551. Patient-reported outcomes in schizophrenia patients treated with once-monthly extended-release risperidone in a long-term clinical study
- Author
-
Dhanda,Rahul, Varghese,Della, Nadipelli,Vijay R., Fava,Maurizio, Joshi,Namita, Solem,Caitlyn T, Graham,James A, Learned,Susan M, Heidbreder,Christian, Dhanda,Rahul, Varghese,Della, Nadipelli,Vijay R., Fava,Maurizio, Joshi,Namita, Solem,Caitlyn T, Graham,James A, Learned,Susan M, and Heidbreder,Christian
- Abstract
Rahul Dhanda,1 Della Varghese,2 Vijay R Nadipelli,1 Maurizio Fava,3 Namita Joshi,2 Caitlyn T Solem,2 James A Graham,4 Susan M Learned,4 Christian Heidbreder51Global Health Economics and Outcomes Research, Indivior Inc, Richmond, VA 23235, USA; 2Real-World Evidence and Data Analytics, Pharmerit International, Bethesda, MD 20814, USA; 3Clinical Trials Network Institute (CTNI), Massachusetts General Hospital (MGH) and Harvard Medical School, Boston, MA 02114, USA; 4Global Medicines Development, Indivior Inc, Richmond, VA 23235, USA; 5Global Research and Development, Indivior Inc, Richmond, VA 23235, USAPurpose: RBP-7000 (PERSERIS™) is a once-monthly subcutaneous extended-release risperidone formulation approved by the United States Food and Drug Administration for the treatment of schizophrenia in adults. The objective of this study was to describe the long-term impact of RBP-7000 on health-related quality of life (HRQoL), subjective well-being, treatment satisfaction and medication preference in patients with schizophrenia.Patients and methods: HRQoL was derived from a 52-week multicentre Phase III single-arm open-label outpatient study that assessed the safety and efficacy of RBP-7000 (120 mg) in patients with schizophrenia. HRQoL was measured using the EuroQol EQ-5D-5L and Short-Form Survey SF-36 version 2; well-being using the Subjective Well-being Under Neuroleptic Treatment – Short Version (SWN-S); satisfaction using the Medication Satisfaction Questionnaire and medication preference using the Preference of Medication questionnaire.Results: Of 482 participants at baseline, 234 remained through the end of study (EOS; week 52). Mean HRQoL and well-being scores remained stable between baseline (EQ-5D-5L index: 0.83; SF-36v2 Physical Component Score: 50; SF-36v2 Mental Component Score: 46; total SWN-S score: 89) and EOS (EQ-5D-5L index: 0.86; SF-36v2 Physical Component Score: 49; SF-36v2 Mental Component Score: 47; total SWN-S score: 90). The prop
- Published
- 2019