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604 results on '"Johnny Huard"'

602. Locus of Control in Women Occupying Middle-Management and Nonmanagement Positions

Author

A. St-Yves, F. Contant, Mark H. Freeston, Johnny Huard, and B. Lemieux

Subjects
Occupational level, 05 social sciences, Significant difference, 050301 education, Middle management, 050109 social psychology, Locus of control, 0501 psychology and cognitive sciences, Psychology, 0503 education, Social psychology, General Psychology, Demography, Social desirability
Abstract

The relationship between locus of control and occupational level was investigated for middle-management ( n = 20) and nonmanagement ( n = 41) women employed at a financial services company. No significant difference was found between the groups for locus of control or for social desirability. Significant correlations were found for the nonmanagement group between externality and schooling ( r = –.39), years of service ( r =.42), and social desirability ( r = –.47), but none were found for women in middle management. A significant moderate correlation of –.39 was obtained between locus of control and social desirability for all 61 women.

Published
1989
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603. The role of CD34 expression and cellular fusion in the regeneration capacity of myogenic progenitor cells.

Author

J, Jankowski Ron, M, Deasy Bridget, Baohong, Cao, Charley, Gates, and Johnny, Huard

Abstract

Characterization of myogenic subpopulations has traditionally been performed independently of their functional performance following transplantation. Using the preplate technique, which separates cells based on their variable adhesion characteristics, we investigated the use of cell surface proteins to potentially identify progenitors with enhanced regeneration capabilities. Based on previous studies, we used cell sorting to investigate stem cell antigen-1 (Sca-1) and CD34 expression on myogenic populations with late adhesion characteristics. We compared the regeneration efficiency of these sorted progenitors, as well as those displaying early adhesion characteristics, by quantifying their ability to regenerate skeletal muscle and restore dystrophin following transplantation into allogenic dystrophic host muscle. Identification and utilization of late adhering populations based on CD34 expression led to differential regeneration, with CD34-positive populations exhibiting significant improvements in dystrophin restoration compared with both their CD34-negative counterparts and early adhering cell populations. Regenerative capacity was found to correspond to the level of myogenic commitment, defined by myogenic regulatory factor expression, and the rate and degree of induced cell differentiation and fusion. These results demonstrate the ability to separate definable subpopulations of myogenic progenitors based on CD34 expression and reveal the potential implications of defining myogenic cell behavioral and phenotypic characteristics in relation to their regenerative capacity in vivo.

Published
2002

604. The role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair

Author

Johnny Huard, Sarah A. Beckman, Arman Saparov, Chien Wen Chen, and Yadong Wang

Subjects
medicine.medical_treatment, Cell- and Tissue-Based Therapy, Review, 030204 cardiovascular system & hematology, Antioxidants, Pathogenesis, lcsh:Chemistry, Mice, 0302 clinical medicine, oxidative stress, Myocardial infarction, lcsh:QH301-705.5, Spectroscopy, 0303 health sciences, Heart, General Medicine, Stem-cell therapy, 3. Good health, Computer Science Applications, myocardial infarction, cardiac repair, medicine.symptom, Stem cell, Inflammation, Biology, Catalysis, Inorganic Chemistry, Immunomodulation, 03 medical and health sciences, Immune system, stem cells, medicine, Animals, Humans, Regeneration, Physical and Theoretical Chemistry, Molecular Biology, 030304 developmental biology, Multipotent Stem Cells, Organic Chemistry, Mesenchymal stem cell, Mesenchymal Stem Cells, medicine.disease, immune system, lcsh:Biology (General), lcsh:QD1-999, Multipotent Stem Cell, inflammation, Immunology, Cancer research, Pericytes, Stem Cell Transplantation
Abstract

Oxidative stress and inflammation play major roles in the pathogenesis of coronary heart disease including myocardial infarction (MI). The pathological progression following MI is very complex and involves a number of cell populations including cells localized within the heart, as well as cells recruited from the circulation and other tissues that participate in inflammatory and reparative processes. These cells, with their secretory factors, have pleiotropic effects that depend on the stage of inflammation and regeneration. Excessive inflammation leads to enlargement of the infarction site, pathological remodeling and eventually, heart dysfunction. Stem cell therapy represents a unique and innovative approach to ameliorate oxidative stress and inflammation caused by ischemic heart disease. Consequently, it is crucial to understand the crosstalk between stem cells and other cells involved in post-MI cardiac tissue repair, especially immune cells, in order to harness the beneficial effects of the immune response following MI and further improve stem cell-mediated cardiac regeneration. This paper reviews the recent findings on the role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair following ischemic heart disease, particularly acute MI and focuses specifically on mesenchymal, muscle and blood-vessel-derived stem cells due to their antioxidant and immunomodulatory properties.

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