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As medical research becomes ever finer-grained, experiments require healthcare data in quantities that single countries cannot provide. Cross-jurisdictional data collection remains, however, extremely challenging due to the diverging legal, professional, linguistic, normative, and technological contexts of the participating countries. Medical data heterogeneity, in particular, is still a largely unsolved problem on the international level, due to the complexity of data combined with strict precision and data protection constraints. We propose a scalable solution based on a novel knowledge architecture and the corresponding knowledge graph integration methodology. Medical knowledge that drives the scalable integration process is divided into multiple functional layers and is maintained in a distributed manner across participating countries. We successfully applied the approach in the context of a research experiment across Scotland and Italy, and are currently adapting it within other initiatives of Europe-wide health data interoperability.

In many settings, as for example wind farms, multiple machines are instantiated to perform the same task, which is called a fleet. The recent advances with respect to the Internet of Things allow control devices and/or machines to connect through cloud-based architectures in order to share information about their status and environment. Such an infrastructure allows seamless data sharing between fleet members, which could greatly improve the sample-efficiency of reinforcement learning techniques. However in practice, these machines, while almost identical in design, have small discrepancies due to production errors or degradation, preventing control algorithms to simply aggregate and employ all fleet data. We propose a novel reinforcement learning method that learns to transfer knowledge between similar fleet members and creates member-specific dynamical models for control. Our algorithm uses Gaussian processes to establish cross-member covariances. This is significantly different from standard transfer learning methods, as the focus is not on sharing information over tasks, but rather over system specifications. We demonstrate our approach on two benchmarks and a realistic wind farm setting. Our method significantly outperforms two baseline approaches, namely individual learning and joint learning where all samples are aggregated, in terms of the median and variance of the results.

Estimating global pairwise interaction effects, i.e., the difference between the joint effect and the sum of marginal effects of two input features, with uncertainty properly quantified, is centrally important in science applications. We propose a non-parametric probabilistic method for detecting interaction effects of unknown form. First, the relationship between the features and the output is modelled using a Bayesian neural network, capable of representing complex interactions and principled uncertainty. Second, interaction effects and their uncertainty are estimated from the trained model. For the second step, we propose an intuitive global interaction measure: Bayesian Group Expected Hessian (GEH), which aggregates information of local interactions as captured by the Hessian. GEH provides a natural trade-off between type I and type II error and, moreover, comes with theoretical guarantees ensuring that the estimated interaction effects and their uncertainty can be improved by training a more accurate BNN. The method empirically outperforms available non-probabilistic alternatives on simulated and real-world data. Finally, we demonstrate its ability to detect interpretable interactions between higher-level features (at deeper layers of the neural network)., 8 pages