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14,324 results on '"Brooks, David"'

605. Hinode/Extreme-Ultraviolet Imaging Spectrometer Observations of the Temperature Structure of the Quiet Corona

Author

Brooks, David H., Warren, Harry P., Williams, David R., and Watanabe, Tetsuya

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We present a Differential Emission Measure (DEM) analysis of the quiet solar corona on disk using data obtained by the Extreme-ultraviolet Imaging Spectrometer (EIS) on {\it Hinode}. We show that the expected quiet Sun DEM distribution can be recovered from judiciously selected lines, and that their average intensities can be reproduced to within 30%. We present a subset of these selected lines spanning the temperature range $\log$ T = 5.6 to 6.4 K that can be used to derive the DEM distribution reliably. The subset can be used without the need for extensive measurements and the observed intensities can be reproduced to within the estimated uncertainty in the pre-launch calibration of EIS. Furthermore, using this subset, we also demonstrate that the quiet coronal DEM distribution can be recovered on size scales down to the spatial resolution of the instrument (1$"$ pixels). The subset will therefore be useful for studies of small-scale spatial inhomogeneities in the coronal temperature structure, for example, in addition to studies requiring multiple DEM derivations in space or time. We apply the subset to 45 quiet Sun datasets taken in the period 2007 January to April, and show that although the absolute magnitude of the coronal DEM may scale with the amount of released energy, the shape of the distribution is very similar up to at least $\log$ T $\sim$ 6.2 K in all cases. This result is consistent with the view that the {\it shape} of the quiet Sun DEM is mainly a function of the radiating and conducting properties of the plasma and is fairly insensitive to the location and rate of energy deposition. This {\it universal} DEM may be sensitive to other factors such as loop geometry, flows, and the heating mechanism, but if so they cannot vary significantly from quiet Sun region to region., Comment: Version accepted by ApJ and published in ApJ 705. Abridged abstract

Published
2009
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606. Flows and Motions in Moss in the Core of a Flaring Active Region: Evidence for Steady Heating

Author

Brooks, David H. and Warren, Harry P.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

We present new measurements of the time variability of intensity, Doppler and non-thermal velocities in moss in an active region core observed by the EUV Imaging Spectrometer on Hinode in 2007, June. The measurements are derived from spectral profiles of the Fe 12 195A line. Using the 2" slit, we repeatedly scanned 150" by 150" in a few mins. This is the first time it has been possible to make such velocity measurements in the moss, and the data presented are the highest cadence spatially resolved maps of moss Doppler and non-thermal velocities ever obtained in the corona. The observed region produced numerous C- and M- class flares with several occurring in the core close to the moss. The magnetic field was therefore clearly changing in the active region core, so we ought to be able to detect dynamic signatures in the moss if they exist. Our measurements of moss intensities agree with previous studies in that a less than 15% variability is seen over a period of 16 hours. Our new measurements of Doppler and non-thermal velocities reveal no strong flows or motions in the moss, nor any significant variability in these quantities. The results confirm that moss at the bases of high temperature coronal loops is heated quasi-steadily. They also show that quasi-steady heating can contribute significantly even in the core of a flare productive active region. Such heating may be impulsive at high frequency, but if so it does not give rise to large flows or motions., Comment: This is the published version (after refereeing)

Published
2009
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607. The Temperature and Density Structure of the Solar Corona. I. Observations of the Quiet Sun with the EUV Imaging Spectrometer (EIS) on Hinode

Author

Warren, Harry P. and Brooks, David H.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Measurements of the temperature and density structure of the solar corona provide critical constraints on theories of coronal heating. Unfortunately, the complexity of the solar atmosphere, observational uncertainties, and the limitations of current atomic calculations, particularly those for Fe, all conspire to make this task very difficult. A critical assessment of plasma diagnostics in the corona is essential to making progress on the coronal heating problem. In this paper we present an analysis of temperature and density measurements above the limb in the quiet corona using new observations from the EUV Imaging Spectrometer (EIS) on \textit{Hinode}. By comparing the Si and Fe emission observed with EIS we are able to identify emission lines that yield consistent emission measure distributions. With these data we find that the distribution of temperatures in the quiet corona above the limb is strongly peaked near 1 MK, consistent with previous studies. We also find, however, that there is a tail in the emission measure distribution that extends to higher temperatures. EIS density measurements from several density sensitive line ratios are found to be generally consistent with each other and with previous measurements in the quiet corona. Our analysis, however, also indicates that a significant fraction of the weaker emission lines observed in the EIS wavelength ranges cannot be understood with current atomic data., Comment: Submitted to ApJ

Published
2009
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608. Active region transition region loop populations and their relationship to the corona

Author

Ugarte-Urra, Ignacio, Warren, Harry P., and Brooks, David H.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The relationships among coronal loop structures at different temperatures is not settled. Previous studies have suggested that coronal loops in the core of an active region are not seen cooling through lower temperatures and therefore are steadily heated. If loops were cooling, the transition region would be an ideal temperature regime to look for a signature of their evolution. The Extreme-ultraviolet Imaging Spectrometer (EIS) on Hinode provides monochromatic images of the solar transition region and corona at an unprecedented cadence and spatial resolution, making it an ideal instrument to shed light on this issue. Analysis of observations of active region 10978 taken in 2007 December 8 -- 19 indicates that there are two dominant loop populations in the active region: core multi-temperature loops that undergo a continuous process of heating and cooling in the full observed temperature range 0.4-2.5 MK and even higher as shown by the X-Ray Telescope (XRT); and peripheral loops which evolve mostly in the temperature range 0.4-1.3 MK. Loops at transition region temperatures can reach heights of 150 Mm in the corona above the limb and develop downflows with velocities in the range of 39-105 km/s., Comment: 15 pages, 8 figures. Accepted for publication in ApJ

Published
2009
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610. Redshift-dependent RSD bias from intrinsic alignment with DESI Year 1 spectra.

Author

Lamman, Claire, Eisenstein, Daniel, Aguilar, Jessica Nicole, Ahlen, Steven, Brooks, David, Claybaugh, Todd, de la Macorra, Axel, Dey, Arjun, Dey, Biprateep, Doel, Peter, Ferraro, Simone, Font-Ribera, Andreu, Forero-Romero, Jaime E, Gontcho, Satya Gontcho A, Guy, Julien, Kehoe, Robert, Kremin, Anthony, Le Guillou, Laurent, Levi, Michael, and Manera, Marc

Subjects
EMISSION-line galaxies, DARK energy, LARGE scale structure (Astronomy), STATISTICAL correlation, REDSHIFT
Abstract

We estimate the redshift-dependent, anisotropic clustering signal in the Dark Energy Spectroscopic Instrument (DESI) Year 1 Survey created by tidal alignments of Luminous Red Galaxies (LRGs) and a selection-induced galaxy orientation bias. To this end, we measured the correlation between LRG shapes and the tidal field with DESI's Year 1 redshifts, as traced by LRGs and Emission-Line Galaxies. We also estimate the galaxy orientation bias of LRGs caused by DESI's aperture-based selection, and find it to increase by a factor of seven between redshifts 0.4−1.1 due to redder, fainter galaxies falling closer to DESI's imaging selection cuts. These effects combine to dampen measurements of the quadrupole of the correlation function (ξ2) caused by structure growth on scales of 10–80 h −1 Mpc by about 0.15 per cent for low redshifts (0.4 < z < 0.6) and 0.8 per cent for high (0.8 < z < 1.1), a significant fraction of DESI's error budget. We provide estimates of the ξ2 signal created by intrinsic alignments that can be used to correct this effect, which is necessary to meet DESI's forecasted precision on measuring the growth rate of structure. While imaging quality varies across DESI's footprint, we find no significant difference in this effect between imaging regions in the Legacy Imaging Survey. [ABSTRACT FROM AUTHOR]

Published
2024
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611. Performance on complex memory tests is associated with β‐amyloid in individuals at risk of developing Alzheimer's disease.

Author

Kjeldsen, Pernille Louise, Damholdt, Malene Flensborg, Madsen, Lasse Stensvig, Nissen, Peter Henrik, Aanerud, Joel Fredrik Astrup, Parbo, Peter, Ismail, Rola, Kaasing, Malene, Eskildsen, Simon Fristed, Østergaard, Leif, and Brooks, David James

Subjects
DISEASE risk factors, MEMORY testing, ASSOCIATIVE memory (Psychology), VERBAL memory, COGNITIVE testing, ALZHEIMER'S disease, APOLIPOPROTEIN E
Abstract

The pathophysiological development of Alzheimer's disease (AD) begins in the brain years before the onset of clinical symptoms. The accumulation of beta‐amyloid (Aβ) is thought to be the first cortical pathology to occur. Carrying one apolipoprotein E (APOE) ε4 allele increases the risk of developing AD at least 2–3 times and is associated with earlier Aβ accumulation. Although it is difficult to identify Aβ‐related cognitive impairment in early AD with standard cognitive tests, more sensitive memory tests may be able to do this. We sought to examine associations between Aβ and performance on three tests within three subdomains of memory, verbal, visual, and associative memory, to elucidate which of these tests were sensitive to Aβ‐related cognitive impairment in at‐risk subjects. 55 APOE ε4 carriers underwent MRI, 11C‐Pittsburgh Compound B (PiB) PET, and cognitive testing. A composite cortical PiB SUVR cut‐off score of 1.5 was used to categorise subjects as either APOE ε4 Aβ+ or APOE ε4 Aβ−. Correlations were carried out using cortical surface analysis. In the whole APOE ε4 group, we found significant correlations between Aβ load and performance on verbal, visual, and associative memory tests in widespread cortical areas, the strongest association being with performance on associative memory tests. In the APOE ε4 Aβ+ group, we found significant correlations between Aβ load and performance of verbal and associative, but not visual, memory in localised cortical areas. Performance on verbal and associative memory tests provides sensitive markers of early Aβ‐related cognitive impairment in at‐risk subjects. [ABSTRACT FROM AUTHOR]

Published
2024
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612. The two-point correlation function covariance with fewer mocks

Author

Trusov, Svyatoslav, primary, Zarrouk, Pauline, additional, Cole, Shaun, additional, Norberg, Peder, additional, Zhao, Cheng, additional, Aguilar, Jessica Nicole, additional, Ahlen, Steven, additional, Brooks, David, additional, de la Macorra, Axel, additional, Doel, Peter, additional, Font-Ribera, Andreu, additional, Honscheid, Klaus, additional, Kisner, Theodore, additional, Landriau, Martin, additional, Magneville, Christophe, additional, Miquel, Ramon, additional, Nie, Jundan, additional, Poppett, Claire, additional, Schubnell, Michael, additional, Tarlé, Gregory, additional, and Zhou, Zhimin, additional

Published
2023
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613. The DESI One-Percent Survey: Exploring A Generalized SHAM for Multiple Tracers with the UNIT Simulation

Author

Yu, Jiaxi, primary, Zhao, Cheng, additional, Gonzalez-Perez, Violeta, additional, Chuang, Chia-Hsun, additional, Brodzeller, Allyson, additional, de Mattia, Arnaud, additional, Kneib, Jean-Paul, additional, Krolewski, Alex, additional, Rocher, Antoine, additional, Ross, Ashley, additional, Wang, Yunchong, additional, Yuan, Sihan, additional, Zhang, Hanyu, additional, Zhou, Rongpu, additional, Aguilar, Jessica Nicole, additional, Ahlen, Steven, additional, Brooks, David, additional, Dawson, Kyle, additional, de la Macorra, Alex, additional, Doel, Peter, additional, Fanning, Kevin, additional, Font-Ribera, Andreu, additional, Forero-Romero, Jaime, additional, Gontcho, Satya Gontcho A, additional, Honscheid, Klaus, additional, Kehoe, Robert, additional, Kisner, Theodore, additional, Kremin, Anthony, additional, Landriau, Martin, additional, Manera, Marc, additional, Martini, Paul, additional, Meisner, Aaron, additional, Miquel, Ramon, additional, Moustakas, John, additional, Nie, Jundan, additional, Percival, Will, additional, Poppett, Claire, additional, Raichoor, Anand, additional, Rossi, Graziano, additional, Seo, Hee-Jong, additional, Tarlé, Gregory, additional, Zhou, Zhimin, additional, and Zou, Hu, additional

Published
2023
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614. DESI luminous red galaxy samples for cross-correlations

Author

Zhou, Rongpu, primary, Ferraro, Simone, additional, White, Martin, additional, DeRose, Joseph, additional, Sailer, Noah, additional, Aguilar, Jessica, additional, Ahlen, Steven, additional, Bailey, Stephen, additional, Brooks, David, additional, Claybaugh, Todd, additional, Dawson, Kyle, additional, de la Macorra, Axel, additional, Dey, Biprateep, additional, Doel, Peter, additional, Font-Ribera, Andreu, additional, Forero-Romero, Jaime E., additional, Gontcho A Gontcho, Satya, additional, Guy, Julien, additional, Kremin, Anthony, additional, Lambert, Andrew, additional, Le Guillou, Laurent, additional, Levi, Michael, additional, Magneville, Christophe, additional, Manera, Marc, additional, Meisner, Aaron, additional, Miquel, Ramon, additional, Moustakas, John, additional, Myers, Adam D., additional, Newman, Jeffrey A., additional, Nie, Jundan, additional, Percival, Will, additional, Rezaie, Mehdi, additional, Rossi, Graziano, additional, Sanchez, Eusebio, additional, Schlegel, David, additional, Schubnell, Michael, additional, Seo, Hee-Jong, additional, Tarlé, Gregory, additional, and Zhou, Zhimin, additional

Published
2023
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615. DESI z ≳ 5 Quasar Survey. I. A First Sample of 400 New Quasars at z ∼ 4.7–6.6

Author

Yang, Jinyi, primary, Fan, Xiaohui, additional, Gupta, Ansh, additional, Myers, Adam D., additional, Palanque-Delabrouille, Nathalie, additional, Wang, Feige, additional, Yèche, Christophe, additional, Aguilar, Jessica Nicole, additional, Ahlen, Steven, additional, Alexander, David M., additional, Brooks, David, additional, Dawson, Kyle, additional, de la Macorra, Axel, additional, Dey, Arjun, additional, Dhungana, Govinda, additional, Fanning, Kevin, additional, Font-Ribera, Andreu, additional, Gontcho, Satya, additional, Guy, Julien, additional, Honscheid, Klaus, additional, Juneau, Stephanie, additional, Kisner, Theodore, additional, Kremin, Anthony, additional, Le Guillou, Laurent, additional, Levi, Michael, additional, Magneville, Christophe, additional, Martini, Paul, additional, Meisner, Aaron, additional, Miquel, Ramon, additional, Moustakas, John, additional, Nie, Jundan, additional, Percival, Will, additional, Poppett, Claire, additional, Prada, Francisco, additional, Schlafly, Edward, additional, Tarlé, Gregory, additional, Vargas Magana, Mariana, additional, Weaver, Benjamin Alan, additional, Wechsler, Risa, additional, Zhou, Rongpu, additional, Zhou, Zhimin, additional, and Zou, Hu, additional

Published
2023
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616. GTC Follow-up Observations of Very Metal-poor Star Candidates from DESI

Author

Allende Prieto, Carlos, primary, Aguado, David S., additional, González Hernández, Jonay I., additional, Rebolo, Rafael, additional, Najita, Joan, additional, Manser, Christopher J., additional, Rockosi, Constance, additional, Slepian, Zachary, additional, Mezcua, Mar, additional, Valluri, Monica, additional, Ezzeddine, Rana, additional, Koposov, Sergey E., additional, Cooper, Andrew P., additional, Dey, Arjun, additional, Gänsicke, Boris T., additional, Li, Ting S., additional, Cunha, Katia, additional, Zou, Siwei, additional, Aguilar, Jessica Nicole, additional, Ahlen, Steven, additional, Brooks, David, additional, Claybaugh, Todd, additional, Cole, Shaun, additional, Eftekharzadeh, Sarah, additional, Fanning, Kevin, additional, Forero-Romero, Jaime, additional, Gontcho A Gontcho, Satya, additional, Honscheid, Klaus, additional, Jablonka, Pascale, additional, Kehoe, Robert, additional, Kisner, Theodore, additional, Landriau, Martin, additional, de la Macorra, Axel, additional, Meisner, Aaron, additional, Miquel, Ramón, additional, Moustakas, John, additional, Nie, Jundan, additional, Poppett, Claire, additional, Prada, Francisco, additional, Rezaie, Mehdi, additional, Rossi, Graziano, additional, Sánchez, Eusebio, additional, Schubnell, Michael, additional, Sharples, Ray, additional, Siudek, Malgorzata, additional, Smith, Verne V., additional, Tarlé, Gregory, additional, Vincenzo, Fiorenzo, additional, Weaver, Benjamin Alan, additional, Zhou, Zhimin, additional, and Zou, Hu, additional

Published
2023
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617. Progression of brain cholinergic dysfunction in patients with isolated rapid eye movement sleep behavior disorder

Author

Stær, Kristian, primary, Iranzo, Alex, additional, Terkelsen, Miriam Højholt, additional, Stokholm, Morten Gersel, additional, Danielsen, Erik Hvid, additional, Østergaard, Karen, additional, Serradell, Mónica, additional, Otto, Marit, additional, Svendsen, Kristina B., additional, Garrido, Alicia, additional, Vilas, Dolores, additional, Santamaria, Joan, additional, Møller, Arne, additional, Gaig, Carles, additional, Brooks, David J., additional, Borghammer, Per, additional, Tolosa, Eduardo, additional, and Pavese, Nicola, additional

Published
2023
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618. The Dark Energy Spectroscopic Instrument: One-dimensional power spectrum from first Lyman-α forest samples with Fast Fourier Transform

Author

Ravoux, Corentin, primary, Abdul Karim, Marie Lynn, additional, Armengaud, Eric, additional, Walther, Michael, additional, Karaçaylı, Naim Göksel, additional, Martini, Paul, additional, Guy, Julien, additional, Aguilar, Jessica Nicole, additional, Ahlen, Steven, additional, Bailey, Stephen, additional, Bautista, Julian, additional, Beltran, Sergio Felipe, additional, Brooks, David, additional, Cabayol-Garcia, Laura, additional, Chabanier, Solène, additional, Chaussidon, Edmond, additional, Chaves-Montero, Jonás, additional, Dawson, Kyle, additional, de la Cruz, Rodrigo, additional, de la Macorra, Axel, additional, Doel, Peter, additional, Fanning, Kevin, additional, Font-Ribera, Andreu, additional, Forero-Romero, Jaime, additional, Gontcho A Gontcho, Satya, additional, Gonzalez-Morales, Alma X, additional, Gordon, Calum, additional, Herrera-Alcantar, Hiram K, additional, Honscheid, Klaus, additional, Iršič, Vid, additional, Ishak, Mustapha, additional, Kehoe, Robert, additional, Kisner, Theodore, additional, Kremin, Anthony, additional, Landriau, Martin, additional, Le Guillou, Laurent, additional, Levi, Michael, additional, Lukić, Zarija, additional, Magneville, Christophe, additional, Meisner, Aaron, additional, Miquel, Ramon, additional, Moustakas, John, additional, Mueller, Eva-Maria, additional, Muñoz-Gutiérrez, Andrea, additional, Napolitano, Lucas, additional, Nie, Jundan, additional, Niz, Gustavo, additional, Palanque-Delabrouille, Nathalie, additional, Percival, Will, additional, Pérez-Ràfols, Ignasi, additional, Pieri, Matthew, additional, Poppett, Claire, additional, Prada, Francisco, additional, Ramírez Pérez, César, additional, Rossi, Graziano, additional, Sanchez, Eusebio, additional, Schlegel, David, additional, Schubnell, Michael, additional, Seo, Hee-Jong, additional, Sinigaglia, Francesco, additional, Tan, Ting, additional, Tarlé, Gregory, additional, Wang, Ben, additional, Weaver, Benjamin, additional, Yèche, Christophe, additional, and Zhou, Zhimin, additional

Published
2023
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619. Analysis of the impact of broad absorption lines on quasar redshift measurements with synthetic observations

Author

García, Luz Ángela, primary, Martini, Paul, additional, Gonzalez-Morales, Alma X, additional, Font-Ribera, Andreu, additional, Herrera-Alcantar, Hiram K, additional, Aguilar, Jessica Nicole, additional, Ahlen, Steve, additional, Brooks, David, additional, de la Macorra, Axel, additional, Doel, Peter, additional, Forero-Romero, Jaime E, additional, Guy, Julien, additional, Kisner, Theodore, additional, Landriau, Martin, additional, Miquel, Ramon, additional, Moustakas, John, additional, Nie, Jundan, additional, Poppett, Claire, additional, Tarlé, Gregory, additional, and Zhou, Zhimin, additional

Published
2023
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621. The DESI One-Percent survey: exploring the Halo Occupation Distribution of Emission Line Galaxies with AbacusSummit simulations

Author

Rocher, Antoine, primary, Ruhlmann-Kleider, Vanina, additional, Burtin, Etienne, additional, Yuan, Sihan, additional, de Mattia, Arnaud, additional, Ross, Ashley J., additional, Aguilar, Jessica, additional, Ahlen, Steven, additional, Alam, Shadab, additional, Bianchi, Davide, additional, Brooks, David, additional, Cole, Shaun, additional, Dawson, Kyle, additional, de la Macorra, Axel, additional, Doel, Peter, additional, Eisenstein, Daniel J., additional, Fanning, Kevin, additional, Forero-Romero, Jaime E., additional, Garrison, Lehman H., additional, Gontcho A Gontcho, Satya, additional, Gonzalez-Perez, Violeta, additional, Guy, Julien, additional, Hadzhiyska, Boryana, additional, Hahn, ChangHoon, additional, Honscheid, Klaus, additional, Kisner, Theodore, additional, Landriau, Martin, additional, Lasker, James, additional, E. Levi, Michael, additional, Manera, Marc, additional, Meisner, Aaron, additional, Miquel, Ramon, additional, Moustakas, John, additional, Mueller, Eva-Maria, additional, Newman, Jeffrey A., additional, Nie, Jundan, additional, Percival, Will J., additional, Poppett, Claire, additional, Qin, Fei, additional, Rossi, Graziano, additional, Samushia, Lado, additional, Sanchez, Eusebio, additional, Schlegel, David, additional, Schubnell, Michael, additional, Seo, Hee-Jong, additional, Tarlé, Gregory, additional, Vargas-Magaña, Mariana, additional, Weaver, Benjamin A., additional, Yu, Jiaxi, additional, Zhang, Hanyu, additional, Zheng, Zheng, additional, Zhou, Zhimin, additional, and Zou, Hu, additional

Published
2023
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622. The Eruption of a Magnetic Flux Rope Observed by Solar Orbiter and Parker Solar Probe

Author

Long, David M., primary, Green, Lucie M., additional, Pecora, Francesco, additional, Brooks, David H., additional, Strecker, Hanna, additional, Orozco-Suárez, David, additional, Hayes, Laura A., additional, Davies, Emma E., additional, Amerstorfer, Ute V., additional, Mierla, Marilena, additional, Lario, David, additional, Berghmans, David, additional, Zhukov, Andrei N., additional, and Rüdisser, Hannah T., additional

Published
2023
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624. Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two phase 3 randomised trials (contRAst 1 and contRAst 2)

Author

Fleischmann, Roy M, primary, van der Heijde, Désirée, additional, Strand, Vibeke, additional, Atsumi, Tatsuya, additional, McInnes, Iain B, additional, Takeuchi, Tsutomu, additional, Taylor, Peter C, additional, Bracher, Marguerite, additional, Brooks, David, additional, Davies, John, additional, Goode, Christopher, additional, Gupta, Anubha, additional, Mukherjee, Sumanta, additional, O’Shea, Ciara, additional, Saurigny, Didier, additional, Schifano, Lorrie A, additional, Shelton, Celia, additional, Smith, Julia E, additional, Wang, Millie, additional, Wang, Reena, additional, Watts, Sarah, additional, and Weinblatt, Michael E, additional

Published
2023
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625. Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3)

Author

Taylor, Peter C, primary, Weinblatt, Michael E, additional, McInnes, Iain B, additional, Atsumi, Tatsuya, additional, Strand, Vibeke, additional, Takeuchi, Tsutomu, additional, Bracher, Marguerite, additional, Brooks, David, additional, Davies, John, additional, Goode, Christopher, additional, Gupta, Anubha, additional, Mukherjee, Sumanta, additional, O’Shea, Ciara, additional, Saurigny, Didier, additional, Schifano, Lorrie A, additional, Shelton, Celia, additional, Smith, Julia E, additional, Wang, Millie, additional, Wang, Reena, additional, Watts, Sarah, additional, and Fleischmann, Roy M, additional

Published
2023
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627. First detection of the BAO signal from early DESI data

Author

Moon, Jeongin, primary, Valcin, David, additional, Rashkovetskyi, Michael, additional, Saulder, Christoph, additional, Aguilar, Jessica Nicole, additional, Ahlen, Steven, additional, Alam, Shadab, additional, Bailey, Stephen, additional, Baltay, Charles, additional, Blum, Robert, additional, Brooks, David, additional, Burtin, Etienne, additional, Chaussidon, Edmond, additional, Dawson, Kyle, additional, de la Macorra, Axel, additional, de M attia, Arnaud, additional, Dhungana, Govinda, additional, Eisenstein, Daniel, additional, Flaugher, Brenna, additional, Font-Ribera, Andreu, additional, Forero-Romero, Jaime E, additional, Garcia-Quintero, Cristhian, additional, Gontcho A Gontcho, Satya, additional, Guy, Julien, additional, Hanif, Malik Muhammad Sikandar, additional, Honscheid, Klaus, additional, Ishak, Mustapha, additional, Kehoe, Robert, additional, Kim, Sumi, additional, Kisner, Theodore, additional, Kremin, Anthony, additional, Landriau, Martin, additional, Le Guillou, Laurent, additional, Levi, Michael, additional, Manera, Marc, additional, Martini, Paul, additional, McDonald, Patrick, additional, Meisner, Aaron, additional, Miquel, Ramon, additional, Moustakas, John, additional, Myers, Adam, additional, Nadathur, Seshadri, additional, Neveux, Richard, additional, Newman, Jeffrey A, additional, Nie, Jundan, additional, Padmanabhan, Nikhil, additional, Palanque-Delabrouille, Nathalie, additional, Percival, Will, additional, Pérez Fernández, Alejandro, additional, Poppett, Claire, additional, Prada, Francisco, additional, Raichoor, Anand, additional, Ross, Ashley J, additional, Rossi, Graziano, additional, Samushia, Lado, additional, Schlegel, David, additional, Seo, Hee-Jong, additional, Tarlé, Gregory, additional, Vargas Magana, Mariana, additional, Variu, Andrei, additional, Weaver, Benjamin Alan, additional, White, Martin J, additional, Yèche, Christophe, additional, Yuan, Sihan, additional, Zhao, Cheng, additional, Zhou, Rongpu, additional, Zhou, Zhimin, additional, and Zou, Hu, additional

Published
2023
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628. Observations of Active Region Loops with the EUV Imaging Spectrometer on Hinode

Author

Warren, Harry P., Ugarte-Urra, Ignacio, Doschek, George A., Brooks, David H., and Williams, David R.

Subjects
Astrophysics
Abstract

Previous solar observations have shown that coronal loops near 1 MK are difficult to reconcile with simple heating models. These loops have lifetimes that are long relative to a radiative cooling time, suggesting quasi-steady heating. The electron densities in these loops, however, are too high to be consistent with thermodynamic equilibrium. Models proposed to explain these properties generally rely on the existence of smaller scale filaments within the loop that are in various stages of heating and cooling. Such a framework implies that there should be a distribution of temperatures within a coronal loop. In this paper we analyze new observations from the EUV Imaging Spectrometer (EIS) on \textit{Hinode}. EIS is capable of observing active regions over a wide range of temperatures (\ion{Fe}{8}--\ion{Fe}{17}) at relatively high spatial resolution (1\arcsec). We find that most isolated coronal loops that are bright in \ion{Fe}{12} generally have very narrow temperature distributions ($\sigma_T \lesssim 3\times10^5$ K), but are not isothermal. We also derive volumetric filling factors in these loops of approximately 10%. Both results lend support to the filament models., Comment: Submitted to ApJL

Published
2008
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630. Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

Author

Gillespie, Eugene J, Ho, Chi-Lee C, Balaji, Kavitha, Clemens, Daniel L, Deng, Gang, Wang, Yao E, Elsaesser, Heidi J, Tamilselvam, Batcha, Gargi, Amandeep, Dixon, Shandee D, France, Bryan, Chamberlain, Brian T, Blanke, Steven R, Cheng, Genhong, de la Torre, Juan Carlos, Brooks, David G, Jung, Michael E, Colicelli, John, Damoiseaux, Robert, and Bradley, Kenneth A

Subjects
Biodefense, Emerging Infectious Diseases, Vaccine Related, Infectious Diseases, Prevention, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Good Health and Well Being, Amines, Animals, Bacterial Toxins, Biological Transport, Caspase 1, Chromatography, Liquid, Endosomes, Flow Cytometry, HeLa Cells, High-Throughput Screening Assays, Humans, Macrophages, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mice, Mice, Transgenic, Microscopy, Fluorescence, Molecular Structure, Phagocytosis, Semicarbazones, Small Molecule Libraries, Structure-Activity Relationship, Virus Internalization, Hela Cells
Abstract

Pathogenic microorganisms and toxins have evolved a variety of mechanisms to gain access to the host-cell cytosol and thereby exert virulent effects upon the host. One common mechanism of cellular entry requires trafficking to an acidified endosome, which promotes translocation across the host membrane. To identify small-molecule inhibitors that block this process, a library of 30,000 small molecules was screened for inhibitors of anthrax lethal toxin. Here we report that 4-bromobenzaldehyde N-(2,6-dimethylphenyl)semicarbazone, the most active compound identified in the screen, inhibits intoxication by lethal toxin and blocks the entry of multiple other acid-dependent bacterial toxins and viruses into mammalian cells. This compound, which we named EGA, also delays lysosomal targeting and degradation of the EGF receptor, indicating that it targets host-membrane trafficking. In contrast, EGA does not block endosomal recycling of transferrin, retrograde trafficking of ricin, phagolysosomal trafficking, or phagosome permeabilization by Franciscella tularensis. Furthermore, EGA does not neutralize acidic organelles, demonstrating that its mechanism of action is distinct from pH-raising agents such as ammonium chloride and bafilomycin A1. EGA is a powerful tool for the study of membrane trafficking and represents a class of host-targeted compounds for therapeutic development to treat infectious disease.

Published
2013

640. Observations of Transient Active Region Heating with Hinode

Author

Warren, Harry P., Ugarte-Urra, Ignacio, Brooks, David H., Cirtain, Jonathan W., Williams, David R., and Harra, Hirohisa

Subjects
Astrophysics
Abstract

We present observations of transient active region heating events observed with the Extreme Ultraviolet Imaging Spectrometer (EIS) and X-ray Telescope (XRT) on Hinode. This initial investigation focuses on NOAA active region 10940 as observed by Hinode on February 1, 2007 between 12 and 19 UT. In these observations we find numerous examples of transient heating events within the active region. The high spatial resolution and broad temperature coverage of these instruments allows us to track the evolution of coronal plasma. The evolution of the emission observed with XRT and EIS during these events is generally consistent with loops that have been heated and are cooling. We have analyzed the most energetic heating event observed during this period, a small GOES B-class flare, in some detail and present some of the spectral signatures of the event, such as relative Doppler shifts at one of the loop footpoints and enhanced line widths during the rise phase of the event. While the analysis of these transient events has the potential to yield insights into the coronal heating mechanism, these observations do not rule out the possibility that there is a strong steady heating level in the active region. Detailed statistical analysis will be required to address this question definitively.

Published
2007
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641. Hinode EUV Imaging Spectrometer Observations of Solar Active Region Dynamics

Author

Mariska, John T., Warren, Harry P., Ugarte-Urra, Ignacio, Brooks, David H., Williams, David R., and Hara, Hirohisa

Subjects
Astrophysics
Abstract

The EUV Imaging Spectrometer (EIS) on the Hinode satellite is capable of measuring emission line center positions for Gaussian line profiles to a fraction of a spectral pixel, resulting in relative solar Doppler-shift measurements with an accuracy of less than a km/s for strong lines. We show an example of the application of that capability to an active region sit-and-stare observation in which the EIS slit is placed at one location on the Sun and many exposures are taken while the spacecraft tracking keeps the same solar location within the slit. For the active region examined (NOAA 10930), we find that significant intensity and Doppler-shift fluctuations as a function of time are present at a number of locations. These fluctuations appear to be similar to those observed in high-temperature emission lines with other space-borne spectroscopic instruments. With its increased sensitivity over earlier spectrometers and its ability to image many emission lines simultaneously, EIS should provide significant new constraints on Doppler-shift oscillations in the corona., Comment: 7 Pages, 7 figures

Published
2007
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642. Selecting the Best Animal Model of Parkinson’s Disease for Your Research Purpose: Insight from in vivo PET Imaging Studies

Author

Real, Caroline Cristiano, Binda, Karina Henrique, Thomsen, Majken Borup, Lillethorup, Thea Pinholt, Brooks, David James, and Landau, Anne M

Subjects
Pharmacology, Disease Models, Animal, Psychiatry and Mental health, alpha-Synuclein/metabolism, Neurology, Positron-Emission Tomography, Disease Progression, Animals, Pharmacology (medical), Neurology (clinical), General Medicine, Parkinson Disease/metabolism, Biomarkers
Abstract

Abstract: Parkinson’s disease (PD) is a debilitating neurodegenerative multisystem disorder leading to motor and non-motor symptoms in millions of individuals. Despite intense research, there is still no cure, and early disease biomarkers are lacking. Animal models of PD have been inspired by basic elements of its pathogenesis, such as dopamine dysfunction, alpha-synuclein accumulation, neuroinflammation and disruption of protein degradation, and these have been crucial for a deeper understanding of the mechanisms of pathology, the identification of biomarkers, and evaluation of novel therapies. Imaging biomarkers are non-invasive tools to assess disease progression and response to therapies; their discovery and validation have been an active field of translational research. Here, we highlight different considerations of animal models of PD that can be applied to future research, in terms of their suitability to answer different research questions. We provide the reader with important considerations of the best choice of model to use based on the disease features of each model, including issues related to different species. In addition, positron emission tomography studies conducted in PD animal models in the last 5 years are presented. With a variety of different species, interventions and genetic information, the choice of the most appropriate model to answer research questions can be daunting, especially since no single model recapitulates all aspects of this complex disorder. Appropriate animal models in conjunction with in vivo molecular imaging tools, if selected properly, can be a powerful combination for the assessment of novel therapies and developing tools for early diagnosis.

Published
2023

643. Teacher Belief, Teacher Action: Connecting Research and the Classroom. Proceedings of the JALT International Conference on Language Teaching and Learning and Educational Materials Expo (25th, Maebashi City, Japan, October 1999).

Author

Japan Association for Language Teaching, Tokyo., Brooks, David, Robbins, Jill, and Long, Robert

Abstract

Forty papers presented at the Japanese Association for Language Teaching (JALT) conference were selected for inclusion in this volume. JALT is a nonprofit professional organization of language teachers dedicated to the improvement of language learning and teaching in Japan. JALT's publications and events serve as vehicles for the exchange of new ideas and techniques, and a means of keeping abreast of new developments in a rapidly changing field. The theme of this conference was connecting research to the classroom. Papers for this volume were selected in part for attention to this larger current running through the second language learning and teaching field. Numerous references are cited in the papers selected for this volume. (KFT)

Published
2000

644. To Be Happy, Marriage Matters More Than Career

Author

Brooks, David

Subjects
Marriage -- Reports -- Analysis, Career development -- Reports -- Analysis, General interest
Abstract

Byline: David Brooks When I'm around young adults I like to ask them how they are thinking about the big commitments in their lives: what career to go into, where [...]

Published
2023

645. 'Human Beings Are Soon Going to Be Eclipsed'

Author

Brooks, David

Subjects
General interest
Abstract

Byline: David Brooks Recently I stumbled across an essay by Douglas Hofstadter that made me happy. Hofstadter is an eminent cognitive scientist and the author of books like 'GÜdel, Escher, [...]

Published
2023

646. Why I Still Love the New York Mets

Author

Brooks, David

Subjects
Baseball (Professional) -- Personal narratives, Sports journalism -- Personal narratives, General interest, News, opinion and commentary, New York Mets -- Appreciation -- Personal narratives
Abstract

Chip ... chip ... chip. I can feel the New York Mets chiseling out a piece of my soul every week. A blown lead here ... chip. A dropped pop-up [...]

Published
2023

647. Why Biden Isn't Getting the Credit He Deserves

Author

Brooks, David

Subjects
Business -- Research, General interest
Abstract

Byline: David Brooks The misery index is a crude but effective way to measure the health of the economy. You add up the inflation rate and the unemployment rate. If [...]

Published
2023

648. America Is Woe and Redemption

Author

Brooks, David

Subjects
Dark Was the Night, Cold Was the Ground (Song), United States cultural history -- Portrayals, Gospel singers -- Works, United States history -- Portrayals, General interest, News, opinion and commentary
Abstract

Let's not pretend we're living through good times. If we're going to understand America, let's dive right into the dark pools of social pain that underlie our bitterness and division. [...]

Published
2023

649. The Age of Spectacle Is Upon Us

Author

Brooks, David

Subjects
Uniforms, General interest
Abstract

Byline: David Brooks If I walked onto the field at Dodger Stadium in Los Angeles and stomped on a Dodger's uniform on home plate, I hope that the Dodgers and [...]

Published
2023

650. How ‘Dark Was the Night, Cold Was the Ground’ Explains America

Author

Brooks, David

Subjects
News, opinion and commentary
Abstract

Let’s not pretend we’re living through good times. If we’re going to understand America, let’s dive right into the dark pools of social pain that underlie our bitterness and division. [...]

Published
2023

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