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BACKGROUND: Early exercise treatment is the main prevention way for traumatic joint contracture and is also a research focus. Swimming may be a potential intervention for joint contracture due to the special physical properties of water. OBJECTIVE: To explore the effects of swimming on the development of joint contracture in a rat model and study its mechanisms. METHODS: Twenty-four Sprague-Dawley rats were randomly divided into a blank control group (n=8) and a joint contracture group (n=16). After the surgical operation of knee joint contracture rat models, the joint contracture group was randomly subdivided into a surgical control group (n=8) and a swimming treatment group (n=8). Swimming started in the swimming treatment group in the second week after surgery and lasted for a total of 5 weeks. At the 6th week after surgery, the body mass, knee joint range of motion, and quadriceps diameter were tested, and the diameter/body mass index was calculated. Hematoxylin-eosin staining was performed to detect the pathological changes in the knee joint capsule and quadriceps muscle, and Masson staining was used to observe fibrotic changes in the knee joint capsule. Furthermore, the protein expression of transforming growth factor β1 and type I collagen in the knee joint capsule was quantified by immunohistochemical assay and western blot was performed to detect the protein expression of MuRF1 in the quadriceps femoris. RESULTS AND CONCLUSION: Compared with the blank control group, the knee range of motion decreased in the surgical control and swimming treatment groups (P < 0.01), and knee extension deficit and arthrogenic extension deficit were significantly increased (P < 0.01), the diameter of the quadriceps muscle was decreased (P < 0.01), the joint capsule showed significant fibrosis, the quadriceps muscle was atrophied, and the diameter/body mass index was decreased (P < 0.01). Compared with the surgical control group, the swimming treatment group showed a significant increase in knee joint range of motion and quadriceps diameter (P < 0.01), and significant improvement in joint capsule fibrosis and quadriceps atrophy. Compared with the blank control group, collagen fiber content and expression of transforming growth factor β1 and type I collagen were increased in the joint capsule of rats in both the surgical control group and the swimming treatment group (P < 0.01). Compared with the surgical control group, collagen fiber content and expression of transforming growth factor β1 and type I collagen protein in the joint capsule were decreased in the swimming treatment group. Compared with the blank control group, the expression of MuRF1 protein in the quadriceps muscle of rats in the surgical control group and the swimming treatment group was increased (P < 0.05). Compared with the surgical control group, the expression of MuRF1 protein in the quadriceps muscle of rats in the swimming treatment group was decreased (P < 0.05). To conclude, early swimming intervention reduces transforming growth factor β1 and type I collagen expression in the joint capsule of traumatic joint contracture rats, decreases MuRF1 expression in the quadriceps muscle, and increases joint range of motion and quadriceps diameter, thereby inhibiting the development of joint contracture. [ABSTRACT FROM AUTHOR]

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【Objective】 To clarify the effects of different amendments on soil salinization indexes, sunflower agronomic characteristics and yield in Hetao Irrigation Area, so as to provide a reference for the improvement of saline-alkali soil in this area.【Methods】 Randomized block test was used,4 treatments with no amendment（S1）,900 kg/hm² organic amendment（S2）,4 500 kg/hm² desulfurized gypsum（S3）,900 kg/hm² organic amendment + 4 500 kg/hm² desulfurized gypsum（S4）,comparative analysis of soil salinization indexes and sunflower agronomic characteristics and yield under different amendments.【Results】 The application of amendments reduced the total salt content and pH value of the soil compared with no amendments. The S4 treatment was significantly lower than the S1 treatment（P<0.05）,which decreased by 1.15 g/kg and 0.32,respectively. The application of amendments increased plant height, stem thickness, and disk diameter, and the S4 treatment was significantly higher than the S1 treatment（P<0.05）. The yield, grain weight per tray, and 100-seed weight of S4 treatment were significantly higher than those of S1 treatment（P<0.05）,increasing by 13.92%,21.15 g and 1.48 g respectively. There was no significant difference between S2 and S3 treatments（P>0.05）.【Conclusion】 900 kg/hm² organic amendment + 4 500 kg/hm² desulfurized gypsum had obvious effects on reducing the total salt content and pH value of the soil, promoting sunflower growth and increasing yield. It was a suitable amendment in saline-alkali soil of Hetao Irrigation Area. [ABSTRACT FROM AUTHOR]

The existing Xin′anjiang model is mathematically represented by algebraic equations, and its solution is limited by first- order accuracy finite difference methods, inevitably resulting in numerical errors. Therefore, exploring new approaches to controlling numerical errors is crucial for increasing the computational accuracy of the model. Within the framework of differential systems, the state variables and fluxes of the Xin′ anjiang model are identified, and the corresponding control equations and constitutive equations are then derived. A differential- form Xin′anjiang model (ODE- XAJ) is proposed and solved using the fourth- order explicit Runge- Kutta method. The results of the numerical experiments show that, when benchmarked against the analytical solution, the absolute error of ODE-XAJ is on the order of 10 - 4 mm or below, enabling a high- order approximation of the analytical solution. With the results of ODE-XAJ as the benchmark, the numerical error of the existing Xin′anjiang model is evaluated to be approximately 8. 7% based on the normalized mean absolute error. The application results for a typical watershed show that the determination coefficient of ODE-XAJ increased by 0. 02 and the relative error of flood volume decreased by 4. 3% . It is concluded that ODE-XAJ theoretically separates the mathematical equations of the model from specific numerical methods, which can effectively control the numerical errors and improve the accuracy of model simulations. [ABSTRACT FROM AUTHOR]

At the time of the reform and adjustment of discipline transformation, the Institute of Respiratory and Critical Care Medicine, the 8th Medical Center of Chinese PLA General Hospital, relies on Beijing Key Laboratory of Organ Transplantation and Immunology Regulatory, to build a multidisciplinary postgraduate joint training mode based on immunology. From the aspects of individualized postgraduate training background, teaching mode, ability training, etc., the practice mode of joint training of postgraduates in multiple clinical disciplines is explored. In order to cultivate medical thinking talents with systematic and holistic theory, and prepare for future clinical work. [ABSTRACT FROM AUTHOR]

Objective: To analyze the expression, clinical significance, and relationship with tumor immune infiltration of serine/arginine-rich splicing factor 9 (SRSF9) in head and neck squamous cell carcinoma (HNSCC) by bioinformatics methods, and to discuss its mechanism. Methods: The expression of SRSF9 in HNSCC and its relationship with clinical pathologic characteristics and prognosis of the patients were analyzed by The Cancer Genome Atlas (TCGA) Database, GSE30784 and GSE13601 datasets in Gene Expression Omnibus (GEO) Database, Clinical Proteomic Tumor Analysis Consortium (CPTAC) Database, Gene Expression Profiling Interactive Analysis (GEPIA) Database, and KaplanMeier plotter Database; the variations of SRSF9 gene were examined through cBioPortal Database; ESTIMATE algorithm and The Tumor Immune Estimation Resource (TIMER) Database were used to assess the correlation between SRSF9 expression and tumor microenvironment, as well as tumor immune cell infiltration; LinkedOmics Database was used to analyze the SRSF9 co-expressed genes and their regulatory pathways in the HNSCC; the TCGA SpliceSeq Database was used to analyze the variable splicing events regulated by SRSF9 in the HNSCC; Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway enrichment analysis were conducted on the target genes. Results: The analysis results from TCGA Database and GSE30784 and GSE13601 datasets in GEO Database showed that the expression level of SRSF9 mRNA in the HNSCC tissue was significantly higher than that in adjacent normal tissue (P<0. 01). The CPTAC Database analysis results showed that compared with normal tissue, the expression level of SRSF9 protein in the HNSCC tissue was significantly increased (P<0. 001). The SRSF9 mRNA expression was associated with pathological grading (P=0. 004) and HPV infection (P=0. 031) in the patients with HNSCC according to TCGA Database analysis. The GEPIA and Kaplan-Meier plotter Database analysis results showed that high expression of SRSF9 mRNA in the HNSCC tissue was correlated with poorer overall survival (OS) of the patients [hazard ratio (HR) = 1. 40, P=0. 019; HR=1. 55, P=0. 003]. The cBioPortal Database analysis results showed that copy number variation (CNV) of SRSF9 gene occurred in 26. 85% in HNSCC, and CNV was positively correlated with SRSF9 mRNA expression levels (r=0. 44, P<0. 001). The ESTIMATE algorithm analysis results showed that high expression of SRSF9 mRNA group had lower stromal and immune score, and higher tumor purity than those in low expression of SRSF9 mRNA group (P<0. 001). The TIMER Database analysis results showed there was a positive correlation between the expression of SRSF9 mRNA and CD4+ T lymphocyte infiltration (r=0. 186, P<0. 001), and there were negative correlations between the expression level SRSF9 mRNA and B lymphocyte, CD8+ T lymphocyte, and dendritic cell infiltrations (r=-0. 269, P<0. 001; r=-0. 353, P<0. 001; r=-0. 304, P<0. 001). The co-expressed gene enrichment analysis results showed upregulation of genes related to ribosomes, spliceosomes, and metabolic pathways, and downregulation of genes associated with focal adhesions, cytokines, and cell adhesion molecules. The main pathways involved in SRSF9-related variable splicing target genes were lipid metabolism, glucagon, and tight junctions. Conclusion: SRSF9 is highly expressed in HNSCC and is associated with poor prognosis and tumor microenvironment immune cell infiltration, suggesting its potential as a molecular target for the diagnosis, prognosis assessment, and treatment of HNSCC. [ABSTRACT FROM AUTHOR]

目的 分析神经眼科体征在脑干梗死中的特点，评价其在脑干梗死诊断中的意义。 方法 收集2013年2月至2015年4月收治的46例脑干梗死患者的临床资料，选取其中出现神经眼科体征的9例患者，回顾性分析其眼部表现、病变部位等。 结果 9例患者中男4例，女5例；发病部位：中脑梗死4例（44.44%），脑桥梗死5例（55.56%）。中脑梗死患者的眼肌麻痹均为核性动眼神经麻痹。脑桥梗死引起的眼球运动异常表现多样，有2例表现为核性神经麻痹，1例为核间性眼肌麻痹（INO），1例伴眼球震颤，1例为核上性眼肌麻痹。 结论 脑干梗死患者眼球运动异常的主要特点包括核性眼肌麻痹、INO、眼球震颤、核上性眼肌麻痹等，神经眼科体征对脑干梗死的诊断具有重要提示作用。 [ABSTRACT FROM AUTHOR]

Objective To investigate the dynamic changes of peripheral blood lymphocyte subsets and their correlation with renal function in recipients with stable graft status after renal transplantation. Methods Forty-five recipients who underwent renal transplantation for the first time and had stable graft function within postoperative 6 months were selected. The proportion and absolute value of lymphocyte subsets were detected by flow cytometry (FCM) in 180 peripheral blood samples from recipients at 15 d, 1, 3 and 6 months after renal transplantation. The dynamic changes of lymphocyte subsets with the extension of postoperative time and their correlation with serum creatinine (Scr) and blood urea nitrogen (BUN) were analyzed. Results The Scr levels did not significantly differ at 4 time points after renal transplantation (all P>0.05). The BUN levels significantly differed between 15 d and 1 month after renal transplantation, and between 1 and 3 months after renal transplantation (P=0.002, P=0.001). The proportion of CD3+ CD8+ T cells, CD3+ CD4+ T cells, natural killer (NK) cells and CD4/CD8 ratio at postoperative 15 d significantly differed from those at 1 month after operation (P=0.009, P=0.004, P<0.001, P=0.004). The proportion of B cells significantly differed between 15 d and 1 month, and between 1 and 3 months after renal transplantation (both P<0.001). The absolute values of CD3+ T cells, CD3+ CD8+ T cells, CD3+ CD4+ T cells and NK cells at postoperative 15 d significantly differed from those at 1 month after renal transplantation (P=0.001, P=0.002, P=0.003, P<0.001). The absolute values of CD3+ CD8+ T cells significantly differed between 3 and 6 months after operation (P=0.015). The absolute value of B cells at 1 month after renal transplantation significantly differed from that at 3 months after renal transplantation (P=0.001). The proportion and absolute value of lymphocyte subsets were not significantly correlated with the Scr level (both P>0.05). The proportion and absolute value of CD3+ CD8+ T cells and NK cells were negatively correlated with BUN (P<0.001-0.05), whereas the proportion of CD3+ CD4+ T cells and B cells was positively correlated with the BUN level (P<0.001-0.05). The absolute value of CD3+ T cells was negatively associated with the BUN level (P<0.05). Conclusions T cells and NK cells in the lymphocyte subsets of stable recipients raise to the stable state within 1 month after renal transplantation, whereas B cells decrease to stable state within 3 months renal transplantation. The dynamic changes of lymphocyte subsets are correlated with the BUN level. [ABSTRACT FROM AUTHOR]

[Objective]In order to obtain the best fertilizer formula for the growth of Camellia oleifera, a 3-year fertilization experiment was carried out on three kinds of Changlin clones in Camellia oleifera, and the optimal fertilization ratio suitable for the growth of Camellia oleifera was selected, which laid the foundation for improving the economic benefits of Camellia oleifera. [Method]Four treatments were set up in this experiment, that is, compound fertilizer ( C0. 5 , 0. 50 kg / plant), compound fertilizer + organic fertilizer ( C0. 25O0. 5, compound fertilizer 0. 25 kg / plant, organic fertilizer 0. 50 kg / plant), organic fertilizer (O1, 1. 00 kg / plant) and the control (CK). Tree height, basic diameter and crown diameter of young Camellia oleifera were measured to compare and analyze the differences between fertilizer types and varieties. [Result]The results showed that fertilization promoted the height growth of Camellia oleifera, but the effect was not significant (P>0. 05), among four types of treatments, the compound fertilizer + special organic fertilizer had the best effect for Camellia oleifera, compared with CK, the two-year growth amount of Changlin 3, Changlin 4 and Changlin 40 was 38. 46%, 10. 77% and 22. 22% higher, respectively. Fertilization significantly affected the growth of ground diameter and crown width of Camellia oleifera (P<0. 05), and the compound fertilizer + special organic fertilizer for Camellia oleifera treatment group had the largest growth amount, compared with CK, the growth amount of ground diameter was 125. 33%, 47. 76% and 12. 87% higher, respectively, and the growth amount of crown width was 30. 30%, 13. 00% and 46. 75% higher, respectively. [Conclusion]The results of this study showed that the combination of compound fertilizer and organic fertilizer for Camellia oleifera had positive effects on improving the quality and efficiency of Changlin clones in Camellia oleifera. [ABSTRACT FROM AUTHOR]

Fish quantity is one of the most meaningful tasks in aquaculture. Precise quantity can greatly contribute to the proper fish density in ponds, thus offering fair fish trade to sales and customers. However, fry (the juvenile fish) counting is still longterm hard work, due to the tiny size and huge batch in practice. This work aims to explore an efficient way for a precise number of fries. A self-built image acquisition device was designed and then applied by image segmentation using edge curvature. A whole closed space was constructed underneath with a white light background in the device. A camera inside was equipped downward to collect images of fries. The fries were in the size of 1-3 cm length and then placed in a 40 cm×30 cm×6 cm transparent box inside 0.9-1.1 cm depth water. Totally 18 000 fry images were acquired, which were of 6 planar density classes, including 0.25, 0.33, 0.42, 0.50, 0.58 and 0.67 fry/cm2 . The preprocessing was carried out to reduce the negative and redundant information in the collected images, such as the noises and the background. Therefore, the images were transferred to the binary images, and then the morphology operations like dilation and erosion were completed next. As the least self-contained unit in a binary image, the individual connected domains were extracted and then saved for the following deeper analysis, as well as their skeleton maps and edge maps. Among them, an individual connected domain was distinguished as a single fry or an adhesion of multiple fries. This identification was determined by two keys-one was the number of branch points of the skeleton map, and another was the distance from the points of the skeleton to the edge. Those domains that were recognized as single fry were directly counted as 1 into the amount. The number of fries needed to be reconfirmed in the domain with an adhesion of multiple fries. The detailed steps were listed as follow: 1) To calculate and filter, the curvature of the edge was purposed to search the points whose quantitative value always were negative, those points were named after ‘pit point’ and thought of as the places that overlaps appeared; 2) If the pit points of the cluster were adjacent and concentrated in a community, those pit points were marked as the pre-segmenting locations, while those locations were named as ‘pit point group’, and all of pit point group on an edge was found and numbered; 3) According to the different pre-segmenting locations, all forms of overlap were classified as three types, including crossed-fries, cascaded-fries, and single-pit cluster. Then potential overlaps were determined; 4) In each overlap, two highlighted segmentation points were picked out from the potential pit point groups, and then linked as a segmentation line to depart the original connected domain; 5) All segmentation lines were tested by presupposed rules to decide whether being saved or not. 6) The number of fries was set as the number of separate domains until all segmentation was realized in a connected domain. Finally, the fry number was calculated as the sum of the number from all domains in a complete image. The results show that the mean absolute percentage error (MAPE) was less than 1.37% after detection when the fry plane density was below 0.58 fry/cm2 . Meantime, both accuracy and efficiency were considered concurrently, if the plane density was kept within 0.33-0.58 fry/cm2 . The overlapping images of high-density fry can be expected to accurately and rapidly count over 1 cm length of fry. The finding can provide algorithmic support for the development of fry counters. [ABSTRACT FROM AUTHOR]

In order to make full use of the characteristic information contained in the partial discharge (PD) signal and improve the recognition rate of the partial discharge type in the transformer, a partial discharge type recognition method based on wavelet transform (WT) and gray-gradient co-occurrence matrix (GGCM) algorithm was proposed. According to the internal structure characteristics of the transformer, four types of partial discharge defects were designed, and the transformer partial discharge experimental detection platform was built in the laboratory, and the high-frequency partial discharge current signal was collected by pulse current method. The flexibility of wavelet transform in non-stationary signal processing was used to construct time-frequency spectrum of partial discharge signal pulse. Then, combined with the GGCM algorithm, the 15-dimensional texture features of the time-frequency spectrum were extracted to form the feature vector. Input the feature vector into the support vector machine (SVM) classifier for pattern recognition. The results show that the recognition method combining wavelet transform and GGCM algorithm can effectively identify different types of partial discharge defects. [ABSTRACT FROM AUTHOR]

Automatic and accurate collection of fishery catch data is an important part of the electronic observer system. However, automated tuna longline catch estimation remains challenging to deploy in practice due to the complexity of the working environment and the instability of tracking. In this study, a lightweight counting network was designed to automate the processing of real-time video data from fishing vessels in order to enable real-time tracking and counting of tuna catches on board fishing vessels. YOLOv5s was selected as the benchmark network in this study. The channel pruning algorithm was first used to prune the backbone network of YOLOv5s, and the results showed that the detection accuracy of the pruned model mAP0.5~0.95 reached 68.8%, and the detection speed was 16.5 frames per second （FPS） under CPU, which was basically unchanged compared with the original model. The number of parameters, model size and computation of the model were reduced by 67.2%, 66.4% and 42.5% respectively, and the detection speed was increased by 33.1%. Secondly, the ByteTrack algorithm was used to achieve real-time tracking of multiple targets, optimize the shape of the counting area and solve the problem of counting deviation caused by the jump in the identity （ID） of the tuna being tracked. The test results of 10 videos showed that the average counting accuracy of the method was 80% and the video processing speed was 50.7 FPS, which meets the requirements of industrial-grade real-time detection. In summary, the model had the advantages of light weight, high accuracy and real-time, which could complete the real-time monitoring of longline catch in complex working environments and provide a solution to realizing fisheries automation. [ABSTRACT FROM AUTHOR]

Objective We aimed to explore the syndrome evolution of re-positive COVID-19 patients who were infected with SARS-CoV-2 Omicron variant BA. 1 and to provide a reference for Chinese medicinebased treatment of COVID-19. Methods Collecting the medical records of patients infected with Omicron variant BA. 1 from January to March 2022 in Qiboshan Hospital and Port Hospital in Henan Province. Selecting 61 patients who have re-positive after infection as the re-positive group, and 60 normal negative patients admitted at the same time as the control group. The TCM syndromes were diagnosed in 1, 4, 7, 14, 21, and 30 days after hospital admission. Results Examination of syndrome evolution in the control group revealed: exterior syndrome, dampness-heat encumbering the lung syndrome, epidemic toxins blocking the lungs, and deficiency syndrome(mainly qi and yin deficiency) Similarly, examination of symptomatic evolution in the re-positive group revealed dampness-heat encumbering the lung syndrome, epidemic toxins blocking the lungs, and deficiency syndrome(mainly qi and yin deficiency). In the re-positive group, the syndrome changed from excess to deficiency in (20. 00± 8. 54) days, and the final successful turning negative occurred after (31. 79±7. 93) days. Re-positive occurred after (28. 27 ± 8. 55) days. In the control group, the syndrome type changed from excess to deficiency in ( 12. 89 ± 2. 77 ) days, and finally turned negative after ( 18. 78 ± 6. 29 ) days. Conclusion Syndrome evolution in re-positive patients is as follows: 1-14 days are dominated by dampness and heat encumbering the lung syndrome, which then develops to the extreme stage of epidemic toxins blocking the lung syndrome. The late stage and recovery period of the disease in 14 - 30 days mainly involve a deficiency syndrome, mostly deficiency of qi and yin. The course of disease in repositive patients is longer than that in patients with common turning negative conversion. [ABSTRACT FROM AUTHOR]

The field of deep learning research in hydrology primarily aims to enhance prediction capabilities. However, the intricate structure of deep learning models often leads to predictions that are difficult to explain and trust, making the development of trustworthy deep learning models a challenging and increasingly important topic. In this paper, we present a novel hybrid model that combines the strengths of deep learning and physical-based hydrological models to improve predictions in hydrology. Utilizing a framework of a residual error model, our approach develops a VB- LSTM (variational Bayesian deep learning model) to quantify hydrological uncertainty and enhance predictive reliability. We applied our model to predict streamflow in the source area of the Yellow River from 1961 to 2015, and the results demonstrate its superiority over traditional methods. Compared to long- short term memory networks (LSTM), the VB-LSTM model achieved stable performance and higher predictive accuracy in the validation period. Additionally, it outperforms the traditional probabilistic hydrological post- processing method that relies on a “linearnormal” assumption, by providing higher predictive accuracy and reliability, and reducing predictive uncertainty. [ABSTRACT FROM AUTHOR]

Fats and oils are the essential in broiler nutition. Adding appropriate amount of fat and oil to broiler diets can effectively increase the energy concentration, improve the palatability of the feed, increase the feed intake and improve the growth performance, thus improve the economic efficiency. The paper reviews the common fats and their fatty acid composition, discusses the digestion and metabolism of fats in broilers and their application in broiler production, to provide reference for the rational development and utilization of fats and fats and the exploration of suitable types and proportions of fats in broiler production. [ABSTRACT FROM AUTHOR]

The incidence of adolescent idiopathic scoliosis (AIS) worldwide is 1%～3%, the base of the diseased population is large, and it causes both physical and psychological pains to patients. Numerous studies have shown that genetic factors may play an important role in the occurrence and development of AIS. The correlation between single nucleotide polymorphisms (SNPs) and AIS is the focus of medical molecular research in recent years. In-depth research on the SNPs of susceptibility genes will help to explore new strategies for the prevention, diagnosis and treatment of AIS. This article reviews the research advances concerning gene SNPs and AIS susceptibility. [ABSTRACT FROM AUTHOR]

Objective To investigate the predictive value of serum soluble triggering receptors expressed on myeloid cells 1 (sTREM1) combined with ABCD-3I score in the prediction of recent acute ischemic stroke (AIS) in patients with transient ischaemic attack (TIA). Methods A total of 288 TIA patients were selected, and they were divided into the lowrisk group (102 cases), the intermediate-risk group (131 cases) and the high-risk group (55 cases) according to their ABCD3I scores. In addition, the patients were sub-divided into the AIS group (41 cases) and the non-AIS group (247 cases) according to whether AIS occurred after 90 days. The clinical data such as age, sex and basic diseases were collected, and the serum sTREM1 level was detected by enzyme-linked immunosorbent assay. Results The age, proportion of diabetes, proportion of hypertension, low-density lipoprotein cholesterol (LDL-C) level, sTREM1 level and AIS ratio were significantly higher in the high-risk group than those in the intermediate-risk group and the low-risk group (P＜0.05). The sTREM1 level was significantly higher in the intermediate-risk group than that in the low-risk group (P＜0.05). The age, proportion of hypertension, LDL-C level, ABCD-3I score and sTREM1 level were significantly higher in the AIS group than those in the non-AIS group (P＜0.05). Multivariate Logistic regression model analysis showed that both higher ABCD-3I score and higher sTREM1 level were risk factors for recent AIS in TIA patients (P＜0.05). The area under the curve of ABCD-3I score and sTREM1 level in predicting AIS in TIA patients were 0.795 (95%CI: 0.723-0.867) and 0.755 (95%CI: 0.672-0.839) respectively, and the area under the curve increased to 0.881 (95%CI: 0.830-0.932) after the combination of ABCD-3I score and sTREM1 level. Conclusion Serum sTREM1 combined with ABCD-3I score has a high predictive value for recent AIS in TIA patients, and which has certain clinical application value. [ABSTRACT FROM AUTHOR]

In order to detect the risky driving status of heavy duty vehicle, the double-layer hidden Markov model（HMM）is used for the rollover warning system of heavy duty vehicle, which can identify the driving status dynamically. The data is collected during the typical driving conditions, and the T-G test method is used to delete the abnormal data. The driving limit value of vehicle status is set based on K-means algorithm. Then finally Baum-Welch algorithm is used to optimize the proposed double-layer HMM, and the optimized HMM is used to identify the driving status in real-time. The identification results show that the proposed model can identify the driving status under every single driving condition as well as under the multiple driving conditions accurately and effectively. At the same time this model has a good real-time capacity. [ABSTRACT FROM AUTHOR]

The experiment was to study the effect of dietary supplementation of different levels of fermented Chinese herbal medicines on late production performance and egg quality of laying hens. A total of 576 healthy 500-day-old Roman pink laying hens were selected and randomly divided into four groups, with six replicates in each group and 24 laying hens in each replicate, which was group Ⅰ (basic diet), group Ⅱ (basic diet + 0.5% fermented Chinese herbal medicine), group Ⅲ (basic diet + 1.0% fermented Chinese herbal medicine), group Ⅳ (basic diet + 1.5% fermented Chinese herbal medicine). The experimental period was 28 d. The results showed that compared with group Ⅰ, the sand)shell egg rate of laying hens in group Ⅱ, group Ⅲ and group Ⅳ was significantly decreased on 14~28 d (P<0.05), and the sand-shell egg rate in whole period was decreased (P>0.05). The addition of fermented Chinese herbal medicine in diet had no significant effect on egg weight, protein height, yolk color, Hastelloy unit, eggshell strength, eggshell thickness and egg shape index on 14 d (P>0.05). Compared with group Ⅰand group Ⅱ, the protein height of group Ⅲ and group Ⅳ was significantly increased on 28 d (P<0.05). Compared with group Ⅰ, the Hastelloy unit of group Ⅲ and group Ⅳ was significantly increased on 28 d (P<0.05). The study indicates that adding 1.0% and 1.5% fermented Chinese herbal medicines can improve the sand-shell egg rate of Roman pink laying hens during late laying period, and increase the egg Hastelloy unit and protein height. [ABSTRACT FROM AUTHOR]

BACKGROUND: Tissue engineering technology was used to construct and form tissue engineering, tubes which can significantly reduce the incidence of various perioperative complications with good anti-urine leakage performance in vitro. OBJECTIVE: To evaluate the feasibility of using adipose stem cells and expanded polytetrafluoroethylene to construct tissue-engineered urine outflow tract in vitro for canine urinary diversion surgery. METHODS: In the experimental group, adipose stem cells were isolated and cultured from four female beagles, and then differentiated into urothelial cells in vitro for 14 days. The differentiated cells were implanted on the inner surface of expanded polytetrafluoroethylene tubes to form a tissue-engineered urinary diversion device. Bladders were removed from dogs ///9only 1.0 cm × 1.0 cm of trigonometric area was retained), and both ends of the tissue engineered urinary diversion device were anastomosed with trigonometric area and abdominal wall respectively to complete the urinary diversion operation. The samples were collected at 1, 2, 4 and 8 weeks postoperatively. The control group (two dogs) underwent urinary diversion with expanded polytetrafluoroethylene engineered tube, and samples were collected 8 weeks after operation. The animal experiment was approved by laboratory animal ethics committee of Renmin Hospital of Wuhan University (approval No. WDRM（Fu）20180810). RESULTS AND CONCLUSION: (1) There were different degrees of adhesion between the two groups of implanted tissue-engineered urinary diversion devices and the abdominal wall or intestinal wall. Two dogs of the experimental group had mild hydronephrosis, and no serious complications such as urinary exosmosis or infection. One dog in the control group developed severe urinary fistula and died 7 weeks after operation. The tissue-engineered urinary diversion device of the other dog was covered with stones. (2) Hematoxylin-eosin staining showed that thin epithelial cells with loose intercellular connections began to grow continuously in the outflow tract lumen of the experimental group 1 week after operation. At 2 weeks postoperatively, the intercellular connections became dense and the number of epithelial cells increased. Four weeks after operation, the cells began to accumulate and thicken, and gradually changed into a multilayer structure. The entire lumen was covered by the epidermis, and neovascularization was observed 8 weeks after surgery. (3) The results showed that it was feasible to construct tissue-engineered urine outflow tract together with expanded polytetrafluoroethylene after adipose stem cells were differentiated into urothelial cells for urinary diversion in beagles. The inner cavity of outflow tract could form a tightly connected urothelial cortex with the function of draining urine and preventing urinary extravasation. [ABSTRACT FROM AUTHOR]

First-principles calculations were performed to systematically study the electronic structure and hydrogen evolution properties of the amorphous carbon monolayers. Our results show that compared with a pristine graphene, the C - C bonds in the disordered structure undergo different degrees of stretching or compression within 26 . 7 %. The atomic charge of C atoms changes in the range of - 0. 17 - + 0. 16 electrons, resulting in electron localization on some C atoms. The localization of electrons enhances the chemical activity of the C atoms and hence the adsorption to alien atoms. The bonding of H atom with C atom and the hydrogen evolution performance were found to be correlated with the bond angles of the C atoms. For a triple - coordinate carbon atom, three valence electrons combine strongly with the nearest carbon atom through the sp2 hybridization and the remaining p, orbital electron being unbonded. This electron could bond with adsorbates with relatively weak bonding. The symmetry of the three sp2 hybrid orbitals is broken by the disordered structure, which affects the bonding between the p, orbitals and hydrogen. We found that the adsorption strength of this bond could be modified by tuning the angles of C - C bonds. Our results could provide deep insight into the correlation of structures and properties of amorphous carbon monolayer. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of dexmedetomidine combined with different doses of midazolam on hemodynamics, postoperative inflammatory mediators and cognitive function in patients with non-small cell lung cancer (NSCLC). Methods: NSCLC patients (n=120) who came to the First Affiliated Hospital of Zhengzhou University for surgical treatment from January 2019 to February 2021 were included and divided into low-dose group (n=60) and high-dose group according to different anesthesia regimens Group (n=60), both groups were given dexmedetomidine, on this basis, the low-dose group was given 0.05 mg/kg midazolam, and the high-dose group was given 0.10 mg/kg midazolam. The hemodynamics, inflammatory mediators, cognitive function, recovery quality and incidence of adverse reactions were compared between the two groups. Results: The heart rate (HR) and mean arterial pressure (MAP) increased and then decreased at the time points from 10 minutes after induction of anesthesia (T1) to 5 minutes after extubation (T3) in the two groups, and immediately after extubation (T2) and T3 time points The high-dose group was lower than the low-dose group (P<0.05). The visual analogue scale (VAS) score of pain after awakening in the high-dose group was lower than that in the low-dose group, and the eye opening time, extubation time, and anesthesia recovery room (PACU) stay time were all shorter than those in the low-dose group (P<0.05). The levels of interleukin-1 (IL-1), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) in the two groups increased before operation, 3 days after operation, and 7 days after operation, and then decreased, and 3 days after operation., 7 days after operation in the high-dose group was lower than that in the low-dose group (P<0.05). There was no significant difference in the Mini Mental State Scale (MMSE) scores between the two groups at 1 day, 3 days and 7 days after operation (P>0.05). There was no statistical difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Compared with 0.05 mg/kg midazolam, dexmedetomidine combined with 0.10 mg/kg midazolam in patients with NSCLC surgery can maintain hemodynamic stability, improve the quality of recovery, and reduce inflammatory stress. The effect is more significant, and it does not increase the incidence of cognitive impairment and adverse reactions. [ABSTRACT FROM AUTHOR]

In the process of melting point measurement of high-lead slag in copper removal anode slime smelting, the results may deviate from the " true value " due to evaporation ( referred to as "uncertainty") . In this article, high-lead slag produced by the Kaldor furnace process for copper removal anode slime smelting was taken as object, a method was suggested to predict the timely slag composition during the heating process based on evaporation mechanism,and to use the timely slag composition to correspond to the measured melting point to eliminate the effect of evaporation. The FactSage 7. 1 software was used to calculate the melting point of the smelting slag and the ΔG of the evaporation reaction, the melting points were measured by the hemisphere method, and the weight loss of the slag samples were measured by TG. The resultss how that the weight loss of lead-containing slag at high temperature is mainly caused by the evaporation of PbO and a small amount of Bi2O3, As4O6, TeO2, SeO2 and Sb4O6 • The evaporation is obvious at the hight emperature of 950～1200 ℃, when the PbO content is 14.52 %, 25.07 %, 28.75 % and 41.25 % respectively, the slag evaporation rates can reach 35.25 %, 49.48 %, 55.92 % and 58.39 % respectively. The melting point calculated by FactSage is higher than the measured hemis pherical point and flow temperature. The measured hemispheric point temperature and flow temperature of the high-lead slag smelted from copper removal anode slime correspond to the timely slag composition (based on the calculation of the original slag composition and evaporation weight loss), and a new composition-melting point relationship closer to the "true value" is obtained. [ABSTRACT FROM AUTHOR]

[Objectives J The study aimed to study the control effect of botanical pesticide azadirachtin against Ostrinia furnacalis in sorghum. [ Methods J The activity of azadirachtin against 0. furnacalis was determined by diet incorporation method in the laboratory, the control efficacy was investigated in the three sorghum fields, and the safety evaluation on three sorghum varieties was determined by pot method. [ Results J Under indoor condition, the LC50 value of 2nd ins tar larvae was 6.44 mg· L- 1 , and the activity was relative high. The efficacy on plant protection and insect control effects in three provinces were ranged from 80.07% to 89.26% and 73.51 % to 87.31 %,and those were significantly better than control pesticides. The growth inhibition rate of 0.3% azadirachtin emulsifiable concentrate at the dosage of 18 g • hm - 2 was significantly higher than 4.5, 9 g • hm - 2 for three sorghum varieties, one plant of all three sorghum varieties showed leaf edge chlorosis,and one plant of 'Chiza No.16' showed leaf edge chlorosis of 0.3% azadirachtin emulsifiable concentrate at the dosage of 9 g • hm - 2 after 14 d of spraying, the growth of three sorghum varieties was normal and safe for sorghum. [ Conclusions] Azadirachtin had good toxicity activity and control effect against O.furnacalis,and it was safe for sorghum. [ABSTRACT FROM AUTHOR]

The variable runoff generation layer concept was proposed based on newly acquired understanding of hillslope hydrological experiments. This concept expands the description of interflow from the soil horizon to the soilweathering bedrock interface and provides a unified description of the infiltration excess and saturation excess runoff and their conversion mechanism via meticulous depiction of the interflow formation and development process. Based on the concept of the variable generation layer and theory of the kinematic wave model, calculation equations for the infiltration excess (Horton) surface runoff, saturation excess (Dunne) surface runoff, and interflow of a unit grid were derived. The nonlinear reservoir method, 2-d diffusion wave equation, and 1-d diffusion wave equation were applied to separately calculate the groundwater flow, surface runoff routing, and channel flow routing, based on which a variable runoff generation layer distributed hydrological model (VRGL) was established. The VRGL was then applied to the Tunxi watershed, a typical humid watershed in the hilly region. A total of 24 flood events from 2010 to 2019 were studied, and the results indicated that the relative error of both the flood peak and flood volume remained within ± 20%, and the Nash- Sutcliffe efficiency value reached approximately 0. 84. It was indicated that the accuracy of the VRGL was sufficiently high for flood forecasting in hilly regions. [ABSTRACT FROM AUTHOR]

Coalbed methane high efficiency production from broken soft and low permeable coal seams has been being a technical bottleneck of restricting coalbed methane industrialization development and coal mine gas control for many years.This paper has investigated the No.8 broken soft and low permeable coal seam in Lulling coal mine of Huaibei mining area in Anhui Province,China.Site investigation,sampling and testing,theoretical analysis,hydraulic fracture physical and numerical simulation have been performed.As a result,a new model of coalbed methane high efficiency production from broken soft and low permeable coal seam by roof strata-in horizontal well and staged hydraulic fracture has been presented,the hydraulic fracture extension and control mechanism under this model have been revealed,and the main technological processes of the model implementation have been given.The results show that the roof strata are relatively brittle and have high propagation pressures,while the broken soft coal seam is relatively plastic and has a low propagation pressure.When case perforation and hydraulic fracture are performed in horizontal well of the roof strata,the hydraulic fractures in roof strata,on the vertical,extend downward and penetrate the broken soft coal seam.At the same time,the hydraulic fractures also get rapid horizontal extension,and the traction engendered by this rapid horizontal extension rips the coal seam to form long hydraulic fractures in the coal seam.Numerical simulation results show that the hydraulic fracture length formed in the broken soft and low permeable coal seam when fracturing in roof strata is long as 6.7 times as that when fracturing directly in the coal seam.Those hydraulic fractures formed in the roof strata and the broken soft coal seam are filled with sand proppant in follow-up adding-sand fracturing,and come into being a coalbed methane migration pathway from the underlying coal seam to the roof strata-in horizontal well.It can be seen that broken soft coal seam can get a good fracturing stimulation effect in this new model.The results of this study are applied to the coalbed methane development demonstration project by roof strata-in horizontal well and staged hydraulic fracture in Luling coal mine of Huaibei mining area in Anhui province,China and have obtained a good gas production effect.The average daily gas production rate of the single coalbed methane horizontal well was respectively 10 358 m3,9 039 m3,7 921 m3 in three,six and twelve consecutive months.As of November,16,2017,this horizontal well already produced 5 million cubic meters of coalbed methane gas,and its daily gas production rate was still over 3 200 m3.This has created a new record of gas production of a single coalbed methane horizontal well from broken soft and low permeable coal seam in China. [ABSTRACT FROM AUTHOR]