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A preceramic polymer route from Ti-based inorganic-organic hybrid networks provides electroconductive N-doped reduced titanium oxides (TinO2n-1) and titanium oxynitrides (TiOxNy) with a monolithic shape as well as well-defined porous structures. This methodology demonstrates an advantageously lower temperature of the crystal phase transition compared to the reduction of TiO2 by carbon or hydrogen. In this study, the effect of calcination conditions on various features of the products has been explored by adopting three different atmospheric conditions and varying the calcination temperature. The detailed crystallographic and elemental analyses disclose the distinguished difference in the phase transition behavior with respect to the calcination atmosphere. The correlation between the crystallization and nitridation behaviors, porous properties, and electric conductivities in the final products is discussed. [ABSTRACT FROM AUTHOR]

Background Abnormal ventricular repolarization is a predictor of cardiovascular mortality. In this study, we tested the hypothesis that glycemic control reverses abnormal ventricular repolarization in patients with type 2 diabetes. Methods We analyzed longitudinal changes in repolarization indices of electrocardiograms in retrospectively enrolled 44 patients with type 2 diabetes and 44 age-matched healthy subjects. Results In the diabetic group, BMI was greater, levels of HbA1c (10.0 ± 1.6 vs. 5.6 ± 0.3%) and triglyceride were higher and level of HDL cholesterol was lower than those in the control group. Although mean QTc intervals were similar (413.6 ± 18.5 vs. 408.3 ± 22.7 ms), QT dispersion (41.8 ± 15.4 vs. 28.7 ± 7.7 ms) and Tpeak-Tend in lead V5 (83.6 ± 13.6 vs. 71.3 ± 10.3 ms) were significantly longer in the diabetic group than in the control group, indicating increased heterogeneity of ventricular repolarization in type 2 diabetes. During follow-up of 36 patients in the diabetic group for 787 ± 301 days, HbA1c level decreased to 7.3 ± 1.6%, while BMI did not significantly change. In contrast to HbA1c, QT dispersion (45.8 ± 15.0 ms) and Tpeak-Tend in lead V5 (83.6 ± 10.6 ms) were not significantly reduced during the follow-up period. There was no correlation between the change in HbA1c and the change in QT dispersion or Tpeak-Tend. Conclusions Increased heterogeneity of ventricular repolarization in type 2 diabetic patients was not reduced during the relatively short follow-up period despite significantly improved glycemic control. [ABSTRACT FROM AUTHOR]

Background: It has not been shown whether accelerated rehabilitation following periacetabular osteotomy (PAO) is effective for early recovery. The purpose of this retrospective study was to compare complication rates in patients with standard and accelerated rehabilitation protocols who underwent PAO. Methods: Between January 2002 and August 2011, patients with a lateral center-edge (CE) angle of < 20°, showing good joint congruency with the hip in abduction, pre- or early stage of osteoarthritis, and age younger than 60 years were included in this study. We evaluated 156 hips in 138 patients, with a mean age at the time of surgery of 30 years. Full weight-bearing with two crutches started 2 months postoperatively in 73 patients (80 hips) with the standard rehabilitation protocol. In 65 patients (76 hips) with the accelerated rehabilitation protocol, postoperative strengthening of the hip, thigh and core musculature was begun on the day of surgery as tolerated. The exercise program included active hip range of motion, and gentle isometric hamstring and quadriceps muscle sets; these exercises were performed for 30 minutes in the morning and 30 minutes in the afternoon with a physical therapist every weekday for 6 weeks. Full weight-bearing with two axillary crutches started on the day of surgery as tolerated. Complications were evaluated for 2 years. Results: The clinical results at the time of follow-up were similar in the two groups. The average periods between the osteotomy and full-weight-bearing walking without support were 4.2 months and 6.9 months in patients with the accelerated and standard rehabilitation protocols (P < 0.001), indicating that the accelerated rehabilitation protocol could achieve earlier recovery of patients. However, postoperative fractures of the ischial ramus and posterior column of the pelvis were more frequently found in patients with the accelerated rehabilitation protocol (8/76) than in those with the standard rehabilitation protocol (1/80) (P = 0.013). Conclusion: The accelerated rehabilitation protocol seems to have advantages for early muscle recovery in patients undergoing PAO; however, postoperative pelvic fracture rates were unacceptably high in patients with this protocol. [ABSTRACT FROM AUTHOR]

This study investigated how parental expectations for their college-age children were related to their children's reaction styles, self-inhibition, and life satisfaction. Undergraduate students (N=367) completed a questionnaire that assessed parental expectations, their feelings about and reactions to these expectations, and students' self-inhibition and life satisfaction. The results indicated that students' reaction styles and life satisfaction differed according to their feelings of parental expectations. Students who thought about parental expectations only in terms of their careers and with regard to being a good child felt more of a burden, whereas students who thought about their parents' high expectations regarding personality, career, and being a good child reacted more positively to the parental expectations. In addition, the personality characteristic of self-inhibition in the latter group appeared to enhance their life satisfaction. These results suggest that not only parental expectations for children's careers, but also children's ways of thinking about their parents' expectations are important for a fuller understanding of the impact of parental expectations. [ABSTRACT FROM AUTHOR]

In the present study, we examined if and how cardiac ion channels are modified by type 2 diabetes mellitus (T2DM). Subendocardial (Endo) myocytes and subepicardial (Epi) myocytes were isolated from left ventricles of Otsuka-Long-Evans-Tokushima Fatty rats (OLETF) rats, a rat model of T2DM, and Otsuka-Long-Evans-Tokushima (LETO) rats (nondiabetic control rats). Endo and Epi myocytes were used for whole cell patch-clamp recordings and for protein and mRNA analyses. Action potential durations in Endo and Epi myocytes were longer in OLETF rats than in LETO rats, and the difference was larger in Endo myocytes. Steady-state transient outward K+ current (Ito) density was reduced in Endo but not Epi myocytes of OLETF rats compared with LETO rats, although the contribution of the fast component of Ito recovery from inactivation was smaller in both Endo and Epi myocytes of OLETF rats than in LETO rats. Kv4.2 protein was reduced only in Endo myocytes in OLETF rats, although voltage-gated K+ channel-interacting protein 2 (KChIP2) protein levels in both Endo and Epi myocytes were lower in OLETF rats than in LETO rats. Corresponding regional differences in mRNA levels of KChIP2 and Kv4.2 were observed between OLETF and LETO rats. mRNA levels of Iroquois homeobox 5 in Endo myocytes were 53% higher in OLETF rats than in LETO rats. Densities of inward rectifier K+ current and L-type Ca2+ current and mRNA levels of Kv4.3 and Kv1.4 were similar in OLETF and LETO rats. In conclusion, T2DM induces Endo-predominant prolongation of the action potential duration via a reduction of the fast component of Ito recovery from inactivation and reduced steady-state Ito, in which downregulation of Kv4.2 and KChIP2 may be involved. Increased Iroquois homeobox 5 expression may underlie Kv4.2 downregulation in T2DM. [ABSTRACT FROM AUTHOR]

This study investigated aspects of analogues of depression. Cluster analysis and a symptoms approach were used to identify characteristics of analogues of depression. Patients with major depressive disorder provided the seed points for the depressed cluster, and non-distressed university students provided the seed points for the non-depressed cluster. The results showed that the non-depressed cluster included all the mild-depression subjects and part of the moderate-depression subjects of the distressed university students. On the other hand, the depressed cluster included other moderate-depression subjects and all the severe-depression subjects. These results indicate that the symptoms of mild depression among distressed university students have little in common with severe clinical depression. However there was a sequence of continuity between the symptoms of severe-depression subjects of the distressed university students and patients with severe clinical depression. [ABSTRACT FROM AUTHOR]

In this study, children in four nations were compared concerning the thinking and activities of children with regard to money. A questionnaire survey was conducted on students in the 5th grade of elementary schools, 2nd grade of junior high schools, and 2nd grade of high schools in Japan, Korea, China, and Vietnam. The questions focused on the following points: how children get money, children's actual behavior and awareness of social norms (judgments of right and wrong), peer relationships, and parent-child relationships, in relation to children's use of money. The results were as follows. Children's experience using money was more profound and their attitudes about using money were more positive in this order: Japan, South Korea, China, and Vietnam. Japanese children were most aware and Vietnamese children least aware that pocket money was their own money. Japanese children, compared to Korean children, had more negative attitudes toward treating friends to foods and lending money within friends. Based on these results, a discussion followed concerning with affluence and poverty. [ABSTRACT FROM AUTHOR]

While the person-situation debate was largely based on a misunderstanding of the magnitude of the correlations that characterize relations between personality traits and behavior, it drew much-needed attention to the importance of situations. However, few attempts have been made to understand the important elements of situations in relation to behavior. Current work developing the Riverside Situational Q-sort (RSQ) aims to provide a useful way to conceptualize and measure the behaviorally important attributes of situations. A current project is applying this method cross-culturally. New data from the US and Japan show that behavioral correlates of two elements of the situation--the presence of a member of the opposite sex and the experience of being criticized by others--have largely similar behavioral correlates between genders and across cultures. These analyses illustrate how the RSQ illuminates the connections between situations and behavior. Future research will extend such analyses to more situational attributes and other cultures around the world. [ABSTRACT FROM AUTHOR]

Sarcolemmal connexin-43 (Cx43) and mitochondrial Cx43 play distinct roles: formation of gap junctions and production of reactive oxygen species (ROS) for redox signaling. In this study, we examined the hypothesis that Cx43 contributes to activation of a major cytoprotective signal pathway, phosphoinositide 3-kinase (PI3K)-Akt-glycogen synthase kinase-3β (GSK-3β) signaling, in cardiomyocytes. A δ-opioid receptor agonist {[D-Ala2,DLeu5] enkephalin acetate (DADLE)}, endothelin-1 (ET-1), and insulin- like growth factor-1 (IGF-1) induced phosphorylation of Akt and GSK-3β in H9c2 cardiomyocytes. Reduction of Cx43 protein to 20% of the normal level by Cx43 small interfering RNA abolished phosphorylation of Akt and GSK-3β induced by DADLE or ET-1 but not that induced by IGF-1. DADLE and IGF-1 protected H9c2 cells from necrosis after treatment with H2O2 or antimycin A. The protection by DADLE or ET-1, but not that by IGF-1, was lost by reduction of Cx43 protein expression. In contrast to Akt and GSK-3β, PKC-å, ERK and p38 mitogen-activated protein kinase were phosphorylated by ET-1 in Cx43-knocked-down cells. Like diazoxide, an activator of the mitochondrial ATP-sensitive K+ channel, DADLE and ET-1 induced significant ROS production in mitochondria, although such an effect was not observed for IGF-1. Cx43 knockdown did not attenuate the mitochondrial ROS production by DADLE or ET-1. Cx43 was coimmunoprecipitated with the β-subunit of G protein (Gβ), and knockdown of Gβ mimicked the effect of Cx43 knockdown on ET-1- induced phosphorylation of Akt and GSK-3β. These results suggest that Cx43 contributes to activation of class IB PI3K in PI3K-Akt- GSK-3β signaling possibly as a cofactor of Gβ in cardiomyocytes. [ABSTRACT FROM AUTHOR]

Endoscopic ultrasound (EUS)-guided intervention has been established as a safe, effective and minimally invasive procedure for various diseases in adults, but there have been limited reports in pediatric patients. Herein, we report our experience with successful EUS-guided drainage of an intra-abdominal abscess in a 1-year-old infant concomitant with disseminated intravascular coagulation. The abscess was punctured via the stomach using a standard, convex-type echoendoscope, and the patient's condition improved after naso-cystic catheter placement. Although the clinical course was complicated by delayed hemorrhage from the puncture site, the bleeding was successfully managed by endoscopic hemostasis using a standard forward-viewing endoscope. [ABSTRACT FROM AUTHOR]

Sirtuins (SIRT) exhibit deacetylation or ADP-ribosyltransferase activity and regulate a wide range of cellular processes in the nucleus, mitochondria, and cytoplasm. The role of the only sirtuin that resides in the cytoplasm, SIRT2, in the development of ischemic injury and cardiac hypertrophy is not known. In this paper, we show that the hearts of mice with deletion of Sirt2 (Sirt2-/-) display improved cardiac function after ischemia-reperfusion (I/R) and pressure overload (PO), suggesting that SIRT2 exerts maladaptive effects in the heart in response to stress. Similar results were obtained in mice with cardiomyocyte-specific Sirt2 deletion. Mechanistic studies suggest that SIRT2 modulates cellular levels and activity of nuclear factor (erythroid-derived 2)-like 2 (NRF2), which results in reduced expression of antioxidant proteins. Deletion of Nrf2 in the hearts of Sirt2-/- mice reversed protection after PO. Finally, treatment of mouse hearts with a specific SIRT2 inhibitor reduced cardiac size and attenuates cardiac hypertrophy in response to PO. These data indicate that SIRT2 has detrimental effects in the heart and plays a role in cardiac response to injury and the progression of cardiac hypertrophy, which makes this protein a unique member of the SIRT family. Additionally, our studies provide a novel approach for treatment of cardiac hypertrophy and injury by targeting SIRT2 pharmacologically, providing a novel avenue for the treatment of these disorders. [ABSTRACT FROM AUTHOR]