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1,479 results on '"Huang, Yulin"'

504. Preoperative anxiety-induced glucocorticoid signaling reduces GABAergic markers in spinal cord and promotes postoperative hyperalgesia by affecting neuronal PAS domain protein 4

Author

Wu, Hao, primary, Huang, Yulin, additional, Tian, Xinyu, additional, Zhang, Zuoxia, additional, Zhang, Ying, additional, Mao, Yanting, additional, Wang, Chenchen, additional, Yang, Shuai, additional, Liu, Yue, additional, Zhang, Wei, additional, and Ma, Zhengliang, additional

Published
2019
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505. Balanced Tikhonov and Total Variation Deconvolution Approach for Radar Forward-Looking Super-Resolution Imaging.

Author

Huo, Weibo, Tuo, Xingyu, Zhang, Yin, Zhang, Yongchao, and Huang, Yulin

Abstract

In radar forward-looking super-resolution imaging, improving the azimuth resolution while acquiring the contour information of the target has significant research value. In this letter, an approach based on the balanced Tikhonov and total variation (TV) deconvolution is proposed for radar forward-looking super-resolution imaging. We combine the Tikhonov regularization and TV regularization to construct the objective function and resolve the respective cost function using the alternating direction method of multipliers (ADMM). In each iteration, the gradient function of the target scattering coefficient is used as the adaptive weighted parameter to control automatically the weighting between the penalty terms from TV and the Tikhonov regularization. For the target with a sharper outline, the proportion of TV regularization penalty terms is increased; for the target with a smoother outline, the proportion of penalty term from the Tikhonov regularization is enhanced. The simulation and experimental results are considered to show the effectiveness of the proposed method. Compared with traditional super-resolution imaging methods, the proposed approach has superior outline retention capacity. [ABSTRACT FROM AUTHOR]

Published
2021
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506. Spinal cannabinoid receptor 2 activation reduces hypersensitivity associated with bone cancer pain and improves the integrity of the blood-spinal cord barrier.

Author

Chenchen Wang, Ke Xu, Yu Wang, Yanting Mao, Yulin Huang, Ying Liang, Yue Liu, Jing Hao, Xiaoping Gu, Zhengliang Ma, Yu'e Sun, Wang, Chenchen, Xu, Ke, Wang, Yu, Mao, Yanting, Huang, Yulin, Liang, Ying, Liu, Yue, Hao, Jing, and Gu, Xiaoping

Abstract

Background: Disruption of the blood-spinal cord barrier (BSCB) can facilitate inflammation that results in pain hypersensitivity. Proinflammatory cytokines produced by activated microglia and astrocytes damage the BSCB. This study aims to explore whether the BSCB is damaged in the bone cancer pain (BCP) model and to investigate a potential role and mechanism of JWH015 ((2-methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone), a selective cannabinoid receptor 2 (CB2R) agonist, in preserving the BSCB integrity in the BCP model.Methods: We used a male mouse model of BCP. Pain hypersensitivity was measured over time. Evans blue dye extravasation, transmission electron microscopy and Western blotting were performed to investigate the permeability and structural integrity of the BSCB. Immunofluorescence staining and western blotting were used to investigate the effect of JWH015 on the activation of glial cells and the levels of proinflammatory cytokines.Results: A single intrathecal injection of JWH015 ameliorated pain hypersensitivity, the BSCB disruption and microglia and astrocyte activation. Decreases in the expression of ZO-1 and claudin-5 were partially restored by JWH015. The levels of the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α and the enzyme MMP9 were reduced by JWH015. However, all effects were prevented by pretreatment with a CB2R-selective antagonist, AM630 ((6-iodo-2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl)(4-methoxyphenyl)methanone).Conclusions: JWH015 alleviates neuroinflammation and maintains the BSCB integrity and permeability in a mouse model of BCP, which is probably mediated by inhibiting glial cells activation. This study reveals the new analgesic mechanism of JWH015 on BCP and provides a perspective to explore novel drugs that target the BSCB to control BCP. [ABSTRACT FROM AUTHOR]

Published
2020
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524. Integrated Analysis of Quantitative Proteome and Transcriptional Profiles Reveals the Dynamic Function of Maternally Expressed Proteins After Parthenogenetic Activation of Buffalo Oocyte

Author

Chen, Fumei, primary, Fu, Qiang, additional, Pu, Liping, additional, Zhang, Pengfei, additional, Huang, Yulin, additional, Hou, Zhen, additional, Xu, Zhuangzhuang, additional, Chen, Dongrong, additional, Huang, Fengling, additional, Deng, Tingxian, additional, Liang, Xianwei, additional, Lu, Yangqing, additional, and Zhang, Ming, additional

Published
2018
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