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Hydrothermal pretreatment (HT) is an effective method to upgrade biochar pellets, while little attention is paid to wood vinegar (WV), the byproduct of biochar pellets production. Therefore, Chinese fir sawdust (FS) and cotton stalk (CS) were hydrothermally pretreated first at 180–280 °C and then pyrolyzed at 350 °C in the study. The effect of hydrothermal pretreatment on the properties of biomass was evaluated by the Van Soest method and thermogravimetric method. The yield, pH, density, and composition of WV were analyzed. The results showed that hemicellulose and cellulose were completely decomposed at HT temperatures of 230 °C and 280 °C respectively. The removal of hemicellulose and the enrichment of cellulose and lignin in the samples pretreated before 230 °C result in a higher density and lower pH of WV, while the yield only increases before 200 °C. Compared with CS samples, the higher content and reactivity of cellulose, especially amorphous cellulose, and lignin in FS samples results in the higher yield of the organic compounds in FSWV. With HT temperature increasing to 230 °C, the content and yield of acids in FSWV/CSWV shows a declining trend, and the content and yield of phenols, ketones, and aldehydes increase. HT pretreatment below 230 °C can upgrade WV. • Evolution of the components in FS and CS during HT pretreatment is given. • Relationship between the components of FS/CS samples and WV is gained. • Less hemicellulose and more amorphous cellulose and lignin improve WV quality. • FS with higher reactivity is more suitable for WV preparation than CS. • WV can be upgraded from the biomass HT pretreated below 230 °C. [ABSTRACT FROM AUTHOR]

Inhibition of the protein-protein interaction between Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2) has been recognized as an attractive approach for treating oxidative stress-related diseases. Here, we present a new series of noncovalent Keap1-Nrf2 inhibitors developed by a conformational restriction strategy of our fluorenone-based compounds previously identified by fragment-based drug discovery. The design was guided by X-ray cocrystal structures, and the subsequent optimization process aimed at improving affinity, cellular activity, and metabolic stability. From the noncyclic compound 7 ( K i = 2.9 μM), a new series of tetrahydroisoquinoline-based Keap1 inhibitors with up to 223-fold improvement in binding affinity ( 57 , K i = 13 nM), better metabolic stability, and enhanced cellular activity was obtained. In addition, the compounds showed selectivity for the Keap1 Kelch domain across a panel of 15 homologous proteins. We thereby demonstrate the utility of cyclic rigidification in the design of potent and more drug-like Keap1-Nrf2 inhibitors.

Thin-plate spline (TPS) is a principal warp that allows for representing elastic, nonlinear transformation with control point motions. With the increase of control points, the warp becomes increasingly flexible but usually encounters a bottleneck caused by undesired issues, e.g., content distortion. In this paper, we explore generic applications of TPS in single-image-based warping tasks, such as rotation correction, rectangling, and portrait correction. To break this bottleneck, we propose the coupled thin-plate spline model (CoupledTPS), which iteratively couples multiple TPS with limited control points into a more flexible and powerful transformation. Concretely, we first design an iterative search to predict new control points according to the current latent condition. Then, we present the warping flow as a bridge for the coupling of different TPS transformations, effectively eliminating interpolation errors caused by multiple warps. Besides, in light of the laborious annotation cost, we develop a semi-supervised learning scheme to improve warping quality by exploiting unlabeled data. It is formulated through dual transformation between the searched control points of unlabeled data and its graphic augmentation, yielding an implicit correction consistency constraint. Finally, we collect massive unlabeled data to exhibit the benefit of our semi-supervised scheme in rotation correction. Extensive experiments demonstrate the superiority and universality of CoupledTPS over the existing State-of-the-Art (SoTA) solutions for rotation correction and beyond.

Existing panoramic layout estimation solutions tend to recover room boundaries from a vertically compressed sequence, yielding imprecise results as the compression process often muddles the semantics between various planes. Besides, these data-driven approaches impose an urgent demand for massive data annotations, which are laborious and time-consuming. For the first problem, we propose an orthogonal plane disentanglement network (termed DOPNet) to distinguish ambiguous semantics. DOPNet consists of three modules that are integrated to deliver distortion-free, semantics-clean, and detail-sharp disentangled representations, which benefit the subsequent layout recovery. For the second problem, we present an unsupervised adaptation technique tailored for horizon-depth and ratio representations. Concretely, we introduce an optimization strategy for decision-level layout analysis and a 1D cost volume construction method for feature-level multi-view aggregation, both of which are designed to fully exploit the geometric consistency across multiple perspectives. The optimizer provides a reliable set of pseudo-labels for network training, while the 1D cost volume enriches each view with comprehensive scene information derived from other perspectives. Extensive experiments demonstrate that our solution outperforms other SoTA models on both monocular layout estimation and multi-view layout estimation tasks.

Trace natural products (TNPs) are still the vital source of drug development. However, the mining of novel TNPs is becoming increasingly challenging due to their low abundance and complex interference. A comprehensive strategy was proposed in which the functionalized magnetic particles integrated with LC-MS for TNPs discovery. Under the guidance of the approach, fifteen trace Nuphar alkaloids including seven new ones, cyanopumiline A sulfoxide (1), cyanopumiline C sulfoxide (8) and cyanopumilines A-E (4-5, 10, 12-13) featuring an undescribed nitrile-containing 6/6/5/6/6 pentacyclic ring system were isolated from the rhizomes of Nuphar pumila. Their structures and absolute configurations were determined on the basis of detailed spectroscopic data analysis and single-crystal X-ray diffraction analysis. Notably, a concise method based on 13 C NMR spectroscopy was established to determine the relative configurations of spiroatoms. Biologically, compounds 1-12 exhibited potent immunosuppressive activities with IC 50 values ranging from 0.1-12.1 μM against anti-CD3/CD28 induced human peripheral T cell proliferation. Mechanistic studies revealed that 4 could dose-dependently decrease pro-inflammatory cytokines and the expression levels of CD25 and CD71., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Image outpainting gains increasing attention since it can generate the complete scene from a partial view, providing a valuable solution to construct 360° panoramic images. As image outpainting suffers from the intrinsic issue of unidirectional completion flow, previous methods convert the original problem into inpainting, which allows a bidirectional flow. However, we find that inpainting has its own limitations and is inferior to outpainting in certain situations. The question of how they may be combined for the best of both has as yet remained under-explored. In this paper, we provide a deep analysis of the differences between inpainting and outpainting, which essentially depends on how the source pixels contribute to the unknown regions under different spatial arrangements. Motivated by this analysis, we present a Cylin-Painting framework that involves meaningful collaborations between inpainting and outpainting and efficiently fuses the different arrangements, with a view to leveraging their complementary benefits on a seamless cylinder. Nevertheless, straightforwardly applying the cylinder-style convolution often generates visually unpleasing results as it discards important positional information. To address this issue, we further present a learnable positional embedding strategy to incorporate the missing component of positional encoding into the cylinder convolution, which significantly improves the panoramic results. It is noted that while developed for image outpainting, the proposed algorithm can be effectively extended to other panoramic vision tasks, such as object detection, depth estimation, and image super-resolution. Code will be made available at https://github.com/KangLiao929/Cylin-Painting.

The marine biopharmaceutical industry (MBI) has been considered as an important part of the blue economy. The high-quality development of this industry depends on the high-level coordinated development of technological innovation system (TIS). In the present study, the coupling mechanism of industrial innovation input subsystem and innovation output subsystem was analyzed for the first time. On this basis, the development level and coupling coordination level of TIS in China's MBI during 2008-2018 were empirically evaluated with the capacity coupling coordination model. Then, the obstacle factors were diagnosed and recognized with the obstacle model. The results showed that the innovation input index fluctuated at a low level in China's MBI. The innovation output index has basically maintained a growth trend, whereas the quality of development was not high. Although the coupling coordination level of TIS showed a positive change as mild disordered → primary coordinated → well-coordinated, the development type of innovation system has changed from the lagging output of innovation into the lagging input of innovation. Insufficient input of innovation factors remained the main obstacle to the improvement of coordination level. Based on the above analysis, suggestions were put forward from the perspectives of policy and fund guarantees to improve the coupling coordination level in China's MBI., (© Ocean University of China, Science Press and Springer-Verlag GmbH Germany 2023.)