523 results on '"Jin Hwa Lee"'
Search Results
502. Direct and indirect bacterial killing functions of neutrophil defensins in lung explants.
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Porro, Giuliana A., Jin-Hwa Lee, De Azavedo, Joyce, Crandall, Ian, Whitehead, Thomas, Tullis, Elizabeth, Ganz, Tomas, Mingyao Liu, Slutsky, Arthur S., and Haibo Zhang
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NEUTROPHILS , *CYSTIC fibrosis , *PATIENTS - Abstract
Examines the function of neutrophil defensins for the direct and indirect bacterial killing in the lung explant. Preparation of bacterial suspension for the analysis; Isolation of defensins from the sputum of patients with cystic fibrosis; Effects of defensins on the host defense.
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- 2001
503. Clinical Outcome and Prognosis of Patients Admitted to the Surgical ICU after Abdomen Surgery
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Jung Hyun Chang, Yon Ju Ryu, Jin Hwa Lee, and Yun Su Sim
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Mechanical ventilation ,Univariate analysis ,medicine.medical_specialty ,business.industry ,Proportional hazards model ,intensive care units ,medicine.medical_treatment ,Mortality rate ,Hazard ratio ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,body mass index ,lcsh:RC86-88.9 ,Surgery ,SAPS II ,surgery ,medicine ,postoperative complications ,business ,Body mass index ,Abdominal surgery - Abstract
Background: Postoperative admission to the surgical intensive care unit (S-ICU) is commonly planned to prevent and treat complications, unnecessary admission to the S-ICU increases medical costs and length of hospital stay. This study aimed evaluated outcome and the predictive factors for mortality in patients admitted to the S-ICU after abdominal surgery. Methods: The 168 patients admitted to the S-ICU immediately after abdominal surgery were reviewed retrospectively from January to December 2011. Results: The mortality rate of patients admitted to the S-ICU after abdominal surgery was 8.9% (15 of 168). Two preoperative factors (body mass index [BMI] < 18.5 kg/m2 [p < 0.001] and serum albumin < 3.0 g/dL [p = 0.018]), two operative factors (the need for transfusion [p = 0.008] or vasopressors [p = 0.013] during surgery), and three postoperative variables (mechanical ventilation immediately following surgery [p < 0.001], sequential organ failure assessment [p = 0.001] and SAPS II [p = 0.001] score) were associated with mortality in univariate analysis. After adjusting for age, gender, and SAPS II by a Cox regression, which revealed that BMI < 18.5 kg/m2 (p < 0.001, hazard ratio [HR] 9.690, 95% confidence interval [CI] 2.990-25.258) and the use of mechanical ventilation on admission to S-ICU (p < 0.001, HR 34.671, 95% CI 6.440-186.649) were independent prognostic factors. Conclusions: In patients in S-ICU after abdominal surgery, low BMI and postsurgical mechanical ventilation should be considered important predictors of mortality.
504. CT scanning-based phenotypes vary with ADRB2 polymorphisms in chronic obstructive pulmonary disease
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Ji Hyun Lee, Ho Il Yoon, Sang Do Lee, Joon Beom Seo, Yeon-Mok Oh, Tae Hyung Kim, Woo Jin Kim, Jin Hwa Lee, Sang Min Lee, Young Kyung Lee, Tae Rim Shin, Eun Kyung Kim, Jin Won Huh, Sung Youn Kwon, Seong Yong Lim, Sangyeub Lee, Namkug Kim, and Joohon Sung
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Pulmonary and Respiratory Medicine ,Male ,Risk ,Pathology ,medicine.medical_specialty ,Genotype ,medicine.drug_class ,FEV1/FVC ratio ,Pulmonary Disease, Chronic Obstructive ,Internal medicine ,Bronchodilator ,Forced Expiratory Volume ,Parenchyma ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,COPD ,Risk factor ,Polymorphism ,Lung ,Computed tomography ,Aged ,Analysis of Variance ,Polymorphism, Genetic ,business.industry ,Smoking ,Middle Aged ,respiratory system ,medicine.disease ,respiratory tract diseases ,Pulmonology ,medicine.anatomical_structure ,Phenotype ,Female ,Receptors, Adrenergic, beta-2 ,business ,Airway ,Tomography, X-Ray Computed - Abstract
Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease that is characterized by varying degrees of involvement of airway and lung parenchyma. Although cigarette smoke is the major risk factor for COPD, the principal determining factors of involvement of the airway or lung parenchyma have not been clearly defined. Genetic variability in COPD patients might influence the varying degrees of involvement of airway and parenchyma. We therefore studied whether airway and parenchyma involvement might be associated with the ADRB2 genotype, which has been reported to be associated with COPD susceptibility and the bronchodilator response. Methods One hundred and eleven COPD subjects, whose post-bronchodilator FEV(1)/FVC values were less than 0.7, and who had histories of smoking exceeding 10 pack-years, were prospectively recruited from pulmonology clinics of 11 hospitals in Seoul, Korea. The degrees of involvement of airway and parenchyma were evaluated by volumetric computed tomography (CT) scans. In-house software automatically calculated luminal areas, airway wall areas, percentages of wall areas in segmental bronchi, emphysema indices, and mean lung densities in the whole lung parenchyma. The ADRB2 genotypes at codon 16 were determined for all patients. Results Gly16 was associated with lumen diameter, luminal area, and percentage of wall area in patients with COPD (p=0.02), whereas neither wall area nor wall thickness differed with ADRB2 genotype. Neither emphysema index nor mean lung density was associated with ADRB2 genotype. Conclusion Gly16 variant in ADRB2 gene was associated with airway wall phenotypes measured using CT scanning in COPD patients.
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505. Lung function in patients with chronic airflow obstruction due to tuberculous destroyed lung
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J.H Chang and Jin Hwa Lee
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Male ,Spirometry ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Vital capacity ,medicine.drug_class ,Vital Capacity ,Chronic airflow obstruction ,Gastroenterology ,Pulmonary Disease, Chronic Obstructive ,FEV1/FVC ratio ,Airway resistance ,Forced Expiratory Volume ,Internal medicine ,Bronchodilator ,Humans ,Medicine ,Tuberculosis ,Tuberculosis, Pulmonary ,Aged ,Respiratory Sounds ,COPD ,Lung ,medicine.diagnostic_test ,business.industry ,Smoking ,Respiratory disease ,Middle Aged ,respiratory system ,medicine.disease ,Surgery ,respiratory tract diseases ,medicine.anatomical_structure ,Female ,business - Abstract
Lung function in cases of chronic airflow obstruction (CAO) due to tuberculous destroyed lung, which is still common in Korea, has not been objectively investigated. We evaluated lung functions and postbronchodilator responses in 21 CAO patients with a forced expiratory volume in 1 s (FEV1) of 30-65% of the predicted value, and compared some of these results with those of age-, sex- and FEV1% predicted-matched patients with chronic obstructive pulmonary disease (COPD). In addition, we analyzed the lung functions of CAO patients with respect to wheezing. The forced vital capacity (FVC) (P < 0.05) and postbronchodilator FEV1 of CAO patients were lower than those of COPD patients (P < 0.05). When a positive bronchodilator response was defined as an absolute change of FEV1 (FEV1 delta(abs)) of more than 0.2 l (P < 0.05) and a percentage of initial FEV1 (FEV1 delta%init) of more than 12%, the positive rates in CAO patients were lower than in COPD patients (P < 0.05). Among the CAO patients, patients with wheezing showed lower forced expiratory flow 25%-75% (FEF(25-75%)) (P < 0.05) and higher airway resistance than those without wheezing (P < 0.05). CAO patients with wheezing were more responsive to bronchodilator than those without wheezing. Although the pathophysiology of CAO differs from that of COPD, bronchodilator therapy could be useful for treating CAO, especially in cases presenting with wheezing.
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506. Periductal mastitis mimicking breast cancer in a male breast.
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Bo Sung Kim, Jin Hwa Lee, Woo Jeong Kim, Dae Cheol Kim, Suyoung Shin, Hee Jin Kwon, Ji Sung Park, and Yeong Mi Park
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FIBROCYSTIC breast disease , *DYSPLASIA , *BREAST cysts , *BREAST cancer , *DISEASES in men , *MAMMOGRAMS - Abstract
Periductal mastitis in a male patient rarely has been reported in the English literature. Herein, we now present a rare case of periductal mastitis mimicking breast cancer, both clinically and radiologically, in a 37-year-old man. Mammogram and sonogram showed a mass with irregular shape, spiculated margin and a nipple retraction, mimicking a male breast cancer. Radiologic and pathologic correlation is provided. [ABSTRACT FROM AUTHOR]
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- 2013
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507. Modulation of Bacterial Growth by Tumor Necrosis Factor-? In Vitro and In Vivo.
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Jin-Hwa Lee, Del Sorbo, Lorenzo, Aye Aye Khine, de Azavedo, Joyce, Low, Donald E., Bell, David, Uhlig, Stefan, Slutsky, Arthur S., and Haibo Zhang
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- 2003
508. Changes of plasma interleukin-1 receptor antagonist, interleukin-8 and other serologic markers during chemotherapy in patients with active pulmonary tuberculosis
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Jin Hwa Lee and Chang, J. H.
509. Predicting survival of patients with idiopathic pulmonary fibrosis using GAP score: a nationwide cohort study
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Jong Wook Shin, Sung Woo Park, Young Whan Kim, Sang Hoon Lee, Hyun Kyung Lee, Hong Lyeol Lee, Jin Woo Song, Yong Bum Park, Eun Joo Lee, Choon-Sik Park, Sung Hwan Jeong, Dong Soon Kim, Jin Hwa Lee, Moo Suk Park, Yong Hyun Kim, Song Yee Kim, Yangin Jegal, Soo Taek Uh, and Man Pyo Chung
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Time Factors ,Idiopathic pulmonary fibrosis ,Kaplan-Meier Estimate ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,DLCO ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Severity of illness ,Republic of Korea ,medicine ,Humans ,GAP stage ,030212 general & internal medicine ,Stage (cooking) ,Lung ,Aged ,Proportional Hazards Models ,Proportional hazards model ,business.industry ,Research ,Interstitial lung disease ,Middle Aged ,respiratory system ,medicine.disease ,Prognosis ,030228 respiratory system ,Predictive value of tests ,Physical therapy ,Female ,business ,Cohort study - Abstract
Background The clinical course of idiopathic pulmonary fibrosis (IPF) varies widely. Although the GAP model is useful for predicting mortality, survivals have not yet been validated for each GAP score. We aimed to elucidate how prognosis is related to GAP score and GAP stage in IPF patients. Methods The Korean Interstitial Lung Disease Study Group conducted a national survey to evaluate various characteristics in IPF patients from 2003 to 2007. Patients were diagnosed according to the 2002 criteria of the ATS/ERS. We enrolled 1,685 patients with IPF; 1,262 had undergone DLCO measurement. Patients were stratified based on GAP score (0–7): GAP score Group 0 (n = 26), Group 1 (n = 150), Group 2 (n = 208), Group 3 (n = 376), Group 4 (n = 317), Group 5 (n = 138), Group 6 (n = 39), and Group 7 (n = 8). Results Higher GAP score and GAP stage were associated with a poorer prognosis (p
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510. Association between mechanical power and intensive care unit mortality in Korean patients under pressure-controlled ventilation.
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Jae Kyeom Sim, Sang-Min Lee, Hyung Koo Kang, Kyung Chan Kim, Young Sam Kim, Yun Seong Kim, Won-Yeon Lee, Sunghoon Park, So Young Park, Ju-Hee Park, Yun Su Sim, Kwangha Lee, Yeon Joo Lee, Jin Hwa Lee, Heung Bum Lee, Chae-Man Lim, Won-Il Choi, Ji Young Hong, Won Jun Song, and Gee Young Suh
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INTENSIVE care units , *KOREANS , *POSITIVE end-expiratory pressure , *LOGISTIC regression analysis , *NEUROMUSCULAR blocking agents - Abstract
Background: Mechanical power (MP) has been reported to be associated with clinical outcomes. Because the original MP equation is derived from paralyzed patients under volume-controlled ventilation, its application in practice could be limited in patients receiving pressure-controlled ventilation (PCV). Recently, a simplified equation for patients under PCV was developed. We investigated the association between MP and intensive care unit (ICU) mortality. Methods: We conducted a retrospective analysis of Korean data from the Fourth International Study of Mechanical Ventilation. We extracted data of patients under PCV on day 1 and calculated MP using the following simplified equation: MPPCV = 0.098 · respiratory rate · tidal volume · (ΔPinsp + positive end-expiratory pressure), where ΔPinsp is the change in airway pressure during inspiration. Patients were divided into survivors and non-survivors and then compared. Multivariable logistic regression was performed to determine association between MPPCV and ICU mortality. The interaction of MPPCV and use of neuromuscular blocking agent (NMBA) was also analyzed Results: A total of 125 patients was eligible for final analysis, of whom 38 died in the ICU. MPPCV was higher in non-survivors (17.6 vs. 26.3 J/min, P<0.001). In logistic regression analysis, only MPPCV was significantly associated with ICU mortality (odds ratio, 1.090; 95% confidence interval, 1.029-1.155; P=0.003). There was no significant effect of the interaction between MPPCV and use of NMBA on ICU mortality (P=0.579). Conclusions: MPPCV is associated with ICU mortality in patients mechanically ventilated with PCV mode, regardless of NMBA use. [ABSTRACT FROM AUTHOR]
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- 2024
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511. Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study
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Barry J. Make, George R. Washko, James D. Crapo, Adam Davey, MeiLan K. Han, David A. Lynch, Carlos H. Martinez, Gerard J. Criner, Victor Kim, Edwin K. Silverman, Jin Hwa Lee, and Alejandro P. Comellas
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Male ,Chronic bronchitis ,Exacerbation ,Respiratory System ,Cardiorespiratory Medicine and Haematology ,Gastroenterology ,Cohort Studies ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,2.1 Biological and endogenous factors ,Airway thickening ,030212 general & internal medicine ,Chronic ,Aetiology ,Tomography ,Lung ,COPD ,Continental Population Groups ,Chronic obstructive pulmonary disease ,Smoking ,Middle Aged ,X-Ray Computed ,3. Good health ,Bronchitis, Chronic ,Predictive value of tests ,Cohort ,Respiratory ,Bronchitis ,Female ,Cohort study ,Pulmonary and Respiratory Medicine ,Chronic Obstructive ,medicine.medical_specialty ,COPDGene® Investigators ,Chronic Obstructive Pulmonary Disease ,Clinical Sciences ,Pulmonary Disease ,03 medical and health sciences ,Sex Factors ,Predictive Value of Tests ,Clinical Research ,Internal medicine ,Tobacco ,medicine ,Humans ,Genetic Association Studies ,Aged ,Asthma ,Tobacco Smoke and Health ,business.industry ,Research ,Racial Groups ,medicine.disease ,Surgery ,respiratory tract diseases ,Cross-Sectional Studies ,030228 respiratory system ,Tomography, X-Ray Computed ,business - Abstract
BackgroundChronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group with moderate to severe airflow obstruction were younger, more likely to be current smokers, male, Caucasian, had worse health related quality of life, more dyspnea, and increased exacerbation history compared to those without CB. We sought to further refine our clinical characterization of chronic bronchitics in a larger cohort and analyze the CT correlates of CB in COPD subjects. We hypothesized that COPD patients with CB would have thicker airways and a greater history of smoking, acute bronchitis, allergic rhinitis, and occupational exposures compared to those without CB.MethodsWe divided 2703 GOLD 1-4 subjects in the Genetic Epidemiology of COPD (COPDGene®) Study into two groups based on symptoms: chronic bronchitis (CB+, n = 663, 24.5%) and no chronic bronchitis (CB-, n = 2040, 75.5%). Subjects underwent extensive clinical characterization, and quantitative CT analysis to calculate mean wall area percent (WA%) of 6 segmental airways was performed using VIDA PW2 (http://www.vidadiagnostics.com). Square roots of the wall areas of bronchi with internal perimeters 10mm and 15mm (Pi10 and Pi15, respectively), % emphysema, %gas trapping, were calculated using 3D Slicer (http://www.slicer.org).ResultsThere were no differences in % emphysema (11.4 ± 12.0 vs. 12.0 ± 12.6%, p = 0.347) or % gas trapping (35.3 ± 21.2 vs. 36.3 ± 20.6%, p = 0.272) between groups. Mean segmental WA% (63.0 ± 3.2 vs. 62.0 ± 3.1%, p
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512. Evaluating the Efficiency of Black Soldier Fly (Hermetia illucens) Larvae in Converting Mackerel Head Waste into Valuable Resources
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Gabriel Tirtawijaya, Jin-Hwa Lee, Khawaja Muhammad Imran Bashir, Hae-Jeung Lee, and Jae-Suk Choi
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alternative feed ,black soldier fly larvae ,biomass conversion ,insect farming ,waste management ,waste-to-biomass ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
The seafood processing industry generates significant waste, including mackerel heads (MH), constituting 20–32% of total waste. This study explored the potential of utilizing MH as a feed source for black soldier fly larvae (BSF larvae). BSF larvae are known for their ability to efficiently convert organic materials into nutrient-rich biomass. Five concentrations of MH (0, 10, 20, 30, 40, and 50% in chicken feed) were fed to BSF larvae for eight days. After harvesting, their growth, MH conversion efficiency, nutritional content, and heavy metals reduction potential were measured. BSF larvae showed optimal growth when fed with a feed containing 20% MH, resulting in a 14.36-fold increase in weight compared to the control group, as determined by the Fisher’s Least Significant Difference Test. BSF larvae maintained a survival rate of 99.33%. With the lowest feed conversion ratio (FCR) of 2.09 at 20% MH, feed efficiency was improved by up to 65.15%, and feed reduction up to 73.53%. MH enhanced lipid and protein content in BSF larvae. Furthermore, BSF larvae in this study showed higher polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as other amino acids which are required for breeding animals. The current study highlights the potential of MH as a feed source for BSF larvae, improving nutritional biomass. It also suggests BSF larvae as an eco-friendly option for handling seafood processing waste and as an alternative feed source for animals.
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- 2024
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513. Establishment of Effective Callus Induction in the Economically Important Brown Seaweed Ecklonia cava
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Jin-Hwa Lee, Khawaja Muhammad Imran Bashir, Gabriel Tirtawijaya, Bertoka Fajar Surya Perwira Negara, and Jae-Suk Choi
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abiotic stresses ,callus ,functional food material ,laminariales ,phaeophyta ,seaweed ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The edible brown seaweed, Ecklonia cava, is highly valued for its bioactive compounds, and is widely used in food supplements and functional foods. The increasing demand for this seaweed in the food industry emphasizes the necessity for sustainable cultivation practices. This study focused on inducing callus in the meristem and stipe of E. cava using different culture media: Provasoli’s enriched seawater medium (PESI), enriched artificial seawater medium (ESAW), artificial enriched seawater medium (ASP2), or Von Stosch’s enriched seawater medium (VS). Various abiotic stress factors (photoperiod, agar concentration, and temperature), growth regulators, carbon sources, polyamines, and plasma treatments were explored for their impact on callus induction. Both stipe and meristem explants developed callus within three to six weeks across all media except ASP2. Callus development was favored at temperatures between 8 to 13 °C and in the absence of light. Stipe explants showed a higher callus induction rate (up to 65.59 ± 6.24%) compared to meristem (up to 57.53 ± 8.32%). Meristem explants showed optimal callus induction in PESI medium with a low concentration of indole-3-acetic acid (IAA; 40.93 ± 8.65%). However, higher concentrations of IAA and 1-naphthaleneacetic acid (NAA) reduced meristem callus induction. Stipe showed high induced-callus (up to 50.37 ± 5.17%) in PESI medium with low concentrations of IAA, NAA, and 6-benzylaminopurine (BAP). Both stipe and meristem explants induced largest callus at 2% sucrose, but higher carbon source concentrations reduced callus induction. Spermine (Spm) at 1 µM resulted in high induced calluses; however, increasing Spm concentrations decreased callus induction. This tissue culture technique not only supports mass cultivation of E. cava, but also holds potential for extending to other seaweed species, contributing to the sustainability of seaweed stocks for the food industry.
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- 2024
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514. Nutritional Composition and Safety Aspects of Deep-Sea Whelks (Buccinum tenuissimum Kuroda)
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Sana Mansoor, Jin-Hwa Lee, Khawaja Muhammad Imran Bashir, Jae-Hak Sohn, and Jae-Suk Choi
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Buccinidae ,deep-sea whelk ,fatty acids ,heavy metals ,proximate composition ,safety ,Chemical technology ,TP1-1185 - Abstract
The deep-sea whelk Buccinum tenuissimum Kuroda is highly sought-after as food in East Asian countries, notably, Korea and Japan. However, it lacks official recognition as a food product in Korea. This study aimed to assess its nutritional composition and safety for the potential development of seafood products. The nutritional analysis revealed high protein (13.54–20.47 g/100 g whelk), fat (0.85–8.59 g/100 g whelk), carbohydrate (1.55–12.81 g/100 g whelk), and dietary fiber (1.25–1.95 g/100 g whelk) contents in both muscle and gut samples, with energy contents ranging from 339.11 ± 1.64 to 692.00 ± 3.21 kJ/100 g. Key minerals, including iron, potassium, calcium, and sodium, and essential fatty acids, including eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, omega-3, and omega-6 fatty acids, were abundant, making it a potential supplementary food. Notably, heavy metal levels met the Korean standards for seafood safety. No trans fats, radioactivity concerning the radioactive isotopes 134Cs/137Cs and 131I, or pathogenic bacteria were detected. This confirms the safety and nutritional value of deep-sea whelks, suggesting their potential for developing seafood products rich in beneficial components, which could enhance nutrition and food security while contributing to economic growth.
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- 2024
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515. Effectiveness of Immature Asian Pear Extract on Pulmonary Injury Caused by Particulate Matter in Mice
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Mi-Ran Kim, Jin-Hwa Lee, Mo-Un Ku, Ki-Young Kim, Su Shin, Eun-Jin Hong, Sae-Kwang Ku, and Jae-Suk Choi
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Asian pear ,Pyrus pyrifolia ,lung injury ,PM2.5 ,mice ,anti-inflammatory activity ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The use of natural products in developing respiratory-function-protective pharmaceuticals is actively progressing. However, in this context, the improvement effects of young Asian pear (Pyrus pyrifolia Nakai) extracts have not been evaluated yet. Thus, this study investigated the anti-inflammatory and lung damage improvement effects of immature Asian pear extract (IAP; 400, 200, and 100 mg/kg) using a particulate matter 2.5 μm (PM2.5)-induced sub-acute lung injury mouse model. The experimental results were compared with dexamethasone (0.75 mg/kg), used as a control drug. After two intranasal instillations of PM2.5 and ten doses of IAP extract for eight days, changes in macroscopic lung autopsy, leukocyte fractionation from bronchoalveolar lavage fluid, lung antioxidant defense system, lung histopathology, and mRNA expression in lung tissue were confirmed. Stress-induced inflammatory lung damage through the increased expression of PM2.5-induced PI3K/Akt and p38 MAPK mRNA was significantly suppressed via the administration of IAP extract (400–100 mg/kg). Furthermore, IAP extract administration promoted serous fluid production in lung tissue, increased substance P and ACh levels, and decreased mucus-production-related expression of MUC5AC and MUC5B mRNA. Interestingly, the observed effects showed a dose-dependent manner without serious hepatotoxicity. The results of this study indicate that a proper oral administration of IAP extract could be helpful in protecting against lung diseases, positioning IAP extract as a potential candidate for an alternative agent to safeguard the respiratory system.
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- 2023
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516. Efficacy Confirmation Test of Immature Asian Pear (Pyrus pyrifolia Nakai) Extract on Ovalbumin-Induced Asthma in Mice
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Mi Ran Kim, Khawaja Muhammad Imran Bashir, Jin-Hwa Lee, Mo-Un Ku, Joo Wan Kim, Ki-Young Kim, Su Shin, Eun-Jin Hong, Sae-Kwang Ku, and Jae-Suk Choi
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Asian pears ,asthma ,functional food ,in vivo ,Pyrus pyrifolia Nakai ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Allergic asthma is a chronic inflammatory disease characterized by the infiltration of leukocytes, particularly eosinophils, into the airways, resulting in respiratory dysfunction. To develop new asthma treatment materials with minimal side effects and excellent bioactivities, we evaluated the efficacy of immature Asian pear extract (IAP extract; 400–100 mg/kg) in alleviating ovalbumin (OVA)-induced asthma in female C57BL/6J mice. This study assesses various parameters associated with OVA-induced allergic asthma including lung weight, macroscopic necropsy findings, the total cell count in bronchoalveolar lavage fluid (BALF), the total leukocyte count and leukocyte differential count, serum ovalbumin-specific Ig E (OVA-sIg E) levels, interleukin (IL)-4 and IL-5 contents in BALF, histopathological changes in the lungs, and alterations in oxidative stress and inflammation-related mRNA expressions. The results of this study demonstrate clear asthma-related findings in the OVA control group. However, the oral administration of IAP extract (at doses ranging from 400 to 100 mg/kg) significantly suppressed the anti-inflammatory and antioxidant activities by regulating the expressions of phosphoinositide 3-kinase/protein kinase B/phosphatase and TENsin homolog deleted on chromosome 10 (PI3K/Akt/PTEN), p38 mitogen-activated protein kinase (p38 MAPK), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in a dose-dependent manner. These effects are comparable to those observed with dexamethasone at a concentration of 0.75 mg/kg. As a result, the oral administration of an appropriate dose of IAP extract holds promise as a potential natural drug or health-functional food material for improving respiratory function.
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- 2023
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517. Degradation pattern prediction of a polymer electrolyte membrane fuel cell stack with series reliability structure via durability data of single cells.
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Suk Joo Bae, Seong-Joon Kim, Jin-Hwa Lee, Inseob Song, Nam-In Kim, Yongho Seo, Ki Buem Kim, Naesung Lee, and Jun-Young Park
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POLYELECTROLYTES , *PROTON exchange membrane fuel cells , *WEIBULL distribution , *CHEMICAL decomposition , *DURABILITY , *REGRESSION analysis - Abstract
The insufficient long-term durability of polymer electrolyte membrane fuel cell (PEMFC) stacks has been blocking commercialization of PEMFC technologies. An accelerated degradation test (ADT) is needed to facilitate the PEMFC development process by reducing the testing time. We propose an ADT procedure for a PEMFC stack with the concept of series reliability structure under startup-shutdown cycling testing conditions. The acceleration factor is estimated to fit the degradation paths of individual cells consisting of the PEMFC stack under normal use conditions via the accelerated degradation data of a single cell. We employ a nonparametric regression method to smooth the degradation curves observed from accelerated operating conditions. We illustrate the methodology for estimating the lifetime of the PEMFC stack using the theory of the smallest-order statistics. We propose a three-parameter Weibull distribution in fuel cell technology to fit the failure data of cells in a PEMFC stack. [ABSTRACT FROM AUTHOR]
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- 2014
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518. The Influence of Abiotic Factors on the Induction of Seaweed Callus
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Gabriel Tirtawijaya, Bertoka Fajar Surya Perwira Negara, Jin-Hwa Lee, Man-Gi Cho, Hye Kyung Kim, Yun-Sik Choi, Sang-Hoon Lee, and Jae-Suk Choi
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seaweed ,callus induction ,abiotic factors ,micropropagation ,tissue culture ,Naval architecture. Shipbuilding. Marine engineering ,VM1-989 ,Oceanography ,GC1-1581 - Abstract
Seaweeds are a major source of functional foods, nutraceuticals, and pharmaceuticals. Seaweed can be sustainably harvested through callus culture, which yields homogenous cells and bioproducts under controlled conditions. Callus induction is a crucial early step in callus culture and is influenced by several abiotic factors. This review aims to discuss the influence of abiotic factors on callus induction in seaweeds, a prerequisite for the application and development of seaweed callus culture. We used three online databases (Springer, Science Direct, and Wiley) to search for the literature on seaweed callus induction published between 1987 and 2020. Thirty-three articles for review were identified and analyzed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The analysis covers 56 seaweed species (3% Chlorophyta, 44% Phaeophyta, and 53% Rhodophyta) under various abiotic treatments, including light irradiance (23%), temperature (15%), media type (21%), plant growth regulators (26%), gelling conditions (9%), and other factors (6%). The information on these abiotic factors is intended to be a practical reference and to foster the further study of the callus culture of seaweed. More studies are needed to determine how to maintain and increase callus mass in suspension culture for the industrial production of seaweed and its metabolites.
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- 2022
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519. Is consumer neural response to visual merchandising types different depending on their fashion involvement?
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Hyoung-Sukh Kim, Jin-Hwa Lee, and So-Hyeon Yoo
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Medicine ,Science - Abstract
This study investigated consumers' responses to fashion visual merchandising (VM) from a neuroscientific perspective. The brain activations of 20 subjects differently involved in fashion were recorded using functional near-infrared spectroscopy in response to three different fashion VM types. According to the types of fashion VM, significant differences were observed, which were significantly higher for the creative VM. Moreover, highly fashion-involved subjects showed activation of the orbital frontal cortex region in response to the creative VM. Based on these results, it is suggested that marketing strategies should be devised explicitly for the brand's targeted audience and goals.
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- 2020
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520. The Effect of Combined Superheated Steam Roasting and Smoking on the Quality Characteristic of Alaska Pollack (Gadus chalcogrammus) Roe
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Gabriel Tirtawijaya, Jin-Hwa Lee, Jong-Su Jang, Do-Youb Kim, Jae-Hak Sohn, and Jae-Suk Choi
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Alaska pollack roe ,superheated steam roasting ,smoking ,product quality ,Chemical technology ,TP1-1185 - Abstract
Alaska pollack roe (APR) is a protein source that is usually salted and fermented, containing a high salt content. Using a combination of superheated steam roasting and smoking, we developed a new low-salt ready-to-eat APR variant, whose quality characteristics we analyzed. The optimal conditions for roasting (216 °C for 4 min) and smoking (64 °C for 14 min) were obtained from sensorial attributes using response surface methodology. Under the optimal conditions, smoke-roasted APR had an overall acceptance (OA) score of 8.89. The combination of roasting and smoking significantly increased volatile basic nitrogen (VBN, 18.6%) and decreased the total bacterial count (TBC, 38.6%), while thiobarbituric acid reactive substances (TBARS) were not affected. Smoke-roasting APR also increased its nutritional content to 30% protein with 44% essential amino acids, and more than 40% DHA and EPA in 4.3% fat. During 30 days of storage, the OA, VBN, TBARS, and TBC values significantly changed with time and storage temperature (p < 0.05). The shelf life of the product was estimated to be 24 d. In conclusion, the combination of roasting and smoking APR could improve product quality and may be an alternative to diversify processed APR.
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- 2021
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521. Association of Galectin 9 Expression with Immune Cell Infiltration, Programmed Cell Death Ligand-1 Expression, and Patient’s Clinical Outcome in Triple-Negative Breast Cancer
- Author
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Mi-Ha Ju, Kyung-Do Byun, Eun-Hwa Park, Jin-Hwa Lee, and Song-Hee Han
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Galectin-9 ,triple-negative breast cancer ,tumor-infiltrating lymphocyte ,PD-L1 ,Biology (General) ,QH301-705.5 - Abstract
Galectin-9 (Gal-9) is an immune checkpoint protein that facilitates T cell exhaustion and modulates the tumor-associated microenvironment, and could be a potential target for immune checkpoint inhibition. This study was conducted to assess Gal-9 expression in triple-negative breast cancer (TNBC) and evaluate its association with programmed cell death ligand 1 (PD-L1) expression and immune cell infiltration in tumors and the clinical outcome of patients. Overall, 109 patients with TNBC were included. Gal-9 expression was assessed its relationships with tumor clinicopathologic characteristics, tumor-infiltrating lymphocyte (TIL) levels, PD-L1+ immune cells, and tumor cells by tissue microarray and immunohistochemistry. Low Gal-9 expression was statistically correlated with higher tumor stage (p = 0.031) and presence of lymphovascular invasion (p = 0.008). High Gal-9 expression was associated with a high level of stromal TILs (sTIL; p = 0.011) and positive PD-L1 expression on tumor cells (p = 0.004). In survival analyses, low Gal-9 expression was associated with significantly poor OS (p = 0.013) in patients with TNBC with PD-L1 negativity in tumor cells. Our findings suggest that increased Gal-9 expression is associated with changes in the antitumor microenvironment, such as increased immune cell infiltration and antimetastatic changes. This study emphasizes the predictive value and promising clinical applications of Gal-9 in TNBC.
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- 2021
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522. Interobserver agreement in breast ultrasound categorization in the Mammography and Ultrasonography Study for Breast Cancer Screening Effectiveness (MUST-BE) trial: results of a preliminary study.
- Author
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Eun Jung Choi, Eun Hye Lee, You Me Kim, Yun-Woo Chang, Jin Hwa Lee, Young Mi Park, Keum Won Kim, Young Joong Kim, Jae Kwan Jun, and Seri Hong
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- *
BREAST ultrasound , *BREAST , *EARLY detection of cancer , *BREAST cancer , *MAMMOGRAMS , *QUALITY control - Abstract
Purpose: The purpose of this study was to record and evaluate interobserver agreement as quality control for the modified categorization of screening breast ultrasound developed by the Alliance for Breast Cancer Screening in Korea (ABCS-K) for the Mammography and Ultrasonography Study for Breast Cancer Screening Effectiveness (MUST-BE) trial. Methods: Eight breast radiologists with 4-16 years of experience participated in 2 rounds of quality control testing for the MUST-BE trial. Two investigators randomly selected 125 and 100 cases of breast lesions with different ratios of malignant and benign lesions. Two versions of the modified categorization were tested. The initially modified classification was developed after the first quality control workshop, and the re-modified classification was developed after the second workshop. The re-modified categorization established by ABCS-K added size criteria and the anterior-posterior ratio compared with the initially modified classification. After a brief lecture on the modified categorization system prior to each quality control test, the eight radiologists independently categorized the lesions using the modified categorization. Interobserver agreement was measured using kappa statistics. Results: The overall kappa values for the modified categorizations indicated moderate to substantial degrees of agreement (initially modified categorization and re-modified categorization: κ=0.52 and κ=0.63, respectively). The kappa values for the subcategories of category 4 were 0.37 (95% confidence interval [CI], 0.24 to 0.52) and 0.39 (95% CI, 0.31 to 0.49), respectively. The overall kappa values for both the initially modified categorization and the re-modified categorization indicated a substantial degree of agreement when dichotomizing the interpretation as benign or suspicious. Conclusion: The preliminary results demonstrated acceptable interobserver agreement for the modified categorization. [ABSTRACT FROM AUTHOR]
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- 2019
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523. Standard chest CT using combined automated tube potential selection and iterative reconstruction: image quality and radiation dose reduction.
- Author
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In Hye Chae, Yookyung Kim, So Won Lee, Ji Eun Park, Sung Shine Shim, and Jin Hwa Lee
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- *
COMPUTED tomography , *IMAGE quality analysis , *RADIATION doses , *COMPARATIVE studies , *DIAGNOSTIC imaging - Abstract
Objective: To evaluate the image quality and radiation dose reduction of chest computed tomography (CT) using combined automated tube potential selection (ATPS) and iterative reconstruction (IR). Materials and Methods: Image quality and radiation dose were compared between conventional contrastenhanced chest CT using 120 kVp and filtered back projection (Protocol A) and CT using ATPS and IR (Protocol B) in 43 patients. Results: The effective radiation dose was 3.6±0.4 mSv for Protocol A and 2.2±0.6 mSv for Protocol B (mean dose reduction, 39.7%). Protocol B showed diagnostic image quality in all patients. Conclusion: ATPS and IR allows for radiation dose reduction while maintaining diagnostic image quality. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
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