301. Substance Use and Depression Impede ART Adherence Among Female Sex Workers Living with HIV in the Dominican Republic.
- Author
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Wang Y, Karver TS, Berg CJ, Barrington C, Donastorg Y, Perez M, Gomez H, Davis W, Galai N, and Kerrigan D
- Subjects
- Humans, Female, Dominican Republic epidemiology, Depression epidemiology, Medication Adherence, HIV Infections drug therapy, HIV Infections epidemiology, HIV Infections diagnosis, Sex Workers, Alcoholism, Substance-Related Disorders complications, Substance-Related Disorders epidemiology, Illicit Drugs
- Abstract
Female sex workers (FSW) have worse HIV outcomes in part due to lower anti-retroviral therapy (ART) adherence. Substance use and depression are important barriers to ART adherence, yet few studies have assessed these relationships among FSW in longitudinal studies. Cross-Lagged Panel Models and autoregressive mediation analyses assessed substance use (illicit drug use and alcohol use disorders) in relation to ART non-adherence and the mediation role of depressive symptoms among 240 FSW living with HIV in the Dominican Republic. In annual visits (T1, T2, T3), the majority (70%, 66%, and 53%) reported at-risk drinking and 15%, 13% and 9% used illicit drug during the past 6 months. Most FSW (70%, 62% and 46%) had mild-to-severe depression. Illicit drug use predicted later ART non-adherence. This relationship was not mediated via depressive symptoms. Integrated substance use and HIV care interventions are needed to promote ART adherence and viral suppression among FSW., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2023
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