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501. LC/QTOF profile and preliminary stability studies of an enriched flavonoid fraction of Cecropia pachystachya Trécul leaves with potential antidepressant-like activity.

Author

Ortmann, Caroline Flach, Abelaira, Helena Mendes, Réus, Gislaine Zilli, Ignácio, Zuleide Maria, Chaves, Vitor Clasen, Santos, Talitha Caldas, Carvalho, Pâmela, Carlessi, Anelise Scussel, Bruchchen, Livia, Danielski, Lucineia G., Cardoso, Simone Gonçalves, Campos, Angela Machado, Petronilho, Fabricia, Rebelo, Joyce, Santos Morais, Meline Oliveira, Vuolo, Francieli, Dal‐Pizzol, Felipe, Streck, Emilio Luiz, Quevedo, João, and Reginatto, Flávio Henrique

Abstract

There is increasing interest in natural antioxidants that are candidates for the prevention of brain damage occurring in major depressive disorders. Cecropia pachystachya is a tropical tree species of Central and South America and a rich source of polyphenols, particularly flavonoids. The aim of this study was to characterize the flavonoid profile of an enriched flavonoid fraction of C. pachystachya (EFF- Cp) and evaluate the antidepressant-like effects of its acute administration in behavior, cytokine levels, oxidative stress and energy metabolism parameters . The EFF- Cp chemical characterization was performed by HPLC/DAD and LC/QTOF. The antidepressant-like effects were performed by the forced swimming test, splash test and open field test. EFF- Cp revealed 15 flavonoids, including seven new glycosyl flavonoids for C. pachystachya. Quantitatively, EFF- Cp showed isoorientin (43.46 mg/g), orientin (23.42 mg/g) and isovitexin (17.45 mg/g) as major C-glycosyl flavonoids. In addition, EFF- Cp at doses 50 and 100 mg/kg reduced the immobility time in the forced swimming test, without changing the locomotor activity and grooming time. In addition, EFF- Cp was able to prevent the oxidative damage in some brain areas. In conclusion, the results of this study suggest that EFF- Cp exerts antidepressant-like effects with its antioxidant properties. [ABSTRACT FROM AUTHOR]

Published
2017
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502. Characterization of Brain-Heart Interactions in a Rodent Model of Sepsis.

Author

Pinto, Bernardo, Ritter, Cristiane, Michels, Monique, Gambarotta, Nicolò, Ferrario, Manuela, Dal-Pizzol, Felipe, and Singer, Mervyn

Abstract

Loss of heart rate variability (HRV) and autonomic dysfunction are associated with poor outcomes in critically ill patients. Neuronal networks comprising brainstem and hypothalamus are involved in the 'flight-or-fight' response via control over the autonomic nervous system and circulation. We hypothesized that sepsis-induced inflammation in brain regions responsible for autonomic control is associated with sympathovagal imbalance and depressed contractility. Sepsis was induced by fecal slurry injection in fluid-resuscitated rats. Sham-operated animals served as controls. Echocardiography-derived peak velocity (PV) was used to separate septic animals into good (PV ≥0.93 m/s, low 72-h mortality) and bad (PV <0.93, high 72-h mortality) prognosis. Cytokine protein levels were assessed by ELISA. All experiments were performed at 24 h post-insult. Increased levels of inflammation and oxidative injury were observed in the hypothalamus (TNF-α, IL-10, nitrite and nitrate and carbonyl groups) and brainstem (IL-1, IL-6, IL-10, nitrite and nitrate and carbonyl groups) of the septic animals ( p < 0.05 vs. sham), but not in the pre-frontal cortex, an area not directly implicated in control of the autonomic nervous system. Good prognosis septic animals had increased sympathetic output and increased left ventricular contractility ( p < 0.05 vs. sham). There was a significant inverse correlation between high frequency power (a marker of parasympathetic outflow) and contractility ( r = −0.73, p < 0.05). We found no correlation between the degree of inflammation or injury to autonomic centers and cardiovascular function. In conclusion, control of autonomic centers and cardiac function in our long-term rodent model of sepsis was related to clinical severity but not directly to the degree of inflammation. [ABSTRACT FROM AUTHOR]

Published
2017
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503. Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration.

Author

Gomes, Lara, Carvalho-Silva, Milena, Teixeira, Letícia, Rebelo, Joyce, Mota, Isabella, Bilesimo, Rafaela, Michels, Monique, Arent, Camila, Mariot, Edemilson, Dal-Pizzol, Felipe, Scaini, Giselli, Quevedo, João, and Streck, Emilio

Subjects
OMEGA-3 fatty acids, MOOD stabilizers, PATHOLOGICAL physiology, OXIDATIVE stress, BIPOLAR disorder
Abstract

Studies have shown that oxidative stress is involved in the pathophysiology of bipolar disorder (BD). It is suggested that omega-3 (ω3) fatty acids are fundamental to maintaining the functional integrity of the central nervous system. The animal model used in this study displayed fenproporex-induced hyperactivity, a symptom similar to manic BD. Our results showed that the administration of fenproporex, in the prevent treatment protocol, increased lipid peroxidation in the prefrontal cortex (143%), hippocampus (58%) and striatum (181%), and ω3 fatty acids alone prevented this change in the prefrontal cortex and hippocampus, whereas the co-administration of ω3 fatty acids with VPA prevented the lipoperoxidation in all analyzed brain areas, and the co-administration of ω3 fatty acids with Li prevented this increase only in the prefrontal cortex and striatum. Moreover, superoxide dismutase (SOD) activity was decreased in the striatum (54%) in the prevention treatment, and the administration of ω3 fatty acids alone or in combination with Li and VPA partially prevented this inhibition. On the other hand, in the reversal treatment protocol, the administration of fenproporex increased carbonyl content in the prefrontal cortex (25%), hippocampus (114%) and striatum (91%), and in prefrontal coxter the administration of ω3 fatty acids alone or in combination with Li and VPA reversed this change, whereas in the hippocampus and striatum only ω3 fatty acids alone or in combination with VPA reversed this effect. Additionally, the administration of fenproporex resulted in a marked increase of TBARS in the hippocampus and striatum, and ω3 fatty acids alone or in combination with Li and VPA reversed this change. Finally, fenproporex administration decreased SOD activity in the prefrontal cortex (85%), hippocampus (52%) and striatum (76%), and the ω3 fatty acids in combination with VPA reversed this change in the prefrontal cortex and striatum, while the co-administration of ω3 fatty acids with Li reversed this inhibition in the hippocampus and striatum. In conclusion, our results support other studies showing the importance of ω3 fatty acids in the brain and the potential for these fatty acids to aid in the treatment of BD. [ABSTRACT FROM AUTHOR]

Published
2017
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504. Biomarkers of Delirium in a Low-Risk Community-Acquired Pneumonia-Induced Sepsis.

Author

Tomasi, Cristiane, Vuolo, Francieli, Generoso, Jaqueline, Soares, Márcio, Barichello, Tatiana, Quevedo, João, Ritter, Cristiane, and Dal-Pizzol, Felipe

Abstract

There are different theories about the pathophysiology of sepsis-associated encephalopathy (SAE), and the majority of our knowledge was derived from critically ill patients. 7In less severe sepsis, it is probable that neuroinflammation can be a major aspect of SAE development. We hypothesized that in non-severe septic patients, blood biomarkers of inflammation, endothelial activation, coagulation, and brain function would be different when compared to patients with and without brain dysfunction. A total of 30 patients presenting with community-acquired pneumonia (CAP)-induced sepsis were included of which 10 (33 %) developed SAE. Eight medical patients admitted to the general ward, except due to sepsis or infection, which developed delirium were included as delirium, non-sepsis group. From all measured biomarkers, only brain-derived neurotrophic factor (BDNF), regulated upon activation normal T cell expressed, and presumably secreted (RANTES), and interleukin (IL)-10 where significantly different when compared to SAE and sepsis groups. In addition, SAE patients presented higher levels of BDNF, vascular cellular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), platelet-derived growth factor (PDGF)-AB/BB and RANTES when compared to delirium patients. In conclusion, the profile of biomarkers differs between SAE, sepsis, and delirium patients, suggesting that pathways related to SAE are different from delirium and from sepsis itself. [ABSTRACT FROM AUTHOR]

Published
2017
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508. MAPK signaling correlates with the antidepressant effects of ketamine

Author

Réus, Gislaine Z., primary, Vieira, Flavio Geraldo, additional, Abelaira, Helena M., additional, Michels, Monique, additional, Tomaz, Débora B., additional, dos Santos, Maria Augusta B., additional, Carlessi, Anelise S., additional, Neotti, Morgana V., additional, Matias, Beatriz I., additional, Luz, Jaíne R., additional, Dal-Pizzol, Felipe, additional, and Quevedo, João, additional

Published
2014
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509. Outcomes for Patients With Cancer Admitted to the ICU Requiring Ventilatory Support

Author

Azevedo, Luciano C.P., primary, Caruso, Pedro, additional, Silva, Ulysses V.A., additional, Torelly, André P., additional, Silva, Eliézer, additional, Rezende, Ederlon, additional, Netto, José J., additional, Piras, Claudio, additional, Lobo, Suzana M.A., additional, Knibel, Marcos F., additional, Teles, José M., additional, Lima, Ricardo. A., additional, Ferreira, Bruno S., additional, Friedman, Gilberto, additional, Rea-Neto, Alvaro, additional, Dal-Pizzol, Felipe, additional, Bozza, Fernando A., additional, Salluh, Jorge I.F., additional, and Soares, Márcio, additional

Published
2014
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510. Abstract 336: Cardiac Function Improvement in Infarcted Rats Treated with an Association of N-acetylcysteine and Deferoxamine

Author

Andrades, Michael, primary, Phaelante, Amanda, additional, Olsen, Virgílio, additional, Tobar, Santiago, additional, Lopes, Amanda, additional, Martinelli, Nidiane, additional, Cohen, Carolina, additional, Dal-Pizzol, Felipe, additional, Biolo, Andreia, additional, Rohde, Luis, additional, and Clausell, Nadine, additional

Published
2014
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511. Evaluation of NCS-1, DARPP-32, and neurotrophins in hippocampus and prefrontal cortex in rats submitted to sepsis

Author

Comim, Clarissa M., primary, Silva, Napoleão C., additional, Mina, Francielle, additional, Dominguini, Diogo, additional, Scaini, Giselli, additional, Morais, Meline O.S., additional, Rosa, Daniela V., additional, Magno, Luiz Alexandre V., additional, Streck, Emilio L., additional, Romano-Silva, Marco A., additional, Quevedo, João, additional, and Dal-Pizzol, Felipe, additional

Published
2014
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512. Neonatal Escherichia coli K1 meningitis causes learning and memory impairments in adulthood

Author

Barichello, Tatiana, primary, Dagostim, Valdemira S., additional, Generoso, Jaqueline S., additional, Simões, Lutiana R., additional, Dominguini, Diogo, additional, Silvestre, Cintia, additional, Michels, Monique, additional, Vilela, Márcia Carvalho, additional, Jornada, Luciano K., additional, Comim, Clarissa M., additional, Dal-Pizzol, Felipe, additional, Teixeira, Antonio Lucio, additional, and Quevedo, João, additional

Published
2014
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514. Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis

Author

Constantino, Larissa, primary, Gonçalves, Renata Casagrande, additional, Giombelli, Vinícius Renê, additional, Tomasi, Cristiane Damiani, additional, Vuolo, Francieli, additional, Kist, Luiza Wilges, additional, de Oliveira, Giovanna Medeiros Tavares, additional, Pasquali, Matheus Augusto de Bittencourt, additional, Bogo, Maurício Reis, additional, Mauad, Thais, additional, Horn, Adolfo, additional, Melo, Karen V, additional, Fernandes, Christiane, additional, Moreira, José Cláudio Fonseca, additional, Ritter, Cristiane, additional, and Dal-Pizzol, Felipe, additional

Published
2014
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515. Effects of Organoselenium Compounds on Early and Late Brain Biochemical Alterations in Sepsis-Survivor Rats

Author

Silvestre, Fernanda, primary, Danielski, Lucinéia Gainski, additional, Michels, Monique, additional, Florentino, Drielly, additional, Vieira, Andriele, additional, Souza, Luana, additional, Cardoso, Larissa Colonetti, additional, Schraiber, Rosiane, additional, Rezin, Gislaine Tezza, additional, Vuolo, Francieli, additional, da Rocha, Joao Batista, additional, Barichello, Tatiana, additional, Quevedo, João, additional, Dal-Pizzol, Felipe, additional, and Petronilho, Fabricia, additional

Published
2014
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520. Coadministration of Branched-Chain Amino Acids and Lipopolysaccharide Causes Matrix Metalloproteinase Activation and Blood–Brain Barrier Breakdown

Author

Scaini, Giselli, primary, Morais, Meline O. S., additional, Galant, Leticia S., additional, Vuolo, Francieli, additional, Dall’Igna, Dhébora M., additional, Pasquali, Matheus A. B., additional, Ramos, Vitor M., additional, Gelain, Daniel P., additional, Moreira, Jose Claudio F., additional, Schuck, Patrícia F., additional, Ferreira, Gustavo C., additional, Soriano, Francisco G., additional, Dal-Pizzol, Felipe, additional, and Streck, Emilio L., additional

Published
2014
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521. Evaluation of the protective effect of Ilex paraguariensis and Camellia sinensis extracts on the prevention of oxidative damage caused by ultraviolet radiation

Author

Barg, Marlon, primary, Rezin, Gislaine T., additional, Leffa, Daniela D., additional, Balbinot, Fernanda, additional, Gomes, Lara M., additional, Carvalho-Silva, Milena, additional, Vuolo, Francieli, additional, Petronilho, Fabricia, additional, Dal-Pizzol, Felipe, additional, Streck, Emilio L., additional, and Andrade, Vanessa M., additional

Published
2014
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522. Inflammation biomarkers and delirium in critically ill patients

Author

Ritter, Cristiane, primary, Tomasi, Cristiane D, additional, Dal-Pizzol, Felipe, additional, Pinto, Bernardo, additional, Dyson, Alex, additional, de Miranda, Aline S, additional, Comim, Clarissa M, additional, Soares, Márcio, additional, Teixeira, Antonio L, additional, Quevedo, João, additional, and Singer, Mervyn, additional

Published
2014
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527. Aplicação do teste do relógio em octogenários e nonagenários participantes de estudo realizado em Siderópolis/SC

Author

Schmidt, Jaqueline Angela, Dal Pizzol, Felipe, Xavier, Flavio Merino de Freitas, Heluany, Claudia Cipriano Vidal, Schmidt, Jaqueline Angela, Dal Pizzol, Felipe, Xavier, Flavio Merino de Freitas, and Heluany, Claudia Cipriano Vidal

Abstract

The objective of this work was to know the variables presented in the application of Clock Drawing Test (CDT) in octogenarians and nonagenarians. We describe here resulted of a carried through tax cross-sectional study with aged of equal or superior age the 80 years, resident in the city of Siderópolis, S.C, Brazil (n=135) at the period of may to December of 2005. The research worked with a questionnaire and cognitive tests as the Clock Drawing Test, Mini Mental Scale Examination (MMSE), Verbal Fluency and Geriatric Depression Scale. The CDT was realized by 65 of 132 participants. The general mean in CDT was 4.5. The study showed that CDT wasn’t a good screening test of dementia in individuals with more than eighty years old and with low educational level. The low significance between CDT and others screening tools, specially MMSE, demonstrates this fact., O objetivo deste trabalho foi conhecer as variáveis apresentadas na aplicação do teste do relógio (TR) em octogenários e nonagenários. Descrevemos aqui o resultado de um estudo transversal censitário com idosos de idade igual ou superior a 80 anos, residentes na cidade de Siderópolis/SC, Brasil (N=135), no período de maio a dezembro de 2005. A pesquisa contou com questionário e testes cognitivos como o Teste do Relógio, Mini Mental (MEEM), Fluência Verbal e Escala de Depressão Geriátrica. O TR foi realizado por 65 idosos do total de 132 participantes. A média geral no neste teste foi de 4,5. O estudo mostrou que o TR não foi um método adequado de screening para demência em indivíduos com mais de 80 anos com baixa escolaridade. A baixa significância entre o TR e outros métodos de rastreio, principalmente o MEEM, demonstra esse fato., El objetivo de esta investigación ha sido conocer las variables presentadas en la aplicación del Test del Reloj (TR) en octogenarios y nonagenarios. Lo que aquí describimos es el resultado de un estudio transversal censitario con mayores de edad igual o superior a 80 años, residentes en la ciudad de Siderópolis/SC, Brasil (n=135), en el periodo de mayo a diciembre de 2005. Para llevar a cabo la investigación utilizamos una encuesta y testes cognitivos como el Test del Reloj, Mini Mental (MEEM), Fluencia Verbal y Escala de Depresión Geriátrica. El TR ha sido hecho en 65 de los 132 participantes. El promedio general en éste test ha sido de 4,5. El estudio há demostrado que el TR no ha resultado en un método adecuado de screening para demencia en individuos con más de 80 años con bajo nivel de escolaridad. La baja significancia entre el TR y otros métodos de rastreo, principalmente el MEEM, comprueba éste hecho.

Published
2009

528. Analysis of non-prescription drug radio advertising in Rio Grande do Sul State, Brazil

Author

Heineck,Isabela, Gallina,Sara Maria, Silva,Tatiane da, Dal Pizzol,Felipe, and Schenkel,Eloir Paulo

Subjects
Publicidade de Medicamento, Legislation, Legislação de Medicamentos, Uso de Medicamentos, Drug Publicity, Drug Utilization
Abstract

As propagandas de medicamentos veiculadas nas principais rádios do Rio Grande do Sul, Brasil, foram analisadas no período de agosto de 1995 a janeiro de 1996. Durante o período de observação foram documentadas 250 peças publicitárias referentes a 28 produtos. A maioria destas propagandas (>80%) não apresenta declarações quanto ao nome genérico, à composição, à posologia e ao laboratório fabricante do produto, infringindo, dessa forma, a legislação vigente no país. Além disso, um número significativo das peças publicitárias (39%) enfatizam a ausência de quaisquer riscos, mediante declarações como "Não tem contra-indicações", caracterizando a indução ao uso indiscriminado. A análise mostra que os medicamentos são promovidos como produtos quaisquer, omitindo-se informações fundamentais a respeito de cuidados, reações adversas e contra-indicações. Drug advertisements for non-prescription (over-the-counter) drugs on the main radio stations in the State of Rio Grande do Sul, Brazil, were analyzed as to the information provided about generic names, pharmaceutical company, composition, and dosage. From August 1995 to January 1996, 250 advertisements for 28 products were recorded. More than 80% of these advertisements provided no information on these topics and thus failed to comply with Brazilian legislation. On the contrary, a large number of advertisements (39%) emphasize absence of risks, with claims such as "no contraindications", inducing consumers to use such drugs indiscriminately. The study showed that drugs were advertised like any other merchandise, with no concern over fundamental information such as product identification, precautions, and possible side effects.

Published
1998

530. Il1-β Involvement in Cognitive Impairment after Sepsis

Author

Mina, Francielle, primary, Comim, Clarissa M., additional, Dominguini, Diogo, additional, Cassol-Jr, Omar J., additional, Dall`Igna, Dhébora M., additional, Ferreira, Gabriela K., additional, Silva, Milena C., additional, Galant, Leticia S., additional, Streck, Emílio L., additional, Quevedo, João, additional, and Dal-Pizzol, Felipe, additional

Published
2013
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531. Effect of Acute Administration of l-Tyrosine on Oxidative Stress Parameters in Brain of Young Rats

Author

Macêdo, Livia G. R. P., primary, Carvalho-Silva, Milena, additional, Ferreira, Gabriela K., additional, Vieira, Júlia S., additional, Olegário, Natália, additional, Gonçalves, Renata C., additional, Vuolo, Francieli S., additional, Ferreira, Gustavo C., additional, Schuck, Patrícia F., additional, Dal-Pizzol, Felipe, additional, and Streck, Emilio L., additional

Published
2013
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532. Lack of association of S100β and neuron-specific enolase with mortality in critically ill patients

Author

Macedo, Roberta Candal de, primary, Tomasi, Cristiane Damiani, additional, Giombelli, Vinicius René, additional, Alves, Sarah Cascaes, additional, Bristot, Maria de Lourdes Ugioni, additional, Locks, Maria Fernanda Topanotti, additional, Petronilho, Fabrícia, additional, Grandi, Carmen, additional, Quevedo, João, additional, Dal-Pizzol, Felipe, additional, and Ritter, Cristiane, additional

Published
2013
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533. Acute exercise induce endothelial nitric oxide synthase phosphorylation via Akt and AMP-activated protein kinase in aorta of rats: Role of reactive oxygen species

Author

Barbosa, Viviane A., primary, Luciano, Thais F., additional, Marques, Scherolin O., additional, Vitto, Marcelo F., additional, Souza, Daniela R., additional, Silva, Luciano A., additional, Santos, João Paulo A., additional, Moreira, José C., additional, Dal-Pizzol, Felipe, additional, Lira, Fabio S., additional, Pinho, Ricardo A., additional, and De Souza, Claudio T., additional

Published
2013
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534. Acute Brain Inflammation and Oxidative Damage Are Related to Long-Term Cognitive Deficits and Markers of Neurodegeneration in Sepsis-Survivor Rats

Author

Schwalm, Mágada T., primary, Pasquali, Matheus, additional, Miguel, Samantha P., additional, dos Santos, João Paulo A., additional, Vuolo, Francieli, additional, Comim, Clarissa M., additional, Petronilho, Fabrícia, additional, Quevedo, João, additional, Gelain, Daniel P., additional, Moreira, José Cláudio F., additional, Ritter, Cristiane, additional, and Dal-Pizzol, Felipe, additional

Published
2013
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536. Late brain alterations in sepsis‐survivor rats

Author

Steckert, Amanda V., primary, Comim, Clarissa M., additional, Mina, Francielle, additional, Mendonça, Bruna P., additional, Dominguini, Diogo, additional, Ferreira, Gabriela K., additional, Carvalho‐Silva, Milena, additional, Vieira, Júlia S., additional, Streck, Emilio L., additional, Quevedo, João, additional, and Dal‐Pizzol, Felipe, additional

Published
2013
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537. Correlation of Acute Phase Inflammatory and Oxidative Markers With Long-term Cognitive Impairment in Sepsis Survivors Rats

Author

Biff, Daiane, primary, Petronilho, Fabrícia, additional, Constantino, Larissa, additional, Vuolo, Francieli, additional, Zamora-Berridi, Grettel J., additional, Dall’Igna, Dhébora Mozena, additional, Comim, Clarissa M., additional, Quevedo, João, additional, Kapczinski, Flávio, additional, and Dal-Pizzol, Felipe, additional

Published
2013
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540. Imipramine reverses alterations in cytokines and BDNF levels induced by maternal deprivation in adult rats

Author

Rus, Gislaine Z., primary, dos Santos, Maria Augusta B., additional, Abelaira, Helena M., additional, Ribeiro, Karine F., additional, Petronilho, Fabrcia, additional, Vuolo, Francieli, additional, Colpo, Gabriela D., additional, Pfaffenseller, Bianca, additional, Kapczinski, Flvio, additional, Dal-Pizzol, Felipe, additional, and Quevedo, Joo, additional

Published
2013
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541. Effects of lamotrigine on behavior, oxidative parameters and signaling cascades in rats exposed to the chronic mild stress model

Author

Abelaira, Helena M., primary, Réus, Gislaine Z., additional, Ribeiro, Karine F., additional, Steckert, Amanda V., additional, Mina, Francielle, additional, Rosa, Daniela V.F., additional, Santana, Cíntia V., additional, Romano-Silva, Marco Aurélio, additional, Dal-Pizzol, Felipe, additional, and Quevedo, João, additional

Published
2013
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542. Central Nervous System Involvement in the Animal Model of Myodystrophy

Author

Comim, Clarissa M., primary, Mendonça, Bruna P., additional, Dominguini, Diogo, additional, Cipriano, Andreza L., additional, Steckert, Amanda V., additional, Scaini, Giselli, additional, Vainzof, Mariz, additional, Streck, Emílio L., additional, Dal-Pizzol, Felipe, additional, and Quevedo, João, additional

Published
2013
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543. Matrix Metalloproteinase-2 and Metalloproteinase-9 Activities are Associated with Blood–Brain Barrier Dysfunction in an Animal Model of Severe Sepsis

Author

Dal-Pizzol, Felipe, primary, Rojas, Hugo Alberto, additional, dos Santos, Emilia Marcelina, additional, Vuolo, Francieli, additional, Constantino, Larissa, additional, Feier, Gustavo, additional, Pasquali, Matheus, additional, Comim, Clarissa M., additional, Petronilho, Fabrícia, additional, Gelain, Daniel Pens, additional, Quevedo, João, additional, Moreira, José Cláudio Fonseca, additional, and Ritter, Cristiane, additional

Published
2013
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545. CD40 expression in the hippocampus and its role in blood-brain barrier permeability, neutrophil infiltration and oxidative stress: implication for brain damage associated with sepsis in rats

Author

Michels, Monique, primary, Danielski, Lucinéia G, additional, da Silva Vieira, Andriele A, additional, Vieira, Luiz, additional, Florentino, Drielly, additional, Laurenano, André, additional, Mina, Francielle, additional, Vuolo, Francieli, additional, Dall'Igna, Dhébora M, additional, Galant, Letícia, additional, Quevedo, João, additional, Dal-Pizzol, Felipe, additional, and Petronilho, Fabrícia, additional

Published
2013
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546. Sepsis-associated brain dysfunction in critically ill patients

Author

Tomasi, Cristiane, primary, Vuolo, Franciele, additional, Constantino, Larissa, additional, Dall'Igna, Dhébora, additional, Mazon, Eduardo, additional, Mafioleti, Renato, additional, Quevedo, João, additional, Ritter, Cristiane, additional, Teixeira, Antonio, additional, and Dal-Pizzol, Felipe, additional

Published
2013
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548. Brain markers of neurodegeneration in sepsis survivor rats

Author

de Souza Constantino, Larissa, primary, Tomasi, Cristiane, additional, Pasquali, Matheus, additional, Miguel, Samantha, additional, dos Santos, João, additional, Vuolo, Francieli, additional, Comim, Clarissa, additional, Petronilho, Fabrícia, additional, Quevedo, João, additional, Gelain, Daniel, additional, Moreira, José, additional, and Dal-Pizzol, Felipe, additional

Published
2013
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550. Cerebral Oedema, Blood-Brain Barrier Breakdown and the Decrease in Na,K-ATPase Activity in the Cerebral Cortex and Hippocampus are Prevented by Dexamethasone in an Animal Model of Maple Syrup Urine Disease.

Author

Rosa, Luciana, Galant, Leticia, Dall'Igna, Dhébora, Kolling, Janaina, Siebert, Cassiana, Schuck, Patrícia, Ferreira, Gustavo, Wyse, Angela, Dal-Pizzol, Felipe, Scaini, Giselli, and Streck, Emilio

Abstract

Maple syrup urine disease (MSUD) is a rare metabolic disorder associated with acute and chronic brain dysfunction. This condition has been shown to lead to macroscopic cerebral alterations that are visible on imaging studies. Cerebral oedema is widely considered to be detrimental for MSUD patients; however, the mechanisms involved are still poorly understood. Therefore, we investigated whether acute administration of branched-chain amino acids (BCAA) causes cerebral oedema, modifies the Na,K-ATPase activity, affects the permeability of the blood-brain barrier (BBB) and alters the levels of cytokines in the hippocampus and cerebral cortex of 10-day-old rats. Additionally, we investigated the influence of concomitant administration of dexamethasone on the alterations caused by BCAA. Our results showed that the animals submitted to the model of MSUD exhibited an increase in the brain water content, both in the cerebral cortex and in the hippocampus. By investigating the mechanism of cerebral oedema, we discovered an association between H-BCAA and the Na,K-ATPase activity and the permeability of the BBB to small molecules. Moreover, the H-BCAA administration increases Il-1β, IL-6 and TNF-α levels in the hippocampus and cerebral cortex, whereas IL-10 levels were decreased in the hippocampus. Interestingly, we showed that the administration of dexamethasone successfully reduced cerebral oedema, preventing the inhibition of Na,K-ATPase activity, BBB breakdown and the increase in the cytokines levels. In conclusion, these findings suggest that dexamethasone can improve the acute cerebral oedema and brain injury associated with high levels of BCAA, either through a direct effect on brain capillary Na,K-ATPase or through a generalized effect on the permeability of the BBB to all compounds. [ABSTRACT FROM AUTHOR]

Published
2016
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