE score, and scores on the subject exams explained 65%-87% of CCSE score variance. Scores on each subject exam-but not rotation order-were statistically significant in predicting corresponding CCSE discipline subscale scores., Conclusions: The results provide evidence that these five subject exams and the CCSE measure similar constructs. This suggests that assessment of clerkship-year students' knowledge using the CCSE is comparable to assessment using this set of subject exams.

Purpose: To examine whether or not aggregated self-assessment data of clerkship readiness can provide meaningful sources of information to evaluate the effectiveness of an educational program., Method: The 39-item Readiness for Clerkship survey was developed during academic year 2009-2010 using several key competence documents and expert review. The survey was completed by two cohorts of students (179 from the class of 2011 in February 2010, 171 from the class of 2012 in November 2010) and of clinical preceptors (384 for class of 2011 preceptors, 419 for class of 2012 preceptors). Descriptive statistics, Pearson correlations coefficients, ANOVA, and generalizability and decision studies were used to determine whether ratings could differentiate between different aspects of a training program., Results: When self-assessments were aggregated across students, their judgments aligned very well with those of faculty raters. The correlation of average scores, calculated for each item between faculty and students, was r=0.88 for 2011 and r=0.91 for 2012. This was only slightly lower than the near-perfect correlations of item averages within groups across successive years (r=0.99 for faculty; r=0.98 for students). Generalizability and decision analyses revealed that one can achieve interrater reliability in this domain with fewer students (9-21) than faculty (26-45)., Conclusions: These results provide evidence that, when aggregated, student self-assessment data from the Readiness for Clerkship Survey provide valid data for use in program evaluation that align well with an external standard.

Purpose: To examine whether the meaning and interpretation of body image are similar for breast cancer survivors and women without breast cancer., Method: Women completed the Multidimensional Body Self-Relations Questionnaire--Appearance Scales as part of two studies. There were 469 women with breast cancer and 385 women without breast cancer. Invariance testing was conducted to examine whether the items assessing the body image dimensions were similar, whether the dimensions were interpreted similarly, whether the items were equally salient and meaningful, and whether there were mean differences on the body image dimensions across the two groups., Results: The meaning and interpretation of body image dimensions related to appearance evaluation and appearance orientation were similar across the groups, yet some group differences were found for overweight preoccupation and body areas satisfaction (and not testable for self-classified weight). Breast cancer survivors reported a small yet significantly higher mean on appearance evaluation and lower mean on appearance orientation compared to the women without breast cancer., Conclusions: Meaningful comparisons in body image across cancer and non-cancer women can be made using two of the Multidimensional Body Self-Relations Questionnaire--Appearance Scales. The overweight preoccupation subscale could be used to assess body image but should not be used if group mean differences are desirable. Assessing satisfaction with body areas across these groups is not recommended and may introduce systematic bias.

The majority of body image measures have largely been developed with younger female samples. Before these measures can be applied to men, and to middle-aged and older women, and used to make gender and age comparisons, they must exhibit adequate cross-group measurement invariance. This study examined the age and gender cross-group measurement invariance of the Appearance Schemas Inventory-Revised (ASI-R) and the Body Image Quality of Life Inventory (BIQLI), with a sample of 1,262 adults (422 men and 840 women) aged 18 to 98 years. For the ASI-R, all groups met requirements for configural and metric invariance. Scalar invariance was found only for the three age groups, which indicated that mean comparisons may be conducted across gender for young, middle-aged, and older adults but should not be conducted across age groups within either gender. Results for the BIQLI indicated that observed mean comparisons may be conducted across all age and gender groups.

Reversible male antifertility activity was obtained with orally administered gossypol acetic acid in rats at 20 mg/kg/day and in hamsters at 10 mg/kg/day but not in mice at dosages up to 40 mg/kg/day. An increased number of degenerating spermatocytes was found in the testicular tubular lumens of rats. Pigment-laden cells containing an intracytoplasmic lipofuscin-like material were noted in the testis and epididymal interstitium in rats and mice. Gossypol was also tested in the female for effects on ovulation and pregnancy. Gossypol did not inhibit ovulation in the rat at dosages up to 80 mg/kg/day but did cause 90% inhibition of pregnancy in mice treated with 80 mg/kg/day during the first two weeks of pregnancy. In several standard endocrine bioassays, gossypol did not demonstrate estrogenic, antiestrogenic, androgenic or antiandrogenic activities, but it did potentiate the androgenicity of methyltestosterone.