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553. Multidisciplinary Treatment of Hepatocellular Carcinoma in 2023: Italian practice Treatment Guidelines of the Italian Association for the Study of the Liver (AISF), Italian Association of Medical Oncology (AIOM), Italian Association of Hepato-Bilio-Pancreatic Surgery (AICEP), Italian Association of Hospital Gastroenterologists (AIGO), Italian Association of Radiology and Clinical Oncology (AIRO), Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP), Italian Society of Surgery (SIC), Italian Society of Gastroenterology (SIGE), Italian Society of Medical and Interventional Radiology (SIRM), Italian Organ Transplant Society (SITO), and Association of Patients with Hepatitis and Liver Disease (EpaC) – Part I – Surgical treatments

Author

Cabibbo, Giuseppe, primary, Daniele, Bruno, additional, Borzio, Mauro, additional, Casadei-Gardini, Andrea, additional, Cillo, Umberto, additional, Colli, Agostino, additional, Conforti, Massimiliano, additional, Dadduzio, Vincenzo, additional, Dionisi, Francesco, additional, Farinati, Fabio, additional, Gardini, Ivan, additional, Giannini, Edoardo Giovanni, additional, Golfieri, Rita, additional, Guido, Maria, additional, Mega, Andrea, additional, Minozzi, Silvia, additional, Piscaglia, Fabio, additional, Rimassa, Lorenza, additional, Romanini, Laura, additional, Pecorelli, Anna, additional, Sacco, Rodolfo, additional, Scorsetti, Marta, additional, Viganò, Luca, additional, Vitale, Alessandro, additional, and Trevisani, Franco, additional

Published
2023
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554. Atezolizumab plus bevacizumab versus active surveillance in patients with resected or ablated high-risk hepatocellular carcinoma (IMbrave050): a randomised, open-label, multicentre, phase 3 trial

Author

Qin, Shukui, primary, Chen, Minshan, additional, Cheng, Ann-Lii, additional, Kaseb, Ahmed O, additional, Kudo, Masatoshi, additional, Lee, Han Chu, additional, Yopp, Adam C, additional, Zhou, Jian, additional, Wang, Lu, additional, Wen, Xiaoyu, additional, Heo, Jeong, additional, Tak, Won Young, additional, Nakamura, Shinichiro, additional, Numata, Kazushi, additional, Uguen, Thomas, additional, Hsiehchen, David, additional, Cha, Edward, additional, Hack, Stephen P, additional, Lian, Qinshu, additional, Ma, Ning, additional, Spahn, Jessica H, additional, Wang, Yulei, additional, Wu, Chun, additional, Chow, Pierce K H, additional, Thompson, Alexander, additional, Danta, Mark, additional, Poursoltan, Pirooz, additional, Kiberu, Andrew, additional, Chittajallu, Renuka, additional, Sood, Siddarth, additional, Stauber, Rudolf, additional, Pinter, Matthias, additional, Peck-Radosavljevic, Markus, additional, Decaestecker, Jochen, additional, Cuyle, Pieter-Jan, additional, Verset, Gontran, additional, Van Vlierberghe, Hans, additional, De Azevedo, Sergio, additional, Andrade, Livia, additional, Cunha Júnior, Ademar, additional, Faria, Luiza, additional, Yen, Cheng Tzu, additional, Colli, Leandro, additional, Asselah, Jamil, additional, Kavan, Petr, additional, Marquez, Vladimir, additional, Brahmania, Mayur, additional, Li, Qiang, additional, Xing, Baocai, additional, Guo, Yabing, additional, Chen, Zhendong, additional, Zhao, Haitao, additional, Peng, Tao, additional, Wang, Liming, additional, Liu, Hongming, additional, Wu, Feixiang, additional, Qin, Lunxiu, additional, Zheng, Qichang, additional, Ying, Jieer, additional, Li, Haitao, additional, Wen, Tianfu, additional, Qin, Shukui, additional, Liu, Yunpeng, additional, Wang, Boqing, additional, Bai, Yuxian, additional, He, Yifu, additional, Zhao, Hong, additional, Zhou, Dong, additional, Dai, Chaoliu, additional, Teng, Gaojun, additional, Cui, Shuzhong, additional, Gao, Yi, additional, Zhang, Xizhi, additional, Lu, Zheng, additional, Yin, Tao, additional, Ding, Youming, additional, Jia, Weidong, additional, Xia, Yongxiang, additional, Sun, Beicheng, additional, Xia, Qiang, additional, Yuan, Yufeng, additional, Sun, Huichuan, additional, Shi, Xuetao, additional, Guzmán, Adrián, additional, Corrales, Luis, additional, Kral, Zdenek, additional, Priester, Peter, additional, Kubala, Eugen, additional, Blanc, Jean Frederic, additional, Bourliere, Marc, additional, Peron, Jean Marie, additional, Borg, Christophe, additional, Bronowicki, Jean-Pierre, additional, Ganne, Nathalie, additional, Decaens, Thomas, additional, Heurgue, Alexandra, additional, Trojan, Joerg, additional, Gonzalez-Carmona, Maria Angeles, additional, Roderburg, Christoph, additional, Ettrich, Thomas, additional, Schotten, Clemens, additional, Kandulski, Arne, additional, Yau, Thomas, additional, Chan, Lam, additional, Scartozzi, Mario, additional, Masi, Gianluca, additional, Fanello, Silvia, additional, Battezzati, Pier Maria, additional, Leonardi, Francesco, additional, Ghidini, Michele, additional, Morimoto, Manabu, additional, Hidaka, Hisashi, additional, Tsuchiya, Kaoru, additional, Yamashita, Tatsuya, additional, Kato, Naoya, additional, Hagihara, Atsushi, additional, Koga, Hironori, additional, Arakawa, Tomohiro, additional, Nakamura, Ikuo, additional, Kawamura, Yusuke, additional, Kawaoka, Tomokazu, additional, Shimada, Mitsuo, additional, Hasegawa, Kiyoshi, additional, Marusawa, Hiroyuki, additional, Nakamura, Shinchiro, additional, Hiraoka, Atsushi, additional, Hayashi, Hiromitsu, additional, Takeda, Shin, additional, Paik, Seung Woon, additional, Kim, Do Young, additional, Lee, Jung Il, additional, Jeong, Sook-Hyang, additional, Kim, Won, additional, Kim, Hyeyeong, additional, Chon, Hong Jae, additional, Cheong, Jaeyoun, additional, Yoon, Seung Kew, additional, Yoon, Jung-Hwan, additional, Villalobos, Ricardo, additional, Martinez Rodriguez, Jorge Luis, additional, Oyervides Juarez, Victor, additional, Hernández, Carlos Alberto, additional, Klumpen, Heinz-Josef, additional, de Vos-Geelen, Judith, additional, Gane, Edward, additional, Montenegro, Paola, additional, Torres Mattos, Cesar, additional, Janczewska, Ewa, additional, Kawecki, Maciej, additional, Nowakowska-Zajdel, Ewa, additional, Fedenko, Alexander, additional, Granov, Dmitrii, additional, Alyasova, Anna, additional, Sekacheva, Marina, additional, Ledin, Evgeny, additional, Samol, Jens, additional, Toh, Han Chong, additional, Calvo Campos, Mariona, additional, Gomez Martin, Carlos, additional, Lopez Lopez, Carlos, additional, Muñoz Martin, Andres Jesus, additional, Calleja Panero, Jose Luis, additional, Montero Alvarez, Jose Luis, additional, Reig Monzón, Maria, additional, Delgado Mingorance, Ignacio, additional, Minguez Rosique, Beatriz, additional, Cheng, Ann Lii, additional, Huang, Yi-Hsiang, additional, Lin, Shi-Ming, additional, Huang, Jee-Fu, additional, Yu, Ming-Lung, additional, Su, Wei-Wen, additional, Korphaisarn, Krittiya, additional, Maneenil, Kunlatida, additional, Samdaengpan, Chayanee, additional, Tharavichitkul, Ekkapong, additional, Ozguroglu, Mustafa, additional, Kose, Fatih, additional, Harputluoglu, Hakan, additional, Buchschacher, Gary, additional, Thuluvath, Paul, additional, Xiong, Henry, additional, Patel, Mital, additional, Gold, Philip, additional, Li, Daneng, additional, Brooks, Gabriel, additional, Masood, Ashiq, additional, Patel, Reema, additional, George, Ben, additional, Salgia, Reena, additional, Manji, Gulam, additional, Crow, Mary, additional, Kaseb, Ahmed, additional, Dugan, Matthew, additional, Kadakia, Kunal, additional, Kardosh, Adel, additional, Gibbs, John, additional, Shah, Ashesh, additional, and Burris III, Howard, additional

Published
2023
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556. Surgical Explantation of Failed Transcatheter Aortic Valve Replacement

Author

Zaid, Syed, primary, Hirji, Sameer A., additional, Bapat, Vinayak N., additional, Denti, Paolo, additional, Modine, Thomas, additional, Nguyen, Tom C., additional, Mack, Michael J., additional, Reardon, Michael J., additional, Kaneko, Tsuyoshi, additional, Tang, Gilbert H.L., additional, Saha, Shekhar, additional, Kiefer, Philipp, additional, Holzhey, David, additional, Noack, Thilo, additional, Voisine, Pierre, additional, Mohammadi, Siamak, additional, Harrington, Katherine B., additional, Squiers, John J., additional, Fukuhara, Shinichi, additional, von Ballmoos, Moritz Wyler, additional, Goel, Sachin S., additional, Atkins, Marvin D., additional, Bhadra, Oliver D., additional, Conradi, Lenard, additional, Shults, Christian, additional, Satler, Lowell F., additional, Pirelli, Luigi, additional, Brinster, Derek R., additional, Algadheeb, Muhanad, additional, Chu, Michael W.A., additional, Bagur, Rodrigo, additional, Ramlawi, Basel, additional, Grubb, Kendra J., additional, Desai, Nimesh D., additional, Robinson, Newell B., additional, Wang, Lin, additional, Petrossian, George A., additional, Leroux, Lionel, additional, Doty, John R., additional, Kempfert, Joerg, additional, Unbehaun, Axel, additional, Rahim, Hussein, additional, Geirsson, Arnar, additional, Forrest, John K., additional, Vincent, Flavien, additional, Van Belle, Eric, additional, Koussa, Mohamad, additional, Goldberg, Joshua B., additional, Ahmad, Hasan A., additional, Ben Ali, Walid, additional, Demers, Philippe, additional, Ibrahim, Reda, additional, Andreas, Martin, additional, Werner, Paul, additional, Goel, Kashish, additional, Shah, Ashish S., additional, Gelpi, Guido, additional, Ruel, Marc, additional, Al-Atassi, Talal, additional, Van Mieghem, Nicholas M., additional, Hokken, Thijmen W., additional, D'Onofrio, Augusto, additional, Tessari, Chiara, additional, Shah, Pinak B., additional, Belluschi, Igor, additional, Garatti, Andrea, additional, Bruschi, Giuseppe, additional, Ouzounian, Maral, additional, Pizano, Alejandro, additional, Di Eusanio, Marco, additional, Capestro, Filippo, additional, Rovin, Joshua, additional, Taramasso, Maurizio, additional, Gennari, Marco, additional, Colli, Andrea, additional, Estevez-Loureiro, Rodrigo, additional, Pinon, Miguel A., additional, Salinger, Michael H., additional, Di Virgilio, Antonio, additional, Whisenant, Brian K., additional, Nazif, Tamim M., additional, Kleiman, Neal S., additional, Szerlip, Molly I., additional, Waksman, Ron, additional, Rodés-Cabau, Josep, additional, George, Isaac, additional, DiMaio, J. Michael, additional, Maisano, Francesco, additional, Deeb, G. Michael, additional, Vitanova, Keti, additional, Lange, Rudiger, additional, Borger, Michael A., additional, Hagl, Christian, additional, and Bavaria, Joseph E., additional

Published
2023
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558. Data formats and standards for opportunistic rainfall sensors

Author

Fencl, Martin, primary, Nebuloni, Roberto, additional, C. M. Andersson, Jafet, additional, Bares, Vojtech, additional, Blettner, Nico, additional, Cazzaniga, Greta, additional, Chwala, Christian, additional, Colli, Matteo, additional, de Vos, Lotte, additional, El Hachem, Abbas, additional, Galdies, Charles, additional, Giannetti, Filippo, additional, Graf, Maximilian, additional, Jacoby, Dror, additional, Victor Habi, Hai, additional, Musil, Petr, additional, Ostrometzky, Jonatan, additional, Roversi, Giacomo, additional, Sapienza, Fabiola, additional, Seidel, Jochen, additional, Spackova, Anna, additional, van de Beek, Remco, additional, Walraven, Bas, additional, Wilgan, Karina, additional, and Zheng, Xin, additional

Published
2023
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571. Existence and boundedness of solutions for a singular phase field system

Author

Bonetti, Elena, Colli, Pierluigi, Fabrizio, Mauro, and Gilardi, Gianni

Subjects
Mathematics - Analysis of PDEs, 35K60, 35Q99, 80A22
Abstract

This paper is devoted to the mathematical analysis of a thermomechanical model describing phase transitions in terms of the entropy and order structure balance law. We consider a macroscopic description of the phenomenon and make a presentation of the model. Then, the initial and boundary value problem is addressed for the related PDE system, which contains some nonlinear and singular terms with respect to the temperature variable. Existence of the solution is shown along with the boundedness of both phase variable $\chi$ and absolute temperature $\theta$. Finally, uniqueness is proved in the framework of a source term depending Lipschitz continuously on $\theta$.

Published
2008

572. A New Species of Enyalius (Squamata, Leiosauridae) Endemic to the Brazilian Cerrado

Author

Breitman, M. Florencia, Domingos, Fabricius M.C.B., Bagley, Justin C., Wiederhecker, Helga C., Ferrari, Tayná B., Cavalcante, Vitor H.G.L., Pereira, André C., Abreu, Tarcísio L.S., De-Lima, Anderson Kennedy Soares, Morais, Carlos J.S., del Prette, Ana C.H., Silva, Izabella P.M.C., de Mello, Rodrigo, Carvalho, Gabriela, de Lima, Thiago M., Silva, Anandha A., Matias, Caroline Azevedo, Carvalho, Gabriel C., Pantoja, João A.L., Gomes, Isabella Monteiro, Paschoaletto, Ingrid Pinheiro, Rodrigues, Gabriela Ferreira, Talarico, Ângela V.C., Barreto-Lima, André F., and Colli, Guarino R.

Published
2018

573. Extracorporeal Membrane Oxygenation for COVID-19 respiratory distress syndrome: an Italian Society for Cardiac Surgery Report

Author

Loforte, Antonio, Di Mauro, Michele, Pellegrini, Carlo, Monterosso, Christian, Pelenghi, Stefano, Degani, Antonella, Rinaldi, Mauro, Cura Stura, Erik, Sales, Gabriele, Montrucchio, Giorgia, Mangino, Domenico, Terrini, Alberto, Pacini, Davide, Affronti, Alessandro, Tarzia, Vincenzo, Bottio, Tomaso, Pantaleo, Antonio, Donatelli, Francesco, Miceli, Antonio, Santini, Francesco, Salsano, Antonio, Colli, Andrea, Ravenni, Giacomo, Montalto, Andrea, Musumeci, Francesco, Salvador, Loris, Gerosa, Gino, Parolari, Alessandro, and Picichè, Marco

Published
2021
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574. Long time convergence for a class of variational phase field models

Author

Colli, Pierluigi, Hilhorst, Danielle, Issard-Roch, Francoise, and Schimperna, Giulio

Subjects
Mathematics - Analysis of PDEs, 35B40, 35K45, 80A22
Abstract

In this paper we analyze a class of phase field models for the dynamics of phase transitions which extend the well-known Caginalp and Penrose-Fife models. Existence and uniqueness of the solution to the related initial boundary value problem are shown. Further regularity of the solution is deduced by exploiting the so-called regularizing effect. Then, the large time behavior of such a solution is studied and several convergence properties of the trajectory as time tends to infinity are discussed.

Published
2008

576. Extinct, obscure or imaginary: The lizard species with the smallest ranges

Author

Meiri, Shai, Bauer, Aaron M., Allison, Allen, Castro-Herrera, Fernando, Chirio, Laurent, Colli, Guarino, Das, Indraneil, Doan, Tiffany M., Glaw, Frank, Grismer, Lee L., Hoogmoed, Marinus, Kraus, Fred, LeBreton, Matthew, Meirte, Danny, Nagy, Zoltán T., de C. Nogueira, Cristiano, Oliver, Paul, Pauwels, Olivier S. G., Pincheira-Donoso, Daniel, Shea, Glenn, Sindaco, Roberto, Tallowin, Oliver J. S., Torres-Carvajal, Omar, Trape, Jean-Francois, Uetz, Peter, Wagner, Philipp, Wang, Yuezhao, Ziegler, Thomas, and Roll, Uri

Published
2018

580. TESTES DE SUBSTRATOS PARA PRODUÇÃO DE HIDROLASES DE INTERESSE BIOTECNOLÓGICO DE FUNGOS FILAMENTOSOS DA AMAZÔNIA

Author

Costa, Bianca Kynseng Barbosa da Silva, primary, Chamy, Michel Nasser Corrêa Lima, additional, Costa, Ana Beatriz Pereira Lélis da, additional, Vasconcelos, Amanda Farias de, additional, Lima, Uatyla de Oliveira, additional, Prá, Alexandre Colli Dal, additional, Souza, Maria da Paz Félix de, additional, Brito, Ricardo Gomes de, additional, and Reis, Renato dos Santos, additional

Published
2020
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581. Amamentação: mitos e verdades

Author

Checchi, Maria Helena Ribeiro De, primary, Souza, Luís Paulo Souza e, additional, Prá, Alexandre Colli Dal, additional, Souza, Amanda Cristina da Silva, additional, Gonçalves, Bruno Pinho Mineiro, additional, Oliveira, Camila Mota, additional, and Ferreira, Henrique Costa, additional

Published
2020
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585. PREFACE

Author

Speer, Andreas, primary, Colli, Andrea, additional, and Bonini, Francesca, additional

Published
2020
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588. Contributors

Author

Agostoni, Pierfrancesco, primary, Landesberg, Amir, additional, Balkan, Wayne, additional, Banerjee, Monisha, additional, Banks, C. Adam, additional, Barac, Yaron, additional, Barker, Colin M., additional, Bejjanki, Harini, additional, Besola, Laura, additional, Bouten, C.V.C., additional, Bridges, Charles R, additional, Budassi, Simone, additional, Burkhoff, Daniel, additional, Burzotta, Francesco, additional, Cherian, Tharian S., additional, Chour, Tony, additional, Christman, Karen L., additional, Cleveland, David, additional, Colli, Andrea, additional, Cooper, David K.C., additional, Davis, Darryl R, additional, Ekser, Burcin, additional, Fargnoli, Anthony S, additional, Fiocco, Alessandro, additional, Folino, Giulio, additional, Gössl, Mario, additional, Garbutt, Tiffany A., additional, Gerosa, Gino, additional, Gheorghe, Livia, additional, Gubara, Sarah M, additional, Hahn, Rebecca T., additional, Hajjar, Roger J, additional, Hamid, Nadira, additional, Hara, Hidetaka, additional, Hare, Joshua M., additional, Hochman-Mendez, Camila, additional, Iwase, Hayato, additional, Jebran, Ahmad-Fawad, additional, Katz, Michael G, additional, Kazory, Amir, additional, Kliger, Chad, additional, Klouda, L., additional, Koratala, Abhilash, additional, Kutschka, Ingo, additional, Lee, Po-Feng, additional, Lenneman, Andrew J., additional, Lilly, Scott M., additional, Liu, Jiandong, additional, Lurier, E.B., additional, Marbán, Eduardo, additional, Nadali, Matteo, additional, Neofytou, Evgenios, additional, Nijenhuis, Vincent J, additional, Pagani, Francis D., additional, Pirelli, Luigi, additional, Prabhu, Sumanth D., additional, Pradegan, Nicola, additional, Qian, Li, additional, Rajapreyar, Indranee N., additional, Reardon, Michael J., additional, Russo, Giulio, additional, Sampaio, Luiz C., additional, Sorajja, Paul, additional, Tang, Liang, additional, Taylor, Doris A., additional, Topaz, Guy, additional, Trani, Carlo, additional, Trapana, Justin, additional, Tung, Roderick, additional, Nussinovitch, Udi, additional, Upadhyay, Gaurav A., additional, Uzendu, Anezi, additional, van der Heyden, Jan, additional, Vigliani, Marguerite B., additional, Wang, Raymond M., additional, Watt, Tessa M.F., additional, Wu, Joseph C., additional, Feld, Yair, additional, Zimmermann, Wolfram-Hubertus, additional, and Zivelonghi, Carlo, additional

Published
2020
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590. The potential role of machine learning in modelling advanced chronic liver disease

Author

Gennaro D'Amico, Agostino Colli, Giuseppe Malizia, and Giovanni Casazza

Subjects
Hepatology, Gastroenterology
Abstract

The use of artificial intelligence is rapidly increasing in medicine to support clinical decision making mostly through diagnostic and prediction models. Such models derive from huge databases (big data) including a large variety of health-related individual patient data (input) and the corresponding diagnosis and/or outcome (labels). Various types of algorithms (e.g. neural networks) based on powerful computational ability (machine), allow to detect the relationship between input and labels (learning). More complex algorithms, like recurrent neural network can learn from previous as well as actual input (deep learning) and are used for more complex tasks like imaging analysis and personalized (bespoke) medicine. The prompt availability of big data makes that artificial intelligence can provide rapid answers to questions that would require years of traditional clinical research. It may therefore be a key tool to overcome several major gaps in the model of advanced chronic liver disease, mostly transition from mild to clinically significant portal hypertension, the impact of acute decompensation and the role of further decompensation and treatment efficiency. However, several limitations of artificial intelligence should be overcome before its application in clinical practice. Assessment of the risk of bias, understandability of the black boxes developing the models and models' validation are the most important areas deserving clarification for artificial intelligence to be widely accepted from physicians and patients.

Published
2023
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591. A ATUAÇÃO DO FARMACÊUTICO NA APLICAÇÃO DE TOXÍNA BOTULÍNICA

Author

Fernanda de Moraes Barcelos and Luciana Ferreira Mattos Colli

Abstract

Nos dias atuais, o aumento progressivo da expectativa de vida, tem gerado uma grande busca por parte da população, em relação ao seu bem-estar, incluindo-se autoestima e estética corporal e facial. Dessa forma a saúde estética está avançando e experimentando permanentes modificações tecnológicas e científicas. A cada dia que passa a população está mais vaidosa, buscando uma aparência mais jovem e atraente, com isso os procedimentos estéticos vêm ganhando um grande espaço no mundo, hoje em dia não só mulheres, assim como homens e pessoas de todas as idades buscam melhorar e aperfeiçoar sua aparência com estes procedimentos. Desse modo observa-se uma grande demanda pela aplicação da toxina botulínica (TBA), mais conhecida popularmente devido a marca Botox®. Esta toxina é produzida por uma bactéria gram positiva denominada Clostridium botulinum, existem oito sorotipos diferentes de toxinas, porém a mais utilizada no âmbito da estética é o tipo A, por ser a mais potente e menos agressiva para o corpo humano. Como procedimento metodológico, foi realizado um estudo de revisões bibliográficas de artigos científicos, com objetivo de avaliar a adequação do farmacêutico na aplicação de toxina botulínica, afim de concluir que o farmacêutico é um profissional devidamente habilitado a atuar na área da aplicação de TBA, tendo em vista o entendimento mais aprofundado da farmacologia e dos benefícios da substância no organismo, pelo fato de ser um produto desenvolvido e fabricado na indústria farmacêutica. Sendo assim este profissional é qualificado para tal atividade.

Published
2023
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593. FERRAMENTAS DIGITAIS NA ATUAÇÃO DO FARMACÊUTICO

Author

Túlio Costa Condack Nogueira and Luciana Ferreira Mattos Colli

Abstract

As ferramentas digitais são nos dias de hoje um importante instrumento no auxílio do profissional farmacêutico no âmbito da assistência farmacêutica. Com a ajuda da tecnologia da informação e comunicação (TIC) é possível identificar e promover a proteção, monitoramento, recuperação do bem-estar físico, prevenção de doenças e de outros problemas de saúde, bem como para a resolução de problemas da farmacoterapia e auxílio ao uso racional de medicamentos. A evolução da profissão farmacêutica é uma das mais notórias tendo em vista que as primeiras ações envolvendo o farmacêutico no Brasil se deve por volta do século XVII onde já constavam documentos que mostravam as primeiras boticas. Estes que eram estabelecimentos que tinham a permissão de comercialização de medicamentos e manipulação e dispensação de produtos voltados para a cura. A população tinha fácil acesso à farmácia e ao farmacêutico pela proximidade do local, sendo assim, supriam a ausência ou distância dos hospitais. Hoje com o avanço tecnológicos e a contínua necessidade de atuação do profissional farmacêutico, o seu papel para a população volta ter importância e tem mostrado novos caminhos para assistência farmacêutica com a chegada da tele farmácia e outras tecnologias digitais.

Published
2023
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595. Robust global mantle flow trajectories and their validation via dynamic topography histories

Author

A Taiwo, H-P Bunge, B S A Schuberth, L Colli, and B Vilacis

Subjects
Geophysics, Geochemistry and Petrology
Abstract

SUMMARY The ability to construct time-trajectories of mantle flow is crucial to move from studies of instantaneous to time-dependent earth models and to exploit geological constraints for mantle convection modelling. However mantle convection is chaotic and subject to the butterfly effect: the trajectories of two identical mantle convection models initialized with slightly different temperature fields diverge exponentially in time until they become uncorrelated. Because one may use seismic inferences about the mantle state as a starting or terminal condition to project mantle flow forward or backward in time, and because the seismic inference is invariably subject to uncertainties, this seemingly would rule out any construction of robust mantle flow trajectories. Here we build upon earlier work which showed that assimilation of the horizontal component of the surface velocity field from a known reference model allows one to overcome the butterfly effect and to construct robust mantle flow trajectories, regardless of the choice of the initial state perturbation. To this end, we use high resolution 3-D spherical mantle convection models in four end-member configurations: an isoviscous purely internally heated model, an isoviscous purely bottom heated model, a model with a radial increase in viscosity along with pure internal heating as well as a model that combines the effects of radial viscosity increase, internal and bottom heating. In order to capture the impact of seismic filtering, we perturb the initial temperature fields of these end-member models through either radial or horizontal smoothing of the temperature field or the application of the tomographic filter of seismic model S20RTS. We assess the quality of the constructed model trajectories via a number of statistical measures as well as comparisons of their dynamic topography histories. The latter is an essential step since mantle flow cannot be directly observed but has to be inferred via its surface manifestations. Importantly, linking mantle flow to surface observations yields patterns representable on a latitude–longitude grid similar to meteorological observables such as precipitation. This invites the application of meteorological quality metrics, such as the power ratio and Taylor diagram, to assess the quality of mantle flow trajectories. We introduce these metrics for the first time in the context of mantle convection and demonstrate their viability based on the compact manner in which they summarize model performance.

Published
2023
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596. SISTEMA DE RECOMENDAÇÃO DE OBJETOS DE APRENDIZAGEM BASEADO EM ESTILOS COGNITIVOS E NA TAXONOMIA DE BLOOM

Author

Emanoel Colli and Sidnei Renato Silveira

Abstract

Este artigo apresenta o desenvolvimento de um protótipo de Sistema de Recomendação de OAs (Objetos de Aprendizagem), baseado nos estilos cognitivos dos alunos e na Taxonomia de Bloom, utilizando tecnologias web, para filtrar e apresentar OAs. O protótipo foi testado e validado com o auxílio de profissionais da educação, assim como de seus discentes, visando trazer credibilidade ao mesmo, atendendo seus objetivos e expectativas, além de apresentar uma ferramenta extremamente útil no âmbito da educação, gerando recomendações para aprimorar e auxiliar o aprendizado dos alunos.

Published
2023
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597. Explant vs Redo-TAVR After Transcatheter Valve Failure

Author

Gilbert H.L. Tang, Syed Zaid, Neal S. Kleiman, Sachin S. Goel, Shinichi Fukuhara, Mateo Marin-Cuartas, Philipp Kiefer, Mohamed Abdel-Wahab, Ole De Backer, Lars Søndergaard, Shekhar Saha, Christian Hagl, Moritz Wyler von Ballmoos, Oliver Bhadra, Lenard Conradi, Kendra J. Grubb, Emily Shih, J. Michael DiMaio, Molly Szerlip, Keti Vitanova, Hendrik Ruge, Axel Unbehaun, Jorg Kempfert, Luigi Pirelli, Chad A. Kliger, Nicholas Van Mieghem, Thijmen W. Hokken, Rik Adrichem, Thomas Modine, Silvia Corona, Lin Wang, George Petrossian, Newell Robinson, David Meier, John G. Webb, Anson Cheung, Basel Ramlawi, Howard C. Herrmann, Nimesh D. Desai, Martin Andreas, Markus Mach, Ron Waksman, Christian C. Schults, Hasan Ahmad, Joshua B. Goldberg, Arnar Geirsson, John K. Forrest, Paolo Denti, Igor Belluschi, Walid Ben-Ali, Anita W. Asgar, Maurizio Taramasso, Joshua D. Rovin, Marco Di Eusanio, Andrea Colli, Tsuyoshi Kaneko, Tamim N. Nazif, Martin B. Leon, Vinayak N. Bapat, Michael J. Mack, Michael J. Reardon, and Janarthanan Sathananthan

Subjects
Cardiology and Cardiovascular Medicine
Published
2023
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599. Benign liver lesions 2022: Guideline for clinical practice of Associazione Italiana Studio del Fegato (AISF), Società Italiana di Radiologia Medica e Interventistica (SIRM), Società Italiana di Chirurgia (SIC), Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB), Associazione Italiana di Chirurgia Epatobilio-Pancreatica (AICEP), Società Italiana Trapianti d'Organo (SITO), Società Italiana di Anatomia Patologica e Citologia Diagnostica (SIAPEC-IAP) – Part I – Cystic lesions

Author

Pompili, Maurizio, Ardito, Francesco, Brunetti, Enrico, Cabibbo, Giuseppe, Calliada, Fabrizio, Cillo, Umberto, de Sio, Ilario, Golfieri, Rita, Grova, Mauro, Gruttadauria, Salvatore, Guido, Maria, Iavarone, Massimo, Manciulli, Tommaso, Pagano, Duilio, Pettinari, Irene, Santopaolo, Francesco, Soresi, Maurizio, Colli, Agostino, Pompili, Maurizio, Ardito, Francesco, Brunetti, Enrico, Cabibbo, Giuseppe, Calliada, Fabrizio, Cillo, Umberto, de Sio, Ilario, Golfieri, Rita, Grova, Mauro, Gruttadauria, Salvatore, Guido, Maria, Iavarone, Massimo, Manciulli, Tommaso, Pagano, Duilio, Pettinari, Irene, Santopaolo, Francesco, Soresi, Maurizio, and Colli, Agostino

Subjects
Settore MED/09 - Medicina Interna, Complicated hepatic cyst, Hepatology, Complicated hepatic cyst, Focal liver lesion, Parasitic hepatic cyst, Polycystic liver disease, Simple hepatic cyst, Humans,Abdomen, Italy, Digestive System Diseases, Cysts, Liver Neoplasms, Digestive System Diseases, Settore MED/18 - CHIRURGIA GENERALE, Liver Neoplasms, Focal liver lesion, Focal nodular hyperplasia, Hepatic hemangioma, Hepatocellular adenoma, Gastroenterology, Hepatic hemangioma, Simple hepatic cyst, Hepatocellular adenoma, Polycystic liver disease, Italy, Abdomen, Focal liver lesion, Focal nodular hyperplasia, Humans, Parasitic hepatic cyst
Abstract

Benign liver lesions are increasingly diagnosed in daily clinical practice due to the growing use of imaging techniques for the study of the abdomen in patients who have non-specific symptoms and do not have an increased risk of hepatic malignancy. They include simple or parasitic cysts and solid benign tumors which differ widely in terms of prevalence, clinical relevance, symptoms and natural history and often lead to significant clinical problems relating to diagnosis and clinical management. Following the need to have updated guidelines on the management of benign focal liver lesions, the Scientific Societies mainly involved in their management have promoted the drafting of a new dedicated document. This document was drawn up according to the present Italian rules and methodologies necessary to produce clinical, diagnostic, and therapeutic guidelines based on evidence. Here we present the first part of the guideline, concerning the characterization of focal hepatic lesions detected by ultrasound, and the diagnosis and clinical management of simple and parasitic hepatic cysts, and of polycystic liver disease.

Published
2022
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