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401. Statistics for Biologists, 2nd edition (Book).

Author

B.S.P., Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
STATISTICS, NONFICTION
Abstract

Reviews the book "Statistics for Biologists," 2nd ed., by R.C. Campbell.

Published
1975
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402. Linkage and Retrieval of Microeconomic Data (Book).

Author

McClung, Nelson, Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
MICROECONOMICS, NONFICTION
Abstract

Reviews the book "Linkage and Retrieval of Microeconomic Data," by Martin H. David, William A. Gates and Roger F. Miller.

Published
1975
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403. Applicable Finite Mathematics (Book).

Author

McKay, Michael D., Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
MATHEMATICS, MATHEMATICAL statistics, NONFICTION
Abstract

Reviews the book "Applicable Finite Mathematics," by David S. Moore and James W. Yackel.

Published
1975
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404. Basic Statistics (Book).

Author

Tiahrt, Kenneth J., Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
STATISTICS, NONFICTION
Abstract

Reviews the book "Basic Statistics: A Modern Approach," by Morris Hamburg.

Published
1975
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405. Applied Statistical Methods (Book).

Author

Larntz, Kinley, Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
STATISTICS, NONFICTION
Abstract

Reviews the book "Applied Statistical Methods," by Irving W. Burr.

Published
1975
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406. Characterization Problems in Mathematical Statistics (Book).

Author

Laha, R.G., Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
MATHEMATICAL statistics, NONFICTION
Abstract

Reviews the book "Characterization Problems in Mathematical Statistics," by A. M. Ragan, Yu V. Linnik and C. Radhakrishna Rao.

Published
1975
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407. Methods for Statistical Analysis of Reliability and Life Data (Book).

Author

Collins, John R., Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., E. Tarter, Michael, Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
QUANTITATIVE research, NONFICTION
Abstract

Reviews the book "Methods for Statistical Analysis of Reliability and Life Data," by Nancy R. Mann, Ray E. Schafer and Nozer D. Singpurwalla.

Published
1975
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408. Statistical Analysis for Administrative Decisions, 2nd edition / Statistical Analysis / Statistical Analysis and Modeling for Management Decision-Making (Book).

Author

Benjamin, Bernard, Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
NONFICTION
Abstract

Reviews three books. "Statistical Analysis for Administrative Decisions," 2nd ed., by Charles T. Clark and Lawrence L. Schkade; "Statistical Analysis: A Decision-Making Approach," by Robert Parsons; "Statistical Analysis and Modeling for Management Decision-Making," by Raymond E. Willis and Norman L. Chervany.

Published
1975
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409. Random Processes, 2nd edition (Book).

Author

M.H.D., Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
STOCHASTIC processes, NONFICTION
Abstract

Reviews the book "Random Processes," 2nd ed., by Murray Rosenblatt.

Published
1975
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410. Statistics for Comparative Studies (Book).

Author

P.K.S., Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
STATISTICS, NONFICTION, COMPARATIVE studies
Abstract

Reviews the book "Statistics for Comparative Studies," by Michael Hills.

Published
1975
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411. Data Analysis for Scientists and Engineers (Book).

Author

Duncan, George T., Aigner, Dennis J., Andrews, david F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
DATA analysis, MATHEMATICAL analysis, NONFICTION
Abstract

Reviews the book "Data Analysis for Scientists and Engineers," by Stuart L. Meyer.

Published
1975
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412. Multivariate Analysis III (Book).

Author

D.S.M, Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
MULTIVARIATE analysis, STATISTICS, NONFICTION
Abstract

Reviews the book "Multivariate Analysis III," edited by Paruchuri R. Krishnaiah.

Published
1975
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413. Living Statistics (Book).

Author

D.S.M., Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
STATISTICS, NONFICTION
Abstract

Reviews the book "Living Statistics: An Introductory Text for West African Students," by John Bibby.

Published
1975
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414. Sturdy Statistics (Book).

Author

D.S.M., Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
STATISTICS, NONFICTION
Abstract

Reviews the book "Sturdy Statistics: Nonparametrics and Order Statistics," by Frederick Mosteller and Robert E.K. Rourke.

Published
1975
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415. Statistics (Book).

Author

Meyer, Donald L., Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
STATISTICS, NONFICTION
Abstract

Reviews the book "Statistics: The Essentials for Research," 2nd ed., by Henry E. Klugh.

Published
1975
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416. Risk, Choice, and Prediction, An Introduction to Experimentation (Book).

Author

Urquhart, N. Scott, Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., and Frankel, Martin

Subjects
PROBABILITY theory, NONFICTION
Abstract

Reviews the book "Risk, Choice, and Prediction, an Introduction to Experimentation," by W.J. Youden.

Published
1975
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417. Linear Statistical Inference and Its Applications, 2nd edition (Book).

Author

Fienberg, Stephen E., Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
MATHEMATICAL statistics, STATISTICS, NONFICTION
Abstract

Reviews the book "Linear Statistical Inference and Its Applications," 2nd ed., by C. Radhakrishna Rao.

Published
1975
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418. Understanding Statistical Reasoning (Book).

Author

Arney, William Ray, Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Qaude, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
PSYCHOLOGY, STATISTICS, NONFICTION
Abstract

Reviews the book "Understanding Statistical Reasoning: How to Evaluate Research Literature in the Behavioral Sciences," by Eleanor Walker Willemsen.

Published
1975
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419. Unemployment and Inflation (Book).

Author

Rhodes, George, Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
UNEMPLOYMENT, NONFICTION
Abstract

Reviews the book "Unemployment and Inflation: The New Economics of the Wage-Price Spiral," by Roger L. Miller and Raburn M. Williams.

Published
1975
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420. Geomathmatics (Book).

Author

Watson, G.S., Aigner, Dennis J., Andrews, David F., Kmenta, J., Ericson, William A., Hinkley, David V., Hoaglin, David C., Quade, Dana, Rausser, Gordon, Sen, P.K., Winkler, Robert L., Tarter, Michael E., Symons, Michael J., Roll, Richard, Rolph, John E., Moore, David, Preston, Samuel H., Frankel, Martin, and Crow, Edwin L.

Subjects
GEOLOGY, GEOMATHEMATICS, NONFICTION
Abstract

Reviews the book "Geomathematics," by F.P. Agterberg.

Published
1975

422. Phi29 pRNA vector for efficient escort of hammerhead ribozyme targeting survivin in multiple cancer cells.

Author

Liu H, Guo S, Roll R, Li J, Diao Z, Shao N, Riley MR, Cole AM, Robinson JP, Snead NM, Shen G, and Guo P

Subjects
Apoptosis, Blotting, Western, Cell Movement, Dimerization, Drug Delivery Systems, Flow Cytometry, Gene Expression, Gene Targeting, Genetic Therapy, Humans, Inhibitor of Apoptosis Proteins, Microtubule-Associated Proteins metabolism, Necrosis, Neoplasm Proteins metabolism, Neoplasms genetics, Neoplasms metabolism, RNA, Catalytic genetics, RNA, Messenger genetics, RNA, Messenger metabolism, Survivin, Transfection, Tumor Cells, Cultured, Bacillus Phages genetics, Gene Silencing, Genetic Vectors, Microtubule-Associated Proteins genetics, Neoplasm Proteins genetics, Neoplasms therapy, RNA Phages genetics, RNA, Catalytic therapeutic use
Abstract

Ribozymes are potential therapeutic agents which suppress specific genes in disease-affected cells. Ribozymes have high substrate cleavage efficiency, yet their medical application has been hindered by RNA degradation, aberrant cell trafficking, or misfolding when fused to a carrier. In this study, we constructed a chimeric ribozyme escorted by the motor pRNA of bacteriophage phi29 to achieve proper folding and enhanced stability. A pRNA molecule contains an interlocking loop domain and a 5'/3' helical domain, which fold independently of one another. When a ribozyme is connected to the helical domain, the chimeric pRNA/ribozyme reorganizes into a circularly permuted form, and the 5'/3' ends are relocated and buried in the original 71'/75' positions. Effective silencing of the anti-apoptotic gene survivin by an appropriately designed chimeric ribozyme, as demonstrated at mRNA and protein levels, led to programmed cell death in various human cancer cell lines, including breast, prostate, cervical, nasopharyngeal, and lung, without causing significant non-specific cytotoxicity. Through the interlocking interaction of right and left loops, monomer pRNA/ribozyme chimeras can be incorporated into multi-functional dimer, trimer and hexamer complexes for specific gene delivery. Using the phi29 motor pRNA as an escort may revive the ribozyme's strength in medical application.

Published
2007
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