451. Integrated genome-wide gene expression map and high-resolution analysis of aberrant chromosomal regions in squamous cell lung cancer
- Author
-
Yongjing Xia, Yiqing Wu, Xiangjun Liu, Feng Tian, Xiaoping Miao, Yongping Cui, Ying Hu, and Xinyu Zhang
- Subjects
Gene expression map ,Lung Neoplasms ,Microarray ,Biophysics ,Biology ,Biochemistry ,Genome ,Loss of heterozygosity ,Aberrant chromosomal region ,Structural Biology ,Squamous cell carcinoma ,Genetics ,medicine ,Humans ,Microarray databases ,Molecular Biology ,Chromosome Aberrations ,Regulation of gene expression ,Genome, Human ,Cancer ,Cell Biology ,medicine.disease ,Gene Expression Regulation, Neoplastic ,Moving-median method ,Carcinoma, Squamous Cell ,Cancer research ,Human genome ,Chromosomes, Human, Pair 3 ,Comparative genomic hybridization - Abstract
The recognition of recurrent aberrant regions in cancer is important to the discovery of candidate cancer related genes. Here we first constructed a genome-wide gene expression map of squamous lung carcinoma from the Stanford Microarray Database. High-resolution detection of aberrant chromosomal regions was performed by using moving-median method. 84% (27 of 32) of our results were consistent with the previous studies of comparative genomic hybridization or loss of heterozygosity. One overrepresented region in Xq28 was newly discovered to be related to squamous cell lung carcinoma. These observations could be of great interest for further studies.
- Full Text
- View/download PDF