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5,584 results on '"Chang, Ling"'

609. Inhibition of CDCP1 by 8‐isopentenylnaringenin synergizes with EGFR inhibitors in lung cancer treatment

Author

Wong, Sze‐Ching, primary, Yeh, Chun‐Chieh, additional, Zhang, Xun‐Yu, additional, Hsieh, Chih‐Ying, additional, Lo, Chia‐Chien, additional, Kuo, Ting‐Ting, additional, Lin, Ching‐Chan, additional, Chao, Chih‐Hua, additional, Liu, Jing‐Pei, additional, Chang, Ling‐Chu, additional, Wang, Lu‐Hai, additional, and Sher, Yuh‐Pyng, additional

Published
2023
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610. Supplementary Data Table 2 from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Author

Lewis, Nuruddeen D., primary, Sia, Chang Ling, primary, Kirwin, Katherine, primary, Haupt, Sonya, primary, Mahimkar, Gauri, primary, Zi, Tong, primary, Xu, Ke, primary, Dooley, Kevin, primary, Jang, Su Chul, primary, Choi, Bryan, primary, Boutin, Adam, primary, Grube, Andrew, primary, McCoy, Christine, primary, Sanchez-Salazar, Jorge, primary, Doherty, Michael, primary, Gaidukov, Leonid, primary, Estes, Scott, primary, Economides, Kyriakos D., primary, Williams, Douglas E., primary, and Sathyanarayanan, Sriram, primary

Published
2023
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611. Supplementary Figure from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Author

Lewis, Nuruddeen D., primary, Sia, Chang Ling, primary, Kirwin, Katherine, primary, Haupt, Sonya, primary, Mahimkar, Gauri, primary, Zi, Tong, primary, Xu, Ke, primary, Dooley, Kevin, primary, Jang, Su Chul, primary, Choi, Bryan, primary, Boutin, Adam, primary, Grube, Andrew, primary, McCoy, Christine, primary, Sanchez-Salazar, Jorge, primary, Doherty, Michael, primary, Gaidukov, Leonid, primary, Estes, Scott, primary, Economides, Kyriakos D., primary, Williams, Douglas E., primary, and Sathyanarayanan, Sriram, primary

Published
2023
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612. Supplementary Table 1 from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Author

Lewis, Nuruddeen D., primary, Sia, Chang Ling, primary, Kirwin, Katherine, primary, Haupt, Sonya, primary, Mahimkar, Gauri, primary, Zi, Tong, primary, Xu, Ke, primary, Dooley, Kevin, primary, Jang, Su Chul, primary, Choi, Bryan, primary, Boutin, Adam, primary, Grube, Andrew, primary, McCoy, Christine, primary, Sanchez-Salazar, Jorge, primary, Doherty, Michael, primary, Gaidukov, Leonid, primary, Estes, Scott, primary, Economides, Kyriakos D., primary, Williams, Douglas E., primary, and Sathyanarayanan, Sriram, primary

Published
2023
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613. 20201229pdtedSupplementaryFigures.pdf from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Author

Lewis, Nuruddeen D., primary, Sia, Chang Ling, primary, Kirwin, Katherine, primary, Haupt, Sonya, primary, Mahimkar, Gauri, primary, Zi, Tong, primary, Xu, Ke, primary, Dooley, Kevin, primary, Jang, Su Chul, primary, Choi, Bryan, primary, Boutin, Adam, primary, Grube, Andrew, primary, McCoy, Christine, primary, Sanchez-Salazar, Jorge, primary, Doherty, Michael, primary, Gaidukov, Leonid, primary, Estes, Scott, primary, Economides, Kyriakos D., primary, Williams, Douglas E., primary, and Sathyanarayanan, Sriram, primary

Published
2023
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614. Table S3 from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Author

Lewis, Nuruddeen D., primary, Sia, Chang Ling, primary, Kirwin, Katherine, primary, Haupt, Sonya, primary, Mahimkar, Gauri, primary, Zi, Tong, primary, Xu, Ke, primary, Dooley, Kevin, primary, Jang, Su Chul, primary, Choi, Bryan, primary, Boutin, Adam, primary, Grube, Andrew, primary, McCoy, Christine, primary, Sanchez-Salazar, Jorge, primary, Doherty, Michael, primary, Gaidukov, Leonid, primary, Estes, Scott, primary, Economides, Kyriakos D., primary, Williams, Douglas E., primary, and Sathyanarayanan, Sriram, primary

Published
2023
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616. Nonlinear Optical Radiation of a Lithium Niobate Microcavity

Author

Yang, Yuan-Hao, primary, Xu, Xin-Biao, additional, Wang, Jia-Qi, additional, Zhang, Mai, additional, Li, Ming, additional, Zhu, Zheng-Xu, additional, Wang, Zhu-Bo, additional, Dong, Chun-Hua, additional, Fang, Wei, additional, Yu, Huakang, additional, Guo, Guang-Can, additional, and Zou, Chang-Ling, additional

Published
2023
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618. Beating the break-even point with a discrete-variable-encoded logical qubit

Author

Ni, Zhongchu, primary, Li, Sai, additional, Deng, Xiaowei, additional, Cai, Yanyan, additional, Zhang, Libo, additional, Wang, Weiting, additional, Yang, Zhen-Biao, additional, Yu, Haifeng, additional, Yan, Fei, additional, Liu, Song, additional, Zou, Chang-Ling, additional, Sun, Luyan, additional, Zheng, Shi-Biao, additional, Xu, Yuan, additional, and Yu, Dapeng, additional

Published
2023
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627. Experimental quantum end-to-end learning on a superconducting processor

Author

Pan, Xiaoxuan, primary, Cao, Xi, additional, Wang, Weiting, additional, Hua, Ziyue, additional, Cai, Weizhou, additional, Li, Xuegang, additional, Wang, Haiyan, additional, Hu, Jiaqi, additional, Song, Yipu, additional, Deng, Dong-Ling, additional, Zou, Chang-Ling, additional, Wu, Re-Bing, additional, and Sun, Luyan, additional

Published
2023
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635. Vector space embedding of DNS query behaviors by deep learning

Author

Chang-ling ZHOU, Xing-long LUAN, and Jian-guo XIAO

Subjects
DNS, deep learning, context, dimension reduction, behavior analysis, hierarchical clustering, Telecommunication, TK5101-6720
Abstract

A novel approach to analyze DNS query behaviors was introduced.This approach embeds queried domains or querying hosts to vector space by deep learning mechan then the relationship between querying of domains or hosts was mapped to vector space operations.By processing two real campus network DNS log datasets,it is found that this method maintains relationships very well.After doing mension reduction and clustering analysis,researchers can not only easily explore hidden relationships intuitively,but also discover abnormal network events like botnet.

Published
2016
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640. Table S3 from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Author

Sriram Sathyanarayanan, Douglas E. Williams, Kyriakos D. Economides, Scott Estes, Leonid Gaidukov, Michael Doherty, Jorge Sanchez-Salazar, Christine McCoy, Andrew Grube, Adam Boutin, Bryan Choi, Su Chul Jang, Kevin Dooley, Ke Xu, Tong Zi, Gauri Mahimkar, Sonya Haupt, Katherine Kirwin, Chang Ling Sia, and Nuruddeen D. Lewis

Abstract

Reagents and antibodies

Published
2023
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641. Data from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Author

Sriram Sathyanarayanan, Douglas E. Williams, Kyriakos D. Economides, Scott Estes, Leonid Gaidukov, Michael Doherty, Jorge Sanchez-Salazar, Christine McCoy, Andrew Grube, Adam Boutin, Bryan Choi, Su Chul Jang, Kevin Dooley, Ke Xu, Tong Zi, Gauri Mahimkar, Sonya Haupt, Katherine Kirwin, Chang Ling Sia, and Nuruddeen D. Lewis

Abstract

The promise of IL12 as a cancer treatment has yet to be fulfilled with multiple tested approaches being limited by unwanted systemic exposure and unpredictable pharmacology. To address these limitations, we generated exoIL12, a novel, engineered exosome therapeutic that displays functional IL12 on the surface of an exosome. IL12 exosomal surface expression was achieved via fusion to the abundant exosomal surface protein PTGFRN resulting in equivalent potency in vitro to recombinant IL12 (rIL12) as demonstrated by IFNγ production. Following intratumoral injection, exoIL12 exhibited prolonged tumor retention and greater antitumor activity than rIL12. Moreover, exoIL12 was significantly more potent than rIL12 in tumor growth inhibition. In the MC38 model, complete responses were observed in 63% of mice treated with exoIL12; in contrast, rIL12 resulted in 0% complete responses at an equivalent IL12 dose. This correlated with dose-dependent increases in tumor antigen–specific CD8+ T cells. Rechallenge studies of exoIL12 complete responder mice showed no tumor regrowth, and depletion of CD8+ T cells completely abrogated antitumor activity of exoIL12. Following intratumoral administration, exoIL12 exhibited 10-fold higher intratumoral exposure than rIL12 and prolonged IFNγ production up to 48 hours. Retained local pharmacology of exoIL12 was further confirmed using subcutaneous injections in nonhuman primates. This work demonstrates that tumor-restricted pharmacology of exoIL12 results in superior in vivo efficacy and immune memory without systemic IL12 exposure and related toxicity. ExoIL12 is a novel cancer therapeutic candidate that overcomes key limitations of rIL12 and thereby creates a therapeutic window for this potent cytokine.

Published
2023
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642. Supplementary Table 1 from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Author

Sriram Sathyanarayanan, Douglas E. Williams, Kyriakos D. Economides, Scott Estes, Leonid Gaidukov, Michael Doherty, Jorge Sanchez-Salazar, Christine McCoy, Andrew Grube, Adam Boutin, Bryan Choi, Su Chul Jang, Kevin Dooley, Ke Xu, Tong Zi, Gauri Mahimkar, Sonya Haupt, Katherine Kirwin, Chang Ling Sia, and Nuruddeen D. Lewis

Abstract

Mean Cytokine Values in Cynomolgus Plasma After Subcutaneous Dosing

Published
2023
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643. Supplementary Data Table 2 from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Author

Sriram Sathyanarayanan, Douglas E. Williams, Kyriakos D. Economides, Scott Estes, Leonid Gaidukov, Michael Doherty, Jorge Sanchez-Salazar, Christine McCoy, Andrew Grube, Adam Boutin, Bryan Choi, Su Chul Jang, Kevin Dooley, Ke Xu, Tong Zi, Gauri Mahimkar, Sonya Haupt, Katherine Kirwin, Chang Ling Sia, and Nuruddeen D. Lewis

Abstract

Fold-change Cytokine Values in Cynomolgus Plasma After Subcutaneous Dosing

Published
2023
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644. Supplementary Figure from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Author

Sriram Sathyanarayanan, Douglas E. Williams, Kyriakos D. Economides, Scott Estes, Leonid Gaidukov, Michael Doherty, Jorge Sanchez-Salazar, Christine McCoy, Andrew Grube, Adam Boutin, Bryan Choi, Su Chul Jang, Kevin Dooley, Ke Xu, Tong Zi, Gauri Mahimkar, Sonya Haupt, Katherine Kirwin, Chang Ling Sia, and Nuruddeen D. Lewis

Abstract

Figures S1 through S6

Published
2023
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645. 20201229pdtedSupplementaryFigures.pdf from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Author

Sriram Sathyanarayanan, Douglas E. Williams, Kyriakos D. Economides, Scott Estes, Leonid Gaidukov, Michael Doherty, Jorge Sanchez-Salazar, Christine McCoy, Andrew Grube, Adam Boutin, Bryan Choi, Su Chul Jang, Kevin Dooley, Ke Xu, Tong Zi, Gauri Mahimkar, Sonya Haupt, Katherine Kirwin, Chang Ling Sia, and Nuruddeen D. Lewis

Abstract

20201229pdtedSupplementaryFigures.pdf from Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12

Published
2023
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649. Experimental quantum end-to-end learning on a superconducting processor

Author

Xiaoxuan Pan, Xi Cao, Weiting Wang, Ziyue Hua, Weizhou Cai, Xuegang Li, Haiyan Wang, Jiaqi Hu, Yipu Song, Dong-Ling Deng, Chang-Ling Zou, Re-Bing Wu, and Luyan Sun

Subjects
Quantum Physics, Computational Theory and Mathematics, Computer Networks and Communications, ComputerSystemsOrganization_MISCELLANEOUS, Computer Science (miscellaneous), FOS: Physical sciences, 81P05, Statistical and Nonlinear Physics, Quantum Physics (quant-ph)
Abstract

Machine learning can be substantially powered by a quantum computer owing to its huge Hilbert space and inherent quantum parallelism. In the pursuit of quantum advantages for machine learning with noisy intermediate-scale quantum devices, it was proposed that the learning model can be designed in an end-to-end fashion, i.e., the quantum ansatz is parameterized by directly manipulable control pulses without circuit design and compilation. Such gate-free models are hardware friendly and can fully exploit limited quantum resources. Here, we report the first experimental realization of quantum end-to-end machine learning on a superconducting processor. The trained model can achieve 98% recognition accuracy for two handwritten digits (via two qubits) and 89% for four digits (via three qubits) in the MNIST (Mixed National Institute of Standards and Technology) database. The experimental results exhibit the great potential of quantum end-to-end learning for resolving complex real-world tasks when more qubits are available., 6 pages, 4 figures and supplement

Published
2023
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