501. Alteration of the cytotoxic action of sensitized lymphocytes by cholinergic agents and activators of adenylate cyclase.
- Author
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Strom TB, Deisseroth A, Morganroth J, Carpenter CB, and Merrill JP
- Subjects
- Acetylcholine pharmacology, Animals, Butyrates pharmacology, Carbachol pharmacology, Cholera, Cyclic AMP pharmacology, Enzyme Activation drug effects, Female, Lymphocytes immunology, Male, Prostaglandins pharmacology, Rats, Rats, Inbred BN, Rats, Inbred Lew, Receptors, Cholinergic, Skin Transplantation, Spleen immunology, Theophylline pharmacology, Thymus Gland immunology, Toxins, Biological pharmacology, Transplantation Immunology, Transplantation, Homologous, Adenylyl Cyclases metabolism, Isoantigens metabolism, Lymphocytes drug effects, Parasympathomimetics pharmacology
- Abstract
The cytotoxic action of lymphocytes upon cells bearing alloantigens to which they are sensitized is inhibited by agents that elevate intracellular amounts of 3':5'-cyclic AMP: prostaglandin E(1), cholera toxin, and theophylline. Cholinergic agents, added in the range of 1 to 100 pM, enhance cytotoxicity, an effect that is blocked by atropine. Because cholinergic agents elevate cyclic GMP in other in vitro systems, these findings suggest that the cytotoxic process effected by sensitized lymphocytes is a secretory phenomenon modulated by cyclic AMP and cyclic GMP.
- Published
- 1972
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