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Your search keyword '"Whitehouse, M. W."' showing total 329 results
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329 results on '"Whitehouse, M. W."'

301. Beta-xylosidase and beta-galactosidase activities of mammalian connective tissues and other sources.

Author

Fisher D, Whitehouse MW, and Kent PW

Subjects
Animals, Aorta enzymology, Brain enzymology, Cattle, Cornea enzymology, Kidney enzymology, Lung enzymology, Mast Cells enzymology, Mice, Myocardium enzymology, Rabbits, Rats, Skin enzymology, Spleen enzymology, Cartilage enzymology, Glycoside Hydrolases analysis, Liver enzymology, Plants enzymology
Published
1967
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302. Catabolism of 2-methyloctanoic acid and 3beta-hydroxycholest-5-en-26-oic acid.

Author

Dean PD and Whitehouse MW

Abstract

1. 2-Methyl[1-(14)C]octanoic acid was synthesized from 2-bromo-octane and (14)CO(2). 2. 2-Methyl[1-(14)C]octanoic acid was readily oxidized to propionic acid and carbon dioxide by mitochondrial preparations from liver, less readily oxidized by adrenal and kidney (mitochondria), and only poorly oxidized by heart, spleen and brown fat (mitochondria). 3. 3beta-Hydroxy[26-(14)C]cholest-5-en-26-oic acid was rapidly oxidized by mammalian-liver mitochondria to propionic acid and carbon dioxide. Caiman-liver and toad-liver mitochondria also oxidized this steroid acid. 4. The oxidation of propionic acid, octanoic acid and palmitic acid by mitochondrial preparations from these various tissues was also studied. 5. Added carnitine did not stimulate 2-methyloctanoic acid oxidation and feebly stimulated 3beta-hydroxycholest-5-en-26-oic acid oxidation. 6. The significance of these results is discussed in relation to sterol catabolism in mammals and non-mammalian species.

Published
1966
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303. Species differences in the albumin binding of 2,4,6-trinitrobenzaldehyde, chlorophenoxyacetic acids, 2-(4'-hydroxybenzeneazo)benzoic acid and some other acidic drugs--the unique behavior of rat plasma albumin.

Author

Witiak DT and Whitehouse MW

Subjects
Animals, Anticholesteremic Agents pharmacology, Cattle, Dialysis, Guinea Pigs, Indoleacetic Acids pharmacology, Indomethacin metabolism, Indomethacin pharmacology, Nicotinic Acids metabolism, Phenylbutazone metabolism, Propionates metabolism, Protein Binding, Rats, Thyroxine pharmacology, Acetates metabolism, Aldehydes metabolism, Benzoates metabolism, Serum Albumin metabolism, Species Specificity
Published
1969
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305. Effect of adjuvant disease in rats on cyclophosphamide and isophosphamide metabolism.

Author

Beck FJ and Whitehouse MW

Subjects
Animals, Arthritis chemically induced, Chromatography, Thin Layer, Cobalt pharmacology, Colorimetry, Cricetinae, Freund's Adjuvant, Graft vs Host Reaction, Liver metabolism, Mice, Mice, Inbred Strains, Microsomes, Liver metabolism, Mononuclear Phagocyte System metabolism, Mycobacterium tuberculosis immunology, Proteins metabolism, Rats, Rats, Inbred Strains, Sleep drug effects, Time Factors, Adjuvants, Immunologic, Arthritis metabolism, Cyclophosphamide metabolism, Dimethoate metabolism
Published
1973
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306. Impaired drug metabolism in rats with adjuvant-induced arthritis: a brief review.

Author

Whitehouse MW and Beck FJ

Subjects
Aminopyrine metabolism, Aniline Compounds metabolism, Animals, Arthritis, Rheumatoid immunology, Barbiturates pharmacology, Carbon Radioisotopes, Corynebacterium, Cricetinae, Cyclophosphamide pharmacology, Cytochrome P-450 Enzyme System metabolism, Disease Models, Animal, Guinea Pigs, Liver drug effects, Methyltransferases metabolism, Mice, Microsomes, Liver enzymology, Mycobacterium, Oxidoreductases metabolism, Phenobarbital pharmacology, Rats, Sleep drug effects, Time Factors, Arthritis, Rheumatoid metabolism, Freund's Adjuvant, Pharmaceutical Preparations metabolism
Published
1973

307. Some biochemical properties of thio analogues of salicylic acid.

Author

Burke JF and Whitehouse MW

Subjects
Alcohol Oxidoreductases metabolism, Animals, In Vitro Techniques, Liver cytology, Malate Dehydrogenase metabolism, Phenols pharmacology, Rats, Antimetabolites pharmacology, Mitochondria metabolism, Oxidative Phosphorylation drug effects, Salicylates pharmacology, Sulfhydryl Compounds pharmacology
Published
1965
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308. Effects of colchicine in rats with urate crystal-induced inflammation.

Author

Denko CW and Whitehouse MW

Subjects
Adrenal Glands drug effects, Animals, Body Weight drug effects, Colchicine toxicity, Crystallization, Edema chemically induced, Edema metabolism, Inflammation chemically induced, Male, Mitosis drug effects, Organ Size, Phosphorus metabolism, Phosphorus Isotopes, Podophyllin pharmacology, Rats, Spleen drug effects, Sulfur metabolism, Sulfur Isotopes, Thymus Gland drug effects, Toxins, Biological pharmacology, Colchicine pharmacology, Gout chemically induced, Inflammation metabolism, Uric Acid
Published
1970
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309. Species difference in the competitive binding of 2-(4'-hydroxybenzeneazo)benzoic acid (HBABA) and alpha-(4-chlorophenoxy)-alpha-methylpropionic acid (CPMPA) to serum albumin. A possible model system for studying allosteric transitions.

Author

Witiak DT, Sokoloski TD, Whitehouse MW, and Hermann F

Subjects
Animals, Benzoates analysis, Dialysis, Guinea Pigs, Humans, Optical Rotatory Dispersion, Postural Balance, Protein Binding, Rabbits, Rats, Serum Albumin analysis, Spectrophotometry, Benzoates metabolism, Propionates metabolism, Serum Albumin metabolism, Species Specificity
Published
1969
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310. Biochemical properties of anti-inflammatory drugs. XII. Inhibition of urate binding to human albumin by salicylate and phenylbutazone analogues and some novel anti-antiflammatory drugs.

Author

Whitehouse MW, Kippen I, and Klinenberg JR

Subjects
Binding Sites, Dimethyl Sulfoxide, Dimethylformamide, Gentisates, Humans, Kidney Tubules physiology, Sulfonamides, Anti-Inflammatory Agents, Dansyl Compounds, Phenylbutazone, Protein Binding drug effects, Salicylates, Serum Albumin, Structure-Activity Relationship, Uric Acid antagonists & inhibitors, Uricosuric Agents
Published
1971
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311. Urate deposition disease. How is it regulated and how can it be modified?

Author

Klinenberg JR, Bluestone R, Schlosstein L, Waisman J, and Whitehouse MW

Subjects
Animals, Blood Proteins metabolism, Disease Models, Animal, Gout metabolism, Gout physiopathology, Humans, Hydrogen-Ion Concentration, Kidney metabolism, Kidney physiopathology, Kidney Diseases chemically induced, Metabolic Diseases physiopathology, Protein Binding, Rats, Sodium blood, Temperature, Uric Acid metabolism, Uricosuric Agents pharmacology, Uric Acid blood
Published
1973
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313. BIOCHEMICAL PROPERTIES OF ANTI-INFLAMMATORY DRUGS--III. UNCOUPLING OF OXIDATIVE PHOSPHORYLATION IN A CONNECTIVE TISSUE (CARTILAGE) AND LIVER MITOCHONDRIA BY SALICYLATE ANALOGUES: RELATIONSHIP OF STRUCTURE TO ACTIVITY.

Author

WHITEHOUSE MW

Subjects
Animals, Cattle, Rats, Anilides, Anti-Inflammatory Agents, Antimetabolites, Azides, Benzoates, Cartilage, Connective Tissue, Hydroxamic Acids, Liver cytology, Manometry, Metabolism, Mitochondria, Mitochondria, Liver, Naphthalenes, Nitrophenols, Oxidative Phosphorylation, Pharmacology, Phosphates, Phosphorus Isotopes, Piperidines, Research, Salicylamides, Salicylates, Sulfates, Sulfur Isotopes, Trachea, ortho-Aminobenzoates
Published
1964
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314. The effects of mepyrapone (SU 4885) and some hypercholesterolaemic drugs on hepatic sterol and fatty acid oxidation.

Author

Dean PD and Whitehouse MW

Subjects
Animals, Carnitine metabolism, Cattle, Drug Antagonism, Female, Liver cytology, Liver enzymology, Male, Mice, Myocardium cytology, NAD metabolism, Oxidation-Reduction, Proadifen pharmacology, Pyridines pharmacology, Rats, Triparanol pharmacology, Anticholesteremic Agents pharmacology, Cholesterol pharmacology, Fatty Acids metabolism, Metyrapone pharmacology, Mitochondria drug effects, Mitochondria metabolism, Oxidoreductases metabolism, Sterols metabolism
Published
1967
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315. Catabolism in vitro of cholesterol. III. Oxidation of 3 alpha, 7 alpha, 12 alpha-trihydroxy-coprostane, 3 alpha, 7 alpha, 12 alpha-trihydroxy-24-ketocoprostane, and 3 alpha, 7 alpha, 12 alpha, 24-tetrahydroxycoprostane by rat liver mitochondria.

Author

WHITEHOUSE MW, STAPLE E, and GURIN S

Subjects
Animals, In Vitro Techniques, Rats, Cholesterol metabolism, Lipid Metabolism, Liver metabolism, Mitochondria metabolism, Mitochondria, Liver, Oxidation-Reduction, Steroids chemistry
Published
1961

318. Effect of gold preparations on the development and passive transfer of experimental allergic encephalomyelitis in rats. 1.

Author

Gerber RC, Whitehouse MW, and Orr KJ

Subjects
Animals, Body Weight drug effects, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental immunology, Gold administration & dosage, Gold blood, Gold pharmacology, Immunity, Maternally-Acquired, Immunization, Immunization, Passive, Lymph Nodes immunology, Male, Paralysis drug therapy, Rats, Rats, Inbred Strains, Time Factors, Encephalomyelitis, Autoimmune, Experimental drug therapy, Gold therapeutic use
Published
1972
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319. Selective inhibition of thymidine incorporation into lymphocytes by cucurbitacins B and D.

Author

Whitehouse MW and Doskotch RW

Subjects
Amino Acids metabolism, Animals, Bursa of Fabricius metabolism, Carbon Isotopes, Chickens, Chromatography, Paper, Electrophoresis, Lymphocytes drug effects, Nucleosides metabolism, Plants analysis, Terpenes isolation & purification, Tritium, Uridine metabolism, Lymphocytes metabolism, Terpenes pharmacology, Thymidine metabolism
Published
1969
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321. Studies with some novel uricosuric agents and their metabolites: correlation between clinical activity and drug-induced displacement of urate from its albumin-binding sites.

Author

Schlosstein LH, Kippen I, Whitehouse MW, Bluestone R, Paulus HE, and Klinenberg JR

Subjects
Adult, Aged, Benzophenones pharmacology, Benzophenones therapeutic use, Binding Sites, Binding, Competitive, Creatinine urine, Dansyl Compounds, Fluorine pharmacology, Fluorine therapeutic use, Gout drug therapy, Halofenate pharmacology, Halofenate therapeutic use, Humans, Male, Middle Aged, Purinones urine, Sulfathiazoles pharmacology, Sulfathiazoles therapeutic use, Sulfonamides pharmacology, Sulfonamides therapeutic use, Uric Acid urine, Uricosuric Agents pharmacology, Serum Albumin metabolism, Uric Acid blood, Uricosuric Agents therapeutic use
Published
1973

323. Effect of some uricosuric and anti-inflammatory drugs on the binding of uric acid to human serum albumin in vitro.

Author

Bluestone R, Kippen I, Klinenberg JR, and Whitehouse MW

Subjects
Allopurinol pharmacology, Aspirin pharmacology, Binding Sites, Caprylates pharmacology, Colchicine pharmacology, Dialysis, Fluorescence, Humans, In Vitro Techniques, Indomethacin pharmacology, Mefenamic Acid pharmacology, Phenylbutazone pharmacology, Probenecid pharmacology, Sodium Salicylate pharmacology, Sulfinpyrazone pharmacology, Anti-Inflammatory Agents pharmacology, Protein Binding drug effects, Serum Albumin, Uric Acid, Uricosuric Agents pharmacology
Published
1970

325. Potential antileukemic and immunosuppressive drugs. II. Further studies with benzo-2,1,3-oxadiazoles (benzofurazans) and their N-oxides (benzofuroxans).

Author

Ghosh PB and Whitehouse MW

Subjects
Amino Acids analysis, Amino Acids biosynthesis, Animals, Bursa of Fabricius cytology, Carbon Isotopes, Chemical Phenomena, Chemistry, Chickens, Lymphocytes metabolism, Rabbits, Thymidine biosynthesis, Thymus Gland cytology, Tritium, Uridine biosynthesis, Antineoplastic Agents pharmacology, Benzofurans chemical synthesis, Benzofurans pharmacology, Immunosuppressive Agents pharmacology
Published
1969
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327. 4-nitrobenzofurazans and 4-nitrobenzofuroxans: a new class of thiol-neutralising agents and potent inhibitors of nucleic acid synthesis in leucocytes.

Author

Whitehouse MW and Ghosh PB

Subjects
Animals, Benzene Derivatives, Ethylmaleimide pharmacology, Glutathione pharmacology, In Vitro Techniques, Indicators and Reagents pharmacology, Lymphocytes metabolism, Naphthoquinones pharmacology, Oximes pharmacology, Sheep, Thiazoles pharmacology, Tritium, Uridine metabolism, ortho-Aminobenzoates pharmacology, Cyclic N-Oxides pharmacology, Leukocytes metabolism, Oxadiazoles pharmacology, RNA biosynthesis, Sulfhydryl Compounds
Published
1968
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328. Uncoupling of oxidative phosphorylation by glycyrrhetic acid, fusidic acid and some related triterpenoid acids.

Author

Whitehouse MW, Dean PD, and Halsall TG

Subjects
Adenine Nucleotides metabolism, Adenosine Triphosphate metabolism, Animals, Cartilage metabolism, Cattle, Citrates metabolism, Glutamates metabolism, In Vitro Techniques, Liver metabolism, Oxygen Consumption drug effects, Phosphorus Isotopes, Pyruvates metabolism, Rats, Serum Albumin, Bovine metabolism, Succinates metabolism, Sulfur Isotopes, Fusidic Acid pharmacology, Mitochondria metabolism, Oxidative Phosphorylation drug effects, Terpenes pharmacology
Published
1967
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