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251. Dementia in Latin America: Paving the way toward a regional action plan

Author

Raffaele Ferrari, Oscar L. Lopez, Leonel T. Takada, José Alberto Avila-Funes, Katherine L. Possin, Marcio Luiz Figueredo Balthazar, Carlos Cano-Gutierrez, Fábio Henrique de Gobbi Porto, David Orozco, Letícia Lessa Mansur, Jeronimo Martin Ramirez, André Luiz Rodrigues Palmeira, Adolfo M. García, Juan de Jesús Llibre, Henry Engler, Elisa de Paula França Resende, Silvia Kochen, Sebastian Moguilner, Lingani Mbakile-Mahlanza, Renata Kochhann, Antônio Lúcio Teixeira, Dominic Trépel, Maritza Pintado Caipa, Patricia Cogram, Yakeel T. Quiroz, Agustín Ibáñez, Ronnielly Melo Tavares, Maira Tonidandel Barbosa, Andrea Slachevsky, Roberta Diehl Rodriguez, Gonzalo A. Farías, Laís Fajersztajn, Bárbara Costa Beber, Maira Okada de Oliveira, Norberto Anizio Ferreira Frota, David Lira, Patricio Fuentes, Laura Morelli, Patricia Lillo, Paulo Caramelli, Renata Eloah de Lucena Ferretti-Rebustini, Stefanie Danielle Piña Escudero, Cecilia Serrano, Sonia Maria Dozzi Brucki, Heather M. Snyder, Sandra Baez, Ana Luisa Sosa, Alejandra Guerrero Barragan, Adelina Comas, Rosa Montesinos, Paulo Henrique Ferreira Bertolucci, Juan F. Cardona, Ioannis Tarnanas, Jerusa Smid, Lea T. Grinberg, Fernanda G. De Felice, Mario A. Parra, Christian Gonzalez-Billault, Cecilia Gonzalez Campo, Eliane Correa Miotto, David Huepe, Jose Manuel Santacruz-Escudero, Maria Aparecida Camargos Bicalho, Bruce L. Miller, P. Solis, Claudia K. Suemoto, Lissette Duque Peñailillo, Patricia J. Garcia, Marcia Lorena Fagundes Chaves, Lucas Porcello Schilling, Rodrigo B. Serafim, Claudia Ramos, Hernando Santamaría-García, Fabricio Joao Pio, Alyne Mendonca Marques Ton, Ignacio F. Mata, Irene Maier, Leonardo Cruz de Souza, Felipe A. Court, Lucas Sedeño, Myriam de la Cruz, Mônica Sanches Yassuda, Jenifer Yokoyama, Jorge J. Llibre Guerra, Fabricio Ferreira de Oliveira, Serggio Lanata, Nilton Custodio, Ricardo Nitrini, Andres Damian, Kenneth S. Kosik, Julián Bustin, Graciela Muniz-Terrera, Ceres Ferretti, Ivan Aprahamian, Diana Matallana, Olivier Piguet, Marcio Soto-Añari, Fiona Kumfor, Sergio T. Ferreira, Francisco Lopera, Mirna Lie Hosogi, and Luis Arnoldo Muñoz-Nevárez

Subjects
0301 basic medicine, MEDICINA BASEADA EM EVIDÊNCIAS, Latin Americans, purl.org/pe-repo/ocde/ford#3.02.25 [https], NONPHARMACOLOGICAL INTERVENTIONS, 0302 clinical medicine, purl.org/becyt/ford/3.2 [https], EPIDEMIOLOGY, genetics, NETWORKING AND TRANSLATIONAL RESEARCH, media_common, KNOWLEDGE TO ACTION FRAMEWORK, Health Policy, DEMENTIA, Public relations, networking and translational research, Psychiatry and Mental health, Action plan, Evidence-Based Practice, Perspective, purl.org/becyt/ford/3 [https], epidemiology, CLINICAL TRIALS, evidence‐based recommendations, GENETICS, media_common.quotation_subject, BIOMARKERS, Translational research, LATIN AMERICA, 03 medical and health sciences, Cellular and Molecular Neuroscience, Developmental Neuroscience, knowledge to action framework, Political science, nonpharmacological interventions, medicine, Dementia, Humans, EVIDENCE-BASED RECOMMENDATIONS, Socioeconomic status, clinical trials, business.industry, biomarkers, Global strategy, medicine.disease, 030104 developmental biology, Transformative learning, Latin America, Socioeconomic Factors, RC0321, Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Diversity (politics)
Abstract

Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF. Fil: Parra, Mario Alfredo. Universidad Autónoma del Caribe; Colombia Fil: Baez, Sandra. Universidad de los Andes; Colombia Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gonzalez Campo, Cecilia. Universidad de San Andrés; Argentina Fil: Santamaría García, Hernando. Pontificia Universidad Javeriana; Colombia Fil: Aprahamian, Ivan. No especifíca; Fil: Bertolucci, Paulo. Universidade Federal de Sao Paulo; Brasil Fil: Bustin, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina Fil: Camargos Bicalho, Maria Aparecida. Universidade Federal de Minas Gerais; Brasil Fil: Cano Gutierrez, Carlos. Hospital Universitario San Ignacio; Colombia Fil: Caramelli, Paulo. Universidade Federal de Minas Gerais; Brasil Fil: Chaves, Marcia L. F.. Universidade Federal do Rio Grande do Sul; Brasil Fil: Perez Cogram, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina Fil: Beber, Bárbara Costa. Universidade Federal do Rio Grande do Sul; Brasil Fil: Court, Felipe A.. Universidad Mayor; Chile Fil: de Souza, Leonardo Cruz. Universidade Federal de Minas Gerais; Brasil Fil: Custodio, Nilton. Peruvian Institute of Neurosciences; Perú Fil: Damian, Andres. Universidad de la República; Uruguay Fil: de la Cruz, Myriam. University of California; Estados Unidos Fil: Diehl Rodriguez, Roberta. Universidade de Sao Paulo; Brasil Fil: Dozzi Brucki, Sonia Maria. Universidade de Sao Paulo; Brasil Fil: Fajersztajn, Lais. Universidade de Sao Paulo; Brasil Fil: Farías, Gonzalo A.. Universidad de Chile; Chile Fil: De Felice, Fernanda G.. Universidade Federal do Rio de Janeiro; Brasil Fil: Ferrari, Raffaele. Colegio Universitario de Londres; Reino Unido Fil: Ferreira de Oliveira, Fabricio. Universidade de Sao Paulo; Brasil Fil: Ferreira, Sergio Teixeira. Universidade Federal do Rio de Janeiro; Brasil Fil: Ferretti, Ceres. Universidade de Sao Paulo; Brasil Fil: Figueredo Balthazar, Marcio Luiz. Universidade Estadual de Campinas; Brasil Fil: Ferreira Frota, Norberto Anizio. Universidade de Fortaleza; Brasil Fil: Fuentes, Patricio. No especifíca; Fil: García, Adolfo Martín. Universidad Nacional de Cuyo; Argentina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Garcia, Patricia J.. Cayetano Heredia University; Perú Fil: de Gobbi Porto, Fábio Henrique. Universidade de Sao Paulo; Brasil Fil: Duque Peñailillo, Lissette. Ecuadorian Dementia Association; Ecuador Fil: Engler, Henry Willy. Universidad de la República; Uruguay Fil: Maier, Irene. Universidad de Chile; Chile Fil: Mata, Ignacio F.. University of Pittsburgh; Estados Unidos Fil: González Billault, Christian. Universidad de Chile; Chile Fil: Lopez, Oscar L.. University of Pittsburgh; Estados Unidos Fil: Morelli, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Nitrini, Ricardo. Universidade de Sao Paulo; Brasil Fil: Quiroz, Yakeel T.. Harvard Medical School; Estados Unidos Fil: Guerrero Barragan, Alejandra. Universidad de la Sabana; Colombia Fil: Huepe, David. Universidad Adolfo Ibañez; Chile Fil: Pio, Fabricio Joao. Hospital Governador Celso Ramos; Brasil Fil: Suemoto, Claudia Kimie. Universidade de Sao Paulo; Brasil Fil: Kochhann, Renata. Pontificia Universidade Católica do Rio Grande do Sul; Brasil Fil: Kochen, Sara Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina Fil: Kumfor, Fiona. University of Western Sydney; Australia Fil: Lanata, Serggio. University of California; Estados Unidos Fil: Miller, Bruce. University of California; Estados Unidos Fil: Lessa Mansur, Leticia. Universidade de Sao Paulo; Brasil Fil: Lie Hosogi, Mirna. Universidade de Sao Paulo; Brasil Fil: Lillo, Patricia. Universidad de Chile; Chile Fil: Llibre Guerra, Jorge. University of California; Estados Unidos Fil: Lira, David. Peruvian Institute of Neurosciences; Perú Fil: Lopera, Francisco. Universidad de Antioquia; Colombia Fil: Comas, Adelina. No especifíca; Fil: Avila Funes, José Alberto. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; México Fil: Sosa, Ana Luisa. Instituto Nacional de Neurología y Neurocirugía; México Fil: Ramos, Claudia. University of California; Estados Unidos Fil: de Paula França Resende, Elisa. University of California; Estados Unidos Fil: Snyder, Heather M.. No especifíca; Fil: Tarnanas, Ioannis. University of California; Estados Unidos Fil: Yokoyama, Jenifer. University of California; Estados Unidos Fil: Llibre, Juan. Centro de Estudios de Alzheimer; Cuba Fil: Cardona Londoño, Juan Felipe. Universidad del Valle; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Possin, Kate. University of California; Estados Unidos Fil: Kosik, Kenneth. University of California; Estados Unidos Fil: Montesinos, Rosa. Peruvian Institute of Neurosciences; Perú Fil: Moguilner, Sebastian Gabriel. University of California; Estados Unidos Fil: Solis, Patricia Cristina Lourdes. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina. Universidad Nacional Arturo Jauretche; Argentina. Universidad de Buenos Aires; Argentina Fil: de Lucena Ferretti Rebustini, Renata Eloah. Universidade de Sao Paulo; Brasil Fil: Ramirez, Jeronimo Martin. No especifíca; Fil: Matallana, Diana. Pontificia Universidad Javeriana; Colombia Fil: Mbakile Mahlanza, Lingani. University of California; Estados Unidos Fil: Mendonça Marques Ton, Alyne. Universidade Federal do Rio de Janeiro; Brasil Fil: Melo Tavares, Ronnielly. Centro Universitario de Belo Horizonte.; Brasil Fil: Miotto, Eliane C.. Universidade de Sao Paulo; Brasil Fil: Muniz-Terrera, Graciela. University of Edinburgh; Reino Unido Fil: MuñozN evárez, Luis Arnoldo. University of California; Estados Unidos Fil: Orozco, David. Universidad Nacional del Sur; Argentina Fil: Okada de Oliveira, Maira. University of California; Estados Unidos Fil: Piguet, Olivier. University of Western Sydney; Australia Fil: Pintado Caipa, Maritza. University of California; Estados Unidos Fil: Piña Escudero, Stefanie Danielle. University of California; Estados Unidos Fil: Porcello Schilling, Lucas. Pontificia Universidade Católica do Rio Grande do Sul; Brasil Fil: Rodrigues Palmeira, André Luiz. Hospital Ernesto Dornelles; Brasil Fil: Sanches Yassuda, Mônica. Universidade de Sao Paulo; Brasil Fil: Santacruz Escudero, Jose Manuel. Pontificia Universidad Javeriana; Colombia Fil: Serafim, Rodrigo Bernardo. Universidade Federal do Rio de Janeiro; Brasil Fil: Smid, Jerusa. Universidade de Sao Paulo; Brasil Fil: Slachevsky, Andrea. Universidad de Chile; Chile Fil: Serrano, Cecilia Mariela. No especifíca; Fil: Soto Añari, Marcio. Universidad Católica San Pablo; Perú Fil: Takada, Leonel Tadao. Universidade de Sao Paulo; Brasil Fil: Tenenholz Grinberg, Lea. Universidade de Sao Paulo; Brasil Fil: Teixeira, Antonio Lucio. Universidade Federal de Minas Gerais; Brasil Fil: Tonidandel Barbosa, Maira. Universidade Federal de Minas Gerais; Brasil Fil: Trépel, Dominic. Trinity College; Estados Unidos Fil: Ibañez, Agustin Mariano. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

Published
2020
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252. Research priorities to reduce the global burden of dementia by 2025.

Author

Shah, Hiral, Albanese, Emiliano, Duggan, Cynthia, Rudan, Igor, Langa, Kenneth M, Carrillo, Maria C, Chan, Kit Yee, Joanette, Yves, Prince, Martin, Rossor, Martin, Saxena, Shekhar, Snyder, Heather M, Sperling, Reisa, Varghese, Mathew, Wang, Huali, Wortmann, Marc, and Dua, Tarun

Subjects
*DEMENTIA, *CHILDREN'S health, *NEUROSCIENCES, *COGNITIVE ability
Abstract

At the First WHO Ministerial Conference on Global Action Against Dementia in March, 2015, 160 delegates, including representatives from 80 WHO Member States and four UN agencies, agreed on a call for action to reduce the global burden of dementia by fostering a collective effort to advance research. To drive this effort, we completed a globally representative research prioritisation exercise using an adapted version of the Child Health and Nutrition Research Initiative method. We elicited 863 research questions from 201 participants and consolidated these questions into 59 thematic research avenues, which were scored anonymously by 162 researchers and stakeholders from 39 countries according to five criteria. Six of the top ten research priorities were focused on prevention, identification, and reduction of dementia risk, and on delivery and quality of care for people with dementia and their carers. Other priorities related to diagnosis, biomarkers, treatment development, basic research into disease mechanisms, and public awareness and understanding of dementia. Research priorities identified by this systematic international process should be mapped onto the global dementia research landscape to identify crucial gaps and inform and motivate policy makers, funders, and researchers to support and conduct research to reduce the global burden of dementia. Efforts are needed by all stakeholders, including WHO, WHO Member States, and civil society, to continuously monitor research investments and progress, through international platforms such as a Global Dementia Observatory. With established research priorities, an opportunity now exists to translate the call for action into a global dementia action plan to reduce the global burden of dementia. [ABSTRACT FROM AUTHOR]

Published
2016
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253. Optimizing quantification of MK6240 tau PET in unimpaired older adults.

Author

Harrison, Theresa M., Ward, Tyler J., Murphy, Alice, Baker, Suzanne L., Dominguez, Pablo A., Koeppe, Robert, Vemuri, Prashanthi, Lockhart, Samuel N., Jung, Youngkyoo, Harvey, Danielle J., Lovato, Laura, Toga, Arthur W., Masdeu, Joseph, Oh, Hwamee, Gitelman, Darren R., Aggarwal, Neelum, Snyder, Heather M., Baker, Laura D., DeCarli, Charles, and Jagust, William J.

Subjects
*OLDER people, *FAMILY history (Medicine), *TAU proteins, *ALZHEIMER'S disease, *POSITRON emission tomography
Abstract

• MK6240 meningeal off-target signal (OTS) is adjacent to target and reference regions. • Across individuals OTS is continuously distributed and related to sex (F>M). • Erosion of the reference region results in greater OTS influence in target regions. • Approaches to optimize MK6240 processing perform similarly to standard processing. Accurate measurement of Alzheimer's disease (AD) pathology in older adults without significant clinical impairment is critical to assessing intervention strategies aimed at slowing AD-related cognitive decline. The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (POINTER) is a 2-year randomized controlled trial to evaluate the effect of multicomponent risk reduction strategies in older adults (60-79 years) who are cognitively unimpaired but at increased risk for cognitive decline/dementia due to factors such as cardiovascular disease and family history. The POINTER Imaging ancillary study is collecting tau-PET ([18F]MK6240), beta-amyloid (Aβ)-PET ([18F]florbetaben [FBB]) and MRI data to evaluate neuroimaging biomarkers of AD and cerebrovascular pathophysiology in this at-risk sample. Here 481 participants (70.0±5.0; 66% F) with baseline MK6240, FBB and structural MRI scans were included. PET scans were coregistered to the structural MRI which was used to create FreeSurfer-defined reference regions and target regions of interest (ROIs). We also created off-target signal (OTS) ROIs to examine the magnitude and distribution of MK6240 OTS across the brain as well as relationships between OTS and age, sex, and race. OTS was unimodally distributed, highly correlated across OTS ROIs and related to younger age and sex but not race. Aiming to identify an optimal processing approach for MK6240 that would reduce the influence of OTS, we compared our previously validated MRI-guided standard PET processing and 6 alternative approaches. The alternate approaches included combinations of reference region erosion and meningeal OTS masking before spatial smoothing as well as partial volume correction. To compare processing approaches we examined relationships between target ROIs (entorhinal cortex (ERC), hippocampus or a temporal meta-ROI (MetaROI)) SUVR and age, sex, race, Aβ and a general cognitive status measure, the Modified Telephone Interview for Cognitive Status (TICSm). Overall, the processing approaches performed similarly, and none showed a meaningful improvement over standard processing. Across processing approaches we observed previously reported relationships with MK6240 target ROIs including positive associations with age, an Aβ+> Aβ- effect and negative associations with cognition. In sum, we demonstrated that different methods for minimizing effects of OTS, which is highly correlated across the brain within subject, produced no substantive change in our performance metrics. This is likely because OTS contaminates both reference and target regions and this contamination largely cancels out in SUVR data. Caution should be used when efforts to reduce OTS focus on target or reference regions in isolation as this may exacerbate OTS contamination in SUVR data. [ABSTRACT FROM AUTHOR]

Published
2023
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254. Actor Seamus Dever Teases Next Week's Episode on AfterBuzz TV

Subjects
Actors, Business, general
Abstract

(PRWEB) March 18, 2015 ABC's Castle star Seamus Dever stopped by Maria Menounos' AfterBuzz TV network to chat with hosts JJ Snyder, Heather Joy Smith and Alexis McLeod-Torres about next [...]

Published
2015

255. Three named field marketing managers at Baltimore-based Williams Scottsman

Subjects
Marketing executives, Business, Business, regional
Abstract

Byline: Daily Record Staff Williams Scotsman has named Lin Snyder, Heather Peoples and Kelly Christopher field marketing managers. Snyder will oversee the west region, Peoples will oversee the east region [...]

Published
2012

256. 40 UNDER 40.

Author

Bertagnoli, Lisa

Subjects
ASSOCIATIONS, institutions, etc., EMPLOYEES, ALZHEIMER'S disease, DISEASES in women, MEDICAL research
Abstract

An interview with Alzheimer's Association senior director of medical and scientific operations, Heather Snyder, is presented. She reminisces on how she became interested in the field of science. She explains the reason why she started a study of Alzheimer's disease in women. She discusses how she assisted in the coordination of research efforts about the disease worldwide.

Published
2016

257. Hospital program to end physical restraints began with staff education.

Author

Bush, Haydn

Subjects
HEALTH care reform, RESTRAINT of patients, HOSPITALS
Abstract

The article presents information on a health reform program, called Hospitals in Pursuit of Excellence, being implemented at Chambersburg Hospital in the U.S. This program was designed to eliminate the use of physical restraints on patients in behavioral health units. This program was initiated by nurses Heather Snyder and Sandra Barton.

Published
2009

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