351. Cyclosporine-induced sebaceous hyperplasia in a hematopoetic stem cell transplant patient: delayed onset of a common adverse event.
- Author
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Wilken R, Fung MA, Shi VY, Cheng MY, Patel F, Sultani H, and Maverakis E
- Subjects
- Adult, Biopsy, Humans, Immunosuppressive Agents adverse effects, Male, Sebaceous Gland Diseases diagnosis, Sebaceous Glands drug effects, Cyclosporine adverse effects, Graft vs Host Disease drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma surgery, Sebaceous Gland Diseases chemically induced, Sebaceous Glands pathology, Stem Cell Transplantation adverse effects
- Abstract
Cyclosporine-induced sebaceous hyperplasia (SH) is a well-documented entity, occurring in up to 30% of renal transplant patients treated with cyclosporine and has also been reported to occur following heart or hematopoetic stem cell transplantation (HCST). Cyclosporine has a stimulatory effect on undifferentiated sebocytes, resulting in the clinical and histologic findings in these patients. Sebaceous hyperplasia most commonly presents as asymptomatic papules over the face, chest, or groin. Herein we describe a case of a 27-year-old man who developed facial sebaceous hyperplasia five months after completing cyclosporine therapy for cutaneous graft versus host disease (GVHD) following HSCT.
- Published
- 2016