427 results on '"Müller, Sven"'
Search Results
402. .
- Author
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Lückerath, Eva and Müller, Sven-David
- Published
- 2013
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403. .
- Author
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Lückerath, Eva and Müller, Sven-David
- Published
- 2013
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404. On the integration of shared mobility services in public and corporate mobility systems
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Frank, Laura, Walther, Grit, and Müller, Sven
- Subjects
public transport ,decision support tool ,bikesharing ,carsharing ,ddc:330 ,mobility systems ,company car - Abstract
Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2023; Aachen : RWTH Aachen University 1 Online-Ressource : Illustrationen, Diagramme, Karten (2023). = Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2023, Private and corporate passenger mobility is still primarily covered by individually used cars. Given the environmental and social challenges caused by this car-centric mobility, the call for a transformation of the public and corporate mobility system is becoming ever stronger. While innovative shared mobility services like car or bike sharing promise great potential to address these challenges, infrastructural, market, and behavioral barriers still prevent a complete transformation to sustainable mobility. Only a systemic transformation of public and corporate mobility systems and coordinated planning of all stakeholders can fully exploit the potential of integrating shared mobility services to address the challenges of passenger transport. Against this background, this cumulative thesis presents four publications that provide a methodological framework for the strategic planning of the integration of shared mobility services in public and corporate mobility systems. The methodological framework is divided into two parts, with two publications each. One part focuses on the integration of shared mobility services in public mobility systems, and one part focuses on the integration in corporate mobility systems. Each part addresses two initial research questions: What is the potential of integrating shared mobility services, and how can these services be optimally integrated? A prolog and epilog frame the cumulative thesis by presenting and discussing the aim of the thesis, the context of the publications, and the current state of related research. The first part of this thesis addresses the integration of shared mobility services in the public mobility system. In this context, the aim is to analyze how an intelligent integration of shared mobility services may support public transportation, i.e., how these services can help to improve the accessibility of public transportation by enabling intermodal travel behavior. The first and second publication of this thesis contribute to fulfilling this aim as described in the following: The first publication presents a quantitative methodology to evaluate the quality of public transportation. By comparing the mobility demand with the supply of public transportation, the methodology identifies critical connections and classifies them according to the need for action. The methodology serves as a primary analysis to gain insights into the public transportation system's weaknesses and provides a transparent planning base for integrating shared mobility services. We apply the methodology to a case study in a rural area in Germany in which we identify critical connections to places of daily need and to workplaces. The second publication introduces a decision support tool to plan the strategic integration of shared mobility services at multimodal mobility hubs. We present a mixed-integer optimization model that simultaneously provides decisions on hub locations, hub composition concerning available shared mobility services, and the required infrastructure, e.g., parking spaces, charging stations, shelters, and signage. The model maximizes the accessibility of the integrated public mobility system while meeting the budget constraints. To account for a systemic transformation, the approach considers interdependencies between public transportation and shared mobility services by enabling new intermodal travel itineraries. Finally, in a real-world case study, we derive managerial insights on the integration of shared mobility services, e.g., regarding the cannibalization of public transportation. The second part of this thesis addresses the integration of shared mobility services in the corporate mobility system. In this context, the aim is to analyze how an extension of traditional company-exclusive mobility services by public shared mobility services can help to improve the efficiency of corporate mobility. The third and fourth publication of this thesis contribute to fulfilling this aim as described in the following: The third publication provides a quantitative methodology to evaluate the potential of an overall fleet size reduction. Herein, we investigate an integrated car sharing system for private and corporate user groups, which uses pooling effects within each group but also between both groups. Given the complexity of the spatio-temporal distribution of mobility demand and vehicle supply, we develop an integer optimization model to compare the minimum fleet size of an integrated system with the size of separate fleets. In an exemplary case study, we quantify the potential fleet size reduction for an integrated car sharing system in Munich. The fourth publication presents a decision support tool to plan the strategic integration of shared mobility services in the corporate mobility system. Based on an integer optimization model, decisions on the fleet size and composition of corporate fleets are derived. The methodology accounts for interdependencies with the public mobility system by shifting parts of the demand to shared mobility services. Further, the model provides decisions on the choice of memberships in these services based on the offered price tariffs. The approach minimizes corporate mobility costs while meeting all structural requirements, such as technical vehicle restrictions and the acceptance of micromobility modes, like bikes and scooters. Finally, we apply the methodology in a case study with driving profiles of 144 companies to derive general insights into the current and future potentials of a multimodal corporate mobility system., Published by RWTH Aachen University, Aachen
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- 2023
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405. Anxiety disorders in youth : the role of neural networks and emotion regulation
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De Witte, Nele, Müller, Sven, and Braet, Caroline
- Subjects
emotion regulation ,autonomic nervous system ,Medicine and Health Sciences ,adolescence ,white matter connectivity ,Anxiety disorders - Published
- 2016
406. Emotional working memory : the role of development and task factors
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Cromheeke, Sofie and Müller, Sven
- Subjects
Social Sciences - Published
- 2015
407. Ausblick: Musikalische Kommunikation und Formen der Aneignung von Musik als Gegenstände der Historiographie
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Hans-Joachim Hinrichsen, University of Zurich, Müller, Sven Oliver, Osterhammel, Jürgen, Rempe, Martin, and Hinrichsen, Hans-Joachim
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10111 Institute of Musicology ,780 Music - Published
- 2015
408. Das deutsche Kaiserreich in der Kontroverse
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MÜLLER, Sven Oliver and TORP, Cornelius
- Abstract
Ausgewiesene Experten geben einen Überblick über den aktuellen internationalen Forschungsstand zum Deutschen Kaiserreich und werfen neue, richtungweisende Fragen auf. Der Band liefert einen wichtigen Beitrag zu den anhaltenden Debatten über das Deutsche Kaiserreich (1871-1918). Ausgewiesene Kaiserreichexperten internationaler Provenienz geben einen Überblick über den aktuellen Forschungsstand und werfen neue, richtungweisende Fragen auf. Das Buch ist an vier Achsen ausgerichtet, die Themen und Probleme markieren, auf die sich die Kontroversen über das Kaiserreich in den letzten Jahren konzentriert haben: die Verortung des Kaiserreichs in der deutschen Geschichte; das Verhältnis von Gesellschaft, Politik und Kultur; Formen militärischer Gewalt mit ihrem Brennpunkt im Ersten Weltkrieg und schließlich die transnationale Verflechtung Deutschlands im Zeitalter der »ersten Globalisierung«. Cornelius Torp und Sven Oliver Müller Das sich wandelnde Bild des Deutschen Kaiserreichs I. Das Kaiserreich in der deutschen Geschichte Helmut Walser Smith Jenseits der Sonderwegs-Debatte Benjamin Ziemann Das Kaiserreich als Epoche der Polykontexturalität Shulamit Volkov Nochmals zum Antimodernismus im Kaiserreich Richard J. Evans Britische Historiker und die deutsche Geschichte Dieter Grimm War das Kaiserreich ein souveräner Staat? John Breuilly Nationalismustheorien und kritische deutsche Gesellschaftsgeschichte II. Gesellschaft, Politik und Kultur James Retallack Obrigkeitsstaat und politischer Massenmarkt Frank Bösch Grenzen des »Obrigkeitsstaates«. Medien, Politik und Skandale im Kaiserreich Heinz-Gerhard Haupt Gewalt als Praxis und Herrschaftsmittel. Das Deutsche Kaiserreich und die Dritte Republik in Frankreich im Vergleich Ute Planert Wie reformfähig war das Kaiserreich? Ein westeuropäischer Vergleich aus geschlechtergeschichtlicher Perspektive Olaf Blaschke Das Deutsche Kaiserreich im Zeitalter der Kulturkämpfe Stephan Malinowski Ihr liebster Feind. Die deutsche Sozialgeschichte und der preußische Adel Manfred Hettling Eine anstrengende Affäre. Die Sozialgeschichte und das Bürgertum Matthew Jefferies Wilhelminischer Monumentalismus. Zur politischen und kulturellen Rolle der Architektur im Deutschen Kaiserreich Sven Oliver Müller Die musikalische Weltmacht. Zum Stellenwert der Musikrezeption im Deutschen Kaiserreich III. Krieg und Gewalt Jörg Echternkamp 1914-1945: Ein zweiter Dreißigjähriger Krieg? Vom Nutzen und Nachteil eines Deutungsmodells der Zeitgeschichte Roger Chickering Ein Krieg, der nicht vergehen will. Zur Frage des methodischen Fortschritts in der Historiographie des Ersten Weltkriegs MacGregor Knox Erster Weltkrieg und ›Military Culture‹. Kontinuität und Wandel im deutsch-italienischen Vergleich Dirk Bönker Ein German Way of War? Deutscher Militarismus und maritime Kriegführung im Ersten Weltkrieg Jürgen Zimmerer Kein Sonderweg im Rassenkrieg? Der Genozid an den Herero und Nama 1904-08 zwischen deutschen Kontinuitäten und der Globalgeschichte der Massengewalt Alan Kramer Deutsche Kriegsverbrechen 1914/1941: Kontinuität oder Bruch? IV. Das Kaiserreich in der Welt Birthe Kundrus Von der Peripherie ins Zentrum? Zur Bedeutung des Kolonialismus für das Deutsche Kaiserreich Thomas Mergel Das Kaiserreich als Migrationsgesellschaft Dieter Gosewinkel Die Nationalisierung der Staatsangehörigkeit im Deutschen Kaiserreich Sebastian Conrad Globalisierungseffekte: Mobilität und Nation im Kaiserreich Cornelius Torp Erste Globalisierung und deutscher Protektionismus Volker Berghahn Deutsche Industrie und amerikanische Geschäftswelt, 1900-1914 Danksagung
- Published
- 2009
409. Nationalismus als kulterelle Konstruktion: Einige Überlegungen
- Author
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Breuilly, John, Echternkamp, Jörg, and Müller, Sven Oliver
- Subjects
DD Germany - Published
- 2002
410. New high-quality HER2 IQFISH pharmDx™ assay with a ½ working day procedure and high concordance to HER2 FISH pharmDx™.
- Author
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Jensen, Kristian, Nielsen, Kirsten Vang, Andresen, Lena, Müller, Sven, Mollerup, Jens, Matthiesen, Steen Hauge, and Schønau, Andreas
- Subjects
- *
HER2 gene , *IMMUNOHISTOCHEMISTRY , *FLUORESCENCE in situ hybridization , *GENE amplification , *CANCER cells , *CANCER patients - Abstract
This abstract was listed as "Withdrawn" in the SABCS Pocket Program and the SABCS Abstract Book and has been reinstated. Introduction: HER2 assessment for selection of patients that may benefit from HER2 targeting treatment can be performed by either immunohistochemistry (IHC), fluorescence or chromogen in situ hybridization (FISH or CISH). FISH is a robust and reliable technique for direct visualization and quantitative determination of gene amplifications, deletions and translocations in human cancer cells, but FISH protocols are time-consuming and involve toxic reagents. By introducing a new non-toxic ethylene carbonate based hybridization buffer that perform with very short hybridization times, the total FISH assay time on breast cancer tissue sections can be reduced from the traditional 16-20 hours to 31/2 -4 1/2hours. Material and methods: The new Dako HER2 IQFISH pharmDx™ was compared with Dako HER2 FISH pharmDx™ in a comparative study on 120 breast cancer specimens, and reproducibility of the HER2 IQFISH pharmDx™ assay was investigated in a study comprising 3 different sites and a total of 6 different observers. Samples for the comparative study was evaluated by Dako HercepTest™ to include all IHC scoring groups (0, 1+, 2+, 3+). Slides were stained according to manufacturer's instructions using microwave oven for heat pretreatment and RTU pepsin for 3-5 minutes at 37 °C. Hybridization was performed for 2 hours when using HER2 IQFISH pharmDx™ and for 17-20 hours when using HER2 FISH pharmDx™ Kit. All slides were blinded before evaluation. HER2 status was classified as "Non-amplified" when the HER2/CEN17 ratio ≥2.0 and "Amplified" when the HER2/CEN17 ratio 2.0. Results: The new non-toxic hybridization buffer introduces a major safety improvement since formamide is no longer needed. Significantly shorter hybridization times are required to generate the same signal intensity (1-2 hour hybridization versus overnight). HER2 IQFISH pharmDx™ was compared with the traditional HER2 FISH pharmDx™ in a comparative study on 120 breast tissue specimens of human breast carcinoma. The preliminary data on HER2 status for 78 patients obtained by the two assays gave an overall agreement of 98.7% with ower and upper 95% confidence limits at 94.2% and 99.9%. The Kappa value was 0.96 (95% CL: 0.89-1.00). The p-value for McNemars test was 1.00 indicating absence of bias between he two assays. Disagreement between the two assays was observed for one specimen - a heterogeneous tissue with a small amplified area. Data from the reproducibility study that ncluded site-to-site variation, day-to-day variation and inter-observer variation showed that the assay has a high degree of reproducibility. Conclusion: The validation studies of the new HER2 IQFISH pharmDx™ showed a very high concordance to the traditional HER2 FISH pharmDx™ and also that the assay is robust and eproducible. Reduction of the overall assay time from a two-day to a half-day procedure for HER2 FISH, offers more flexible laboratory routines and same day reporting for all working days of the week, which could be used for fast and simultaneous FISH and IHC answers and mproved patient care. Taken together, the study demonstrates the potential of a new evolutionary platform that enables optimization and acceleration of FISH analysis to the benefit of cancer patients and laboratory personnel. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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411. Synthesis of α-Branched Enones via Chloroacylation of Terminal Alkenes.
- Author
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Kim J, Müller S, and Ritter T
- Abstract
Here, we show the conversion of unactivated alkenes into α-branched enones via regioselective chloroacylation with acyl chlorides. The method relies upon the initial in situ generation of chlorine radicals directly from the acyl chloride precursor under cooperative nickel/photoredox catalysis. Subsequent HCl elimination provides enones and α,β-unsaturated esters that are not accessible via the conventional acylation approaches that provide the other, linear constitutional isomer., (© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
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- 2023
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412. Prophylactic effect of retromuscular mesh placement during loop ileostomy closure on incisional hernia incidence-a multicentre randomised patient- and observer-blind trial (P.E.L.I.O.N trial).
- Author
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Müller S, Weyhe D, Herrle F, Horvath P, Bachmann R, von Ehrlich-Treuenstätt V, Heger P, Nasir N, Klose C, Ritz A, Sander A, Grohmann E, Dörr-Harim C, and Mihaljevic AL
- Subjects
- Humans, Ileostomy adverse effects, Surgical Mesh adverse effects, Incidence, Incisional Hernia etiology, Incisional Hernia prevention & control, Surgical Stomas, Abdominal Wound Closure Techniques adverse effects
- Abstract
Background: Incisional hernia is a frequent complication following loop ileostomy reversal. Incisional hernias are associated with morbidity, loss of health-related quality of life and costs and warrant the investigation of prophylactic measures. Prophylactic mesh implantation at the time of surgical stoma reversal has shown to be a promising and safe method to prevent incisional hernias in this setting. However, the efficacy of this method has not yet been investigated in a large multicentre randomised-controlled trial (RCT) with adequate external validity. The P.E.L.I.O.N. trial will evaluate the efficacy of prophylactic mesh reinforcement after loop ileostomy closure in decreasing the rate of incisional hernia versus standard closure alone., Methods: P.E.L.I.O.N. is a multicentre, patient- and observer-blind RCT. Patients undergoing loop ileostomy closure will undergo intraoperative 1:1 randomisation into either abdominal wall closure with a continuous slowly absorbable suture in small-stitch technique without mesh reinforcement (control group) or abdominal wall closure with an additional reinforcement with a retromuscular non-absorbable, macro-pore (pore size ≥ 1000 μm or effective porosity >0%) light-weight monofilament or mixed structure mesh. A total of 304 patients (152 per group) will need to be randomised in the study. Based on inclusion and exclusion criteria, 1,014 patients are expected to be screened for eligibility in order to recruit the necessary number of patients. The primary endpoint will be the frequency of incision hernias within 24 months according to the European Hernia Society definition. Secondary endpoints will be the frequency of surgical site occurrences (including surgical site infections, wound seromas and hematomas, and enterocutaneous fistulas), postoperative pain, the number of revision surgeries and health-related quality of life. Safety will be assessed by measuring postoperative complications ≥ grade 3 according to the Dindo-Clavien classification., Discussion: Depending on the results of the P.E.L.I.O.N. trial, prophylactic mesh implantation could become the new standard for loop ileostomy reversal., Trial Registration: DRKS00027921, U1111-1273-4657., (© 2023. The Author(s).)
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- 2023
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413. Nondirected Pd-catalyzed aerobic C-H alkenylation of ruthenocene and ferrocene.
- Author
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Müller S, Lee W, Song JY, Kang E, and Joo JM
- Subjects
- Ferrous Compounds, Ligands, Metallocenes, Organometallic Compounds, Alkenes, Palladium
- Abstract
Pd-catalyzed alkenylations of metallocenes via C-H activation were developed using electronically tunable pyrazolonaphthyridine (PzNPy) ligands. Ferrocene was alkenylated using the most electron-deficient ligand in the series, whereas the less reactive ruthenocene needed balancing of the electrophilicity and stability of catalysts. Various alkenes were installed, allowing fine-tuning of redox potentials.
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- 2022
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414. Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients.
- Author
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Aaberg-Jessen C, Halle B, Jensen SS, Müller S, Rømer UM, Pedersen CB, Brünner N, and Kristensen BW
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- Adult, Aged, Aged, 80 and over, Cohort Studies, DNA Copy Number Variations, Denmark, Female, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Male, Middle Aged, Tissue Array Analysis, Brain Neoplasms blood, Brain Neoplasms genetics, Glioblastoma blood, Glioblastoma genetics, Tissue Inhibitor of Metalloproteinase-1 blood, Tissue Inhibitor of Metalloproteinase-1 genetics
- Abstract
Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been associated with poor prognosis and resistance towards chemotherapy in several cancer forms. In a previous study we found an association between a low TIMP-1 tumor immunoreactivity and increased survival for glioblastoma patients, when compared to moderate and high TIMP-1 tumor immunoreactivity. The aim of the present study was to further evaluate TIMP-1 as a biomarker in gliomas by studying TIMP-1 gene copy numbers by fluorescence in situ hybridization (FISH) on 33 glioblastoma biopsies and by measuring levels of TIMP-1 in plasma obtained pre-operatively from 43 patients (31 gliomas including 21 glioblastomas) by enzyme-linked immunosorbent assay (ELISA). The results showed TIMP-1 gene copy numbers per cell ranging from 1 to 5 and the TIMP-1/CEN-X ratio ranging between 0.7 and 1.09, suggesting neither amplification nor loss of the TIMP-1 gene. The TIMP-1 protein levels measured in plasma were not significantly higher than TIMP-1 levels measured in healthy subjects. No correlation was identified between TIMP-1 tumor cell immunoreactivities and the TIMP-1 gene copy numbers or the plasma TIMP-1 levels. In conclusion, high immunohistochemical TIMP-1 protein levels in glioblastomas were not caused by TIMP-1 gene amplification and TIMP-1 in plasma was low and not directly related to tumor TIMP-1 immunoreactivity. The study suggests that TIMP-1 immunohistochemistry is the method of choice for future clinical studies evaluating TIMP-1 as a biomarker in glioblastomas., Competing Interests: The authors declare no conflict of interest.
- Published
- 2016
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415. [Not Available].
- Author
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Müller S, Scuffi B, Manncke S, Beck M, and Königsrainer A
- Subjects
- Germany, Humans, Clinical Coding, Hospitals
- Published
- 2016
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416. Beam position and energy monitoring in compact linear accelerators for radiotherapy.
- Author
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Ruf M, Müller S, Setzer S, and Schmidt LP
- Subjects
- Equipment Design, Feedback, Models, Theoretical, Particle Accelerators instrumentation, Radiotherapy instrumentation
- Abstract
The experimental verification of a novel sensor topology capable of measuring both the position and energy of an electron beam inside a compact electron linear accelerator for radiotherapy is presented. The method applies microwave sensing techniques and allows for the noninterceptive monitoring of the respective beam parameters within compact accelerators for medical or industrial purposes. A state space feedback approach is described with the help of which beam displacements, once detected, can be corrected within a few system macropulses. The proof-of-principle experiments have been conducted with a prototype accelerator and customized hardware. Additionally, closed-loop operation with high accuracy is demonstrated.
- Published
- 2014
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417. [Surgery].
- Author
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Givel JC, Hübner M, Müller S, Ksontini R, Vuilleumier H, Cerantola Y, and Demartines N
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- Humans, Length of Stay, Salivary Gland Diseases surgery, Esophageal Neoplasms surgery, Minimally Invasive Surgical Procedures methods, Surgical Procedures, Operative classification
- Abstract
2007 was marked by a growing trend towards minimal invasive surgery and enhanced recovery, especially in visceral surgery. In comparison to the laparoscopic revolution in the eighties, Natural orifice transluminal endoscopic surgery (NOTES) must be watched on closely, and will probably have to be taken into account in a near future. Minimal invasive procedures in oesophageal cancer surgery have proved both efficient and oncologically safe. Implementation of Fast track protocols now permits a much faster patient's return to normal daily activity. In hepatobiliary and pancreatic surgery, multidisciplinary efforts have been done to better select patients, widen the indications and increase efficiency.
- Published
- 2008
418. [An algorithm for passive marker localization in interventional MRI].
- Author
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Rauschenberg J, de Oliveira A, Müller S, Semmler W, and Bock M
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- Algorithms, Equipment Design, Phantoms, Imaging, Reproducibility of Results, Robotics, Sensitivity and Specificity, Magnetic Resonance Imaging, Interventional instrumentation, Magnetic Resonance Imaging, Interventional methods
- Abstract
The localization of passive marker systems in interventional MRI is necessary to monitor the position and orientation of medical instruments that do not emit an MR signal. In this work an algorithm is presented that automatically detects a given marker system in an MR image with a precision better than one pixel. Therefore, a combination of a phase-only cross correlation algorithm with a subsequent center-of-mass analysis is utilized. The algorithm was evaluated in simulations and phantom experiments with respect to precision, noise sensitivity as well as the influence of unwanted signal amplitudes. Above a signal-to-noise ratio (SNR) of 4.5 a localization precision significantly better than the pixel dimension could be achieved. For SNR values of 6 and more the influence of unwanted signals on the localization could not be detected in the simulations. In phantom experiments the predicted precision of the marker localization could be realized which results for typical measurement parameters in a maximal deviation of the needle tip in an MR-guided needle injection of 0.6 mm.
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- 2007
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419. B1 field-insensitive transformers for RF-safe transmission lines.
- Author
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Krafft A, Müller S, Umathum R, Semmler W, and Bock M
- Subjects
- Equipment Design, Equipment Failure Analysis, Hot Temperature, Phantoms, Imaging, Radiation Injuries etiology, Radiation Protection methods, Radiation-Protective Agents, Temperature, Time Factors, Radiation Injuries prevention & control, Radiation Protection instrumentation, Radio Waves adverse effects
- Abstract
Objective: Integration of transformers into transmission lines suppresses radiofrequency (RF)-induced heating. New figure-of-eight-shaped transformer coils are compared to conventional loop transformer coils to assess their signal transmission properties and safety profile., Materials and Methods: The transmission properties of figure-of-eight-shaped transformers were measured and compared to transformers with loop coils. Experiments to quantify the effect of decoupling from the B1 field of the MR system were conducted. Temperature measurements were performed to demonstrate the effective reduction of RF-induced heating. The transformers were investigated during active tracking experiments., Results: Coupling to the B1 field was reduced by 18 dB over conventional loop-shaped transformer coils. MR images showed a significantly reduced artifact for the figure-of-eight- shaped coils generated by local flip-angle amplification. Comparable transmission properties were seen for both transformer types. Temperature measurements showed a maximal temperature increase of 30 K/3.5 K for an unsegmented/segmented cable. With a segmented transmission line a robotic assistance system could be successfully localized using active tracking., Conclusion: The figure-of-eight-shaped transformer design reduces both RF field coupling with the MR system and artifact sizes. Anatomical structure close to the figure-of-eight-shaped transformer may be less obscured as with loop-shaped transformers if these transformers are integrated into e.g. intravascular catheters.
- Published
- 2006
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420. Alternative protein secretion: the Mam1 ABC transporter supports secretion of M-factor linked GFP in fission yeast.
- Author
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Kjaerulff S, Müller S, and Jensen MR
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- Amino Acid Sequence, Intercellular Signaling Peptides and Proteins, Molecular Sequence Data, Protein Precursors metabolism, Recombinant Fusion Proteins metabolism, Sequence Alignment, ATP-Binding Cassette Transporters physiology, Green Fluorescent Proteins metabolism, Peptides metabolism, Schizosaccharomyces metabolism, Schizosaccharomyces pombe Proteins metabolism, Schizosaccharomyces pombe Proteins physiology
- Abstract
To examine whether the fission yeast Mam1 ABC transporter can be used for secretion of heterologous proteins, thereby bypassing the classical secretion pathway, we have analyzed chimeric forms of the M-factor precursor. It was demonstrated that GFP can be exported when fused to both the amino-terminal prosequence from mfm1 and a CaaX motif. This secretion was dependent on the Mam1 transporter and not the classical secretion pathway. The secretion efficiency of GFP, however, was relatively low and most of the reporter protein was trapped in the vacuolar membranes. Our findings suggest that the Mam1 ABC protein is a promiscuous peptide transporter that can accommodate globular proteins of a relatively large size. Furthermore, our results help in defining the sequences required for processing and secretion of natural M-factor.
- Published
- 2005
- Full Text
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421. [Prebiotic ballast stuff. New developments in infant nutrition].
- Author
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Matentzoglu S and Müller SD
- Subjects
- Humans, Immunity, Infant, Infant, Newborn, Intestines microbiology, Milk, Human, Infant Formula, Infant Nutritional Physiological Phenomena, Oligosaccharides administration & dosage
- Published
- 2004
422. [Burns and nutrition: stress challenges body mass equilibrium].
- Author
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Drewe I, Wüller J, and Müller SD
- Subjects
- Body Mass Index, Body Surface Area, Burns physiopathology, Humans, Nutritional Requirements, Patient Care Planning, Burns nursing, Energy Metabolism physiology, Enteral Nutrition nursing, Fluid Therapy nursing, Nursing Assessment, Water-Electrolyte Balance physiology
- Published
- 2003
423. [Proper nutrition for the elderly: more vitamins and minerals, fewer calories].
- Author
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Drewe I, Raschke K, Rösler D, Müller SD, and Pütz K
- Subjects
- Aged, Aged, 80 and over, Dehydration nursing, Geriatric Assessment, Humans, Nutrition Assessment, Nutritional Requirements, Chronic Disease nursing, Diet Therapy nursing, Energy Intake, Minerals administration & dosage, Vitamins administration & dosage
- Published
- 2003
424. [Diet therapy in hyperuricemia and gout: warnings about meat and alcohol].
- Author
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Müller SD
- Subjects
- Gout diet therapy, Gout etiology, Humans, Hyperuricemia diet therapy, Hyperuricemia etiology, Risk Factors, Alcohol Drinking adverse effects, Diet Therapy nursing, Diet, Vegetarian, Gout nursing, Hyperuricemia nursing, Meat adverse effects
- Published
- 2002
425. [Drinking from the nutrition medicine viewpoint--II: Importance of stable water-electrolyte balance].
- Author
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Pütz K and Müller SD
- Subjects
- Fluid Therapy nursing, Humans, Nursing Assessment, Water-Electrolyte Imbalance physiopathology, Drinking physiology, Enteral Nutrition nursing, Water-Electrolyte Balance physiology, Water-Electrolyte Imbalance nursing
- Published
- 2002
426. [Drinking from the nutrition medicine viewpoint--I: Water is the elixier of life--also for the aged].
- Author
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Pütz K and Müller SD
- Subjects
- Aged, Aged, 80 and over, Dehydration physiopathology, Humans, Nutritional Requirements, Water-Electrolyte Balance physiology, Dehydration nursing, Drinking, Geriatric Assessment, Nutritional Sciences education
- Published
- 2002
427. [New guidelines for nutrition in diabetics. Diet in change].
- Author
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Müller SD
- Subjects
- Animals, Diabetes Complications, Humans, Nutritional Physiological Phenomena, Diabetes Mellitus diet therapy, Diet, Guidelines as Topic
- Published
- 2002
- Full Text
- View/download PDF
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