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6,103 results on '"Maxwell, M."'

504. The Impact of Treatments for OSA on Monetized Health Economic Outcomes

Author

Wickwire, Emerson M., primary, Albrecht, Jennifer S., additional, Towe, Maxwell M., additional, Abariga, Samuel A., additional, Diaz-Abad, Montserrat, additional, Shipper, Andrea G., additional, Cooper, Liesl M., additional, Assefa, Samson Z., additional, Tom, Sarah E., additional, and Scharf, Steven M., additional

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2019
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512. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data

Author

Campbell, Bruce C V, primary, Majoie, Charles B L M, additional, Albers, Gregory W, additional, Menon, Bijoy K, additional, Yassi, Nawaf, additional, Sharma, Gagan, additional, van Zwam, Wim H, additional, van Oostenbrugge, Robert J, additional, Demchuk, Andrew M, additional, Guillemin, Francis, additional, White, Philip, additional, Dávalos, Antoni, additional, van der Lugt, Aad, additional, Butcher, Kenneth S, additional, Cherifi, Aboubaker, additional, Marquering, Henk A, additional, Cloud, Geoffrey, additional, Macho Fernández, Juan M, additional, Madigan, Jeremy, additional, Oppenheim, Catherine, additional, Donnan, Geoffrey A, additional, Roos, Yvo B W E M, additional, Shankar, Jai, additional, Lingsma, Hester, additional, Bonafé, Alain, additional, Raoult, Hélène, additional, Hernández-Pérez, María, additional, Bharatha, Aditya, additional, Jahan, Reza, additional, Jansen, Olav, additional, Richard, Sébastien, additional, Levy, Elad I, additional, Berkhemer, Olvert A, additional, Soudant, Marc, additional, Aja, Lucia, additional, Davis, Stephen M, additional, Krings, Timo, additional, Tisserand, Marie, additional, San Román, Luis, additional, Tomasello, Alejandro, additional, Beumer, Debbie, additional, Brown, Scott, additional, Liebeskind, David S, additional, Bracard, Serge, additional, Muir, Keith W, additional, Dippel, Diederik W J, additional, Goyal, Mayank, additional, Saver, Jeffrey L, additional, Jovin, Tudor G, additional, Hill, Michael D, additional, Mitchell, Peter J, additional, Fransen, Puck SS, additional, van den Berg, Lucie A, additional, Lingsma, Hester F, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, additional, Williams, J, additional, Wiegner, R, additional, Casaubon, LK, additional, Jaigobin, C, additional, del Campo, JM, additional, Elamin, E, additional, Schaafsma, JD, additional, Agid, R, additional, Farb, R, additional, ter Brugge, K, additional, Sapkoda, BL, additional, Baxter, BW, additional, Barton, K, additional, Knox, A, additional, Porter, A, additional, Sirelkhatim, A, additional, Devlin, T, additional, Dellinger, C, additional, Pitiyanuvath, N, additional, Patterson, J, additional, Nichols, J, additional, Quarfordt, S, additional, Calvert, J, additional, Hawk, H, additional, Fanale, C, additional, Bitner, A, additional, Novak, A, additional, Huddle, D, additional, Bellon, R, additional, Loy, D, additional, Wagner, J, additional, Chang, I, additional, Lampe, E, additional, Spencer, B, additional, Pratt, R, additional, Bartt, R, additional, Shine, S, additional, Dooley, G, additional, Nguyen, T, additional, Whaley, M, additional, McCarthy, K, additional, Teitelbaum, J, additional, Poon, W, additional, Campbell, N, additional, Cortes, M, additional, Lum, C, additional, Shamloul, R, additional, Robert, S, additional, Stotts, G, additional, Shamy, M, additional, Steffenhagen, N, additional, Blacquiere, D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez- Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, P, additional, Golob, D, additional, Gladstone, D, additional, Boyle, K, additional, Boulos, M, additional, Hopyan, J, additional, Yang, V, additional, Da Costa, L, additional, Holmstedt, CA, additional, Turk, AS, additional, Navarro, R, additional, Jauch, E, additional, Ozark, S, additional, Turner, R, additional, Phillips, S, additional, Shankar, J, additional, Jarrett, J, additional, Gubitz, G, additional, Maloney, W, additional, Vandorpe, R, additional, Schmidt, M, additional, Heidenreich, J, additional, Hunter, G, additional, Kelly, M, additional, Whelan, R, additional, Peeling, L, additional, Burns, PA, additional, Hunter, A, additional, Wiggam, I, additional, Kerr, E, additional, Watt, M, additional, Fulton, A, additional, Gordon, P, additional, Rennie, I, additional, Flynn, P, additional, Smyth, G, additional, O'Leary, S, additional, Gentile, N, additional, Linares, G, additional, McNelis, P, additional, Erkmen, K, additional, Katz, P, additional, Azizi, A, additional, Weaver, M, additional, Jungreis, C, additional, Faro, S, additional, Shah, P, additional, Reimer, H, additional, Kalugdan, V, additional, Saposnik, G, additional, Bharatha, A, additional, Li, Y, additional, Kostyrko, P, additional, Marotta, T, additional, Montanera, W, additional, Sarma, D, additional, Selchen, D, additional, Spears, J, additional, Heo, JH, additional, Jeong, K, additional, Kim, DJ, additional, Kim, BM, additional, Kim, YD, additional, Song, D, additional, Lee, K-J, additional, Yoo, J, additional, Bang, OY, additional, Rho, S, additional, Lee, J, additional, Jeon, P, additional, Kim, KH, additional, Cha, J, additional, Kim, SJ, additional, Ryoo, S, additional, Lee, MJ, additional, Sohn, S-I, additional, Kim, C-H, additional, Ryu, H-G, additional, Hong, J-H, additional, Chang, H-W, additional, Lee, C-Y, additional, Rha, J, additional, Campbell, Bruce CV, additional, Churilov, Leonid, additional, Yan, Bernard, additional, Dowling, Richard, additional, Oxley, Thomas J, additional, Wu, Teddy Y, additional, Silver, Gabriel, additional, McDonald, Amy, additional, McCoy, Rachael, additional, Kleinig, Timothy J, additional, Scroop, Rebecca, additional, Dewey, Helen M, additional, Simpson, Marion, additional, Brooks, Mark, additional, Coulton, Bronwyn, additional, Krause, Martin, additional, Harrington, Timothy J, additional, Steinfort, Brendan, additional, Faulder, Kenneth, additional, Priglinger, Miriam, additional, Day, Susan, additional, Phan, Thanh, additional, Chong, Winston, additional, Holt, Michael, additional, Chandra, Ronil V, additional, Ma, Henry, additional, Young, Dennis, additional, Wong, Kitty, additional, Wijeratne, Tissa, additional, Tu, Hans, additional, Mackay, Elizabeth, additional, Celestino, Sherisse, additional, Bladin, Christopher F, additional, Loh, Poh Sien, additional, Gilligan, Amanda, additional, Ross, Zofia, additional, Coote, Skye, additional, Frost, Tanya, additional, Parsons, Mark W, additional, Miteff, Ferdinand, additional, Levi, Christopher R, additional, Ang, Timothy, additional, Spratt, Neil, additional, Kaauwai, Lara, additional, Badve, Monica, additional, Rice, Henry, additional, de Villiers, Laetitia, additional, Barber, P. Alan, additional, McGuinness, Ben, additional, Hope, Ayton, additional, Moriarty, Maurice, additional, Bennett, Patricia, additional, Wong, Andrew, additional, Coulthard, Alan, additional, Lee, Andrew, additional, Jannes, Jim, additional, Field, Deborah, additional, Salinas, Simon, additional, Cowley, Elise, additional, Snow, Barry, additional, Kolbe, John, additional, Stark, Richard, additional, King, John, additional, Macdonnell, Richard, additional, Attia, John, additional, D'Este, Cate, additional, Diener, Hans-Christoph, additional, Levy, Elad I., additional, Mendes Pereira, Vitor, additional, Albers, Gregory W., additional, Cognard, Christophe, additional, Cohen, David J., additional, Hacke, Werner, additional, Jovin, Tudor G., additional, Mattle, Heinrich P., additional, Nogueira, Raul G., additional, Siddiqui, Adnan H., additional, Yavagal, Dileep R., additional, von Kummer, Rüdiger, additional, Smith, Wade, additional, Turjman, Francis, additional, Hamilton, Scott, additional, Chiacchierini, Richard, additional, Amar, Arun, additional, Sanossian, Nerses, additional, Loh, Yince, additional, Baxter, B, additional, Reddy, VK, additional, Horev, A, additional, Star, M, additional, Siddiqui, A, additional, Hopkins, LN, additional, Snyder, K, additional, Sawyer, R, additional, Hall, S, additional, Costalat, V, additional, Riquelme, C, additional, Machi, P, additional, Omer, E, additional, Arquizan, C, additional, Mourand, I, additional, Charif, M, additional, Ayrignac, X, additional, Menjot de Champfleur, N, additional, Leboucq, N, additional, Gascou, G, additional, Moynier, M, additional, du Mesnil de Rochemont, R, additional, Singer, O, additional, Berkefeld, J, additional, Foerch, C, additional, Lorenz, M, additional, Pfeilschifer, W, additional, Hattingen, E, additional, Wagner, M, additional, You, SJ, additional, Lescher, S, additional, Braun, H, additional, Dehkharghani, S, additional, Belagaje, SR, additional, Anderson, A, additional, Lima, A, additional, Obideen, M, additional, Haussen, D, additional, Dharia, R, additional, Frankel, M, additional, Patel, V, additional, Owada, K, additional, Saad, A, additional, Amerson, L, additional, Horn, C, additional, Doppelheuer, S, additional, Schindler, K, additional, Lopes, DK, additional, Chen, M, additional, Moftakhar, R, additional, Anton, C, additional, Smreczak, M, additional, Carpenter, JS, additional, Boo, S, additional, Rai, A, additional, Roberts, T, additional, Tarabishy, A, additional, Gutmann, L, additional, Brooks, C, additional, Brick, J, additional, Domico, J, additional, Reimann, G, additional, Hinrichs, K, additional, Becker, M, additional, Heiss, E, additional, Selle, C, additional, Witteler, A, additional, Al-Boutros, S, additional, Danch, M-J, additional, Ranft, A, additional, Rohde, S, additional, Burg, K, additional, Weimar, C, additional, Zegarac, V, additional, Hartmann, C, additional, Schlamann, M, additional, Göricke, S, additional, Ringlestein, A, additional, Wanke, I, additional, Mönninghoff, C, additional, Dietzold, M, additional, Budzik, R, additional, Davis, T, additional, Eubank, G, additional, Hicks, WJ, additional, Pema, P, additional, Vora, N, additional, Mejilla, J, additional, Taylor, M, additional, Clark, W, additional, Rontal, A, additional, Fields, J, additional, Peterson, B, additional, Nesbit, G, additional, Lutsep, H, additional, Bozorgchami, H, additional, Priest, R, additional, Ologuntoye, O, additional, Barnwell, S, additional, Dogan, A, additional, Herrick, K, additional, Takahasi, C, additional, Beadell, N, additional, Brown, B, additional, Jamieson, S, additional, Hussain, MS, additional, Russman, A, additional, Hui, F, additional, Wisco, D, additional, Uchino, K, additional, Khawaja, Z, additional, Katzan, I, additional, Toth, G, additional, Cheng-Ching, E, additional, Bain, M, additional, Man, S, additional, Farrag, A, additional, George, P, additional, John, S, additional, Shankar, L, additional, Drofa, A, additional, Dahlgren, R, additional, Bauer, A, additional, Itreat, A, additional, Taqui, A, additional, Cerejo, R, additional, Richmond, A, additional, Ringleb, P, additional, Bendszus, M, additional, Möhlenbruch, M, additional, Reiff, T, additional, Amiri, H, additional, Purrucker, J, additional, Herweh, C, additional, Pham, M, additional, Menn, O, additional, Ludwig, I, additional, Acosta, I, additional, Villar, C, additional, Morgan, W, additional, Sombutmai, C, additional, Hellinger, F, additional, Allen, E, additional, Bellew, M, additional, Gandhi, R, additional, Bonwit, E, additional, Aly, J, additional, Ecker, RD, additional, Seder, D, additional, Morris, J, additional, Skaletsky, M, additional, Belden, J, additional, Baker, C, additional, Connolly, LS, additional, Papanagiotou, P, additional, Roth, C, additional, Kastrup, A, additional, Politi, M, additional, Brunner, F, additional, Alexandrou, M, additional, Merdivan, H, additional, Ramsey, C, additional, Given II, C, additional, Renfrow, S, additional, Deshmukh, V, additional, Sasadeusz, K, additional, Vincent, F, additional, Thiesing, JT, additional, Putnam, J, additional, Bhatt, A, additional, Kansara, A, additional, Caceves, D, additional, Lowenkopf, T, additional, Yanase, L, additional, Zurasky, J, additional, Dancer, S, additional, Freeman, B, additional, Scheibe-Mirek, T, additional, Robison, J, additional, Roll, J, additional, Clark, D, additional, Rodriguez, M, additional, Fitzsimmons, B-FM, additional, Zaidat, O, additional, Lynch, JR, additional, Lazzaro, M, additional, Larson, T, additional, Padmore, L, additional, Das, E, additional, Farrow-Schmidt, A, additional, Hassan, A, additional, Tekle, W, additional, Cate, C, additional, Jansen, O, additional, Cnyrim, C, additional, Wodarg, F, additional, Wiese, C, additional, Binder, A, additional, Riedel, C, additional, Rohr, A, additional, Lang, N, additional, Laufs, H, additional, Krieter, S, additional, Remonda, L, additional, Diepers, M, additional, Añon, J, additional, Nedeltchev, K, additional, Kahles, T, additional, Biethahn, S, additional, Lindner, M, additional, Chang, V, additional, Gächter, C, additional, Esperon, C, additional, Guglielmetti, M, additional, Arenillas Lara, JF, additional, Martínez Galdámez, M, additional, Calleja Sanz, AI, additional, Cortijo Garcia, E, additional, Garcia Bermejo, P, additional, Perez, S, additional, Mulero Carrillo, P, additional, Crespo Vallejo, E, additional, Ruiz Piñero, M, additional, Lopez Mesonero, L, additional, Reyes Muñoz, FJ, additional, Brekenfeld, C, additional, Buhk, J-H, additional, Krützelmann, A, additional, Thomalla, G, additional, Cheng, B, additional, Beck, C, additional, Hoppe, J, additional, Goebell, E, additional, Holst, B, additional, Grzyska, U, additional, Wortmann, G, additional, Starkman, S, additional, Duckwiler, G, additional, Jahan, R, additional, Rao, N, additional, Sheth, S, additional, Ng, K, additional, Noorian, A, additional, Szeder, V, additional, Nour, M, additional, McManus, M, additional, Huang, J, additional, Tarpley, J, additional, Tateshima, S, additional, Gonzalez, N, additional, Ali, L, additional, Liebeskind, D, additional, Hinman, J, additional, Calderon-Arnulphi, M, additional, Liang, C, additional, Guzy, J, additional, Koch, S, additional, DeSousa, K, additional, Gordon-Perue, G, additional, Elhammady, M, additional, Peterson, E, additional, Pandey, V, additional, Dharmadhikari, S, additional, Khandelwal, P, additional, Malik, A, additional, Pafford, R, additional, Gonzalez, P, additional, Ramdas, K, additional, Andersen, G, additional, Damgaard, D, additional, Von Weitzel-Mudersbach, P, additional, Simonsen, C, additional, Ruiz de Morales Ayudarte, N, additional, Poulsen, M, additional, Sørensen, L, additional, Karabegovich, S, additional, Hjørringgaard, M, additional, Hjort, N, additional, Harbo, T, additional, Sørensen, K, additional, Deshaies, E, additional, Padalino, D, additional, Swarnkar, A, additional, Latorre, JG, additional, Elnour, E, additional, El-Zammar, Z, additional, Villwock, M, additional, Farid, H, additional, Balgude, A, additional, Cross, L, additional, Hansen, K, additional, Holtmannspötter, M, additional, Kondziella, D, additional, Hoejgaard, J, additional, Taudorf, S, additional, Soendergaard, H, additional, Wagner, A, additional, Cronquist, M, additional, Stavngaard, T, additional, Cortsen, M, additional, Krarup, LH, additional, Hyldal, T, additional, Haring, H-P, additional, Guggenberger, S, additional, Hamberger, M, additional, Trenkler, J, additional, Sonnberger, M, additional, Nussbaumer, K, additional, Dominger, C, additional, Bach, E, additional, Jagadeesan, BD, additional, Taylor, R, additional, Kim, J, additional, Shea, K, additional, Tummala, R, additional, Zacharatos, H, additional, Sandhu, D, additional, Ezzeddine, M, additional, Grande, A, additional, Hildebrandt, D, additional, Miller, K, additional, Scherber, J, additional, Hendrickson, A, additional, Jumaa, M, additional, Zaidi, S, additional, Hendrickson, T, additional, Snyder, V, additional, Killer-Oberpfalzer, M, additional, Mutzenbach, J, additional, Weymayr, F, additional, Broussalis, E, additional, Stadler, K, additional, Jedlitschka, A, additional, Malek, A, additional, Mueller-Kronast, N, additional, Beck, P, additional, Martin, C, additional, Summers, D, additional, Day, J, additional, Bettinger, I, additional, Holloway, W, additional, Olds, K, additional, Arkin, S, additional, Akhtar, N, additional, Boutwell, C, additional, Crandall, S, additional, Schwartzman, M, additional, Weinstein, C, additional, Brion, B, additional, Prothmann, S, additional, Kleine, J, additional, Kreiser, K, additional, Boeckh-Behrens, T, additional, Poppert, H, additional, Wunderlich, S, additional, Koch, ML, additional, Biberacher, V, additional, Huberle, A, additional, Gora-Stahlberg, G, additional, Knier, B, additional, Meindl, T, additional, Utpadel-Fischler, D, additional, Zech, M, additional, Kowarik, M, additional, Seifert, C, additional, Schwaiger, B, additional, Puri, A, additional, Hou, S, additional, Wakhloo, A, additional, Moonis, M, additional, Henninger, N, additional, Goddeau, R, additional, Massari, F, additional, Minaeian, A, additional, Lozano, JD, additional, Ramzan, M, additional, Stout, C, additional, Patel, A, additional, Tunguturi, A, additional, Onteddu, S, additional, Carandang, R, additional, Howk, M, additional, Ribó, M, additional, Sanjuan, E, additional, Rubiera, M, additional, Pagola, J, additional, Flores, A, additional, Muchada, M, additional, Meler, P, additional, Huerga, E, additional, Gelabert, S, additional, Coscojuela, P, additional, Tomasello, A, additional, Rodriguez, D, additional, Santamarina, E, additional, Maisterra, O, additional, Boned, S, additional, Seró, L, additional, Rovira, A, additional, Molina, CA, additional, Millán, M, additional, Muñoz, L, additional, Pérez de la Ossa, N, additional, Gomis, M, additional, Dorado, L, additional, López-Cancio, E, additional, Palomeras, E, additional, Munuera, J, additional, García Bermejo, P, additional, Remollo, S, additional, Castaño, C, additional, García-Sort, R, additional, Cuadras, P, additional, Puyalto, P, additional, Hernández-Pérez, M, additional, Jiménez, M, additional, Martínez-Piñeiro, A, additional, Lucente, G, additional, Dávalos, A, additional, Chamorro, A, additional, Urra, X, additional, Obach, V, additional, Cervera, A, additional, Amaro, S, additional, Llull, L, additional, Codas, J, additional, Balasa, M, additional, Navarro, J, additional, Ariño, H, additional, Aceituno, A, additional, Rudilosso, S, additional, Renu, A, additional, Macho, JM, additional, San Roman, L, additional, Blasco, J, additional, López, A, additional, Macías, N, additional, Cardona, P, additional, Quesada, H, additional, Rubio, F, additional, Cano, L, additional, Lara, B, additional, de Miquel, MA, additional, Aja, L, additional, Serena, J, additional, Cobo, E, additional, Lees, Kennedy R, additional, Arenillas, J, additional, Roberts, R, additional, Al-Ajlan, F, additional, Zimmel, L, additional, Patel, S, additional, Martí-Fàbregas, J, additional, Salvat-Plana, M, additional, Bracard, S, additional, Ducrocq, Xavier, additional, Anxionnat, René, additional, Baillot, Pierre-Alexandre, additional, Barbier, Charlotte, additional, Derelle, Anne-Laure, additional, Lacour, Jean-Christophe, additional, Samson, Yves, additional, Sourour, Nader, additional, Baronnet-Chauvet, Flore, additional, Clarencon, Frédéric, additional, Crozier, Sophie, additional, Deltour, Sandrine, additional, Di Maria, Federico, additional, Le Bouc, Raphael, additional, Leger, Anne, additional, Mutlu, Gurkan, additional, Rosso, Charlotte, additional, Szatmary, Zoltan, additional, Yger, Marion, additional, Zavanone, Chiara, additional, Bakchine, Serge, additional, Pierot, Laurent, additional, Caucheteux, Nathalie, additional, Estrade, Laurent, additional, Kadziolka, Krzysztof, additional, Leautaud, Alexandre, additional, Renkes, Céline, additional, Serre, Isabelle, additional, Desal, Hubert, additional, Guillon, Benoît, additional, Boutoleau-Bretonniere, Claire, additional, Daumas-Duport, Benjamin, additional, De Gaalon, Solène, additional, Derkinderen, Pascal, additional, Evain, Sarah, additional, Herisson, Fanny, additional, Laplaud, David-Axel, additional, Lebouvier, Thibaud, additional, Lintia-Gaultier, Alina, additional, Pouclet-Courtemanche, Hélène, additional, Rouaud, Tiphaine, additional, Rouaud Jaffrenou, Violaine, additional, Schunck, Aurélia, additional, Sevin-Allouet, Mathieu, additional, Toulgoat, Frederique, additional, Wiertlewski, Sandrine, additional, Gauvrit, Jean-Yves, additional, Ronziere, Thomas, additional, Cahagne, Vincent, additional, Ferre, Jean-Christophe, additional, Pinel, Jean-François, additional, Mas, Jean-Louis, additional, Meder, Jean-François, additional, Al Najjar-Carpentier, Amen-Adam, additional, Birchenall, Julia, additional, Bodiguel, Eric, additional, Calvet, David, additional, Domigo, Valérie, additional, Godon-Hardy, Sylvie, additional, Guiraud, Vincent, additional, Lamy, Catherine, additional, Majhadi, Loubna, additional, Morin, Ludovic, additional, Naggara, Olivier, additional, Trystram, Denis, additional, Turc, Guillaume, additional, Berge, Jérôme, additional, Sibon, Igor, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Rouanet, François, additional, Debruxelles, Sabrina, additional, Kazadi, Annabelle, additional, Renou, Pauline, additional, Fleury, Olivier, additional, Pasco-Papon, Anne, additional, Dubas, Frédéric, additional, Caroff, Jildaz, additional, Godard Ducceschi, Sophie, additional, Hamon, Marie-Aurélie, additional, Lecluse, Alderic, additional, Marc, Guillaume, additional, Giroud, Maurice, additional, Ricolfi, Frédéric, additional, Bejot, Yannick, additional, Chavent, Adrien, additional, Gentil, Arnaud, additional, Kazemi, Apolline, additional, Osseby, Guy-Victor, additional, Voguet, Charlotte, additional, Mahagne, Marie-Hélène, additional, Sedat, Jacques, additional, Chau, Yves, additional, Suissa, Laurent, additional, Lachaud, Sylvain, additional, Houdart, Emmanuel, additional, Stapf, Christian, additional, Buffon Porcher, Frédérique, additional, Chabriat, Hugues, additional, Guedin, Pierre, additional, Herve, Dominique, additional, Jouvent, Eric, additional, Mawet, Jérôme, additional, Saint-Maurice, Jean-Pierre, additional, Schneble, Hans-Martin, additional, Nighoghossian, Norbert, additional, Berhoune, Nadia-Nawel, additional, Bouhour, Françoise, additional, Cho, Tae-Hee, additional, Derex, Laurent, additional, Felix, Sandra, additional, Gervais-Bernard, Hélène, additional, Gory, Benjamin, additional, Manera, Luis, additional, Mechtouff, Laura, additional, Ritzenthaler, Thomas, additional, Riva, Roberto, additional, Salaris Silvio, Fabrizio, additional, Tilikete, Caroline, additional, Blanc, Raphael, additional, Obadia, Michaël, additional, Bartolini, Mario Bruno, additional, Gueguen, Antoine, additional, Piotin, Michel, additional, Pistocchi, Silvia, additional, Redjem, Hocine, additional, Drouineau, Jacques, additional, Neau, Jean-Philippe, additional, Godeneche, Gaelle, additional, Lamy, Matthias, additional, Marsac, Emilia, additional, Velasco, Stephane, additional, Clavelou, Pierre, additional, Chabert, Emmanuel, additional, Bourgois, Nathalie, additional, Cornut-Chauvinc, Catherine, additional, Ferrier, Anna, additional, Gabrillargues, Jean, additional, Jean, Betty, additional, Marques, Anna-Raquel, additional, Vitello, Nicolas, additional, Detante, Olivier, additional, Barbieux, Marianne, additional, Boubagra, Kamel, additional, Favre Wiki, Isabelle, additional, Garambois, Katia, additional, Tahon, Florence, additional, Ashok, Vasdev, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Lapergue, Bertrand, additional, Bourdain, Frédéric, additional, Evrard, Serge, additional, Graveleau, Philippe, additional, Decroix, Jean Pierre, additional, Wang, Adrien, additional, Sellal, François, additional, Ahle, Guido, additional, Carelli, Gabriela, additional, Dugay, Marie-Hélène, additional, Gaultier, Claude, additional, Lebedinsky, Ariel Pablo, additional, Lita, Lavinia, additional, Musacchio, Raul Mariano, additional, Renglewicz-Destuynder, Catherine, additional, Tournade, Alain, additional, Vuillemet, Françis, additional, Montoro, Francisco Macian, additional, Mounayer, Charbel, additional, Faugeras, Frederic, additional, Gimenez, Laetitia, additional, Labach, Catherine, additional, Lautrette, Géraldine, additional, Denier, Christian, additional, Saliou, Guillaume, additional, Chassin, Olivier, additional, Dussaule, Claire, additional, Melki, Elsa, additional, Ozanne, Augustin, additional, Puccinelli, Francesco, additional, Sachet, Marina, additional, Sarov, Mariana, additional, Bonneville, Jean-François, additional, Moulin, Thierry, additional, Biondi, Alessandra, additional, De Bustos Medeiros, Elisabeth, additional, Vuillier, Fabrice, additional, Courtheoux, Patrick, additional, Viader, Fausto, additional, Apoil-Brissard, Marion, additional, Bataille, Mathieu, additional, Bonnet, Anne-Laure, additional, Cogez, Julien, additional, Touze, Emmanuel, additional, Leclerc, Xavier, additional, Leys, Didier, additional, Aggour, Mohamed, additional, Aguettaz, Pierre, additional, Bodenant, Marie, additional, Cordonnier, Charlotte, additional, Deplanque, Dominique, additional, Girot, Marie, additional, Henon, Hilde, additional, Kalsoum, Erwah, additional, Lucas, Christian, additional, Pruvo, Jean-Pierre, additional, Zuniga, Paolo, additional, Arquizan, Caroline, additional, Costalat, Vincent, additional, Machi, Paolo, additional, Mourand, Isabelle, additional, Riquelme, Carlos, additional, Bounolleau, Pierre, additional, Arteaga, Charles, additional, Faivre, Anthony, additional, Bintner, Marc, additional, Tournebize, Patrice, additional, Charlin, Cyril, additional, Darcel, Françoise, additional, Gauthier-Lasalarie, Pascale, additional, Jeremenko, Marcia, additional, Mouton, Servane, additional, Zerlauth, Jean-Baptiste, additional, Lamy, Chantal, additional, Hervé, Deramond, additional, Hassan, Hosseini, additional, Gaston, André, additional, Barral, Francis-Guy, additional, Garnier, Pierre, additional, Beaujeux, Rémy, additional, Wolff, Valérie, additional, Herbreteau, Denis, additional, Debiais, Séverine, additional, Murray, Alicia, additional, Ford, Gary, additional, Clifton, Andy, additional, Freeman, Janet, additional, Ford, Ian, additional, Markus, Hugh, additional, Wardlaw, Joanna, additional, Molyneux, Andy, additional, Robinson, Thompson, additional, Lewis, Steff, additional, Norrie, John, additional, Robertson, Fergus, additional, Perry, Richard, additional, Dixit, Anand, additional, Clifton, Andrew, additional, Roffe, Christine, additional, Nayak, Sanjeev, additional, Lobotesis, Kyriakos, additional, Smith, Craig, additional, Herwadkar, Amit, additional, Kandasamy, Naga, additional, Goddard, Tony, additional, Bamford, John, additional, Subramanian, Ganesh, additional, Lenthall, Rob, additional, Littleton, Edward, additional, Lamin, Sal, additional, Storey, Kelley, additional, Ghatala, Rita, additional, Banaras, Azra, additional, Aeron-Thomas, John, additional, Hazel, Bath, additional, Maguire, Holly, additional, Veraque, Emelda, additional, Harrison, Louise, additional, Keshvara, Rekha, additional, and Cunningham, James, additional

Published
2019
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513. Teaching Old Drugs New Tricks: Repositioning Pharmaceuticals for Bench to Bedside Success

Author

Maxwell M. Krem and Levi J. Beverly

Subjects
medicine.medical_specialty, Phosphatidylinositol 3-Kinases, business.industry, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, TOR Serine-Threonine Kinases, medicine, Humans, Medical physics, General Medicine, Anesthetics, Local, business, Proto-Oncogene Proteins c-akt, Bench to bedside
Published
2017

514. Impact of the Make Healthy Normal mass media campaign (Phase 1) on knowledge, attitudes and behaviours

Author

Kite, J, Gale, J, Grunseit, A, Bellew, W, Li, V, Lloyd, B, Maxwell, M, Vineburg, J, and Bauman, A

Subjects
Adult, Male, Health Knowledge, Attitudes, Practice, Adolescent, Carbonated Beverages, Health Promotion, Intention, 1117 Public Health and Health Services, 1402 Applied Economics, 1605 Policy and Administration, Cohort Studies, Young Adult, Humans, Female, Public Health, Mass Media, Obesity, New South Wales, Exercise, Program Evaluation
Abstract

Objective: To determine the impact of the first phase of the Make Healthy Normal mass media campaign on NSW adults’ active living and healthy eating knowledge, attitudes, intentions and behaviour. Methods: Cohort design with NSW adults, followed up three times over 12 months, with n=939 participants completing all three waves. We used generalised linear mixed models to examine campaign awareness, knowledge, attitudes, intentions and behaviours over time. Results: Campaign recognition built to a reasonable level (45% at Wave 3), although unprompted recall was low (9% at Wave 3). There were significant increases in knowledge of physical activity recommendations (46% to 50%), the health effects of obesity (52% to 64%), and weight loss benefits (53% to 65%), with stronger effects in campaign recognisers. Conversely, we found declines in self-efficacy and intention to increase physical activity (39% to 31%) and decrease soft drink consumption (31% to 24%). Conclusions: Overall, there are some positives for the campaign but intentions need to be a focus of future campaign phases. Continued investment over the medium- to long-term is needed. Implications: Mass media campaigns can play a role in obesity prevention but robust evaluations are needed to identify the characteristics of effective campaigns.

Published
2017

515. Haploidentical vs sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia

Author

Wieduwilt, Matthew J., Metheny, Leland, Zhang, Mei-Jie, Wang, Hai-Lin, Estrada-Merly, Noel, Marks, David I., Al-Homsi, A. Samer, Muffly, Lori, Chao, Nelson, Rizzieri, David, Gale, Robert Peter, Gadalla, Shahinaz M., Cairo, Mitchell, Mussetti, Alberto, Gore, Steven, Bhatt, Vijaya Raj, Patel, Sagar S., Michelis, Fotios V., Inamoto, Yoshihiro, Badawy, Sherif M., Copelan, Edward, Palmisiano, Neil, Kharfan-Dabaja, Mohamed A., Lazarus, Hillard M., Ganguly, Siddhartha, Bredeson, Christopher, Diaz Perez, Miguel Angel, Cassaday, Ryan, Savani, Bipin N., Ballen, Karen, Martino, Rodrigo, Wirk, Baldeep, Bacher, Ulrike, Aljurf, Mahmoud, Bashey, Asad, Murthy, Hemant S., Yared, Jean A., Aldoss, Ibrahim, Farhadfar, Nosha, Liu, Hongtao, Abdel-Azim, Hisham, Waller, Edmund K., Solh, Melhem, Seftel, Matthew D., van der Poel, Marjolein, Grunwald, Michael R., Liesveld, Jane L., Kamble, Rammurti T., McGuirk, Joseph, Munker, Reinhold, Cahn, Jean-Yves, Lee, Jong Wook, Freytes, César O., Krem, Maxwell M., Winestone, Lena E., Gergis, Usama, Nathan, Sunita, Olsson, Richard F., Verdonck, Leo F., Sharma, Akshay, Ringdén, Olle, Friend, Brian D., Cerny, Jan, Choe, Hannah, Chhabra, Saurabh, Nishihori, Taiga, Seo, Sachiko, George, Biju, Baxter-Lowe, Lee Ann, Hildebrandt, Gerhard C., de Lima, Marcos, Litzow, Mark, Kebriaei, Partow, Hourigan, Christopher S., Abid, Muhammad Bilal, Weisdorf, Daniel J., and Saber, Wael

Abstract

The role of haploidentical hematopoietic cell transplantation (HCT) using posttransplant cyclophosphamide (PTCy) for acute lymphoblastic leukemia (ALL) is being defined. We performed a retrospective, multivariable analysis comparing outcomes of HCT approaches by donor for adults with ALL in remission. The primary objective was to compare overall survival (OS) among haploidentical HCTs using PTCy and HLA-matched sibling donor (MSD), 8/8 HLA-matched unrelated donor (MUD), 7 /8 HLA-MUD, or umbilical cord blood (UCB) HCT. Comparing haploidentical HCT to MSD HCT, we found that OS, leukemia-free survival (LFS), nonrelapse mortality (NRM), relapse, and acute graft-versus-host disease (aGVHD) were not different but chronic GVHD (cGVHD) was higher in MSD HCT. Compared with MUD HCT, OS, LFS, and relapse were not different, but MUD HCT had increased NRM (hazard ratio [HR], 1.42; P = .02), grade 3 to 4 aGVHD (HR, 1.59; P = .005), and cGVHD. Compared with 7/8 UD HCT, LFS and relapse were not different, but 7/8 UD HCT had worse OS (HR, 1.38; P = .01) and increased NRM (HR, 2.13; P ≤ .001), grade 3 to 4 aGVHD (HR, 1.86; P = .003), and cGVHD (HR, 1.72; P ≤ .001). Compared with UCB HCT, late OS, late LFS, relapse, and cGVHD were not different but UCB HCT had worse early OS (≤18 months; HR, 1.93; P < .001), worse early LFS (HR, 1.40; P = .007) and increased incidences of NRM (HR, 2.08; P < .001) and grade 3 to 4 aGVHD (HR, 1.97; P < .001). Haploidentical HCT using PTCy showed no difference in survival but less GVHD compared with traditional MSD and MUD HCT and is the preferred alternative donor HCT option for adults with ALL in complete remission.

Published
2022
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518. Characterization of Structure and Growth Evolution for nc-Si:H in the Tandem Photovoltaic Device Configuration

Author

Puruswottam Aryal, Lila Raj Dahal, Sylvain Marsillac, Nikolas J. Podraza, Zhiquan Huang, Maxwell M. Junda, and Robert W. Collins

Subjects
Coalescence (physics), Materials science, Silicon, Tandem, business.industry, Doping, Analytical chemistry, chemistry.chemical_element, Condensed Matter Physics, Nanocrystalline material, Electronic, Optical and Magnetic Materials, Amorphous solid, Optics, chemistry, Ellipsometry, NC-SI, Crystallite, Electrical and Electronic Engineering, business
Abstract

Spectroscopic ellipsometry (SE) is used to study the growth evolution of the bottom cell p-type doped and intrinsic hydrogenated silicon (Si:H) layers in p-i-n amorphous/nanocrystalline Si:H (a-Si:H/nc-Si:H) tandem photovoltaic (PV) devices. SE data collected in situ during the growth enables the identification of crystallite coalescence transitions in the surface roughness evolution, as well as the variations in optical response in the form of the complex dielectric function ( $\varepsilon = \varepsilon _{1} + i\varepsilon _{2}$ ). The latter indicates relative amounts of the a-Si:H and nc-Si:H components during mixed-phase Si:H growth. A growth evolution diagram for the i-layer in the tandem PV device configuration is constructed. Device properties are related to p- and i-layer structure and can be understood on the basis of the growth evolution diagram.

Published
2015

519. Mechanisms and clinical applications of chromosomal instability in lymphoid malignancy

Author

Marshall S. Horwitz, Oliver W. Press, Timothy Tidwell, and Maxwell M. Krem

Subjects
DNA Replication, Recombination, Genetic, DNA Breaks, Aneuploidy, Chromosomal translocation, DNA, Neoplasm, Hematology, Biology, medicine.disease, medicine.disease_cause, Telomere, Lymphoma, Malignant transformation, Chromosomal Instability, Hematologic Neoplasms, Chromosome instability, Immunology, medicine, Humans, Carcinogenesis, Multiple myeloma
Abstract

Lymphocytes are unique among cells in that they undergo programmed DNA breaks and translocations, but that special property predisposes them to chromosomal instability (CIN), a cardinal feature of neoplastic lymphoid cells that manifests as whole chromosome- or translocation-based aneuploidy. In several lymphoid malignancies translocations may be the defining or diagnostic markers of the diseases. CIN is a cornerstone of the mutational architecture supporting lymphoid neoplasia, though it is perhaps one of the least understood components of malignant transformation in terms of its molecular mechanisms. CIN is associated with prognosis and response to treatment, making it a key area for impacting treatment outcomes and predicting prognoses. Here we will review the types and mechanisms of CIN found in Hodgkin lymphoma, non-Hodgkin lymphoma, multiple myeloma and the lymphoid leukaemias, with emphasis placed on pathogenic mutations affecting DNA recombination, replication and repair; telomere function; and mitotic regulation of spindle attachment, centrosome function, and chromosomal segregation. We will discuss the means by which chromosome-level genetic aberrations may give rise to multiple pathogenic mutations required for carcinogenesis and conclude with a discussion of the clinical applications of CIN and aneuploidy to diagnosis, prognosis and therapy.

Published
2015

520. Spectroscopic Ellipsometry Applied in the Full p-i-n a-Si:H Solar Cell Device Configuration

Author

Maxwell M. Junda, Prakash Koirala, Nikolas J. Podraza, Robert W. Collins, and Ambalanath Shan

Subjects
Amorphous silicon, Materials science, business.industry, Band gap, Plasma, Condensed Matter Physics, Spectral line, Electronic, Optical and Magnetic Materials, law.invention, Monocrystalline silicon, chemistry.chemical_compound, Optics, chemistry, law, Solar cell, Optoelectronics, Quantum efficiency, Crystallite, Electrical and Electronic Engineering, business
Abstract

Assessment of the performance of single-junction hydrogenated amorphous silicon (a-Si:H) p-i-n configuration solar cells has been developed with a combination of real-time spectroscopic ellipsometry (RTSE) and current-voltage (I-V) measurements. For each layer, RTSE measurements enabled the determination of thickness and optical properties in the form of the complex dielectric function (e = e 1 + ie 2 ) spectra. RTSE tracked changes in a as a function of depth and was used to extract profiles in the i-layer bandgap and crystallite fraction in the n-layer. Through mapping I-V characteristic measurements, spatial variations in device performance were determined. By comparing individual devices at the location of the RTSE beam spot, the influence of a and thickness for each layer on device performance was identified through simulations of quantum efficiency yielding the shortcircuit current. This study compares two devices prepared with different superstrate preheating processes and finds that the combination of RTSE and I-V measurements along with quantum efficiency simulations were able to identify plasma damage to the transparent conducting oxide as the likely cause for variation in device performance. This comparison serves as one example of how the optically obtained information, such as thickness and a for each layer, can be used to understand the final device performance.

Published
2015

521. Prevalence and Determinants of Masked Hypertension in Nigeria: The REMAH Study.

Author

Odili, Augustine N, Danladi, Benjamin, Chori, Babangida S, Oshaju, Henry, Nwakile, Peter C, Okoye, Innocent C, Abdullahi, Umar, Nwegbu, Maxwell M, Zawaya, Kefas, Essien, Ime, Sada, Kabiru, Ogedengbe, John O, Aje, Akinyemi, and Isiguzo, Godsent C

Subjects
BLOOD pressure, SPHYGMOMANOMETERS, BLOOD sugar, AMBULATORY blood pressure monitoring, HYPERTENSION, ODDS ratio, CONFIDENCE intervals
Abstract

Background Estimating the burden of hypertension in Nigeria hitherto relied on clinic blood pressure (BP) measurement alone. This excludes individuals with masked hypertension (MH), i.e. normotensive clinic but hypertensive out-of-clinic BP. Methods In a nationally representative sample of adult Nigerians, we obtained clinic BP using auscultatory method and out-of-clinic BP by self-measured home BP with semi-automated oscillometric device. Clinic BP was average of 5 consecutive measurements and home BP was average of 3 days duplicate morning and evening readings. MH was clinic BP <140 mm Hg systolic and 90 mm Hg diastolic and home BP ≥135 mm Hg systolic and/or 85 mm Hg diastolic. Results Among 933 participants, the prevalence of sustained hypertension, MH, and white-coat hypertension was 28.3%, 7.9%, and 11.9%, respectively. Among subjects whose clinic BP were in the normotensive range (n = 558), the prevalence of MH was 13%; 12% among untreated and 27% among treated individuals. The mutually adjusted odds ratios of having MH among all participants with normotensive clinic BP were 1.33 (95% confidence interval, 1.10–1.60) for a 10-year higher age, 1.59 (1.09–2.40) for a 10 mm Hg increment in systolic clinic BP, and 1.16 (1.08–1.28) for a 10 mg/dl higher random blood glucose. The corresponding estimates in the untreated population were 1.24 (1.03–1.51), 1.56 (1.04–2.44), and 1.16 (1.08–1.29), respectively. Conclusions MH is common in Nigeria and increasing age, clinic systolic BP, and random blood glucose are the risk factors. [ABSTRACT FROM AUTHOR]

Published
2021
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525. Optical and electrical properties of H2 plasma-treated ZnO films prepared by atomic layer deposition using supercycles

Author

Uprety, Prakash, Macco, B., Junda, Maxwell M., Grice, Corey R., Kessels, W.M.M., Podraza, Nikolas J., Uprety, Prakash, Macco, B., Junda, Maxwell M., Grice, Corey R., Kessels, W.M.M., and Podraza, Nikolas J.

Abstract

High mobility H-doped ZnO (ZnO:H) thin films are prepared on thermal oxide coated silicon wafers by a novel supercycle approach of thermal atomic layer deposition (ALD) technique. The influence of H2 plasma treatment and substrate composition on optical and electrical properties of ZnO films are studied using spectroscopic ellipsometry (SE) and direct electrical measurements. This work significantly expands the measured range of ZnO:H optical properties into the far infrared to obtain the complex dielectric function (ε = ε1 + iε2) spectra from 0.4 meV to 5.89 eV compared to what has been previously investigated by using SE. A blue shift in the optical band gap energy is observed with decreasing cycle ratio (n) or more frequent H2 plasma treatments during deposition. The amplitude of phonon absorption is increased with decreasing n. Free carrier transport characteristics are determined by applying the Drude model in modeling ε and the result indicates lower n improves material conductivity as confirmed by direct electrical measurements. Regarding the effect of substrate composition, the samples prepared using the same n but on bare thermal oxide, a 5 nm ZnO:H film, or a 5 nm intrinsic ZnO film each have differences in ε and free carrier transport characteristics resulting from substrate composition, demonstrating an additional method of tailoring material properties. Effective carrier mass (m*) for the ZnO films are determined by combining results from Hall effect measurements with UV to THz spectra in ε. Thus, variation of n and substrate composition are demonstrated as an effective mean of controlling the resultant opto-electronic film properties.

Published
2018

526. Impact of the Make Healthy Normal mass media campaign (Phase 1) on knowledge, attitudes and behaviours.

Author

Kite, J, Gale, J, Grunseit, A, Bellew, W, Li, V, Lloyd, B, Maxwell, M, Vineburg, J, Bauman, A, Kite, J, Gale, J, Grunseit, A, Bellew, W, Li, V, Lloyd, B, Maxwell, M, Vineburg, J, and Bauman, A

Abstract

Objective: To determine the impact of the first phase of the Make Healthy Normal mass media campaign on NSW adults’ active living and healthy eating knowledge, attitudes, intentions and behaviour. Methods: Cohort design with NSW adults, followed up three times over 12 months, with n=939 participants completing all three waves. We used generalised linear mixed models to examine campaign awareness, knowledge, attitudes, intentions and behaviours over time. Results: Campaign recognition built to a reasonable level (45% at Wave 3), although unprompted recall was low (9% at Wave 3). There were significant increases in knowledge of physical activity recommendations (46% to 50%), the health effects of obesity (52% to 64%), and weight loss benefits (53% to 65%), with stronger effects in campaign recognisers. Conversely, we found declines in self-efficacy and intention to increase physical activity (39% to 31%) and decrease soft drink consumption (31% to 24%). Conclusions: Overall, there are some positives for the campaign but intentions need to be a focus of future campaign phases. Continued investment over the medium- to long-term is needed. Implications: Mass media campaigns can play a role in obesity prevention but robust evaluations are needed to identify the characteristics of effective campaigns.

Published
2018

532. The SERCA residue Glu340 mediates interdomain communication that guides Ca2+ transport.

Author

Geurts, Maxwell M. G., Clausen, Johannes D., Arnou, Bertrand, Montigny, Cédric, Lenoir, Guillaume, Corey, Robin A., Jaxel, Christine, Møller, Jesper V., Nissen, Poul, Andersen, Jens Peter, le Maire, Marc, and Bublitz, Maike

Subjects
*MOLECULAR dynamics, *MEMBRANE transport proteins, *ADENOSINE triphosphatase, *HYDROGEN bonding
Abstract

The sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) is a P-type ATPase that transports Ca2+ from the cytosol into the sarco(endo) plasmic reticulum (SR/ER) lumen, driven by ATP. This primary transport activity depends on tight coupling between movements of the transmembrane helices forming the two Ca2+-binding sites and the cytosolic headpiece mediating ATP hydrolysis. We have addressed the molecular basis for this intramolecular communication by analyzing the structure and functional properties of the SERCA mutant E340A. The mutated Glu340 residue is strictly conserved among the P-type ATPase family of membrane transporters and is located at a seemingly strategic position at the interface between the phosphorylation domain and the cytosolic ends of 5 of SERCA's 10 transmembrane helices. The mutant displays a marked slowing of the Ca2+-binding kinetics, and its crystal structure in the presence of Ca2+ and ATP analog reveals a rotated headpiece, altered connectivity between the cytosolic domains, and an altered hydrogen bonding pattern around residue 340. Supported by molecular dynamics simulations, we conclude that the E340A mutation causes a stabilization of the Ca2+ sites in a more occluded state, hence displaying slowed dynamics. This finding underpins a crucial role of Glu340 in interdomain communication between the headpiece and the Ca2+-binding transmembrane region. [ABSTRACT FROM AUTHOR]

Published
2020
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534. To b(ortezomib) or not to be: the stroma's the thing

Author

Maxwell M. Krem and Jun Yan

Subjects
0301 basic medicine, Stromal cell, Bortezomib, medicine.medical_treatment, Cell migration, Biology, medicine.disease, Pathology and Forensic Medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Cytokine, Stroma, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, Immunology, medicine, Proteasome inhibitor, Cytotoxic T cell, Multiple myeloma, medicine.drug
Abstract

The proteasome inhibitor bortezomib has been widely used to treat patients with multiple myeloma (MM). However, some patients show primary or secondary resistance. In recent work published in The Journal of Pathology, Beyar-Katz et al demonstrate that bortezomib treatment stimulates a host inflammatory response, which in turn promotes MM cell migration, viability, and proliferation. These effects appear to be mediated by pro-inflammatory M1-like stromal macrophages partly via secretion of cytokine IL-16. These unexpected findings imply that the binary M1/M2 definition of macrophages may not accurately describe the complexity and heterogeneity of macrophages associated with MM tumour growth and progression, and further suggest that bortezomib treatment stimulates host-driven tumour-promoting activity in addition to its cytotoxic activity, thus leading to potential bortezomib resistance in MM patients. Understanding the underlying mechanisms may identify novel targets to overcome or prevent bortezomib resistance. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Published
2016

535. Determination of the absolute configuration of the novel anti-trypanosomal iridoid molucidin isolated from Morinda lucida by X-ray analysis

Author

Osamu Morinaga, Nobuo Ohta, Kofi Dadzie Kwofie, Maxwell M. Sakyiamah, Takuhiro Uto, Yasuchika Yamaguchi, William K. Anyan, Frederic Aboagye, Michael Amoa-Bosompem, Irene Ayi, Alfred Ampomah Appiah, Kwadwo K. Frempong, Taizo Yamashita, Frederick Ayertey, Kenji Yoza, Daniel A. Boakye, Philip Atchoglo, Isaac Tuffour, Kwadwo A. Koram, Alexander K. Nyarko, Kofi Baffour-Awuah Owusu, Nguyen Huu Tung, Mitsuko Suzuki, Shoji Yamaoka, Richard Adegle, Satoru Karasawa, Regina Appiah-Opong, Dominic Edoh, and Yukihiro Shoyama

Subjects
Iridoid, Chemistry, Stereochemistry, medicine.drug_class, Organic Chemistry, Absolute configuration, Biochemistry, chemistry.chemical_compound, Spirolactone, Morinda lucida, Drug Discovery, medicine, Molecule, Enantiomer, X ray analysis, Single crystal
Abstract

The strong anti-trypanosomal active compound, molucidin, contains a spirolactone tetracyclic iridoid skeleton and is isolated from Morinda lucida as an enantiomer of oruwacin, which is isolated from the same plant. To confirm the absolute configuration of molucidin, we prepared single crystals of molucidin for X-ray analysis. The absolute configuration of the afforded single crystal was determined by X-ray crystallography using a Cu radiation source. X-ray diffraction data were collected at 93 K in the 2 θ range 7.468–134.99° and analyzed using the SHELXL-2014 program. The corresponding chiral quaternary carbon atoms in molucidin were unambiguously determined as 1 R , 5 S , 8 S , 9 S , and 10 S . Notably, both enantiomers of a single molecule, molucidin and oruwacin, with a rigid structure have been isolated from the same plant species. The biosynthetic pathway for the formation of molucidin is also discussed on the basis of the absolute configuration. Our results for the first time support for structural elucidation of tetracyclic iridoids using X-ray analysis.

Published
2015

536. Preliminary Evaluation of a Point-of-Care Testing Device (SickleSCAN™) in Screening for Sickle Cell Disease

Author

Chinatu Ohiaeri, Ngozi Immaculata Ugwu, Ijeoma N. Diaku-Akinwumi, Adekunle Adekile, Ifeoma J Emodi, EC Okocha, Biyaya B. Nwankwo, Dorathy Adaunwa Okoh, Chinedu C. Okeke, N. O. Akinola, Ahmed Girei, Abdulaziz Hassan, TO Ulasi, Taiwo Modupe Balogun, Hezekiah Isa, A. A. Okolo, John C Aneke, Sani Awwalu, Maxwell M. Nwegbu, Biobele J. Brown, Usman Abjah, Anazoeze Jude Madu, John Ayodele Olaniyi, Uduak J Edet-Offong, and Obiageli E Nnodu

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Point-of-care testing, Point-of-Care Systems, Clinical Biochemistry, Hemoglobin, Sickle, Disease, Anemia, Sickle Cell, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Disease Screening, Primary health, Internal medicine, Diagnostic equipment, medicine, Humans, 030212 general & internal medicine, Child, Genetics (clinical), Point of care, business.industry, Biochemistry (medical), Infant, Newborn, Infant, Hematology, Electrophoresis, Cellulose Acetate, Child, Preschool, Test efficiency, Female, Cellulose acetate electrophoresis, business
Abstract

Sickle cell disease affects about 150,000 births annually in Nigeria. Early diagnosis is hampered by factors such as centralized and urban localization of laboratories, high cost of diagnostic equipment and inadequate skilled manpower to operate them. The need for a low-cost, portable, easy-to-use diagnostic test for sickle cell disease is critical, especially in resource-poor countries. In this study, we evaluated the performance characteristics of a novel point-of-care testing device (SickleSCAN™), and its acceptability and feasibility, as a possible screening tool for sickle cell disease. In the first phase, we assessed the performance characteristics of SickleSCAN™ by evaluating 57 subjects comprising both children and adults attending a primary health center, for Hb SS (βS/βS; HBB: c.20A>T), Hb SC (βS/βC; HBB: c.19G>A) and Hb AS (βA/βS) using SickleSCAN™, cellulose acetate electrophoresis (CAE) and high performance liquid chromatography (HPLC). Performance characteristics such as diagnostic sensitivity and specificity were compared to HPLC as a standard method. We subsequently undertook a second phase wherein the acceptability and feasibility of the device for sickle cell disease screening, was evaluated using semi-structured and structured questionnaires among 197 healthcare personnel and 221 subjects, respectively. Sickle cell disease was carried by 3.4% of the subjects. The diagnostic sensitivity, specificity and test efficiency of SickleSCAN™ for sickle cell disease (Hb SS and Hb SC), were 100.0, 98.2 and 98.2%, respectively. Findings from this study showed SickleSCAN™ to be a viable screening tool that can easily be applied in community-based screening for early diagnosis of sickle cell disease with little expertise and low cost.

Published
2017

537. Magnetron Sputtered Hydrogenated Silicon Thin Films: Assessment for Application in Photovoltaics

Author

Nikolas J. Podraza, Dipendra Adhikari, Sylvain Marsillac, Maxwell M. Junda, and Robert W. Collins

Subjects
Materials science, Silicon, Physics::Instrumentation and Detectors, business.industry, Nucleation, Nanocrystalline silicon, Physics::Optics, chemistry.chemical_element, Amorphous solid, Condensed Matter::Materials Science, chemistry, Photovoltaics, Cavity magnetron, Optoelectronics, Crystallite, Thin film, business
Abstract

Hydrogenated amorphous and nanocrystalline silicon (a-Si:H, nc-Si:H) thin films have been prepared by radio frequency magnetron sputtering with process parameters used to manipulate optical properties, structure, and growth evolution. Insitu real time spectroscopic ellipsometry is applied to construct growth evolution diagrams by tracking nucleation and coalescence of crystallites from the amorphous phase, as well as surface roughening within the amorphous growth regime, as functions of hydrogen-to-argon gas ratio. Infrared spectroscopic ellipsometry determines Si-Hs vibrational modes, and grazing incidence x-ray diffraction provides crystallite orientation. The suitability of these materials for photovoltaics is assessed.

Published
2017

538. Optical Properties of and Alloys and Their Application for CdTe Photovoltaics

Author

Maxwell M. Junda, Prakash Koirala, Nikolas J. Podraza, Robert W. Collins, Corey R. Grice, and Yanfa Yan

Subjects
Materials science, business.industry, Band gap, Photovoltaic system, Wide-bandgap semiconductor, medicine.disease_cause, Cadmium telluride photovoltaics, Photovoltaics, medicine, Optoelectronics, Quantum efficiency, Crystallite, business, Ultraviolet
Abstract

Opto-electronic property gradients in CdTe solar cells can lead to improved photovoltaic (PV) device performance. Near infrared to ultraviolet complex optical response (e) is measured for polycrystalline CdSe1-xSx and CdSe1-yTey alloys. Monotonic variation in e and the bandgap are observed for CdSe1-xSx, whereas bandgap bowing is observed for CdSe1-yTey. Spectroscopic e serves as input for simulations of external quantum efficiency (EQE) for CdTe PV incorporating Se. Comparison with experimental EQE indicates increases at short wavelengths are due to current generated in CdSe1-xSx and CdSe1-yTey components and increases at long wavelengths arise from red-shifting of the CdSe1-yTey bandgap relative to CdTe.

Published
2017

539. Close-Space Sublimated CdTe Solar Cells with Co-Sputtered CdSxSe1-x Alloy Window Layers

Author

Yanfa Yan, Alexander Archer, Maxwell M. Junda, Corey R. Grice, and Jian V. Li

Subjects
Materials science, business.industry, Voltage control, Load modeling, Alloy, Numerical models, engineering.material, Cadmium telluride photovoltaics, engineering, Optoelectronics, Power quality, Sublimation (phase transition), Thin film, business
Abstract

Thin film CdTe solar cells devices are fabricated using homogenous alloys of CdS-CdSe, deposited by a co-sputter process and of varying compositions, as the window layer materials. After close-space sublimation of the CdTe layer and subsequent device finishing processes, the cells are characterized in terms of electo-optical performance as well as structural and compositional properties.

Published
2017

540. Electrical Transport Properties from Long Wavelength Ellipsometry

Author

Nikolas J. Podraza, Maxwell M. Junda, David V. Forbes, Michael A. Slocum, Seth M. Rubbard, Indra Subedi, and Prakash Uprety

Subjects
Materials science, Semiconductor, Effective mass (solid-state physics), Electrical resistivity and conductivity, Phonon, Ellipsometry, business.industry, Optoelectronics, Free carrier absorption, business, Drude model, Cadmium telluride photovoltaics
Abstract

Electrical transport properties (resistivity, scattering time, carrier concentration, mobility, effective mass) can be deduced from the Drude model for free carrier optical absorption. Optical response of materials may include simultaneous contributions from free carriers, phonon modes, and electronic transitions, however. Improved sensitivity to free carrier absorption and electrical transport properties is obtained through the use of long wavelength extended spectroscopic ellipsometry in the infrared (IR) and millimeter (THz) ranges. Non-contacting optical measurement and analysis methodologies are designed for semiconductors and transparent conductors used in photovoltaics (PV). Case studies include ZnO:Al, InP, wafer Si, and slnale crystal CdTe.

Published
2017

541. Application of Mapping Spectroscopic Ellipsometry for CdSe/CdTe Solar Cells: Optimization of Low-Temperature Processed Devices with All-Sputtered Semiconductors

Author

Maxwell M. Junda, Adam B. Phillips, Michael J. Heben, Nikolas J. Podraza, Fadhil K. Alfadhili, Mohammed A. Razooqi, Geethika K. Liyanage, Prakash Koirala, and Robert W. Collins

Subjects
Fabrication, Materials science, Semiconductor, Photovoltaics, business.industry, Optoelectronics, Quantum efficiency, Thin film, business, Current density, Cadmium telluride photovoltaics, Metrology
Abstract

The incorporation of CdSe as a top component layer in superstrate CdTe photovoltaics (PV) technology has led to improvements in short-circuit current due to collection at both violet and near-infrared edges of the external quantum efficiency spectra. The achievable improvements are very sensitive to the details of device fabrication including the individual CdSe and CdTe layer thicknesses and the thermal profile of the entire process. In this research, mapping spectroscopic ellipsometry (M-SE) is being applied at different stages of the process, in conjunction with previously-established capabilities of through-the-glass SE (TG-SE) and variable-angle SE (VA-SE), all toward the development of an advanced metrology for this new absorber layer alloy system. In this report, correlations are presented between the effective thickness (or volume/area) of thin film CdSe, obtained by M-SE prior to CdTe deposition, and the ultimate device performance.

Published
2017

542. Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study

Author

James Scott, Timothy K. Takaro, Joseph Macri, Christoffer Dharma, Anita L. Kozyrskyj, James A. Scott, Hartmut Grasemann, M.R. Sears, Maxwell M. Tran, Tobias R. Kollmann, Malcolm R. Sears, M.B. Azad, Elinor Simons, Michael S. Kobor, Felix Ratjen, Richard G. Hegele, Clare D. Ramsey, Andrew J. Sandford, Edith Chen, Perry Hystad, Catherine Laprise, D. L. Holness, Stuart E. Turvey, P. Subbarao, Michael M Cyr, Padmaja Subbarao, P. J. Mandhane, Sonia S. Anand, Peter D. Paré, David Dai, Allan B. Becker, Gregory E. Miller, Frances Silverman, Judah A. Denburg, Denise Daley, Kent T. HayGlass, Q. L. Duan, Theo J Moraes, Scott Sj Tebbutt, W.Y.W. Lou, S.E. Turvey, A D Befus, Wendy Y. W. Lou, Diana L. Lefebvre, Michael Brauer, J.R. Brook, Sharon D. Dell, A.B. Becker, Piush J. Mandhane, Teresa To, and Thomas Eiwegger

Subjects
Male, medicine.medical_specialty, Immunology, Dermatitis, Atopic, Allergic sensitization, 03 medical and health sciences, 0302 clinical medicine, Food allergy, Risk Factors, medicine, Immunology and Allergy, Humans, 030212 general & internal medicine, Longitudinal Studies, Asthma, Skin Tests, 2. Zero hunger, business.industry, Confounding, Absolute risk reduction, Age Factors, Infant, Atopic dermatitis, medicine.disease, Dermatology, 3. Good health, body regions, 030228 respiratory system, Relative risk, Concomitant, Child, Preschool, Female, business
Abstract

Background The atopic march describes the progression from atopic dermatitis during infancy to asthma and allergic rhinitis in later childhood. In a Canadian birth cohort we investigated whether concomitant allergic sensitization enhances subsequent development of these allergic diseases at age 3 years. Methods Children completed skin prick testing at age 1 year. Children were considered sensitized if they produced a wheal 2 mm or larger than that elicited by the negative control to any of 10 inhalant or food allergens. Children were also assessed for atopic dermatitis by using the diagnostic criteria of the UK Working Party. At age 3 years, children were assessed for asthma, allergic rhinitis, food allergy, and atopic dermatitis. Data from 2311 children were available. Results Atopic dermatitis without allergic sensitization was not associated with an increased risk of asthma at age 3 years after adjusting for common confounders (relative risk [RR], 0.46; 95% CI, 0.11-1.93). Conversely, atopic dermatitis with allergic sensitization increased the risk of asthma more than 7-fold (RR, 7.04; 95% CI, 4.13-11.99). Atopic dermatitis and allergic sensitization had significant interactions on both the additive (relative excess risk due to interaction, 5.06; 95% CI, 1.33-11.04) and multiplicative (ratio of RRs, 5.80; 95% CI, 1.20-27.83) scales in association with asthma risk. There was also a positive additive interaction between atopic dermatitis and allergic sensitization in their effects on food allergy risk (relative excess risk due to interaction, 15.11; 95% CI, 4.19-35.36). Conclusions Atopic dermatitis without concomitant allergic sensitization was not associated with an increased risk of asthma. In combination, atopic dermatitis and allergic sensitization had strong interactive effects on both asthma and food allergy risk at age 3 years.

Published
2017

543. Changing teachers’ practice in the Creative Arts classroom: The case for educational technologies

Author

Maxwell M. Sauls and Alethea de Villiers

Subjects
Dance, creative arts, media_common.quotation_subject, educational technologies, The arts, Arts in education, lcsh:Social Sciences, Perception, Pedagogy, ComputingMilieux_COMPUTERSANDEDUCATION, lcsh:Science, Curriculum, media_common, 060201 languages & linguistics, 05 social sciences, Professional development, Educational technology, 050301 education, 06 humanities and the arts, lcsh:H, changing practice teachers, 0602 languages and literature, lcsh:Q, Psychology, 0503 education, Drama
Abstract

The study described in this essay explores the use of educational technology as a resource in the Creative Arts classroom. Many teachers are not qualified to teach Creative Arts. They then tend to rely on curriculum documents and textbooks to help guide their planning, teaching and assessment. Most of the teachers who participated in this case study were not specialists in any of the arts, and in the education district where this study took place, there was a lack of ongoing professional development for the Creative Arts. To enable the teachers from Grades R to 7 to mediate more meaningful classroom teaching and learning in the Creative Arts, the researchers introduced the teachers to technology as a means to facilitate learning and teaching.This study follows a phenomenological approach to explore the use of educational technology in the teaching of dance, drama and music, which are three of the art forms in the Creative Arts. The researchers describe the teachers’ perceptions and attitudes towards using technology in the classroom. Eight teachers participated in the study (seven female and one male), ranging in age from 22 to 41 years. There were three teachers from the Foundation Phase, three teachers from the Intermediate Phase and two teachers from the Senior Phase. Data were collected from (1) unstructured open-ended conversational interviews, (2) observations of the participants during contact time with learners and (3) audio-visual recordings of the teachers in the classroom.Findings from the study showed that after the 10-month intervention of using educational technology in the classroom, there was divergence in the teachers’ use of technology. The findings also suggest that classroom practice in dance, drama and music improved.

Published
2017

544. A Comparison of Personality, Life Events, Comorbidity, and Health in Monozygotic Twins Discordant for Anorexia Nervosa

Author

Trace, S.E., Bulik, C.M., Thornton, L.M., Lichtenstein, P., Bergin, J.E., Pedersen, N.L., Brownley, K.A., Maxwell, M., Mazzeo, S.E., and Ålgars, M.

Abstract

Genetic and environmental factors contribute to the etiology of anorexia nervosa (AN). The co-twin control design is one of the most powerful methods available to evaluate environmental factors that could contribute to differences between monozygotic (MZ) twins who are discordant for AN. Using available data from a unique and rare sample of 22 Swedish female MZ pairs discordant for AN, we compared personality, life events, comorbidity, and health factors. Twins with AN had significantly higher perfectionism scores than unaffected co-twins and reported younger ages at first diet than unaffected co-twins who had dieted. Consistent with previous literature, more twins with AN reported gastrointestinal problems than unaffected co-twins. Although not significant due to low statistical power, more unaffected co-twins reported experiencing emotional neglect than twins with AN. Early dieting may be a harbinger of the development of AN or an early symptom. Higher perfectionism may represent a risk factor, sequela, or both. Sibling perception of neglect is noteworthy given the impact of an ill child with AN on family function and wellbeing. The health and wellbeing of siblings should be addressed clinically when one child in the family suffers from AN.

Published
2017
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545. Office and Home Blood Pressures as Determinants of Electrocardiographic Left Ventricular Hypertrophy Among Black Nigerians Compared With White Flemish

Author

Zhenyu Zhang, Lutgarde Thijs, Fang Fei Wei, Tim S. Nawrot, Maxwell M. Nwegbu, Jan A. Staessen, Tatiana Kuznetsova, Augustine N. Odili, John O. Ogedengbe, Ying Mei Feng, Lotte Jacobs, and Wen-Yi Yang

Subjects
Male, Office Visits, Original Contributions, Blood Pressure, risk stratification, 030204 cardiovascular system & hematology, Left ventricular hypertrophy, 0302 clinical medicine, Belgium, population science, Risk Factors, Odds Ratio, Prevalence, 030212 general & internal medicine, special populations, Morning, medicine.diagnostic_test, Nigerians, 1. No poverty, blood pressure, Middle Aged, left ventricular hypertrophy, 3. Good health, Cardiology, ethnicity, Female, Hypertrophy, Left Ventricular, Adult, medicine.medical_specialty, hypertension, Evening, electrocardiography, Black People, Nigeria, White People, 03 medical and health sciences, QRS complex, home blood pressure, Predictive Value of Tests, Internal medicine, Internal Medicine, medicine, Humans, cardiovascular diseases, Chi-Square Distribution, business.industry, Blood Pressure Determination, medicine.disease, Confidence interval, Self Care, Editor's Choice, Blood pressure, Multivariate Analysis, Linear Models, business, Electrocardiography
Abstract

BACKGROUND The association of electrocardiographic left ventricular hypertrophy (ECG-LVH) with blood pressure (BP) in Blacks living in sub-Saharan Africa remains poorly documented. METHODS In 225 Black Nigerians and 729 White Flemish, we analyzed QRS voltages and voltage-duration products and 12 criteria diagnostic of ECG-LVH in relation to office BP (mean of 5 consecutive readings) and home BP (duplicate morning and evening readings averaged over 1 week). RESULTS In multivariable analyses, QRS voltage and voltage-duration indexes were generally higher in Blacks than Whites. By using any of 12 criteria, ECG-LVH was more prevalent among Black than White men (54.4% vs. 36.0%) with no ethnic difference among women (17.1%). Precordial voltages and voltage-duration products increased with office and home systolic BP (SBP), and increases were up to 3-fold steeper in Blacks. In Blacks vs. Whites, increases in the Sokolow-Lyon voltage associated with a 10-mm Hg higher SBP were 0.18 mV (95% confidence interval [CI], 0.09-0.26) vs. 0.06 mV (0.02-0.09) and 0.17 mV (0.07-0.28) vs. 0.11 mV (CI, 0.07-0.15) for office and home BP, respectively, with a significant ethnic gradient (P < 0.05). The risk of ECG-LVH increased more with office and home BP in Blacks than Whites. CONCLUSIONS Associations of ECG voltages and voltage-duration products and risk of ECG-LVH with BP are steeper in Black Nigerians compared with a White reference population. In resource-poor settings of sub-Saharan Africa, the ECG in combination with office and home BP is an essential instrument in risk stratification across the entire BP range. The authors gratefully acknowledge the expert clerical assistance of Mrs. Vera De Leebeeck and Mrs. Renilde Wolfs (Studies Coordinating Centre, Leuven, Belgium). The European Union (HEALTH-FP7-278249-EUMASCARA, HEALTH-F7-305507 HOMAGE and the European Research Council (Advanced Researcher Grant 2011-294713-EPLORE and Proof-of-Concept Grant 713601-uPROPHET) and the Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Ministry of the Flemish Community, Brussels, Belgium (G.0881.13, G.088013, and 11Z0916N) currently support the Studies Coordinating Centre in Leuven.

Published
2017
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548. Approach for extracting complex dielectric function spectra in weakly-absorbing regions

Author

Nikolas J. Podraza, L. Karki Gautam, Maxwell M. Junda, D. B. Saint John, and Hamna F. Haneef

Subjects
Materials science, business.industry, Metals and Alloys, chemistry.chemical_element, Surfaces and Interfaces, Classification of discontinuities, Bismuth germanate, Molecular physics, Nanocrystalline material, Spectral line, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Amorphous solid, Bismuth, Condensed Matter::Materials Science, chemistry.chemical_compound, Optics, chemistry, Materials Chemistry, Thin film, business, Single crystal
Abstract

Ellipsometric spectra have been analyzed using a procedure whereby the complex dielectric function (e = e1 + ie2) is parameterized using different, physically realistic models in isolated regions of a single spectrum while layer thicknesses are kept common. The isolated spectral ranges correspond to regions where the material of interest is either non-absorbing or heavily absorbing and physically realistic models describing e are available. Common structural parameters (thicknesses) obtained by this divided spectral range approach are used to extract e by numerical inversion over the full spectral range. The divided spectral range analysis has been applied to study amorphous hydrogenated silicon, nanocrystalline zinc oxide, and epitaxial bismuth stannate thin films, as well as single crystal bismuth germanate. Layer thicknesses obtained from the divided range analysis are compared to those using continuous, but not necessarily physically supported, parameterizations of e over the full spectral range. The divided spectral range analysis yields inverted spectra in e which are free of discontinuities beyond noise present in experimental data and whose determination does not require any assumption to be made about the line shape of e in weakly absorbing regions.

Published
2014

550. Concurrent administration of aqueous extract of Cryptolepis sanguinolenta reduces the effectiveness of Artesunate against Plasmodium berghei in Rats

Author

Augustine Ocloo, Olga Quasie, Wennie Edem Okpattah, Laud Kenneth Okine, and Maxwell M. Sakyiamah

Subjects
Aqueous extract, Pretreatment Period, biology, business.industry, Cryptolepis sanguinolenta, Medicine (miscellaneous), Parasitemia, Pharmacology, medicine.disease, biology.organism_classification, chemistry.chemical_compound, chemistry, Artesunate, Medicine, Pharmacology (medical), Plasmodium berghei, General Pharmacology, Toxicology and Pharmaceutics, business
Abstract

treated with aqueous extract of C. sanguinolenta for two weeks whilst groups 1 (no drug) and 4 (Art) served as negative and positive controls, respectively and were given water. The rats were inoculated with P. berghei after the two weeks pretreatment period and were either not treated (no drug) or treated with artesunate (Art) or C. sanguinolenta (Cryp and Cryp/Art) 2 days post-inoculation. Parasitemia and chemosuppression were then determined in 4 and 6-day suppressive tests. The parasitemia in group 3 rats (Cryp/Art) was significantly (p < 0.05) higher (270%) than in group 4 (Art) on day 8. Consequently, the chemosuppression of artesunate only group was significantly (p < 0.05) higher (133%) than that of the concurrently administered Cryp/Art group. The findings show that concurrent usage of C. sanguinolenta and artesunate reduces the effectiveness of artesunate as an antimalarial. Therefore, patients should be advised on the implication of the practice of taking C. sanguinolenta and artesunate concurrently.

Published
2014

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