251. Contrast enhanced MR venography with gadofosveset trisodium: evaluation of the intracranial and extracranial venous system.
- Author
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Kramer LA, Cohen AM, Hasan KM, Heimbigner JH, Barreto AD, Brod SA, Narayana PA, and Wolinsky JS
- Subjects
- Adult, Artifacts, Cerebrovascular Circulation, Contrast Media, Female, Humans, Male, Middle Aged, Multiple Sclerosis pathology, Prospective Studies, Sensitivity and Specificity, Veins pathology, Gadolinium, Magnetic Resonance Angiography methods, Organometallic Compounds, Veins anatomy & histology
- Abstract
Purpose: To demonstrate the efficacy of contrast enhanced magnetic resonance venography (CEMRV) using gadofosveset trisodium in the comprehensive evaluation of the intracranial and extracranial venous system., Materials and Methods: Temporal signal decay, in-plane saturation and flow artifacts were assessed in an institutional review board approved, HIPAA compliant CEMRV study of 99 subjects. In a 39 subject subset, percent diameter narrowing of the internal jugular (IJ), brachiocephalic and azygous veins were coded according to the following ordinal grades for both catheter venography (CV) and CEMRV: grade 0 ≤ 50%, grade 1 >50% and ≤ 75%, grade 2 >75% and <100% and grade 3 = 100% and compared with pressure gradient measurements obtained during CV., Results: There was no significant signal decay, in-plane saturation or flow artifacts identified on CEMRV or hemodynamically significant pressure gradients identified on CV. All brachiocephalic and azygous veins had matched grade 0 narrowing on both modalities. Discrepancy between modalities occurred in the IJ veins at the level of thyroid gland where 15% of IJ veins had CEMRV grade ≥ 1 narrowing compared with 4% for CV or below the thyroid gland where 5% of IJ veins had CEMRV grade ≥ 1 narrowing compared with 20% for CV. There was fair agreement (κ = 0.24) between modalities for grade of narrowing in the combined data set of all coded veins., Conclusion: CEMRV using gadofosveset trisodium is accurate in the evaluation of the venous system., (© 2013 Wiley Periodicals, Inc.)
- Published
- 2014
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