510 results on '"Ng, Eric"'
Search Results
502. Science fiction to reality: imagining what's possible in future military technology.
- Author
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Ng, Eric P. and Ng, Eric P.
- Abstract
Imagination and a continuously evolving understanding of physical principles serve as the only bounds of future technological capabilities as the United States Army transforms itself into a force capable of dominating in multi-domain operations (MDO), technology's role in establishing and maintaining an advantage over America's adversaries increases. The American governmental apparatus contains organizations tasked with funding, researching, developing, and integrating new technologies into the force as they grow. This monograph describes capabilities presently under development that will serve as the foundation for next-generation concepts that only currently exist in science fiction but realistically have the potential to come to fruition. It outlines the potential opportunities these in-progress technologies provide and how they can integrate into the future operating environment across all domains.
503. Reproduction, larviculture and early development of the Bluebanded goby, Lythrypnus dalli, an emerging model organism for studies in evolutionary developmental biology and sexual plasticity
- Author
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Archambeault, Sophie, Ng, Eric, Rapp, Lyle, Cerino, David, Bourque, Bradford, Solomon-Lane, Tessa, Grober, Matthew S., Rhyne, Andrew, Crow, Karen, Archambeault, Sophie, Ng, Eric, Rapp, Lyle, Cerino, David, Bourque, Bradford, Solomon-Lane, Tessa, Grober, Matthew S., Rhyne, Andrew, and Crow, Karen
504. Laser welding of high carbon steels
- Author
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Ng, Eric Eng Seng and Ng, Eric Eng Seng
- Abstract
Laser welding, unlike conventional arc or gas welding, can be effectively utilised to produce high quality, clean and tough welds in high carbon steels. Results of welding high carbon steel are presented. The weld characteristics related to the fast cooling rate were critically evaluated and methods to reduce the rate of cooling were developed. The grain size produced in the fusion and narrow heat affected zones significantly affected the mechanical properties of the welded joint. Three lasers were used: Nd:YAG, CO2 and a high power laser diode (HPDL). The investigations were carried out using a pulsed, 400 W, Nd:YAG laser, a CW, 1.2 kW, CO2 laser and a CW, 1.4 kW high power diode laser. For the Nd:YAG laser, the dual beam delivery system was achieved with a step index fibre to produce in-line process heat-treatment during welding. The spatial and temporal temperature distribution was controlled in the weld region to generate the desired mechanical properties, without losing the benefits of this low distortion joining process. For the CO2 laser system, a dual beam system was successfully designed, fabricated and the performance of the multiple beam system was evaluated. The welding quality was characterised by quantifying the effect of different laser parameters and welding geometry, including flat, angular, clamped and unclamped. The welding performance of the Nd-YAG laser was dependent on the welding speed, pulse width and pulse repetition frequency (PRF). The effect of varying the laser parameters was quantified by measuring the hardness profiles, tensile strength, weld width, weld penetration and the rare of weld volume formation. Furthermore, microscopic examination was conducted at the welded joint. The quality of the welds was improved by increasing the pulse width and pulse repetition frequency (PRF), achieving a deeper penetration, wider weld width and greater weld volume formation rate and a tougher weld. At a slower welding speed, and for the higher pulse
505. Laser welding of high carbon steels
- Author
-
Ng, Eric Eng Seng and Ng, Eric Eng Seng
- Abstract
Laser welding, unlike conventional arc or gas welding, can be effectively utilised to produce high quality, clean and tough welds in high carbon steels. Results of welding high carbon steel are presented. The weld characteristics related to the fast cooling rate were critically evaluated and methods to reduce the rate of cooling were developed. The grain size produced in the fusion and narrow heat affected zones significantly affected the mechanical properties of the welded joint. Three lasers were used: Nd:YAG, CO2 and a high power laser diode (HPDL). The investigations were carried out using a pulsed, 400 W, Nd:YAG laser, a CW, 1.2 kW, CO2 laser and a CW, 1.4 kW high power diode laser. For the Nd:YAG laser, the dual beam delivery system was achieved with a step index fibre to produce in-line process heat-treatment during welding. The spatial and temporal temperature distribution was controlled in the weld region to generate the desired mechanical properties, without losing the benefits of this low distortion joining process. For the CO2 laser system, a dual beam system was successfully designed, fabricated and the performance of the multiple beam system was evaluated. The welding quality was characterised by quantifying the effect of different laser parameters and welding geometry, including flat, angular, clamped and unclamped. The welding performance of the Nd-YAG laser was dependent on the welding speed, pulse width and pulse repetition frequency (PRF). The effect of varying the laser parameters was quantified by measuring the hardness profiles, tensile strength, weld width, weld penetration and the rare of weld volume formation. Furthermore, microscopic examination was conducted at the welded joint. The quality of the welds was improved by increasing the pulse width and pulse repetition frequency (PRF), achieving a deeper penetration, wider weld width and greater weld volume formation rate and a tougher weld. At a slower welding speed, and for the higher pulse
506. Redefining Route Clearance For Future Operations.
- Author
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Weakley, James B. and Ng, Eric P.
- Subjects
- *
RAILROAD clearances , *IMPROVISED explosive devices , *MILITARY tactics , *MILITARY science - Abstract
The article discusses the route clearance missions of the U.S. Army which entails eliminating improvised explosive devices and other explosive hazards along a route. It explores the tendency of designating the extent to which a route is clear to oversimplify the route's tactical condition. It notes the significance to include the neutralization of obstacles along an assigned route in the clearance operation. It also emphasizes how explosive hazards risk route clearance assets.
- Published
- 2014
507. Revised physical parameters and study on magnetic activities for the eclipsing binary USNO-B1.0 1387-0467554.
- Author
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Wang, Jianhua, Gu, Shenghong, Wang, Xiaobin, Yeung, Bill, Ng, Eric, Yu, Kamfung, Sun, Leilei, Xiang, Yue, Cao, Dongtao, Bai, Jinming, Fan, Yufeng, Xu, Fukun, Liu, Yisi, Xu, Xiaoyun, and Luo, Nanping
- Subjects
- *
ECLIPSING binaries , *SOLAR chromosphere , *STELLAR chromospheres , *LIGHT curves , *TIDAL forces (Mechanics) , *MAGNETIC fields , *OBSERVATORIES - Abstract
We present optimized physical parameters of the active eclipsing binary system USNO-B1.0 1387-0467554 discovered recently in Yunnan–Hong Kong wide-field photometric (YNHK) survey, based on the analysis of its two colour light curves and low resolution spectra obtained at Yunnan Observatories, China. Its spot distributions are derived by means of the Wilson–Devinney code, using photometric data of the YNHK survey from 2016 to 2021. There exist active longitude belts for the spot activities on the primary star, for which the effect of tidal force seems dominant comparing with the one of common magnetic field of the binary system. We have investigated its chromospheric activities through the indicators including Hα, Hβ, CaII H&K, and HeI D3 lines covered by the low resolution spectroscopic observations. There are obvious spatial correlations between the magnetic activities in its photosphere and chromosphere. The E H α/ E H β values suggest that both plages and prominences led to the emissions seen in the Balmer lines at most phases. A prominence structure appeared around the phase of 0.8 on 2018 October 25 and evolved in November and December, 2018. The spectra demonstrate that there were frequent flare events in the system. Moreover, the decay part of a white-light flare event was hunted by the YNHK survey on 2021 October 26. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
508. Additives interactions in the thermo-oxidative degradation of metallocene polyethylene
- Author
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HoaÌ€ng, Eric MiÌnh
- Subjects
- 668, Plastics
- Abstract
During the 1990's the development of metallocene catalysts has made a dramatic impact on the polyethylene industry. A large amount of work can be found in the literature regarding the degradation and stabilisation of conventional polyethylenes. However, very few studies have been devoted to these novel metallocene polymers. The first part of this thesis deals with the thermo-oxidative degradation of various metallocene polyethylenes (mPE's) in the solid state (oven ageing at 90°C in air) and the melt state (via mastication in air in a Brabender® mixer). For each mPE, essentially one characteristic (melt index, molar mass distribution, density and ash content) was changed at a time. In the second part, the effect of different grades (animal versus vegetable) and types (calcium versus zinc stearates) of metallic stearates in combination with phenolic and phosphite antioxidants was investigated in the melt stabilisation of a standard metallocene LLDPE (mLLDPE). Finally, interactions between additives present in a typical stabiliser package used for film grade LLDPE were assessed in the stabilisation of the mLLDPE with help of a two-level factorial design of experiments. The response included melt flow protection and discolouration during processing, as well as long-term stability. Outstanding thermo-oxidative stability was exhibited for all the mPE's in the solid state. This remarkable oxidative stability was believed to be due to the presence of low concentrations of innocuous metal catalyst residues, as well as low initial vinyl unsaturation content and degree of branching. Furthermore, polymer density/crystallinity appeared to reduce the spreading rate of oxidation. In the case of thermo-oxidation in the melt state, the polymer melt viscosity appeared to govern the processing stability of the metallocene polymers. In the second part, it was found that the quality of the metal stearates, i.e., peroxide content, metal oxide and unsaturation, may affect the performance of the phenolic and phosphite antioxidants in the melt stabilisation of the mLLDPE. Finally, the statistical design of experiments proved to be a very useful tool for screening the effects of each additive and the possible interactions between additives present in the investigated stabiliser system.
- Published
- 2003
509. Detecting HLA loss of heterozygosity within a standard diagnostic sequencing workflow for prognostic and therapeutic opportunities.
- Author
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Lozac'hmeur A, Danek T, Yang Q, Rosasco MG, Welch JS, Go WY, Ng EW, Mardiros A, Maloney DG, Garon EB, Kirtane K, Simeone DM, Molina JR, Salahudeen AA, Stein MM, and Hecht JR
- Abstract
To enable interrogation of tumor HLA LOH as a clinical diagnostic for precision oncology, we developed and validated an assay that detects HLA LOH within the context of an FDA-approved clinical diagnostic test, Tempus xT CDx. Validation was conducted via: (1) analytical evaluation of 17 archival patient samples and 42 cell line admixtures and (2) independent clinical evaluation of LOH prevalence in the HLA-A gene (HLA-A LOH) across 10,982 patients. To evaluate the prognostic relevance of HLA-A LOH we assessed 256 immunotherapy-treated non-small cell lung cancer (NSCLC) patients. To determine the feasibility of prospectively identifying and enrolling HLA-A LOH patients into a clinical trial, we established BASECAMP-1 (NCT04981119). We observed a positive predictive agreement of 97% and a negative predictive agreement of 100% in samples with ≥ 40% tumor purity. We observed HLA-A LOH in 16.1% of patients (1771/10,982), comparable to previous reports. HLA-A LOH was associated with longer survival among NSCLC adenocarcinoma patients (HR = 0.60, 95% CI [0.37, 0.96], p = 0.032) with a trend towards shorter survival among squamous cell patients (HR = 1.64, 95% CI [0.80, 3.41], p = 0.183). In 20 months, we prospectively screened 1720 subjects using the Tempus AWARE program, identifying 26 HLA-A*02 LOH patients at 8 sites, with 14 (54%) enrolled into BASECAMP-1. In conclusion, we developed and validated an investigational assay that detects tumor HLA LOH within an FDA-approved clinical diagnostic test, enabling HLA LOH utilization in diagnostic, prognostic, and therapeutic applications., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
510. Sinorhizobium meliloti BR-bodies promote fitness during host colonization.
- Author
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Mallikaarachchi KS, Huang JL, Madras S, Cuellar RA, Huang Z, Gega A, Rathnayaka-Mudiyanselage IW, Al-Husini N, Saldaña-Rivera N, Ma LH, Ng E, Chen JC, and Schrader JM
- Abstract
Biomolecular condensates, such as the nucleoli or P-bodies, are non-membrane-bound assemblies of proteins and nucleic acids that facilitate specific cellular processes. Like eukaryotic P-bodies, the recently discovered bacterial ribonucleoprotein bodies (BR-bodies) organize the mRNA decay machinery, yet the similarities in molecular and cellular functions across species have been poorly explored. Here, we examine the functions of BR-bodies in the nitrogen-fixing endosymbiont Sinorhizobium meliloti , which colonizes the roots of compatible legume plants. Assembly of BR-bodies into visible foci in S. meliloti cells requires the C-terminal intrinsically disordered region (IDR) of RNase E, and foci fusion is readily observed in vivo , suggesting they are liquid-like condensates that form via mRNA sequestration. Using Rif-seq to measure mRNA lifetimes, we found a global slowdown in mRNA decay in a mutant deficient in BR-bodies, indicating that compartmentalization of the degradation machinery promotes efficient mRNA turnover. While BR-bodies are constitutively present during exponential growth, the abundance of BR-bodies increases upon cell stress, whereby they promote stress resistance. Finally, using Medicago truncatula as host, we show that BR-bodies enhance competitiveness during colonization and appear to be required for effective symbiosis, as mutants without BR-bodies failed to stimulate plant growth. These results suggest that BR-bodies provide a fitness advantage for bacteria during infection, perhaps by enabling better resistance against the host immune response.
- Published
- 2024
- Full Text
- View/download PDF
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