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502. Cardiovascular complications in CKD 5D (2)

Author

Nobuyuki Oyake, Valentina Romano, Amirhossein Davarpanah, Kosmas Pappas, Martin Auinger, Kamil amboch, Andreana De Mauri, Władysław Sułowicz, Rigas Kalaitzidis, Alessandro Amore, Guangyu Bi, Kunisirou Makino, Erhan Tatar, Carlo Ratti, Eirini Stavrinou, Acar Tuzuner, Solenne Pelletier, Paolo Raggi, Stefano Severi, Toshio Shimada, Natascia Miani, Yongxi Chen, Karl Lhotta, Hiroshi Kimura, Alessandro Zuccalà, Sawako Kato, Satoshi Nomura, Fatih Kircelli, Dan Radulescu, Cristina Karohl, Karine Marquis, Rosanna Coppo, Kazuaki Tanabe, Adrian Covic, Botond Csiky, Giulia Magliano, Ozkan Gungor, Mieczysław Pasowicz, Josep Bonet, Irina Florentina Secara, Peter Kotanko, Oktay Oymak, Ted Trajceski, Selcuk Hazinedaroglu, Renée-Claude Loignon, Roberto Albiani, Giovanni Petrillo, Francesco Romeo, Ismail Kocyigit, Ezequiel Rodriguez-Reimundes, Stig Molsted, Doriana Lucaciu, Yukio Yuzawa, Endre Sulyok, Danuta Galicka-Latała, Denis Steckiph, Alina Stefan, Hideyuki Mukai, Ping Zhu, Antonio Santoro, Meltem Sezis Demirci, Mehmet Ozkahya, Guglielmo Bracco, Antonio Sturniolo, Erika Schuh, Gladziewa Ulrich, Marianna Sgueglia, Bulent Erbay, Rossella Domini, Cengiz Utas, Yasuharu Maeda, Roberta Camilla, Kostas C. Siamopoulos, Fabio Grandi, Reyhan Calayoglu, Sule Sengul, Changying Xing, Takahito Ito, Amparo Galan, Atsuhiro Maeda, Juergen Floege, Stephanos Kountouris, Silvia Badarau, Gernot Schilcher, Stephan Thijssen, Henri Carrara, Rui Chen, Melek Karakurt, Dominiki Economidou, Arzu Ensari, Manfred Wallner, Andreas Vychytil, Pavlina Dzekova, Maria Paola Puccinelli, Manuel Heras Benito, Maria Astrid Rodriguez Gomez, Iva Nikorjaková, Xiaonong Chen, Theresa Gross, Nilufer Oguzhan, Eustatio Leanca, Mihai S. Utescu, Chrysostomos Dimitriadis, Kenan Keven, Giovanni B. Forleo, István Wittmann, Ramon Romero, Saki Ito, Tibor Vas, Galina Severova, Anna-Maria Belechri, Mojgan Mortazavi Najafabadi, George Spanos, Marek Kuzniewski, Cristiana Corsi, Richard Larivière, Oliviero Panzetta, Maddalena Brustia, Adrian P. Harrison, Chris Gamboa, Diego Galli, Matthias Koenig, Georgios Efstratiadis, Sophie Ignace, Stefanie M. Bode-Böger, Maria Kapusta, Michael Etter, Nicola Di Daniele, Roberto Bonaudo, Mihaela Oleniuc, Aydin Unal, Gérard M. London, Muge Ozcan, Konstantinos Pliakos, Katarzyna Janda, Ayse Bilgic, Bulent Tokgoz, Usama Elewa, Akira Itoh, Maria Jose Fernandez-Reyes Luis, Ali Mohammad Faizei, Geoffrey Block, Jens Martens-Lobenhoffer, Dimitrios Memmos, Khaled Abouseif, Gulay Asci, Laurent Juillard, Inga Bayh, Seyed Mohamad Saadatnia, Andrew L. Smith, Maho Watanabe, Hitoshi Nakashima, Athina Tatsioni, Gergely Tóth, Ercan Ok, Havva Cilan, Maria Silvia Borzacchi, Robert Owen Wilson, Lada Trajceska, Brandenburg Vincent, Nan Chen, Inge Eidemak, Luis D'Marco Gascón, Ziba Farajzadegan, Nathan W. Levin, Paul Muntner, Marie Marsova, Leonardo Cagnoli, Laura Cañas, Anne Jolivot, Waled Bichari, Laura-Dumitrita Buimistriuc, Paola David, Amir Ahmad Nassiri, Lucile Mercadal, Bogdan Solnica, Charles R. Swanepoel, Elena Buzdugan, Yoshinari Tsuruta, Len A. Usvyat, Mihai Onofriescu, Nurhan Ozdemir, Norihisa Hosokawa, Yaowen Xu, Panagiotis Giamalis, Firoozeh Moinzadeh, Beata Kusnierz-Cabala, Jordi Bonal, Luca Santini, Huseyin Toz, Kenji Ito, Silvia Cipriani, Rebeca Nicolais, Shuhei Miura, Federica Capurro, Jochen G. Raimann, Shunichi Fukuhara, Carlo Navino, Pier Giorgio Bolasco, Michalis Spartalis, Robert Freercks, Noriaki Kurita, Ionut Nistor, Saso Gelev, Rosa Sanchez Hernandez, Asma Abdeljaouad, Efstratios Kasimatis, Paulina Dumnicka, Beatriz Bayés, Ketteler Markus, A. Filella, Daniele Marcelli, Denis Fouque, Kazuhito Takeda, Shahrzad Shahidi, Elena Ferrer, Véronique Couture, Hirotsugu Uchihara, Gjulsen Selim, Béla Melegh, Friedemann Awiszus, Gernot Lingenhel, Feridun Kavuncu, Takao Saito, H. Fessy, Jana Zahálková, Alvaro Molina Ordas, Mohsen Agharazii, Aleksandar Sikole, Reza Asadzadeh, Maurice Laville, Schurgers Leon, Satoru Ogahara, Martino De Leo, Marek Švesták, Gokhan Nergizoglu, Aikaterini Papagianni, Antonio Bellasi, Murat Sipahioglu, Yoshinari Yasuda, Nicolas Rognant, Emanuel Zitt, Juan Jesus Carrero, Vili Amitov, Monir Sadat Hakemi, Yasuhiro Abe, Efthymios Pappas, Sorin Crisan, Maggie Lam, Junichi Makino, Marco Fernàndez, Danuta Fedak, Despina Karasavvidou, Ariana Condor, Brian Rayner, Shoichi Maruyama, E. Ferramosca, Jesper Løvind Andersen, Emiliano Staffolani, and Siren Sezer

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine, Intensive care medicine, business
Published
2011

503. Renal Nutrition: Progress on Fast Track

Author

Daniel Teta and Denis Fouque

Subjects
Nutrition and Dietetics, Nutritional Support, Nephrology, business.industry, Humans, Kidney Failure, Chronic, Medicine (miscellaneous), Medicine, Nutritional Physiological Phenomena, Fast track, business, Data science
Published
2011

504. Wegener's granulomatosis with antiproteinase-3 antibodies occurring after Hodgkin's disease

Author

Pierre Gratadour, Denis Fouque, Roland Loire, Maurice Laville, Françoise Berger, Zech P, Jacques Fourcade, Simone Colon, Marline Ffrench, and Jean-François Cordier

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Systemic disease, Myeloblastin, Kidney Glomerulus, Disease, Kidney, Antibodies, immune system diseases, Renal Dialysis, hemic and lymphatic diseases, medicine, Rapidly progressive glomerulonephritis, Humans, Lung, Wegener s, biology, business.industry, Vascular disease, Serine Endopeptidases, Granulomatosis with Polyangiitis, medicine.disease, Hodgkin Disease, humanities, Lymphoma, Immunology, biology.protein, Kidney Failure, Chronic, Lymph Nodes, Antibody, business, Vasculitis, Tomography, X-Ray Computed
Abstract

We describe the first association between Hodgkin's lymphoma and Wegener's granulomatosis, heralded by renal involvement. A 43-year-old man developed rapidly progressive glomerulonephritis requiring chronic hemodialysis 8 months after remission of Hodgkin's lymphoma. At that moment, no extrarenal involvement was found, despite extensive investigation. Antineutrophil cytoplasm antibodies were positive, without specificity for proteinase-3 or myeloperoxydase. Six months after beginning hemodialysis, multiple pulmonary nodules appeared, along with rapid clinical worsening. A surgical biopsy was performed which disclosed a giant cell granuloma. Antimyeloperoxydase antibodies remained negative, whereas proteinase-3 antibodies became positive. Wegener's granulomatosis was diagnosed and treatment with cyclophosphamide and steroids was started. Clinical and radiological improvement occurred promptly. Eleven months after treatment, both Wegener's disease and Hodgkin's lymphoma remained in remission.

Published
1993

505. Éditorial

Author

Christian Combe and Denis Fouque

Subjects
medicine.medical_specialty, Nephrology, Calcinosis, business.industry, medicine, Nutritional status, Inflammation, medicine.symptom, Dialysis patients, Intensive care medicine, medicine.disease, business
Published
2010

506. Reply from the authors

Author

Walid Arkouche, Jules Traeger, Ehsaw Delawari, Roula Sibai-Galland, Elias Abdullah, Roland Galland, Philippe Leitienne, Denis Fouque, and Maurice Laville

Subjects
Nephrology
Published
2000
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507. Guest editorial

Author

Denis Fouque and William E Mitch

Subjects
Nutrition and Dietetics, Nephrology, Medicine (miscellaneous)
Published
2000

508. Early Impairment of Trabecular Microarchitecture Assessed With HR-pQCT in Patients With Stage II-IV Chronic Kidney Disease

Author

Pierre D. Delmas, Justine Bacchetta, Laurent Juillard, Elisabeth Sornay-Rendu, Nicolas Rognant, Fitsum Guebre-Egziabher, Pawel Szulc, Denis Fouque, Stephanie Boutroy, Nicolas Vilayphiou, Roland Chapurlat, and Maurice Laville

Subjects
Male, Risk, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Urology, Parathyroid hormone, Renal function, Fractures, Bone, Bone Density, Internal medicine, medicine, Humans, Diabetic Nephropathies, Orthopedics and Sports Medicine, Tibia, Quantitative computed tomography, Aged, Bone mineral, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Radius, Cross-Sectional Studies, Endocrinology, Diabetes Mellitus, Type 2, Parathyroid Hormone, Chronic Disease, Cohort, Osteoporosis, Female, Kidney Diseases, Tomography, X-Ray Computed, Complication, business, Kidney disease
Abstract

Bone fragility is a complication of chronic kidney disease (CKD). The aim of this study was to assess whether volumetric bone mineral density (vBMD) and microarchitecture could be impaired early in the course of CKD. Bone microarchitecture was examined with a noninvasive 3D imaging technique [high-resolution peripheral quantitative computed tomography (HR-pQCT)] at the tibia and radius in 70 stage II-IV CKD patients older than 50 years of age; controls belonged to two cohorts of healthy subjects comparable for age and gender (OFELY cohort in women and STRAMBO cohort in men). We examined 46 men and 24 women; 19 patients were diabetic. Mean age was 70.8 ± 8.5 years, mean glomerular filtration rate (GFR) was 34 ± 12 mL/min per 1.73 m2, and mean serum parathyroid hormone (PTH) level was 87 ± 59 pg/mL. Both CKD men and women experienced a moderate but significant trabecular (Tb) impairment, positioning CKD patient values between those of normal and osteopenic controls (e.g., CKD men versus healthy controls: Tb vBMD 172 ± 35 versus 188 ± 34 mg HA/cm3; Tb number 1.75 ± 0.27 versus 1.86 ± 0.26 mm−1, and Tb separation 503 ± 94 versus 465 ± 78 µm; p

Published
2009

509. Effect of a Very Low-Protein Diet on Long-term Outcomes

Author

Michel Aparicio, Denis Fouque, and Philippe Chauveau

Subjects
Pediatrics, medicine.medical_specialty, business.industry, medicine.medical_treatment, Treatment outcome, MEDLINE, Subject (documents), Tryptophan Metabolism, Chronic disease, Low-protein diet, Nephrology, Long term outcomes, Medicine, Table (database), business
Abstract

articles, the lettermust be received no more than 4 weeks after the article’sdate of print publication. The body of the letter should beas concise as possible and in general should not exceed250 words. A maximum of 3 authors may write a letter,and up to 10 references and 1 figure or table may beincluded. There is no guarantee that letters will bepublished. Letters are subject to editing and abridgmentwithout notice.Letters should be submitted via

Published
2009

510. Lab methods, progression & risk factors for CKD - 1

Author

Ligia Regina Franco Sansigolo Kerr, Bjørn Egil Vikse, Paulo Mota, Michel Daudon, Sue Carr, Claudia Modesto Velludo, M. Turan Gumus, Djordje Miljković, Nam Ju Heo, Noriaki Iino, Jae-Yoon Park, Giuseppe Garigali, Janusz Solski, Masashi Suzuki, Krzysztof Janicki, Fabiana M. R. Sanches, Luciana Almeida, Viviane O. Leal, Plamen H. Yovchevski, Reem Al-Jayyousi, Katia Toffolo, Nauman Tarif, Agnieszka Grzebalska, Panayotis Foundas, Sotirios Mikros, Natalia Polanco, Andrzej Ksiazek, Takashi Takei, Ciriaco Carru, José M. López-Novoa, Ashraf El-Saeed, Thomas Elung-Jensen, Hayne Cho Park, Tayfun Eyileten, Hasan Kayabasi, Etienne Cavalier, Victor Gutierrez-Millet, Marcelo M. Lemos, Yoshiki Nishizawa, M. Emin Yilmaz, Alice C. Smith, Abdel-Bassit El-Shaarawy, Svend Strandgaard, Ana Huerta, Catherine Bessin, Yosuke Nakayama, Laura Sola, Eirini Karvela, Zulfikar Yilmaz, Aikaterini Tselenti, Maria P. Hernandez-Fuentes, Francisco J. López-Hernández, Santosh Kumar Singh, Caroline Freguin, Manuel Praga, Jean-Marie Krzesinski, Deepak Jain, Christine Cleaud, Morad Amar, Dusan Bastac, Tiziana Cena, Abdulkareem Al Suwaida, Alexandre Braga Libório, Kayser Caglar, Sergio Antonio Draibe, Michel Godin, Nikolaos Tentolouris, Régis Radermecker, Tetsuro Takeda, Bruno Legallicier, Lucia Andrade, Inkara Mansurova, Pinar Sezgin Karatas, Ken Tsuchiya, Fabrice Bauer, Simona Verdesca, Denis Fouque, Maria Eugênia Fernandes Canziani, Bjarne M. Iversen, Ayuko Fujiu, Maria Heloisa M. Shimizu, Giacomina Loriga, Hajeong Lee, Durdana Hammad, Lorentz Irgens, Dominique Guerrot, Marcelle Rorive, Dmitry Putintsev, Masafumi Kurajoh, Pierre Delanaye, Hari Krishan Aggarwal, João L. Viana, Tetsuo Shoji, Han Kyu Lee, Danica Bukvic, Jocelyne Drai, Ryotaro Ando, Evgeniy Goshev, Shoko Tsuchikura, Adriano Luiz Ammirati, Nikolaos Katsilambros, Virginia Lee, Alper Sonmez, Maria Aparecida Dalboni, Suhnggwon Kim, Maurilo Leite, Christina L. Olsson, Keiko Yamamoto, Nicolette C. Bishop, Hak Jong Lee, Dong-Wan Chae, Fitsum Guebre-Egziabher, R. Swaminathan, Yusuf Oguz, Eun Jin Cho, Alicia Sans, Ivko Maric, Andrzej Drop, Seiji Ueda, Alan Bevington, W. Arkouche, Yaremi Quiros, Biserka Tirmenstajn Jankovic, Julie Lin, Imtiaz Shah, Dede Sit, Nigel J. Brunskill, Milton Urrutia, Sho-ichi Yamagishi, Masaaki Inaba, Carlos Martinez-Salgado, Ana M. Blazquez-Medela, Elisa Lazzarich, Ki Young Na, Zhannat Kuanshalieva, Elena Gutierrez-Solis, Eduardo Gutiérrez, Felipe Rizzetto, Torbjørn Leivestad, Mahir Gulec, Jamal Al Wakeel, Selim Kilic, Jorge González, Ali Kemal Kadiroglu, Adriana Forti, Lucyna Janicka, Tetsuya Ogawa, Maria Mylonopoulou, Jeong Myung Ahn, Carla Cavalheiro da Silva Lemos, Keiko Uchida, Carmine Zoccali, Geraldo Bezerra da Silva Junior, Joel Claudio Heimann, Renato Watanabe, Antonio Carlos Seguro, Shinsuke Yamada, Roberta Fenoglio, Isabel Fuentes-Calvo, Deise de Boni Monteiro de Carvalho, Eduardo Hernández, Ljubica Djukanovic, Rolv Skjærven, Masami Bessho, Bruno Cauliez, Seiya Okuda, Hans Bendz, Matthew Hall, Nelson Mazzuchi, Mahmut Ilker Yilmaz, Ho Jun Chin, Ana Hernández, JoséWellington Lima, Emma Schwedt, Emma L. Clapp, Natalia Shcherban, Kosta Kostov, Yasuo Imanishi, John Feehally, Fogazzi Giovanni Battista, Eiji Ishimura, Nada Dimkovic, Maki Toyonaga, Paulo Roberto Santos, Anne-Lise Kamper, Elizabeth De Francesco Daher, Kei Fukami, Ayako Fujimi-Hayashida, Lene Boesby, Anne-Marie L. Seymour, George Kosmadakis, Rachel Bregman, Abdülgaffar Vural, Abdulrauf Chaudhary, Mujdat Yenicesu, Luciana Nicolau, Patrizia Pergolini, Gary Curhan, Andrea Airoldi, Grzegorz Staskiewicz, André Scheen, Yury Landyshev, Piero Stratta, Visnja Lezaic, David Goldsmith, Tae Woo Lee, Marco Aurélio de Biato, Esther González, Ann Chalmers, Sergey Tseluyko, Daniele Venturoli, Cristina Scheeffer, Frances Valéria Costa e Silva, Ivana Novakovic, Casimiro Valle Domínguez, Konstantinos Katsaros, Bengt Rippe, Sung-Il Hwang, Giorgio Bellomo, Pablo Ríos, Ikue Kobayashi, Elzbieta Czekajska, Yusuke Kaida, Lilian Cuppari, Nancy De Souza, Denise Mafra, Mutlu Saglam, William Smith, Daniele N. Ferreira, Yukako Sawara, Angelo Zinellu, Croci Daniela, Fumitake Gejyo, Yoshiharu Tsubakihara, Maria Inês Barreto Silva, Marija Mostarica-Stojkovic, Adilson C. Rodrigues, Andrea Satta, Izabella Z.A. Pawluczyk, Maria Ayako Kamimura, Enrique Morales, Dariusz Duma, Akihiko Saito, Zorica Krcunovic, Nami Matsuda, Hidenori Koyama, Hiromichi Suzuki, Stavros Antonopoulos, Masanori Emoto, Michael Bubenheim, Odile Rivault, and Kosaku Nitta

Subjects
03 medical and health sciences, Transplantation, medicine.medical_specialty, 0302 clinical medicine, Nephrology, business.industry, 030232 urology & nephrology, Medicine, business, Intensive care medicine
Published
2009

511. Metabolic and other complications of ESRD - 2

Author

Fernandez-Lucas Milagros, Filippos Karakasis, Ezio Movilli, Nathan W. Levin, Alan Chapman, Ela Tules Firat, Pinggao Zhang, Giuseppe Mazzola, Ralf Wojke, Ettore Balestreri, Carolina Martinatto, Bernd Stegmayr, Giulio Romano, Weihong Zhao, Jianhui Zhou, Lorena Citterio, Girish Narayan, Naoyuki Yao, Marcelo Orias, Elena Donadio, Konstantinos Tellis, Fatma Albiladi, Zhifang Ma, Roberta Camilla, Kazutaka Murakami, Victor Gomez-S, Espejo Beatriz, Yoshiro Fujita, Elisabetta Giovannetti, Fansan Zhu, Sara Beati, Jung Sik Park, Viktoriya Kuntsevich, Christopher W. McIntyre, Tania Monzón, Milan Radovic, Tracey Wheeler, Fotini Stasini, Christofer Stegmayr, Gaetano Ferrara, Yoon Ji Kim, Marianne Rix, Martin Wilkie, Licia Peruzzi, Galeano Cristina, Ortuno Joaquin, Ali Kemal Kadiroglu, Francisco Coronel, Heikki Saha, Alexandros D. Tselepis, Marc G. Vervloet, Nikolaos Kaperonis, Ping Qiu, Romano Felicioli, Francesca Valerio, Stauroula Ziakka, Teruel Jose Luis, Valentina Panetta, Simona Delli Carpini, Jose A. Diaz-Buxo, Ulf Forsberg, Antonios Lagouranis, Edward A. Ross, Valentina Daprà, Hector Perez-Grovas, Stuart M. Sprague, Alessandro Amore, Fouque Denis, Pearl Pai, Saeed M G Al-Ghamdi, Luisa Persichini, Kiran Patro, Jorge Lauxmann, Kazumasa Wakamatsu, Romano Vrabec, Roberto Zubani, B. Srinivas Rao, Emanuel Zitt, Alessandra Grosso, Sang Youb Han, Deniz Ayli, Ali Riza Odabas, Kenjiro Kikuchi, Martha Franco-Guevara, Zweiacker Carole, Caldes Silvia, Fatih Dede, Hyun Sook Chi, Xiangmei Chen, Per Jonsson, Jing Xiang, Donatella Spotti, Claudio Mannari, Michele Messa, Fabio Malberti, Jochen G. Raimann, Wolfgang Ries, Aldo J. Peixoto, Zoran Vatavuk, Eirini Grapsa, Bayés Beatriu, Xuefeng Sun, Burnier Michel, Calum N. Ross, Fernández Pilar, Magdalena Stojakowska, James F. Winchester, Kyoung Hyoub Moon, Neil Ashman, Hyun Kee Lee, Caecilia Scholz, Luca Giovannini, Carlo Donadio, Francesco Piccolomini, Carolina Ramonda, Yong Wang, Friedrich Schulze, Romero Ramón, Dakshinamurty Kaligotlavenkata, Nunzia Casamassima, Teta Daniel, Miroslav Ryba, Vincenzo Panichi, Marcen Roberto, Dimitra Biblaki, Cristina Toso, Sean Leavey, Franca Giacchino, Diego Marquez, Li Liu, Denis Fouque, Costas Kostopoulos, Charalabos Kostopoulos, Gabriel Papadakis, Paola Della Guardia, Maria Grazia Chiappini, Christoph C. Haufe, Antonio Felicioli, Domenico Montanaro, Jovan Popovic, Ayla Yildiz, Elisa Loiacono, Pablo Ureña, Corrado Camerini, Olgierd Smolenski, Tomoya Hirayama, Veronika Bencova, Stefan H. Jacobson, Gangadhar Taduri, Piotr J Thor, Roberto Martin, Thomas Ammann, Erdal Eskioglu, Miljenka Martinovic, Bonet Josep, Bastian Dehmel, Shosuke Ito, Ratan Jha, Heinz-Juergen Roth, Massimiliano Migliori, Alberto Barrientos, Battista Fabio Viola, Rivera Maite, Valeria Vukelic, Ralf Czerwinski, Rolfdieter Krause, Eleni Tsanatou Exarxou, M. Emin Yilmaz, Benjamin Arthur, Urszula Blaut, Jin Uk Jeong, Paraskevi Tseke, Jae Young Kang, Ljubisa Veljancic, Lukasz Dobrek, Murat Hayri Sipahioglu, Stephen Yongu Lee, Ingrid Os, Ioannis Karabinis, Yunshuang Chen, Apostolos Kokkalis, Pablo Novoa, Eleni Chelioti, Franco Bonello, Jutta Passlick-Deetjen, Veronica Dimuccio, Cesar Montes, Hyang Jin Ryu, Graham Warwick, Alex Toft, Maria Bracale, Leopoldo Pisla, Michalis Theodorakis, Pascal Dabel, Leon Frenken, Stephan Thijssen, Merino Jose Luis, Sabina Leonardi, Naoyuki Hasebe, J. Conesa, Quereda Carlos, Drasko Pavlovic, Roberto Mioni, Qing Xiao, Hyun Ju Jeon, Evagelia Chrisanthopoulou, Naoki Nakagawa, Kum Hyun Han, William F. Finn, Nujen Colak, Sotiris Mikros, Alessandro Armini, Chiara Lanzani, Satoshi Sugiyama, Nikolaos Papagalanis, Giada Bernabini, Cesar Romero, Giovanni Cancarini, Lemonia Velenza, Anja Kruse, Andre Warnke, Zulfikar Yilmaz, Alfonso Mariscal, Michaela Ursu, Patrik Deleaval, Riccardo Cianti, Peter Ahrenholz, Ahmet Dağ, Takayuki Fujino, George Paradelis, Manisha Bangar, Hyungjong Kim, Peter Kotanko, Shekhar Shiradhonkar, José Antonio Herrero, Rosanna Coppo, Soon Bae Kim, Luca Bini, Paola Gaggia, Georgios Tsagallis, Dongho Yang, Paolo Manunta, Belen Barron, and Hun Jeong

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine, Intensive care medicine, business
Published
2009

512. Epidemiology and outcome - 1

Author

Bradford Strijack, Manish M. Sood, Mohamed Zaki, Yoshihide Fujigaki, Alfonso M. Cueto-Manzano, K.S. Nayak, Jacques Bildet, Raymond D. Pratt, Tee Chau Keng, Yukitoshi Sakao, Akira Hishida, Anna Casula, Francesco Rossa, Yoshitaka Isaka, Pilar Martinez, Carla Estremadoyro, Maryam Sharifian, Ruth Da Silva, Kenichiro Iio, Miriam Alvo, Yvonne Jeanes, Stephanie Stringer, Julie Mojica, B. Roszkowiak, Giada Bernabini, Svjetlana Čala, D. Drobnik, Graham Warwick, Mariusz Kusztal, Margarita Velkova, Tilman B. Drüeke, Beatriz Leimman, Victor Andreucci, A. Kaczmarek, Raffaele Caprioli, Yoko Kato, Enzo Corghi, Akihiko Kato, Li Ping Tan, Valery Pilotovich, Joelle Cridlig, Chew Ming Wong, Marcelo Bastos, Rasha Elfar, Pavlina Dzekova-Vidimliski, F. Mallamaci, Leticia Elgueta, Alicia Fernandez, Alireza Shekariyan, Marco Pignocco, Sepideh Amirifard, Giuseppe Bueti, Gilbert Deray, Marian Klinger, Fergus Caskey, Adriano Casela, V. Leki, Rachel Bregman, Jalal Etemadi, Tomoaki Fujioka, Hiraku Kadoguchi, Suma Prakash, S. Cutrupi, Juan Antonio Quiroga, Carole Loos-Ayav, Emilio Glez Parra, Leigh Gibson, María Eugenia Sanhueza, Yip Boon Chong, A. Grzegorzewska, Juan J. Cruz, Yoko Takeda, Lennize Pereira Paulo, Mohammadreza Ardalan, Antonio R. Vilches, Gustavo Laham, Nicole Larroumet, Yosuke Fujishima, J. Wojciechowski, Silvio Bertoli, Minako Wakasugi, Antonio Nicolucci, Corinne Isnard Bagnis, Dina Khawnekar, Toshiyuki Onoda, N. P. Singh, Arben Asani, G. Nisiewicz, Kazuyoshi Itai, Mohammad Moujerloo, Ugo Teatini, Carlos H. Díaz, Jose Maria Alcazar de la Osa, Masaaki Inaba, Motoko Tanaka, Yasuyuki Nagasawa, Luc Frimat, Peter Rutherford, Toshiyuki Ojima, R. Kohli, Katarzyna Babska, Luca E. Bernardi, Vili Amitov, Mehdi Tazhibi, Susan Crail, Mirfarhad Ghalehbandi, Sabrina Valle, Afsoon Emami Naeini, Ammar Tabikh, Louise Moist, Ahmed Belal, Giuliano Barsotti, Jorgen Hegbrant, Ryohei Yamamoto, Laura Cortés-Sanabria, Claudio Pozzi, Michał Nowicki, Giulietta Sbragia, Si Yen Tan, Sakumi Kazama, Hirotsugu Iwatani, Mohan Sathyanarayanan, Ajmal Younis, Hanna Augustyniak Bartosik, J. Molenda, Jamshid Roozbeh, Mario Espinosa, Rakesh S. Patel, Manuel Arias, Palepu B Gopal, Vicente Carreño, Paul Komenda, Michio Umezu, Silvia Furiani, Sanaz Shabani, Stefano De Pietro, Hristo Shivarov, Pinggao Zhang, Leticia Krauss, J. Zachwieja, J. Sobolewski, Valeria Maria Saglimbene, Masaki Ohsawa, Umezurike Okafor, Delfina Costa, Matthew Howse, Daniele Hue, Fumio Endo, Tomasz Gołębiowski, Saghafi Sharareh, Gérard M. London, J. Waszczuk, Dolores Arenas, Aurelio Limido, Mariacristina Vecchio, Rubén Torres, Catherine Tourette Turgis, D. Firlej, Ahmad Gahanizadeh, Mohammadali Mohajel Shoja, Gulsen Selim, Wacław Weyde, Enyu Imai, Asheesh Sharma, Ines Held, Suzanne Stewart, Vincenzo Panichi, C. Marino, Jean-Louis Bouchet, Manish Gautam, Anteo Di Napoli, Paul Lawton, Héctor R. Martínez-Ramírez, Saso Gelev, D. Frankiewicz, Marco Pozzi, A Casolaro, Senji Okuno, Marcin Tkaczyk, Yoshiyuki Furumatsu, Yoshiki Nishizawa, Rodolfo Rodriguez, Aleksandar Sikole, Udaya Udayaraj, Hubert Roth, Eiji Ishimura, Angel L.M. de Francisco, Maud Grimault, Nicolas Peters, Sankar D. Navaneethan, Sara Llorente, Sabrina Paoletti, Juan Gracia-Valdecasas, Keiji Kono, M. Postorino, Eloy Fernandez, Carlo Donadio, Michèle Kessler, Cristina Consani, Gianna D'Adamo, Domenico Di Lallo, Kimitoshi Nakamura, Antonella Costantino, Senussi Elbeshti, Ankur Gupta, F. Mattace-Raso, Serena Chicca, Wai Yew Kong, Takaya Abe, Kiyomi Sakata, Peter C. Austin, Sayed Hossein Hejazi, Brunella Andreini, Anindita Chowdhury, Martine Giraud, Dan Roberts, Investigators, Jyoti Baharani, Shunsuke Goto, Claudio Rigatto, Magdalena Krajewska, W. Ratajewski, Vincenzo De Cristofaro, David Ansell, Ewa Trafidlo, Kozo Tanno, Masafumi Fukagawa, Marinella Ruospo, Hiromi Rakugi, Aurelie Untas, Laeticia Idier, Fumi Horiguchi, Paul Roderick, Blanca Casale, A. Swiderski, Ali Hashemi, George Hranov, Mayoor V. Prabhu, Lisa A. Rocca Rey, Javier Bartolome, C. Zoccali, Lucile Mercadal, Akira Okayama, Yoshifumi Maeno, Giovanni F.M. Strippoli, Tatsuya Shoji, Pedro Sfeir, Vinay Kumar Saini, Ana María Cusumano, Ruben Ayala, Ichiei Narita, Nikola Stojcev, Alejandro Pacheco, Philippe Chauveau, Patrizio Pezzotti, Jose Carlos Diaz Bailon, Hideki Fujii, Carmen Sanchez, Patrik Finne, Deven Juneja, Atif Mohiuddin, Halima Resić, L. Niepolski, Guillermina Barril, Ewerton Roberto, Su Hooi Teo, Dulce Lessi, M. Kicki, Alberto Lippi, Charles R.V. Tomson, Boris Bikbov, Enisa Mesic, J. Witteman, Ryuichiro Konda, Shahrzad Shahidi, Tetsuari Onishi, Graeme L. Close, E Mantuano, Denis Fouque, Cosimo Spinelli, Rosamund Wilson, Innocent Ekwem, G. Tripepi, Diego Brancaccio, Osama El-Minshawy, Natalia Tomilina, Yoav Ben-Shlomo, Hirotaka Komaba, Tomoyuki Fujikura, Osamu Uchikoga, Mehdi Azami, Gervasio Soler Pujol, Karen Kato, Keevin Bernstein, Luca Neri, Lada Trajceska, Giuseppe Pontoriero, Khairi Ayad, Yumi Ito, Nuria Garcia Fernandez, Junichiro James Kazama, Galina Severova-Andreevska, Mario Davalos, P. Pizzini, Virginia Aielli, Soo Kun Lim, Sara Beati, Sreepada Subhramanyam, Inmaculada Castillo, Valentina Marchetti, Boriana Delijska, Ann M. O’Hare, and Carola Grönhagen-Riska

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Epidemiology, medicine, Intensive care medicine, business, Outcome (game theory)
Published
2009

513. How Is Body Mass Index Protective in Maintenance Dialysis?

Author

Denis Fouque and Denise Mafra

Subjects
medicine.medical_specialty, Nutrition and Dietetics, business.industry, Urology, Medicine (miscellaneous), Body Mass Index, Renal Dialysis, Risk Factors, Nephrology, Body Composition, medicine, Humans, Kidney Failure, Chronic, Obesity, Dialysis (biochemistry), business, Body mass index
Published
2008

514. Good Evidence Evaluation for Good Risk Assessment

Author

Sophie, Ignace, Nicolas, Girerd, and Denis, Fouque

Subjects
Ontario, Cardiac Catheterization, Actuarial science, business.industry, Myocardial Infarction, Coronary Angiography, Text mining, Good evidence, Internal Medicine, Humans, Medicine, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Crystallization, business, Risk assessment, Aged, Embolism, Cholesterol, Randomized Controlled Trials as Topic
Published
2007

516. Reply to A Sandek et al

Author

Stefan D. Anker, Denis Fouque, and Kamyar Kalantar-Zadeh

Subjects
Nutrition and Dietetics, business.industry, Medicine (miscellaneous), Medicine, business
Published
2006

517. Guest Editorial

Author

Alejandro Trevinho, Denis Fouque, and Maria Chan

Subjects
Nutrition and Dietetics, Nephrology, business.industry, Medicine (miscellaneous), Medicine, Library science, business
Published
2005

518. Guest editorial

Author

Denis Fouque, Gianfranco Guarnieri, George Kaysen, and Jordi Goldstein-Fuchs

Subjects
Nutrition and Dietetics, Nephrology, Medicine (miscellaneous)
Published
2005

519. Phosphate intake and the CARE study

Author

Denis Fouque

Subjects
business.industry, Acetates, Calcium Compounds, Phosphate, Diet, Phosphates, chemistry.chemical_compound, chemistry, Renal Dialysis, Nephrology, Polyamines, Humans, Medicine, Food science, business
Published
2004

520. Why is the diet intervention so critical during chronic kidney disease?

Author

denis fouque

Subjects
Nephrology, medicine.medical_specialty, Nutrition and Dietetics, business.industry, MEDLINE, Potassium, Dietary, Medicine (miscellaneous), medicine.disease, Kidney Transplantation, Renal Dialysis, Intervention (counseling), Internal medicine, medicine, Humans, Kidney Failure, Chronic, Phosphorus, Dietary, Dietary Proteins, Energy Intake, business, Kidney transplantation, Kidney disease
Published
2003

521. A 'new' Journal of Renal Nutrition

Author

Jordi Goldstein-Fuchs and Denis Fouque

Subjects
medicine.medical_specialty, Nutrition and Dietetics, Nephrology, business.industry, medicine, Medicine (miscellaneous), Intensive care medicine, business
Published
2003

522. Chronic renal disease

Author

Denis Fouque and Maurice Laville

Subjects
Nephrology, medicine.medical_specialty, business.industry, medicine.medical_treatment, Psychological intervention, Renal function, General Medicine, Disease, Low-protein diet, Internal medicine, Intervention (counseling), medicine, medicine.symptom, Intensive care medicine, business, Wasting, Dialysis
Abstract

Sir—We disagree with Ruggenenti and colleagues’ (May 19, p 1601) interpretation of nutritional control of renal insufficiency. A systematic review has provided evidence-based data supporting the effectiveness of reduced protein intake in delaying end-stage renal disease. Ruggenenti and colleagues do not discuss those data. Although the impact of reduced protein intake is probably less than researchers have expected from experimental research in the past 20 years, it is still a powerful and valuable way to delay the start of maintenance dialysis, whether because of metabolic improvement or sparing of renal function. The number of patients who need to be treated (NNT) by a low protein diet to spare one chronic dialysis treatment ranges from two to 17 for a 3-year treatment duration, and favourably compares with large primary or secondary mortality prevention studies, in which NNT ranges from 30 to 111. The limiting of protein intake thus should be proposed to patients in combination with other nephroprotective interventions, such as optimum blood-pressure control and treatment with inhibitors of angiotensin-converting enzyme (ACE). The addition of nutritional intervention to ACE inhibitors is estimated to double their beneficial effect. Finally, although we see daily the beneficial effects of ACE inhibitors in renal patients, not all can tolerate these medications and alternatives need to be offered to intolerant patients, even if they are less efficient. Thus, improvement of patients’ follow-up during renal diseases seems the main goal, and the dietary survey has never been so justified as today. Nutritional control of chronic diseases can be a difficult task for both patients and physicians. Dieticians might be of greatest help to patients who would be under dietary control for years if their renal function worsened to end-stage renal insufficiency. We have shown that a mean of three to four dietary interviews allows adequate training of renal patients in answering food questionnaires, and thus permits monitoring of protein intake and identification of spontaneous lowenergy intake. The long-term benefit of such dietary survey is widely recognised, and can prevent severe wasting status seen in patients who ignore their renal disease and acutely enter maintenance dialysis treatment. Provision of a negative message on protein control during chronic renal insufficiency might further prevent patients from important counselling and survey; already in many countries, some renal patients have no access to dietary programmes.

Published
2001

523. Introduction

Author

William F. Keane, William E. Mitch, and Denis Fouque

Subjects
Nephrology
Published
2001

524. Meta-analysis: Dietary protein restriction delays progression in renal disease

Author

Denis Fouque

Subjects
business.industry, Meta-analysis, Medicine, Protein restriction, General Medicine, Disease, Bioinformatics, business
Abstract

Source Citation Pedrini MT, Levey AS, Lau J, Chalmers TC, Wang PH. The effect of dietary protein restriction on the progression of diabetic and nondiabetic renal diseases: a meta-analysis. Ann Inte...

Published
1996

526. Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function.

Author

Fitsum Guebre-Egziabher, Jacques Bernhard, Tohru Funahashi, Aoumeur Hadj-Aissa, and Denis Fouque

Subjects
KIDNEY diseases, HYPOGLYCEMIC agents, CHRONIC kidney failure, DIALYSIS (Chemistry)
Abstract

Background. Adiponectin, a newly discovered collagen-like protein of the collectin family exclusively produced by adipocytes, possesses anti-inflammatory properties. Plasma adiponectin is associated with a decreased cardiovascular risk in non-renal patients, and is reduced in obesity and insulin-resistant states. Although reports show an increase in the adiponectin level in maintenance haemodialysis, peritoneal dialysis and end-stage renal disease, there is no documentation of adiponectin levels and regulation in the early stages of chronic kidney disease (CKD).Methods. We prospectively measured glomerular filtration rate (GFR) in 48 patients with CKD using inulin clearance. Fasting blood was drawn to determine insulin, leptin, adiponectin and C-reactive protein (CRP) levels. Body fat mass was calculated using skinfold thickness measurements.Results. The patients mean GFR was 53.524.9 (SD) ml/min/1.73?m2. Adiponectin was in the normal range in men (9.82.9?mg/l) and women (16.65.0?mg/l) with CKD, being significantly higher in women than men (P<0.001). Serum leptin was above normal (10.410.7?g/l), whereas serum insulin and CRP were within their normal ranges (3.53.3?U/ml and 2.65.0?mg/l, respectively). In linear regression analysis, adiponectin was negatively correlated with GFR (P = 0.02), fat mass (P = 0.03) and body mass index (P = 0.002), and strongly positively correlated with serum leptin (P = 0.003). A positive relationship was also found between plasma adiponectin and the urinary albumin/creatinine ratio (P = 0.007). No relationship was found between adiponectin and insulin or adiponectin and CRP. In multiple regression analysis, adiponectin was significantly positively correlated with leptin (P<0.0001), negatively with body mass index (P<0.0001) and only weakly with GFR (P = 0.04).Conclusions. Despite an adverse metabolic environment in chronic renal insufficiency, serum adiponectin increases in non-obese patients when renal function deteriorates. Adiponectin is only weakly affected by renal function per se, but appears influenced by proteinuria, and more significantly by body mass index and the change in serum leptin that accompanies decline in renal function. [ABSTRACT FROM AUTHOR]

Published
2005
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527. Low protein diets in chronic renal insufficiency: Authors' reply

Author

P Zech, R. Chifflet, J. P. Boissel, M. Labeeuw, Denis Fouque, and Maurice Laville

Subjects
medicine.medical_specialty, Low protein, business.industry, Internal medicine, General Engineering, medicine, General Earth and Planetary Sciences, Chronic renal insufficiency, Letters, General Medicine, business, Gastroenterology, General Environmental Science
Published
1992

528. Handgrip strength and its dialysis determinants in hemodialysis patients

Author

Najla E. Farage, Luciana Nicolau Aranha, Milena B. Stockler-Pinto, Viviane O. Leal, Denise Mafra, Denis Fouque, and Luiz Antonio dos Anjos

Subjects
Adult, Male, medicine.medical_specialty, Cross-sectional study, medicine.medical_treatment, Endocrinology, Diabetes and Metabolism, Urology, Diastole, Nutritional Status, Blood Pressure, Weight Gain, Body Mass Index, Renal Dialysis, Hand strength, Internal medicine, medicine, Humans, Urea, Muscle strength dynamometer, Dialysis, Aged, Nutrition and Dietetics, business.industry, Middle Aged, Hand, Nutritional assessment, Blood pressure, Endocrinology, Cross-Sectional Studies, Nutrition Assessment, Hemodialysis, Female, medicine.symptom, business, Weight gain, Body mass index
Abstract

OBJECTIVE: To evaluate muscle function (MF) of patients on hemodialysis (HD) and to investigate the dialysis determinants of maximal voluntary handgrip strength (HGS). METHODS: Forty-three patients on HD (25 men, six diabetics, 54.5 ± 12.2 y of age, 62.2 ± 51.4 mo on dialysis) were studied. HGS was measured three times with a mechanical dynamometer (Jamar) before and after HD sessions on the non-fistula side and the highest value was used for analysis. HGS values lower than the 10th percentile of an age-, gender-, and region-specific reference were considered MF loss. Biochemical and dialysis variables (ultrafiltration, interdialytic body weight gain, urea clearance, urea before and after HD, systolic and diastolic blood pressures before and after HD, and difference in systolic and diastolic blood pressures) were also examined. RESULTS: The HGS values before and after HD values were significantly higher in men but were not statistically different before and after the HD sessions (29.8 ± 10.3 and 30.2 ± 9.9 kg for men, 14.1 ± 7.0 and 14.5 ± 6.3 kg for women). MF loss was observed in 24 patients (55.8%), 12 women and 12 men. Dialysis variables were not different between patients with and without MF loss and did not correlate with HGS measured before or after an HD session. CONCLUSIONS: Patients using HD presented a high prevalence of MF loss as assessed by HGS, and it was not influenced by dialysis variables. HGS may be used as a reliable nutritional marker in HD, measured before or after HD sessions.

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529. Synbiotic supplementation promotes improvement of chronic diarrhea of unknown etiology in patient with chronic kidney disease and provides better outcomes in dialysis

Author

Natália A. Borges, Denise Mafra, Dennis de Carvalho Ferreira, Denis Fouque, Najla E. Farage, and Amanda F. Barros

Subjects
Diarrhea, Male, medicine.medical_specialty, medicine.medical_treatment, 030232 urology & nephrology, Medicine (miscellaneous), Synbiotics, Simbióticos, 03 medical and health sciences, 0302 clinical medicine, Chronic diarrhea, Renal Dialysis, medicine, Humans, In patient, Enfermedad renal crónica, lcsh:RC620-627, Dialysis, Aged, Gynecology, Nutrition and Dietetics, Hemodiálisis, business.industry, Microbiota, medicine.disease, Surgery, lcsh:Nutritional diseases. Deficiency diseases, Treatment Outcome, Chronic Disease, Etiology, Kidney Failure, Chronic, 030211 gastroenterology & hepatology, business, Diarrea, Kidney disease
Abstract

Introducción: los pacientes con enfermedad renal crónica (ERC) a menudo tienen síntomas gastrointestinales que pueden provocar desnutrición y un impacto negativo en su calidad de vida. La modulación de la microbiota intestinal puede ser una estrategia para promover la salud del huésped y la homeostasis.Caso clínico: los autores presentan un caso de diarrea crónica de etiología desconocida en un paciente en hemodiálisis (HD). Después de varias intervenciones fallidas durante un año, se realizó el tratamiento simbiótico. Los episodios de diarrea cesaron después de tres meses de la suplementación diaria y ambos parámetros bioquímicos y nutricionales mejoraron. La terapia con simbióticos promovió beneficios clínicos para este paciente.Discusión: por lo tanto, esta sencilla terapia puede ser una alternativa prometedora en la ERC y debe ser probada en estudios más amplios.

530. Nutritional requirements in maintenance hemodialysis

Author

Denis Fouque

Subjects
medicine.medical_specialty, Parenteral Nutrition, medicine.medical_treatment, Energy metabolism, Nutritional Status, Anorexia, Enteral administration, Renal Dialysis, medicine, Humans, Intensive care medicine, Dialysis, business.industry, Nutritional Requirements, Nutritional status, Maintenance hemodialysis, Vitamins, Trace Elements, Calcium, Dietary, Parenteral nutrition, Nephrology, Dietary Supplements, Phosphorus, Dietary, medicine.symptom, business, Energy Metabolism
Abstract

There is a high prevalence of nutritional disorders in maintenance hemodialysis patients. This fact has been recently confirmed because larger routine assessments of MHD patients body composition are now performed. Food records and dietary interviews show spontaneous low intakes of protein and energy in many patients. An increasing dialysis dose above a Kt/V (single pool) of 1.5 may not improve patients nutritional intakes. Inflammation may further impair the balance between protein synthesis and catabolism and cause anorexia. In response to these abnormalities, the management of energy, protein, vitamins, and trace elements intake will be discussed with special emphasis on calcium, phosphorus, enteral support, and parenteral nutrition.

532. inflammation increases the resting energy expenditure in hemodialysis patients

Author

Viviane O. Leal, Najla E. Farage, Julie Calixto Lobo, Milena B. Stockler-Pinto, Denis Fouque, and Denise Mafra

Subjects
lcsh:Internal medicine, medicine.medical_specialty, Urea clearance, lcsh:Specialties of internal medicine, business.industry, Urology, medicine.medical_treatment, Inflammation, medicine.disease, Gastroenterology, Endocrinology, Energy expenditure, lcsh:RC581-951, Nephrology, Diabetes mellitus, Internal medicine, medicine, Resting energy expenditure, Hemodialysis, medicine.symptom, Specific dynamic action, lcsh:RC31-1245, business, Dialysis
Abstract

Resting energy expenditure (REE) is the predominant component of total daily energy expenditure (TEE). Metabolic disorders and comorbities, such as inflammation and diabetes, can affect the REE in hemodialysis (HD) patients. The objective of this study was to evaluate the relationship between inflammation and REE estimated by TEE in HD patients. Twenty-five HD patients (54.5±11.7 years, 15 men, BMI, 24.4±4.7 kg/m 2 , urea clearance (Kt/V sp ) of 1.43±0.26 and 58.2±42.7 months on HD) were studied. TEE was measured during two days (one dialysis and one Download full-size image nondialysis day) by SWA (SenseWear Pro2 Armband, BodyMedia Inc, Pittsburgh, PA, USA). This monitor provides directly the TEE and the physical active energy expenditure (PAEE); the REE measurement was obtained by the subtraction of PAEE and thermic effect of food (approximately 10% of TEE) from TEE. C-reactive protein (CRP) was measured by immunoturbidimetric method. The REE was 1677.7±273.5 kcal/d for men and 1267.0±221.6 kcal/d for women (p〈0.0001). The CRP levels values were 0.27 ± 0.26 mg/dL and nine patients (36%) had CRP 〉0.3 mg/dL, compatible with chronic inflammation. A trend for high REE was observed in patients with inflammation (1865±216 kcal/d for men with CRP≥0.3 mg/dL and 1584±257kcal/d with CRP〈0.3 mg/dL (p= 0.05); 1361.4±181.5 kcal/d for women with CRP≥0.3 mg/dL and 1204.1±238.2kcal/d with CRP〈0.3 mg/dL (p = 0.27). CRP was positively correlated with REE (r=0.41; p=0.04). In conclusion, chronic mild inflammation can increase the REE in HD patients.

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533. Role of lipotoxicity in insulin resistance in subtotally nephrectomized mouse model

Author

Caroline C. Pelletier, Laetitia Koppe, Christophe O. Soulage, Roxane E. Vella, Fitsum Guebre-Egziahber, and Denis Fouque

Subjects
lcsh:Internal medicine, medicine.medical_specialty, lcsh:Specialties of internal medicine, medicine.diagnostic_test, business.industry, Cholesterol, Urology, Insulin, medicine.medical_treatment, medicine.disease, chemistry.chemical_compound, Endocrinology, Insulin resistance, Western blot, Lipotoxicity, chemistry, lcsh:RC581-951, Nephrology, Internal medicine, medicine, lcsh:RC31-1245, business, Protein kinase B, Dyslipidemia, Kidney disease
Abstract

Chronic kidney disease (CKD) is associated with a large range of metabolic alterations among which insulin resistance and dyslipidemia. We hypothesize that a phenomenon of lipotoxicity and ectopic fat redistribution could be responsible for the insulin-resistance associated to CKD. C57BL/6 mice underwent a 5/6 nephrectomy and were compared to pair fed sham-operated mice. Insulin sensitivity was estimated through intra-peritoneal insulin (ipITT) and glucose tolerance (ipGTT) tests. Anthropometric (body weight, lean and fad pad mass) and metabolic parameters (glycemia, insulin, cholesterol, triglycerides) were measured. The phosphorylation of a key protein of insulin signaling pathway (protein kinase B, PKB/Akt) was studied by Western blot. The intra-muscular and intra-hepatic lipids were extracted using Chloroform-Methanol (2:1, v/v). The CKD mice exhibited a marked decrease in insulin sensitivity (−76%, p

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534. Preserved residual renal function is associated with lower oxidative stress in peritoneal dialysis patients.

Author

Sophie Ignace, Denis Fouque, Walid Arkouche, Jean-Paul Steghens, and Fitsum Guebre-Egziabher

Subjects
*KIDNEY function tests, *OXIDATIVE stress, *PERITONEAL dialysis, *MULTIVARIATE analysis, *INFLAMMATION, *STATISTICAL correlation, *PATIENTS
Abstract

Background. Residual renal function (RRF) correlates with survival in peritoneal dialysis (PD). We investigated the association between oxidative stress and RRF in PD. Methods. Adequacy of dialysis, total and free malondialdehydes (MDA), and lipid hydroperoxides (LHP) were obtained from 23 stable PD patients. Results. Free MDA level decreased with total weekly Kt/ V urea (r = −0.51, P = 0.013) and urinary Kt/V (KRU) (r = −0.53, P = 0.009), but not with peritoneal Kt/V. Similar results were found with LHP level. In multivariate analysis, total weekly Kt/V urea and KRU remained associated with free MDA and LHP, independently of gender, nutritional or inflammatory status, and peritoneal permeability. Conclusion. A preserved RRF is associated with lower serum levels of lipid peroxidation products among PD patients. [ABSTRACT FROM AUTHOR]

Published
2009
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535. Use of a renal-specific oral supplement by haemodialysis patients with low protein intake does not increase the need for phosphate binders and may prevent a decline in nutritional status and quality of life.

Author

Denis Fouque, Jane McKenzie, Renée de Mutsert, Raymond Azar, Daniel Teta, Mathias Plauth, Noel Cano, and the Renilon Multicentre Trial Study Group

Subjects
*HEMODIALYSIS patients, *BLOOD plasma, *C-reactive protein, *BLOOD filtration
Abstract

Background. Protein-energy wasting is a frequent and debilitating condition in maintenance dialysis. We randomly tested if an energy-dense, phosphate-restricted, renal-specific oral supplement could maintain adequate nutritional intake and prevent malnutrition in maintenance haemodialysis patients with insufficient intake. Methods. Eighty-six patients were assigned to a standard care (CTRL) group or were prescribed two 125-ml packs of Renilon 7.5® daily for 3 months (SUPP). Dietary intake, serum (S) albumin, prealbumin, protein nitrogen appearance (nPNA), C-reactive protein, subjective global assessment (SGA) and quality of life (QOL) were recorded at baseline and after 3 months. Results. While intention to treat analysis (ITT) did not reveal strong statistically significant changes in dietary intake between groups, per protocol (PP) analysis showed that the SUPP group increased protein (P < 0.01) and energy (P < 0.01) intakes. In contrast, protein and energy intakes further deteriorated in the CTRL group (PP). Although there was no difference in serum albumin and prealbumin changes between groups, in the total population serum albumin and prealbumin changes were positively associated with the increment in protein intake (r = 0.29, P = 0.01 and r = 0.27, P = 0.02, respectively). The SUPP group did not increase phosphate intake, phosphataemia remained unaffected, and the use of phosphate binders remained stable or decreased. The SUPP group exhibited improved SGA and QOL (P < 0.05). Conclusion. This study shows that providing maintenance haemodialysis patients with insufficient intake with a renal-specific oral supplement may prevent deterioration in nutritional indices and QOL without increasing the need for phosphate binders. [ABSTRACT FROM AUTHOR]

Published
2008

537. EBPG Guideline on Nutrition.

Author

Denis Fouque, Marianne Vennegoor, Piet Ter Wee, Christoph Wanner, Ali Basci, Bernard Canaud, Patrick Haage, Klaus Konner, Jeroen Kooman, Alejandro Martin-Malo, Lucianu Pedrini, Francesco Pizzarelli, James Tattersall, Jan Tordoir, and Raymond Vanholder

Published
2007
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538. EBPG guideline on dialysis strategies.

Author

James Tattersall, Alejandro Martin-Malo, Luciano Pedrini, Ali Basci, Bernard Canaud, Denis Fouque, Patrick Haage, Klaus Konner, Jeroen Kooman, Francesco Pizzarelli, Jan Tordoir, Marianne Vennegoor, Christoph Wanner, Piet ter Wee, and Raymond Vanholder

Published
2007
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539. EBPG on Vascular Access.

Author

Jan Tordoir, Bernard Canaud, Patrick Haage, Klaus Konner, Ali Basci, Denis Fouque, Jeroen Kooman, Alejandro Martin-Malo, Luciano Pedrini, Francesco Pizzarelli, James Tattersall, Marianne Vennegoor, Christoph Wanner, Piet ter Wee, and Raymond Vanholder

Published
2007
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540. EBPG guideline on haemodynamic instability.

Author

Jeroen Kooman, Ali Basci, Francesco Pizzarelli, Bernard Canaud, Patrick Haage, Denis Fouque, Klaus Konner, Alejandro Martin-Malo, Luciano Pedrini, James Tattersall, Jan Tordoir, Marianne Vennegoor, Christoph Wanner, Piet ter Wee, and Raymond Vanholder

Published
2007
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542. Cognitive disorders in patients with chronic kidney disease: specificities of clinical assessment

Author

Michelangela Barbieri, Aleksandra Klimkowicz-Mrowiec, Goce Spasovski, Liliana Garneata, Sophie Liabeuf, Carmen Antonia Mocanu, Carmine Zoccali, Sol Carriazo, Olivier Godefroy, Konstantinos Giannakou, Mustafa Arici, Andrzej Wiecek, Evgueniy Vazelov, Tomasz Grodzicki, Marion Pépin, Ziad A. Massy, Giuseppe Paolisso, Pilar Delgado, Davide Viggiano, Maie Bachman, Justina Kurganaite, Ana Carina Ferreira, Inga Arune Bumblyte, Hôpital Ambroise Paré [AP-HP], Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hospital Curry Cabral [Lisbon, Portugal], Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Hacettepe University = Hacettepe Üniversitesi, Tallinn University of Technology (TTÜ), University of the Study of Campania Luigi Vanvitelli, Lithuanian University of health Sciences [Kaunas], Fundacion Jimenez Diaz [Madrid] (FJD), Universitat Autònoma de Barcelona (UAB), University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), European University of Cyprus, Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Medical University of Sofia [Bulgarie], Medical University of Silesia (SUM), CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target): Giovambattista Capasso, Alexandre Andrade, Maie Bachmann, Inga Bumblyte, Adrian Constantin Covic, Pilar Delgado, Nicole Endlich, Andreas Engvig, Denis Fouque, Casper Franssen, Sebastian Frische, Liliana Garneata, Loreto Gesualdo, Konstantinos Giannakou, Dimitrios Goumenos, Ayşe Tuğba Kartal, Laila-Yasmin Mani, Hans-Peter Marti, Christopher Mayer, Rikke Nielsen, Vesna Pešić, Merita Rroji, Giorgos Sakkas, Goce Spasovski, Kate I Stevens, Evgueniy Vazelov, Davide Viggiano, Lefteris Zacharia, Ana Carina Ferreira, Jolanta Malyszko, Ewout Hoorn, Andreja Figurek, Robert Unwin, Carsten Wagner, Christoph Wanner, Annette Bruchfeld, Marion Pepin, Andrzej Wiecek, Dorothea Nitsch, Ivo Fridolin, Gaye Hafez, Maria José Soler Romeo, Michelangela Barbieri, Bojan Batinić, Laura Carrasco, Sol Carriazo, Ron Gansevoort, Gianvito Martino, Francesco Mattace Raso, Ionut Nistor, Alberto Ortiz, Giuseppe Paolisso, Daiva Rastenytė, Gabriel Stefan, Gioacchino Tedeschi, Ziad Massy, Boris Bikbov, Karl Hans Endlich, Olivier Godefroy, Jean-Marc Chillon, Anastassia Kossioni, Justina Kurganaite, Norberto Perico, Giuseppe Remuzzi, Tomasz Grodzicki, Francesco Trepiccione, Carmine Zoccali, Mustafa Arici, Peter Blankestijn, Kai-Uwe Eckardt, Danilo Fliser, Eugenio Gutiérrez Jiménez, Maximilian Konig, Ivan Rychlik, Michela Deleidi, George Reusz, DESSAIVRE, Louise, Internal Medicine, Pepin, M., Ferreira, A. C., Arici, M., Bachman, M., Barbieri, M., Bumblyte, I. A., Carriazo, S., Delgado, P., Garneata, L., Giannakou, K., Godefroy, O., Grodzicki, T., Klimkowicz-Mrowiec, A., Kurganaite, J., Liabeuf, S., Mocanu, C. A., Paolisso, G., Spasovski, G., Vazelov, E. S., Viggiano, D., Zoccali, C., Massy, Z. A., and Wiecek, A.

Subjects
medicine.medical_specialty, Review, urologic and male genital diseases, comprehensive battery, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Pharmacotherapy, medicine, Cognitive decline, Intensive care medicine, Cognitive impairment, AcademicSubjects/MED00340, Kidney transplantation, cognitive impairment, Transplantation, business.industry, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Cognition, cognitive screening test, clinical assessment, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Cognitive test, Nephrology, business, Neurocognitive, chronic kidney disease, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Kidney disease
Abstract

Neurocognitive disorders are frequent among chronic kidney disease (CKD) patients. Identifying and characterizing cognitive impairment (CI) can help to assess the ability of adherence to CKD risk reduction strategy, identify potentially reversible causes of cognitive decline, modify pharmacotherapy, educate the patient and caregiver and provide appropriate patient and caregiver support. Numerous factors are associated with the development and progression of CI in CKD patients and various conditions can influence the results of cognitive assessment in these patients. Here we review clinical warning signs that should lead to cognitive screening; conditions frequent in CKD at risk to interfere with cognitive testing or performance, including specificities of cognitive assessment in dialysis patients or after kidney transplantation; and available tests for screening and observed cognitive patterns in CKD patients., Graphical Abstract Graphical abstract

Published
2022

543. Brain dysfunction in tubular and tubulointerstitial kidney diseases

Author

Viggiano D, Bruchfeld A, Carriazo S, de Donato A, Endlich N, Ferreira AC, Figurek A, Fouque D, Franssen CFM, Giannakou K, Goumenos D, Hoorn EJ, Nitsch D, Arduan AO, Pešić V, Rastenyté D, Soler MJ, Rroji M, Trepiccione F, Unwin RJ, Wagner CA, Wiecek A, Zacchia M, Zoccali C, Capasso G, CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target)., Viggiano, D, Bruchfeld, A, Carriazo, S, de Donato, A, Endlich, N, Ferreira, Ac, Figurek, A, Fouque, D, Franssen, Cfm, Giannakou, K, Goumenos, D, Hoorn, Ej, Nitsch, D, Arduan, Ao, Pešić, V, Rastenyté, D, Soler, Mj, Rroji, M, Trepiccione, F, Unwin, Rj, Wagner, Ca, Wiecek, A, Zacchia, M, Zoccali, C, Capasso, G, CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative, Target)., NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), CarMeN, laboratoire, University of the Study of Campania Luigi Vanvitelli, Karolinska University Hospital [Stockholm], Linköping University (LIU), IIS‑Fundación Jiménez Diaz‑Autonoma University [Madrid, Spain], University of Medicine Greifswald, Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Universität Zürich [Zürich] = University of Zurich (UZH), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hospices Civils de Lyon (HCL), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), University of Groningen [Groningen], European University of Cyprus, General University Hospital of Patras, Erasmus University Medical Center [Rotterdam] (Erasmus MC), London School of Hygiene and Tropical Medicine (LSHTM), University of Belgrade [Belgrade], Lithuanian University of health Sciences [Kaunas], Vall d’Hebron Research Institute (VHIR), University Hospital Center 'Mother Tereza' [Tirana, Albania] (UHCMT), University College of London [London] (UCL), Medical University of Silesia (SUM), Renal Research Institute [New York, NY, USA] (2RI), CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target): Giovambattista Capasso, Alexandre Andrade, Maie Bachmann, Inga Bumblyte, Adrian Constantin Covic, Pilar Delgado, Nicole Endlich, Andreas Engvig, Denis Fouque, Casper Franssen, Sebastian Frische, Liliana Garneata, Loreto Gesualdo, Konstantinos Giannakou, Dimitrios Goumenos, Ayşe Tuğba Kartal, Laila-Yasmin Mani, Hans-Peter Marti, Christopher Mayer, Rikke Nielsen, Vesna Pšić, Merita Rroji Molla, Giorgos Sakkas, Goce Spasovski, Kate I Stevens, Evgueniy Vazelov, Davide Viggiano, Lefteris Zacharia, Ana Carina Ferreira, Jolanta Malyszko, Ewout Hoorn, Andreja Figurek, Robert Unwin, Carsten A Wagner, Christoph Wanner, Annette Bruchfeld, Marion Pépin, Andrzej Wieçek, Dorothea Nitsch, Ivo Fridolin, Gaye Hafez, Maria José Soler, Michelangela Barbieri, Bojan Batinić, Laura Carrasco, Sol Carriazo, Ron Gansevoort, Gianvito Martino, Francesco Mattace Raso, Ionut Nistor, Alberto Ortiz, Giuseppe Paolisso, Daiva Rastenytė, Gabriel Stefan, Gioacchino Tedeschi, Ziad A Massy, Boris Bikbov, Karl Hans Endlich, Olivier Godefroy, Jean-Marc Chillon, Anastassia Kossioni, Justina Kurganaite, Norberto Perico, Giuseppe Remuzzi, Tomasz Grodzicki, Francesco Trepiccione, Carmine Zoccali, Mustafa Arici, Peter Blankestijn, Kai-Uwe Eckardt, Danilo Fliser, Eugenio Gutiérrez Jiménez, Maximilian König, Ivan Rychlik, Michela Deleidi, George Reusz, and Internal Medicine

Subjects
ACIDOSIS, [SDV]Life Sciences [q-bio], Review, Disease, electrolyte, 030204 cardiovascular system & hematology, urologic and male genital diseases, 0302 clinical medicine, Child, 610 Medicine & health, MUTATION, 0303 health sciences, Kidney, Proteinuria, Reabsorption, female genital diseases and pregnancy complications, 3. Good health, [SDV] Life Sciences [q-bio], BARTTER-SYNDROME, medicine.anatomical_structure, Nephrology, Child, Preschool, GITELMANS-SYNDROME, Kidney Diseases, medicine.symptom, Glomerular Filtration Rate, medicine.medical_specialty, brain, chronic kidney disease, cognitive function, tubulointerstitial, Urology, Renal function, 03 medical and health sciences, SDG 3 - Good Health and Well-being, medicine, Humans, Renal Insufficiency, Chronic, AcademicSubjects/MED00340, NEPHRITIS, 030304 developmental biology, Rheumatology and Autoimmunity, Transplantation, Reumatologi och inflammation, HYPONATREMIA, business.industry, urogenital system, AQP2, medicine.disease, Nephrogenic diabetes insipidus, GENE, KLOTHO, MODEL, Nephritis, Interstitial, business, Tubulointerstitial Disease, Kidney disease
Abstract

Funding: This article is published as part of a supplement financially supported by the COST Action CA19127-Cognitive Decline in Nephro-Neurology: European Cooperative Target (CONNECT). Kidney function has two important elements: glomerular filtration and tubular function (secretion and reabsorption). A persistent decrease in glomerular filtration rate (GFR), with or without proteinuria, is diagnostic of chronic kidney disease (CKD). While glomerular injury or disease is a major cause of CKD and usually associated with proteinuria, predominant tubular injury, with or without tubulointerstitial disease, is typically non-proteinuric. CKD has been linked with cognitive impairment, but it is unclear how much this depends on a decreased GFR, altered tubular function or the presence of proteinuria. Since CKD is often accompanied by tubular and interstitial dysfunction, we explore here for the first time the potential role of the tubular and tubulointerstitial compartments in cognitive dysfunction. To help address this issue we selected a group of primary tubular diseases with preserved GFR in which to review the evidence for any association with brain dysfunction. Cognition, mood, neurosensory and motor disturbances are not well characterized in tubular diseases, possibly because they are subclinical and less prominent than other clinical manifestations. The available literature suggests that brain dysfunction in tubular and tubulointerstitial diseases is usually mild and is more often seen in disorders of water handling. Brain dysfunction may occur when severe electrolyte and water disorders in young children persist over a long period of time before the diagnosis is made. We have chosen Bartter and Gitelman syndromes and nephrogenic diabetes insipidus as examples to highlight this topic. We discuss current published findings, some unanswered questions and propose topics for future research. publishersversion published

Published
2022

544. Metabolic effect of omega 3 fatty acids in health and chronic kidney disease

Author

Guebre-Egziabher, Fitsum, Régulations métaboliques, nutrition et diabètes (RMND), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Claude Bernard - Lyon I, Denis Fouque, and STAR, ABES

Subjects
Inflammation, Acides gras polyinsaturés n-3, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Adipokines, Omega-3 polyunsaturated fatty acids, Chronic kidney disease, Maladies rénales chroniques, Adipocytes, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Omega 3 fatty acids play an important modulatory role in metabolic and inflammatory responses, the progression of atherosclerosis and gene expression. Recent studies suggest their beneficial impact on adipocyte morphology and function. Chronic kidney disease (CKD) patients have an increased cardiovascular morbi-mortality and suffer from a cluster of metabolic disorders. On the basis of previous studies there are reasons to suggest that omega 3 supplementation may offer a host of benefits to CKD patients. Unfortunatly, published studies on the effect of such supplementation are characterized by supra physiological omega 3 doses, that may be difficult to implement for extended periods in one hand and in the other hand the metabolic effect of different doses of omega 3 hasn’t been studied in detail. Simple dietary modifications can help achieve the recommended n-6/n-3 ratio in healthy subjects. In CKD patients supplementation with n-3 shows a differential dose response effect. Further studies are required to test the faisability and metabolic impact of dietary modifications in order to decrease n-6/n-3 ratio and to assess the long term effect of omega supplementation in CKD patients. Finally the molecular pathways implicated in this differential dose response should be assessed in animal models, Les omégas trois ont un bénéfice prouvé dans la prévention de maladie cardiovasculaire et l’inflammation. Un apport optimal peut être réalisé avec des modifications diététiques simples permettant d’avoir un enrichissement des membranes cellulaires et un effet métabolique. Le tissu adipeux de part son rôle important dans la genèse du syndrome métabolique semble être une cible importante du traitement par oméga trois. Les patients avec une maladie rénale chronique (MRC) ont un risque cardiovasculaire accru et cumulent les perturbations métaboliques comme le syndrome métabolique et un état micro inflammatoire. Des doses supra physiologiques d’oméga trois ont été utilisés dans le passé dans des études de prévention rénale ou traitement de dyslipidémie. Or l’effet métabolique en fonction de la dose d’oméga 3 n’est pas connu. En accord, avec les études chez le sujet sain, en fonction de la dose administrée, les omégas 3 ont un impact différent métabolique et sur l’expression génique. Des études complémentaires sont nécessaires pour vérifier la faisabilité et l’impact métabolique d’une modification de régime afin de diminuer le rapport n-6/n-3, ainsi que l’effet à long terme des omégas trois chez ces patients. Par ailleurs, les mécanismes impliqués dans les différences de dose réponse devront être caractérisés sur un modèle animal

Published
2010

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