351. Oral vitamin C administration increases lipid peroxidation in hemodialysis patients.
- Author
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De Vriese AS, Borrey D, Mahieu E, Claeys I, Stevens L, Vanhaeverbeke A, Roelens M, and Langlois MR
- Subjects
- Administration, Oral, Aged, Aged, 80 and over, Ascorbic Acid adverse effects, Female, Humans, Lipid Peroxidation physiology, Male, Middle Aged, Oxidative Stress drug effects, Oxidative Stress physiology, Renal Dialysis methods, Ascorbic Acid administration & dosage, Lipid Peroxidation drug effects, Renal Dialysis trends
- Abstract
Background: Since vitamin C (ascorbic acid, AA) deficiency is common in hemodialysis patients, systematic supplementation has been recommended. Further, vitamin C has been advocated as a potential adjuvant to erythropoietin by virtue of its capacity to improve iron utilization. However, vitamin C may have a paradoxical pro-oxidant effect in the presence of iron., Methods: In 109 hemodialysis patients, oral vitamin C was administered at 360 and 1,500 mg/week during 3 months each, followed by a wash-out period of 3 months., Results: Serum AA increased from 0.22 to 0.33 and 0.63 mg/dl after 360 and 1,500 mg/week, respectively. However, a commensurate increase of plasma malondialdehyde (MDA), a parameter of lipid peroxidation, with 9 and 26% was observed. Serum AA and plasma MDA returned to baseline after withdrawal of vitamin C. Parameters of iron status, nutrition, inflammation, dialysis efficiency and plasma lipids remained unaltered. In a stepwise multiple regression analysis, serum AA and ferritin were strong and independent predictors of MDA., Conclusion: Oral vitamin C supplementation in hemodialysis patients increases lipid peroxidation, especially in patients with increased serum ferritin. The potential benefits of restored vitamin C status and improved erythropoiesis may be entirely overruled by the adverse consequences of oxidative tissue injury., ((c) 2007 S. Karger AG, Basel.)
- Published
- 2008
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