547 results on '"K. Brodersen"'
Search Results
502. Zur Bestimmung von äthylendiamintetraessigsaurem Natrium
- Author
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K. Brodersen
- Subjects
Engineering ,business.industry ,Environmental chemistry ,Clinical Biochemistry ,General Materials Science ,Analytical Chemistry (journal) ,General Medicine ,business ,Analytical Chemistry - Published
- 1957
503. Eine Methode zur Bestimmung von Kupfer, Kupfer(I)-oxyd und Kupfer(II)-oxyd nebeneinander
- Author
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K. Brodersen
- Subjects
Chemistry ,Clinical Biochemistry ,General Materials Science ,General Medicine ,Biochemistry ,Analytical Chemistry ,Nuclear chemistry - Published
- 1954
504. Zur Abtrennung saurer oder basischer Anteile in Steinkohlenteer und Pech
- Author
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K. Brodersen
- Subjects
Chemistry ,Clinical Biochemistry ,Radiochemistry ,General Materials Science ,General Medicine ,Analytical Chemistry - Published
- 1957
505. Neuere Struktur-Untersuchungen an Edelmetall-Verbindungen
- Author
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K. Brodersen
- Subjects
Chemistry ,General Medicine - Published
- 1964
506. Über die komplexometrische Caleiumbestimmung in biologischen Flüssigkeiten
- Author
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K. Brodersen
- Subjects
Engineering ,business.industry ,Environmental chemistry ,Clinical Biochemistry ,General Materials Science ,Analytical Chemistry (journal) ,General Medicine ,business ,Analytical Chemistry - Published
- 1956
507. Eine Lösung Ton Cer(IV)-di(äthylendiamin)-sulfat
- Author
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K. Brodersen
- Subjects
Chemistry ,Clinical Biochemistry ,General Materials Science ,General Medicine ,Analytical Chemistry ,Nuclear chemistry - Published
- 1957
508. Notizen: IR-Spektrum des Kohlenstoffmonofluorids
- Author
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W. Rüdorff and K. Brodersen
- Subjects
Chemistry ,Physical chemistry ,General Chemistry - Published
- 1957
509. Kupferronanaloge von Tetralin als analytische Reagentien
- Author
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K. Brodersen
- Subjects
Chemistry ,Clinical Biochemistry ,Organic chemistry ,General Materials Science ,General Medicine ,Analytical Chemistry - Published
- 1957
510. Persepolis Tablets
- Author
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Henkelman, Wouter, Henkelman, Wouter, R.S. Bagnall, K. Brodersen, C.B. Champion, A. Erskine, S.R. Huebner, École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL), Mondes Iranien et Indien - UMR 7528, Université Sorbonne Nouvelle - Paris 3-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National des Langues et Civilisations Orientales (Inalco)-Centre National de la Recherche Scientifique (CNRS), R.S. Bagnall, K. Brodersen, C.B. Champion, A. Erskine, and S.R. Huebner
- Subjects
Achaemenid administration ,[SHS] Humanities and Social Sciences ,Elamite ,Persepolis Fortification Archive ,ComputingMilieux_MISCELLANEOUS ,[SHS]Humanities and Social Sciences - Abstract
International audience
- Published
- 2013
511. South Arabian and Ge‘ez
- Author
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Gorea, Maria, Archéologie du Proche-Orient Hellénistique et Romain (APOHR), Archéologies et Sciences de l'Antiquité (ArScAn), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS), Université Paris 8 Vincennes-Saint-Denis - UFR Langues et cultures étrangères (UP8 UFR LLCER-LEA), Université Paris 8 Vincennes-Saint-Denis (UP8), R. S. Bagnall, K. Brodersen, C. B. Champion, A. Erskine, and S. A. Huebner
- Subjects
[SHS]Humanities and Social Sciences - Abstract
It is generally admitted that South Arabic and Ethiopic languages are closely related and form a dialectal unity within the Semitic languages. The South Arabic presence in the North of Ethiopia is well attested and vice-versa. The later Axumite dominance in Yemen is evidenced by reliable sources. Even though South Arabia and Ethiopia were connected from a political point of view, Ethiopic is not an offshoot of the South Arabic. Geʿez, the classical Ethiopic, shares some phonological and morphological characteristics with a part of the South Arabic languages, mostly with the Epigraphic South Arabic, but there are significant differences between them.
- Published
- 2018
512. Tremblers ( tresantes ) at Sparta
- Author
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Marcello Lupi, Lupi Marcello, R. Bagnall, K. Brodersen, C. Champion, A. Erskine, S. Huebner, and Lupi, Marcello
- Subjects
Sparta ,Trembler ,beautiful death - Abstract
“Tremblers” (tresantes) were those Spartans who had fled from the enemy. Since the Spartan code of values required them to remain in their ranks until victory or death, those who survived a defeat were socially humiliated and marginalized. While the term is already attested in Tyrtaios, the formalization of their status is elusive: the episodes that refer to some kind of social degradation and/or legal punishment of one or more Spartan tremblers are rare, limited to the years between 480 and 331 BCE, and not reducible to a common pattern.
- Published
- 2018
513. Chiliarchos
- Author
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MUCCIOLI, FEDERICOMARIA, AA.VV, R.S. BAGNALL, K. BRODERSEN, C.B. CHAMPION, A. ERSKINE, S. HUEBNER, and F. Muccioli
- Subjects
REGALITÀ ELLENISTICA ,AMMINISTRAZIONE ,STORIA PERSIANA ,STORIA GRECA - Abstract
Voce riguardante una delle cariche principali nelle regalità antiche, dal mondo achemenide fino a quello ellenistico.
- Published
- 2013
514. Memnon of Herakleia Pontica
- Author
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Federicomaria Muccioli, R.S. BAGNALL, K. BRODERSEN, C.B. CHAMPION, A. ERSKINE, S.R. HUEBNER, and F. Muccioli
- Subjects
STORIA ROMANA ,History ,Cultural history ,Second Sophistic ,Historiography ,Ancient Greek ,Ancient history ,language.human_language ,History of religions ,Political history ,language ,Social history ,Environmental history ,Humanities ,STORIA GRECA ,STORIOGRAFIA ANTICA - Abstract
Memnon was a local historian of Herakleia Pontica on the south coast of the Black Sea. Some scholars place him in the first century ce, others in the second – especially on somehow doubtful stylistic grounds, associating him with the Second Sophistic. A date in the first century bce is less likely, although not completely to be dismissed. Memnon wrote a history of his polis in at least sixteen books (we do not know the exact title; it could well have been Peri Herakleias). This work is known only through the long summary given by Photios. No other piece of ancient Greek local historiography is preserved to such an extent (FGrH 434). Photios declares that he was unable to find and read other parts of it, adding that Memnon's style was plain, clear, and with a conventional vocabulary, apart from some unusual words. Keywords: agriculture; cultural history; environmental history; farming; religious history; Roman history; social history
- Published
- 2013
515. Diadem
- Author
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MUCCIOLI, FEDERICOMARIA, AA.VV., R.S. BAGNALL, K. BRODERSEN, C.B. CHAMPION, A. ERSKINE, S. HUEBNER, and F. Muccioli
- Subjects
STORIA ROMANA ,REGALITÀ ELLENISTICA ,STORIA PERSIANA ,STORIA GRECA - Abstract
Voce riguardante uno dei simboli principali della regalità, dal mondo achemenide fino al Tardoantico.
- Published
- 2013
516. Mardonios
- Author
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MUCCIOLI, FEDERICOMARIA, R.S. BAGNALL, K. BRODERSEN, C.B. CHAMPION, A. ERSKINE, S. HUEBNER, and F. Muccioli
- Subjects
GUERRE PERSIANE ,STORIA PERSIANA ,STORIA GRECA - Abstract
Profilo sintetico, con bibliografia aggiornata, di un protagonista della storia persiana del V secolo
- Published
- 2013
517. Demochares of Athens
- Author
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Federicomaria Muccioli, R.S. BAGNALL, K. BRODERSEN, C.G. CHAMPION, A. ERSKINE, S.R. HUEBNER, and F. Muccioli
- Subjects
History ,Demochares ,media_common.quotation_subject ,PROSOPOGRAFIA GRECA ,Ancient history ,Intellectual history ,Democracy ,Nephew and niece ,Ancient Greece ,Politics ,government.politician ,government ,STORIA ELLENISTICA ,STORIA GRECA ,Classics ,STORIOGRAFIA ANTICA ,media_common - Abstract
Athenian democratic statesman, orator and historian, nephew and political heir of Demosthenes. Keywords: ancient Greece; chronicles and histories; Greek history; intellectual history
- Published
- 2013
518. Latifundia /large estates
- Author
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Annalisa Marzano, R. Bagnall, K. Brodersen, C. Champion, A. Erskine, S. Huebner, Marzano, and Annalisa
- Subjects
Ancient society ,Geography ,medicine.anatomical_structure ,Fundus (uterus) ,Roman history ,medicine ,Estate ,Ancient history ,estates, ancient society, latifundia, rural estates, ancient Rome ,Genealogy ,Ancient Rome - Abstract
Latifundia (from Lat. latus=large and fundus= estate) is a term that does not occur often in Latin sources; the majority of the texts concerned date to the first century ce. Keywords: agriculture; Roman history
- Published
- 2012
519. Ionian Revolt
- Author
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BOFFO, LAURA, Bagnall R., K. Brodersen, S.R. Huebner, C.B. Champion, A. Erskine, and Boffo, Laura
- Subjects
Istieo ,Aristagora ,Mileto - Published
- 2012
520. Villa
- Author
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Marzano Annalisa, R. Bagnall, K. Brodersen, C. Champion, A. Erskine, S. Huebner, Marzano, and Annalisa
- Subjects
agriculture, social systems ,ancient villa - Abstract
n/a
- Published
- 2012
521. Ergasterion, ergastulum
- Author
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Marzano Annalisa, R. Bagnall, K. Brodersen, C. Champion, A. Erskine, S. Huebner, Marzano, and Annalisa
- Subjects
ancient slavery ,erastula, ergasteria, production, slaves in ancient Greece, slaves in ancient Rome - Abstract
n/a
- Published
- 2012
522. Histiaios of Miletos
- Author
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Laura Boffo, Bagnall R., K. Brodersen, S.R. Huebner, C.B. Champion, A. Erskine, and Boffo, Laura
- Subjects
History ,Aristagora ,Rivolta ionica ,Political history ,Ancient history ,Mileto ,Classics - Abstract
Histiaios (ca. 555–493 bce), son of Lysagoras, from a distinguished family, was tyrant of Miletos, directly from ca. 515 to ca. 511, and through his relative Aristagoras. Keywords: Greek history; political history
- Published
- 2012
523. Aristagoras
- Author
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BOFFO, LAURA, Bagnall R., K. Brodersen, S.R. Huebner, C.B. Champion, A. Erskine, and Boffo, Laura
- Subjects
Istieo ,Rivolta ionica ,Mileto - Published
- 2012
524. Delos
- Author
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Chankowski, Véronique, Histoire, Archéologie et Littérature des Mondes Anciens - UMR 8164 (HALMA), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), R. Bagnall, K. Brodersen, C. Champion, A. Erskine, and S. Huebner
- Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory ,[SHS.CLASS]Humanities and Social Sciences/Classical studies ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2012
525. Panionion
- Author
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Boffo, Laura, Bagnall R., K. Brodersen, S.R. Huebner, C.B. Champion, A. Erskine, and Boffo, Laura
- Subjects
Panionio ,Rivolta ionica ,Micale - Published
- 2012
526. Temple Treasuries
- Author
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Chankowski, Véronique, Histoire Archéologie Littérature des Mondes Anciens - UMR 8164 (HALMA), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), R. Bagnall, K. Brodersen, C. Champion, A. Erskine, S. Huebner, and Histoire, Archéologie et Littérature des Mondes Anciens - UMR 8164 (HALMA)
- Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory ,[SHS.CLASS]Humanities and Social Sciences/Classical studies ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2012
527. Age-Class System (Ephebes, Neoi)
- Author
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Chankowski, Andrzej, Histoire, Archéologie et Littérature des Mondes Anciens - UMR 8164 (HALMA), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), R. Bagnall (éd.), K. Brodersen (éd.), C. B. Champion (éd.), A. Erskine (éd.), and S. R. Hübner (éd.)
- Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory ,[SHS.HIST]Humanities and Social Sciences/History ,[SHS.CLASS]Humanities and Social Sciences/Classical studies ,[SHS]Humanities and Social Sciences - Abstract
Notice de l'Encyclopedia of Ancient History (Malden - Oxford - Chichester, Wiley-Blackwell, éditeurs: R. Bagnall, K. Brodersen, C. B. Champion, A. Erskine, S. R. Hübner).
- Published
- 2012
528. Goya, Bramante and the Others on the Artemidorus Papyrus?
- Author
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ADORNATO, GIANFRANCO, K. Brodersen - J. Elsner, and Adornato, Gianfranco
- Published
- 2009
529. Thurioi
- Author
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FRISONE, Flavia, R. Bagnall, K. Brodersen, C. Champion, A. Erskine, S. Heubnes, and Frisone, Flavia
- Subjects
Greek History ,Colonisation ,Magna Graecia - Abstract
Synthetic history of the polis from shortly before its foundation to the period of its abandonement
- Published
- 2009
530. Increased Insulin Secretion and Glucose Effectiveness in Obese Patients with Type 2 Diabetes following Bariatric Surgery.
- Author
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Visentin R, Brodersen K, Richelsen B, Møller N, Dalla Man C, Pedersen AK, Abrahamsen J, Holst JJ, and Nielsen MF
- Subjects
- Humans, Glucose metabolism, Insulin Secretion, Blood Glucose metabolism, Obesity complications, Obesity surgery, Obesity metabolism, Insulin, Glucagon-Like Peptide 1, Gastrectomy methods, Insulin Resistance physiology, Diabetes Mellitus, Type 2, Bariatric Surgery, Gastric Bypass methods
- Abstract
Background: β -cell dysfunction and insulin resistance are the main mechanisms causing glucose intolerance in type 2 diabetes (T2D). Bariatric surgeries, i.e., sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), are procedures both known to induce weight loss, increase insulin action, and enhance β -cell function, but hepatic insulin extraction and glucose effectiveness may also play a role., Methods: To determine the contribution of these regulators on glucose tolerance after bariatric surgery, an oral glucose tolerance test (OGTT) was performed before and 2 months after surgery in 9 RYGB and 7 SG subjects. Eight healthy subjects served as metabolic controls. Plasma glucose, insulin, C-peptide, GLP-1, and GIP were measured during each OGTT. Insulin sensitivity and secretion, glucose effectiveness, and glucose rate of appearance were determined via oral minimal models., Results: RYGB and SG resulted in similar weight reductions (13%, RYGB ( p < 0.01); 14%, SG ( p < 0.05)). Two months after surgery, insulin secretion ( p < 0.05) and glucose effectiveness both improved equally in the two groups (11%, RYGB ( p < 0.01); 8%, SG ( p > 0.05)), whereas insulin sensitivity remained virtually unaltered. Bariatric surgery resulted in a comparable increase in the GLP-1 response during the OGTT, whereas GIP concentrations remained unaltered. Following surgery, oral glucose intake resulted in a comparable increase in hepatic insulin extraction, the response in both RYGB and SG patients significantly exceeding the response observed in the control subjects., Conclusions: These results demonstrate that the early improvement in glucose tolerance in obese T2D after RYGB and SG surgeries is attributable mainly to increased insulin secretion and glucose effectiveness, while insulin sensitivity seems to play only a minor role. This trial is registered with NCT02713555., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2023 Roberto Visentin et al.)
- Published
- 2023
- Full Text
- View/download PDF
531. Nanoengineering of electrodes via infiltration: an opportunity for developing large-area solid oxide fuel cells with high power density.
- Author
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Tong X, Li C, Xu K, Wang N, Brodersen K, Yang Z, and Chen M
- Abstract
Although nanoengineering of electrodes opens up the way to the development of solid oxide fuel cells (SOFCs) with improved performance, the practical implementation of such advances in cells suitable for widespread use remains a challenge. Here, the demonstration of large-area, commercially relevant SOFCs with two nanoengineered electrodes that display excellent performance is reported. The self-assembled nanocomposite La
0.6 Sr0.4 CoO3- δ and Co3 O4 is strategically designed and deposited into the well-interconnected Ce0.9 Gd0.1 O2- δ backbone as a cathode to enable an ultra-large electrochemically active region. The nanometer-scale Ce0.8 Gd0.2 O2- δ is deposited into a conventional Ni/yttria-stabilized zirconia (YSZ) anode to provide more active oxygen exchange kinetics and electronic conductivity compared to YSZ. The resulting nanoengineered cell with an effective size of 4 cm × 4 cm delivers a remarkable power output of 19.2 W per single cell at 0.6 V and 750 °C. These advancements have potential to facilitate the future development of high-performance SOFCs at a large scale by nanoengineering of electrodes and are expected to pave the way for the commercialization of this technology.- Published
- 2023
- Full Text
- View/download PDF
532. Psychometric evaluation of a quality of recovery score for the postanesthesia care unit-A preliminary validation study.
- Author
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Kahl U, Brodersen K, Kaiser S, Krause L, Klinger R, Plümer L, Zöllner C, and Fischer M
- Subjects
- Adult, Humans, Female, Psychometrics, Reproducibility of Results, Surveys and Questionnaires, Self Report, Anesthesia Recovery Period
- Abstract
Introduction: Patients' perception of postoperative recovery is a key aspect of perioperative care. Self-reported quality of recovery (QoR) has evolved as a relevant endpoint in perioperative research. Several psychometric instruments have been introduced to assess self-reported recovery 24 hours after surgery. However, there is no questionnaire suitable for use in the postanesthesia care unit (PACU). We aimed to develop and psychometrically evaluate a QoR questionnaire for the PACU (QoR-PACU)., Methods: The QoR-PACU was developed in German language based on the 40-item QoR-40 questionnaire. Between March and November 2020, adult patients scheduled for elective urologic surgery completed the QoR-PACU preoperatively and during the PACU stay. We evaluated feasibility, validity, reliability, and responsiveness., Results: We included 375 patients. After two piloting phases including 72 and 48 patients, respectively, we administered the final version of the QoR-PACU to 255 patients, with a completion rate of 96.5%. Patients completed the QoR-PACU at a median of 125.0 (83.0; 156.8) min after arrival in the PACU. Construct validity was good with postoperative QoR-PACU sum scores correlating with age (r = 0.23, 95% CI: 0.11 to 0.35, p < 0.001), length of PACU stay (r = -0.15, 95%CI: -0.27 to -0.03, p = 0.02), pain in the PACU (r = -0.48, 95% CI: -0.57 to -0.37, p < 0.001) and piritramide dose administered (r = -0.29, 95% CI: -0.40 to -0.17, p < 0.001). Cronbach's alpha was 0.67 (95% CI: 0.61-0.73) with moderate test-retest reliability (ICC of 0.67, 95% CI: 0.38 to 0.83). Cohen's effect size was 3.08 and the standardized response mean was 1.65 indicating adequate responsiveness., Conclusion: The assessment of QoR in the early postoperative period is feasible. We found high acceptability, good validity, adequate responsiveness, and moderate reliability. Future studies should evaluate the psychometric properties of the QoR-PACU in more heterogeneous patient populations including female and gender-diverse patients with varying degress of perioperative risk., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Kahl et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2023
- Full Text
- View/download PDF
533. Is excessive smartphone use associated with weight status and self-rated health among youth? A smart platform study.
- Author
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Brodersen K, Hammami N, and Katapally TR
- Subjects
- Humans, Adolescent, Cross-Sectional Studies, Obesity, Surveys and Questionnaires, Smartphone, Mobile Applications
- Abstract
Background: In Canada, it is recommended that youth limit screen time to less than two hours per day, yet, the majority of youth are reportedly spending a significantly higher amount of time in front of a screen. This is particularly concerning given that these recommendations do not take into account smartphone devices, which is the most common screen time technology of choice for the younger generations. This study implements an innovative approach to understanding screen time behavior and aims to investigate the unique relationship between smartphone specific screen time and physical health outcomes., Methods: This cross-sectional study is part of the Smart Platform, a digital epidemiological and citizen science initiative. 436 youth citizen scientists, aged 13-21 years, provided all data via their own smartphones using a custom-built smartphone application. Participants completed a 124-item baseline questionnaire which included validated self-report surveys adapted to collect data specifically on smartphone use (internet use, gaming, and texting), demographic characteristics, and physical health outcomes such as weight status and self-rated health. Binary regression models determined the relationship between smartphone use and physical health outcomes., Results: Overall participants reported excessive smartphone use in all categories. 11.4% and 12% of the 436 youth participants reported using their smartphone excessively (greater than 2 h per day) during the week and weekend respectively for gaming and were over 2 times more likely than their peers to fall within an overweight/obese BMI status. Excessive weekend gaming was also associated with self-rated health where participants were over 2 times more likely than their peers to report poor self-rated health., Conclusions: The results indicate that excessive screen time on smartphones does have complex associations with youth health. Further investigation with more robust study designs is needed to inform smartphone-specific screen time guidelines for youth., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
534. Comparable Effects of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass on Basal Fuel Metabolism and Insulin Sensitivity in Individuals with Obesity and Type 2 Diabetes.
- Author
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Brodersen K, Nielsen MF, Richelsen B, Lauritzen ES, Pahle E, Abrahamsen J, Hartmann B, Holst JJ, and Møller N
- Subjects
- Humans, Blood Glucose metabolism, Gastrectomy methods, Glucose metabolism, Insulin, Obesity complications, Obesity surgery, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 surgery, Gastric Bypass methods, Insulin Resistance, Obesity, Morbid complications, Obesity, Morbid surgery
- Abstract
Aim: Bariatric surgery improves insulin sensitivity and glucose tolerance in obese individuals with type 2 diabetes (T2D), but there is a lack of data comparing the underlying metabolic mechanisms after the 2 most common surgical procedures Roux-en-Y gastric bypass surgery (RYGB) and sleeve gastrectomy (SG). This study was designed to assess and compare the effects of RYGB and SG on fuel metabolism in the basal state and insulin sensitivity during a two-step euglycemic glucose clamp., Materials and Methods: 16 obese individuals with T2D undergoing either RYGB ( n = 9) or SG ( n = 7) were investigated before and 2 months after surgery, and 8 healthy individuals without obesity and T2D served as controls. All underwent a 2 h basal study followed by a 5 h 2-step hyperinsulinemic euglycemic glucose clamp at insulin infusion rates of 0.5 and 1.0 mU/kg LBM/min., Results: RYGB and SG induced comparable 15% weight losses, normalized HbA1c, fasting glucose, fasting insulin, and decreased energy expenditure. In parallel, we recorded similar increments (about 100%) in overall insulin sensitivity ( M -value) and glucose disposal and similar decrements (about 50%) in endogenous glucose production and FFA levels during the clamp; likewise, basal glucose and insulin concentrations decreased proportionally., Conclusion: Our data suggest that RYGB and SG improve basal fuel metabolism and two-step insulin sensitivity in the liver, muscle, and fat and seem equally favourable when investigated 2 months after surgery. This trial is registered with NCT02713555., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2022 Katrine Brodersen et al.)
- Published
- 2022
- Full Text
- View/download PDF
535. Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY: A human-randomized cross-over trial.
- Author
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Brodersen K, Mose M, Ramer Mikkelsen U, Jørgensen JOL, Festersen Nielsen M, Møller N, Wegeberg AM, Brock C, Hartmann B, Holst JJ, and Rittig N
- Subjects
- Cross-Over Studies, Gastrointestinal Motility, Glucagon-Like Peptide 1, Humans, Inflammation, Lipopolysaccharides, Male, Nausea chemically induced, Gastrointestinal Hormones, Peptide YY
- Abstract
Severe systemic inflammation is associated with nausea, loss of appetite, and delayed gastric emptying, which increases hospitalization admission length and mortality rate. There is a lack of human controlled studies exploring gastric emptying rates and underlying mechanisms during inflammatory conditions. We aimed to investigate if systemic inflammation in young men delays gastro-intestinal transit times, lowers motility, and affects gastrointestinal hormone secretion. This substudy of a randomized crossover trial investigated eight healthy young men on two separate occasions; (I) following an overnight fast (healthy conditions/HC) and (II) fasting and bedrest combined with two lipopolysaccharide (LPS) injections of 1 ng kg
-1 following an overnight fast and 0.5 ng kg-1 following another 24 h (systemic inflammation/SI). A standardized protein beverage and a SmartPill capsule (a wireless gastrointestinal monitoring system) were swallowed during each occasion. Whole gut transit time was comparable between HC and SI. SI decreased gastric mean pressure peak amplitude (p = 0.04) and increased pH rise across the pylorus and small bowel pH (p = 0.02) compared with HC. Glucagon-like peptide-1 was elevated during SI compared with HC (p = 0.04). Peptide YY was lower during SI compared with HC (p = 0.007). Prolonged LPS exposure combined with fasting and bedrest elevated glucagon-like peptide 1 concentrations, which may play a role for the nausea and loss of appetite typically associated with SI., (© 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)- Published
- 2022
- Full Text
- View/download PDF
536. Production of a monolithic fuel cell stack with high power density.
- Author
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Pirou S, Talic B, Brodersen K, Hauch A, Frandsen HL, Skafte TL, Persson ÅH, Høgh JVT, Henriksen H, Navasa M, Miao XY, Georgolamprou X, Foghmoes SPV, Hendriksen PV, Nielsen ER, Nielsen J, Wulff AC, Jensen SH, Zielke P, and Hagen A
- Abstract
The transportation sector is undergoing a technology shift from internal combustion engines to electric motors powered by secondary Li-based batteries. However, the limited range and long charging times of Li-ion batteries still hinder widespread adoption. This aspect is particularly true in the case of heavy freight and long-range transportation, where solid oxide fuel cells (SOFCs) offer an attractive alternative as they can provide high-efficiency and flexible fuel choices. However, the SOFC technology is mainly used for stationary applications owing to the high operating temperature, low volumetric power density and specific power, and poor robustness towards thermal cycling and mechanical vibrations of conventional ceramic-based cells. Here, we present a metal-based monolithic fuel cell design to overcome these issues. Cost-effective and scalable manufacturing processes are employed for fabrication, and only a single heat treatment is required, as opposed to multiple thermal treatments in conventional SOFC production. The design is optimised through three-dimensional multiphysics modelling, nanoparticle infiltration, and corrosion-mitigating treatments. The monolithic fuel cell stack shows a power density of 5.6 kW/L, thus, demonstrating the potential of SOFC technology for transport applications., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
537. Validation of a translated Quality of Recovery-15 questionnaire in German patients undergoing elective noncardiac surgery.
- Author
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Kahl U, Gebhardt N, Brodersen K, Kainz E, Schirren L, Yu Y, Krause L, Klinger R, Zöllner C, and Fischer M
- Subjects
- Adult, Elective Surgical Procedures methods, Female, Germany, Humans, Male, Prospective Studies, Psychometrics, Reproducibility of Results, Anesthesia Recovery Period, Perioperative Care methods, Surveys and Questionnaires
- Published
- 2021
- Full Text
- View/download PDF
538. Anabolic effects of oral leucine-rich protein with and without β-hydroxybutyrate on muscle protein metabolism in a novel clinical model of systemic inflammation-a randomized crossover trial.
- Author
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Mose M, Brodersen K, Rittig N, Schmidt J, Jessen N, Mikkelsen UR, Jørgensen JOL, and Møller N
- Subjects
- 3-Hydroxybutyric Acid administration & dosage, Adult, Cross-Over Studies, Energy Metabolism, Gene Expression Regulation drug effects, Humans, Lactoglobulins administration & dosage, Lipopolysaccharides toxicity, Male, Muscle Proteins genetics, Signal Transduction, Young Adult, 3-Hydroxybutyric Acid pharmacology, Inflammation chemically induced, Lactoglobulins pharmacology, Lipid Peroxidation, Muscle Proteins metabolism
- Abstract
Background: β-lactoglobulin (BLG) stimulates muscle protein synthesis and β-hydroxybutyrate (BHB) inhibits muscle breakdown. Whether combining the 2 can additively attenuate disease-induced muscle loss is unknown., Objective: Based on previous observations of anticatabolic effects of protein and ketone bodies during inflammation, and using a novel model combining ongoing systemic inflammation, fasting, and immobilization, we tested whether the anticatabolic muscle response to oral amino acids is altered compared with control conditions, as well as whether coadministration of oral BHB and BLG further improves the muscle anabolic response. Muscle net balance (NBphe) was the primary outcome and intramyocellular signals were assessed., Methods: In a randomized crossover design, 8 young men underwent either preconditioning with LPS (prestudy day: 1 ng/kg, study day: 0.5 ng/kg) combined with a 36-h fast and bed rest to mimic catabolic inflammatory disease (CAT) or an overnight fast (control [CTR]) prior to isocaloric nutritional interventions on 3 occasions separated by ∼6 wk (range 42 to 83 d)., Results: NBphe increased similarly upon all conditions (interaction P = 0.65). From comparable baseline rates, both Rdphe [muscle synthesis, median ratio (95% CI): 0.44 (0.23, 0.86) P = 0.017] and Raphe [muscle breakdown, median ratio (95% CI): 0.46 (0.27, 0.78) P = 0.005] decreased following BHB + BLG compared with BLG. BLG increased Rdphe more under CAT conditions compared with CTR (interaction P = 0.02). CAT increased inflammation, energy expenditure, and lipid oxidation and decreased Rdphe and anabolic signaling [mammalian target of rapamycin (mTOR) and eukaryotic translation initiation factor 4E-binding protein 1 (4EPB1) phosphorylation]., Conclusion: In contrast to our initial hypothesis, NBphe increased similarly following BLG during CAT and CTR conditions; CAT however, specifically stimulated the BLG-mediated increase in protein synthesis, whereas BHB coadministration did not affect NBphe, but distinctly dampened the BLG-induced increase in muscle amino acid fluxes thereby liberating circulating amino acids for anabolic actions elsewhere., (© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.)
- Published
- 2021
- Full Text
- View/download PDF
539. A 4 × 4 cm 2 Nanoengineered Solid Oxide Electrolysis Cell for Efficient and Durable Hydrogen Production.
- Author
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Tong X, Ovtar S, Brodersen K, Hendriksen PV, and Chen M
- Abstract
Despite various advantages of high-temperature solid oxide electrolysis cells (SOECs) over their low-temperature competitors, the insufficient long-term durability has prevented the commercialization of SOECs. Here, we address this challenge by employing two nanoengineered electrodes. The O
2 electrode consists of a La0.6 Sr0.4 CoO3-δ (LSC) and Gd,Pr-co-doped CeO2 (CGPO) nanocomposite coating deposited on a Gd-doped CeO2 (CGO) scaffold, and the H2 electrode comprises a Ni/yttria stabilized zirconia (YSZ) electrode modified with a nanogranular CGO coating. The resulting cell with an active area of 4 × 4 cm2 exhibits a current density exceeding 1.2 A cm-2 at 1.3 V and 750 °C for steam electrolysis while also offering excellent long-term durability at 1 A cm-2 with a high steam-to-hydrogen conversion of ∼56%. We further unravel the degradation mechanism of the most commonly used Ni/YSZ electrode under these conditions and describe the mitigation of the discussed mechanism on our nanoengineered electrode. Our findings demonstrate the potential of designing robust SOECs by nanoengineering electrodes through infiltration and have significant implications for the practical integration of SOEC technology in the future sustainable energy system.- Published
- 2019
- Full Text
- View/download PDF
540. [Acute aortic syndrome].
- Author
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Hill-Madsen L, Brodersen K, and Høgh A
- Subjects
- Acute Disease therapy, Aortic Dissection diagnosis, Aortic Dissection diagnostic imaging, Aortic Dissection therapy, Aortic Aneurysm diagnosis, Aortic Aneurysm diagnostic imaging, Aortic Aneurysm therapy, Aortography, Hematoma diagnosis, Hematoma diagnostic imaging, Hematoma therapy, Humans, Plaque, Atherosclerotic diagnosis, Plaque, Atherosclerotic diagnostic imaging, Plaque, Atherosclerotic therapy, Syndrome, Tomography, X-Ray Computed, Ulcer diagnosis, Ulcer diagnostic imaging, Ulcer therapy, Aortic Diseases diagnosis, Aortic Diseases diagnostic imaging, Aortic Diseases therapy
- Abstract
Acute aortic syndrome is a group of pathogenic conditions including aortic dissection, intramural haematoma, penetrating ulcer and aortic aneurysm. The syndrome is a challenging clinical diagnosis because the symptoms are numerous and diverse with similarity to other more common conditions. Delayed diagnosis and treatment can be fatal. Computed tomography angiography is the most important diagnostic tool and is the first choice when acute aortic syndrome is suspected. With this article, we wish to raise awareness of the incidence of acute aortic syndrome and the clinical features of the syndrome.
- Published
- 2016
541. Impaired hepatic counterregulatory response to insulin-induced hypoglycemia in hepatic denervated pigs.
- Author
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Nielsen MF, Roelsgaard K, Keiding S, Brodersen K, Møller N, Vyberg M, and Vilstrup H
- Abstract
Objective: The liver reacts to hypoglycemia by increasing its glucose output. This response is assumed to depend both on glucose sensing at the liver and the brain, as well as efferent impulses from the brain to the liver. We tested the importance of this signaling pathway by studying the hepatic response to insulin-induced hypoglycemia in hepatic complete denervated pigs., Materials/methods: Two weeks prior to the metabolic study, 36-kg pigs underwent either total hepatic denervation (DN; n = 12) or sham operation (sham; n = 12). On the metabolic study day, measurements were performed at baseline conditions and during a hypoglycemic hyperinsulinemic (5 mU/kg/min) clamp. Endogenous insulin and glucagon secretions were inhibited by somatostatin, and glucagon was replaced at baseline levels. Endogenous glucose production (EGP) and glucose utilization (Rd) were determined by [3-
3 H] glucose infusion., Results: Baseline plasma concentrations of glucose, insulin, EGP and Rd did not differ significantly between the two groups of animals. During insulin infusion, the plasma glucose concentration was clamped at ~3 mmol/L in both groups of animals resulting in an increase in plasma concentrations of epinephrine and norepinephrine in sham pigs (both P < 0.05), while this effect was abolished in DN pigs. While insulin action (P = 0.09) and glucose utilization (P = 0.44) were similar, EGP was markedly decreased in the DN pigs (P < 0.05)., Conclusion: The findings indicate a blunted hepatic counterregulatory response to hypoglycemia following complete hepatic denervation. This implies that intact neural impulses to and from the liver are necessary to maintain the increase in EGP that protects the organism against hypoglycemia.- Published
- 2015
- Full Text
- View/download PDF
542. [Intussusception of the appendix].
- Author
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Brodersen K
- Subjects
- Adult, Appendix surgery, Cecal Diseases surgery, Colectomy, Endometriosis surgery, Female, Humans, Intussusception surgery, Appendix pathology, Cecal Diseases etiology, Endometriosis complications, Intussusception etiology
- Abstract
Intussusception of the appendix is a rare condition with an incidence of approximately 0.01%. In adults, the lead point for the intussusception is most frequently endometriosis, whereas in children, acute inflammation of the appendix is usually the cause (76%). This case report presents a 41-year-old woman who was referred to hospital care primarily due to blood in her stool and a 1 × 3 cm polypous tumour in her caecum, observed during colonoscopy. She had no gynaecologic history and a normal exam. A right-sided hemicolectomy was performed and pathology showed endometriosis and acute and chronic inflammation.
- Published
- 2015
543. Patients' participation in and evaluation of a follow-up program following intensive care.
- Author
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Glimelius Petersson C, Bergbom I, Brodersen K, and Ringdal M
- Subjects
- APACHE, Aged, Female, Follow-Up Studies, Humans, Intensive Care Units, Male, Middle Aged, Nurses, Recovery of Function, Research Design, Surveys and Questionnaires, Telephone, Critical Care, Patient Participation
- Abstract
Background: Patients' difficulties following critical illness and the willingness of intensive care units (ICU) to take an expanded responsibility during the recovery period have led to the development of different follow-up programs. The aim of this study was to explore and describe patients' participation in and evaluation of a follow-up program at a nurse-led clinic (NLC)., Methods: Patients with a length of stay ≥72 h, discharged from the ICU, participated in a follow-up program based on three contacts, as a visit to the NLC, telephone contact, ward visit or as an indirect contact, during a 6-month period. A specially developed database recorded information regarding patients' participation and questionnaires were used to obtain patients' views of the follow-up program., Results: Of 96 study patients, 51% visited the NLC once or twice. These patients were younger (P<0.001) and had lower Acute Physiology and Chronic Health Evaluation II (P=0.017) compared with those who did not visit the clinic. The most common reason for not visiting the clinic was not enough strength, chiefly physical. In the evaluation, patients answered that they received advice and information, an opportunity to talk, increased knowledge and re-evaluated memories and experiences from the ICU stay. Patients appreciated the follow-up and expressed gratitude to the competent and obliging staff., Conclusion: The current follow-up program, adjusted to individual patients' conditions and needs in terms of different types of contacts and continuity, was found to be of great value. Effects of the program other than the patient perspective are also relevant to evaluate., (© 2011 The Authors. Acta Anaesthesiologica Scandinavica © 2011 The Acta Anaesthesiologica Scandinavica Foundation.)
- Published
- 2011
- Full Text
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544. [Computer-assisted blood glucose control in intensive care units patients].
- Author
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Brodersen K
- Subjects
- Critical Illness therapy, Evidence-Based Medicine, Humans, Hypoglycemic Agents administration & dosage, Insulin administration & dosage, Software, Blood Glucose analysis, Critical Care methods, Monitoring, Physiologic methods
- Published
- 2005
545. [An ethically credible intensive care shields the terminally ill patient].
- Author
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Lundberg D, Brodersen K, Hermerén G, Hvarfner A, Nilstun T, Ranklev-Twetman E, Romner B, and Roth B
- Subjects
- Humans, Physician's Role, Sweden, Tissue Donors ethics, Tissue Donors legislation & jurisprudence, Critical Care ethics, Terminally Ill, Tissue and Organ Procurement ethics
- Published
- 2003
546. The influence of ionic strength and pH on the aggregation properties of zinc-free insulin studied by static and dynamic laser light scattering.
- Author
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Kadima W, Ogendal L, Bauer R, Kaarsholm N, Brodersen K, Hansen JF, and Porting P
- Subjects
- Chemical Phenomena, Chemistry, Physical, Kinetics, Lasers, Light, Scattering, Radiation, Hydrogen-Ion Concentration, Insulin chemistry, Osmolar Concentration, Zinc chemistry
- Abstract
The aggregation properties of zinc-free insulin have been studied using static and dynamic light scattering. The aggregation has been investigated as a function of three parameters, the concentration of sodium chloride (in the range 10-100 mM), the pH value (in the range pH 7.5-10.5), and the insulin concentration (1.8-13.4 mg/mL). The measured homodyne autocorrelation function was used to determine the apparent mean hydrodynamic diameter as well as the apparent weight-averaged molar mass of the insulin species in solution. A method of data analysis was employed, which allows the separation of light scattering contributions from the insulin oligomers and from irrelevant macromolecules and possible impurities present in the sample solutions. Also, a simple phenomenological equilibrium model describing the association of oligomers of insulin is presented. One aspect of this model is that it makes it possible to determine weight average molar masses corrected for virial effects on the Rayleigh ratio. This was necessary because virial effects cannot be isolated and corrected for by dilution since this would change the equilibrium distribution of oligomers. The basis of the model is a positive contribution to Gibbs free energy from charge repulsion depending on the protein charge and the number of monomers in the oligomers, and an assumed constant negative contribution to Gibbs free energy arising from either an entropic gain or hydrogen bonding upon association. The equilibrium model gives a good description of both the apparent weight average molar masses and the apparent hydrodynamic diameters, when the effect of the insulin concentration is taken into account by including virial effects arising from charge-charge repulsion (Donnan effect). The result shows that the association of insulin as a function of pH and ionic strength can be described by an effective charge equal to the charge derived from proton titration reduced by the number of sodium ions binding to insulin. At the lowest pH and highest salt concentration (pH 7.5, 100 mM NaCl, 12 mg/mL insulin), the weight average molar mass is close to that of the hexamer, and at the highest pH and lowest salt concentration (pH 10.5, 10 mM NaCl, 1.9 mg/mL), the weight average molar mass is close to that of the monomer. In all cases, however, a distribution of oligomers is present with a relative Gaussian width of about 30%.(ABSTRACT TRUNCATED AT 400 WORDS)
- Published
- 1993
- Full Text
- View/download PDF
547. Indirect determination of traces of thiosulphate by differential-pulse polarography.
- Author
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Brodersen K, Werner U, Gawargious YA, and Huang S
- Abstract
Two methods are reported for the indirect determination of thiosulphate down to ca. 0.02 microg/ml by differential-pulse polarography. Both methods involve prior oxidation of thiosulphate with iodine, either in acidic medium to tetrathionate or in alkaline medium to sulphate, whereby ultimately one and eight equivalents of iodate are obtained, respectively. The concentration of iodate in the resulting solution is then measured by differential-pulse polarography under optimum conditions. The average recovery for each method amounted to 100.1%, and the relative standard deviations were 1.3 and 1.4% for the two methods.
- Published
- 1991
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