378 results on '"A. Delignières"'
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352. Exercices sur la physique... le calcul différentiel et intégral... la méchanique, l'astronomie, la gnomonique, le calendrier, l'économie animale, la chymie et la physique expérimentale, dans la salle des actes du collège d'Amiens... le... 11 août 1777... par Honoré Tempez,... Louis Petit,... Charles-André Delignières,...
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Petit, Jean-Louis (1674-1750). Auteur du texte, Delignières, Charles-André. Auteur du texte, Petit, Jean-Louis (1674-1750). Auteur du texte, and Delignières, Charles-André. Auteur du texte
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Appartient à l’ensemble documentaire : CGSomme, Appartient à l’ensemble documentaire : Picardi1, Avec mode texte
353. Extraits des Procès-verbaux des séances de la Société d'émulation d'Abbeville pendant les années 1869 (-1876). [Par Ém. Delignières.]
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Delignières, Émile (1836-1910). Auteur du texte and Delignières, Émile (1836-1910). Auteur du texte
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Avec mode texte
354. Extraits des Procès-verbaux des séances de la Société d'émulation d'Abbeville pendant les années 1869 (-1876). [Par Ém. Delignières.]
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Delignières, Émile (1836-1910). Auteur du texte and Delignières, Émile (1836-1910). Auteur du texte
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Avec mode texte
355. About the need for an epistemological reflection in sport sciences.
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Delignières, Didier
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SPORTS sciences ,CURRICULUM ,PHYSICAL education ,EDUCATION - Abstract
An introduction is presented in which the author discusses the contents within the issue including the importance of the interdisciplinary approach in the study of sports science, the aspect of sports science as an academic discipline, and the concept of competence in physical education.
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- 2016
356. De la nécessité d'une réflexion épistémologique en STAPS.
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Delignières, Didier
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- 2016
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357. Liste des auteurs
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Amalberti, F., Béguin, A.-M., Belmin, J., Berbezier, Y., Bernard, M.-F., Bruhat, A., Bruyère, A., Bussone, M., Clément, R., Delignières, M., Denis, B., Dondelinger, R., Geoffre, C., Givaudan, M., Hamon-Mekki, F., Hugonot, R., Jouteau-Neves, C., Le Corre, C., Lefebvre-Chapiro, S., Lefebvre Des Noettes, V., Malaquin-Pavan, E., Marzais, M., Meaume, S., Mémin, C., Michel, J.-P., Michot, P., Moulias, R., Muller, F., Oasi, C., Ollivet, C., Pariel-Madjlessi, S., Perret, C., Petit, C., Pierrot, M., Plissier, S., Pottiez, S., Rainfray, M., Renaud, O., Robcis, I., Rodat, O., Sebag-Lanoë, R., Teillet, L., Trivalle, C., and Vassel, P.
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- 2005
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358. Effects of vehicle supplementation on total estradiol absorption from a transdermal estradiol delivery system
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Smith, Rosella D., Robinson, Denise E., Delignieres, Bruno, Albertson, Barry D., Tomai, Thomas P., Zinaman, Michael J., and Simon, James A.
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- 1991
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359. The Dynamic Adjustment of Physical Self in Adults.
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Ninot, Grégory, Fortes, Marina, Delignières, Didier, and Maïano, Christophe
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PSYCHOLOGICAL adaptation , *SELF-esteem , *SELF-acceptance , *PERSONALITY , *ADULTS - Abstract
This study examined the dynamics of global self-esteem and physical self- perception in eight sedentary adults. Each participant completed the shortened version of the Physical Self Inventory, which measured global self-esteem (GSE), physical self- worth, and four physical sub-domains, everyday between 7:00 and 9:00 a.m. and 7:00 and 9:00 p.m. over the year 2001. Two weeks later, they completed the same inventory, in an isolated room every 5 minutes for 4 hours and 15 minutes. The auto-regressive integrated moving average (ARIMA) procedures showed that the dynamics of GSE and physical self dimensions were non-stationary over two consecutive semesters or one year. The ARIMA indicated that all the perceived dimensions functioned as a moving average model (0.1,1) without significant constant. Inversely, the time series obtained in an isolated room showed 88% random oscillations around a local value, which indicated a (0,0,0) model. [ABSTRACT FROM AUTHOR]
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- 2004
360. Interpersonal Synchronization Processes in Discrete and Continuous Tasks.
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Ezzina, Samar, Scotti, Maxime, Roume, Clément, Pla, Simon, Blain, Hubert, and Delignières, Didier
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Three frameworks have been proposed to account for interpersonal synchronization: The information processing approach argues that synchronization is achieved by mutual adaptation, the coordination dynamics perspective supposes a continuous coupling between systems, and complexity matching suggests a global, multi-scale interaction. We hypothesized that the relevancy of these models was related to the nature of the performed tasks. 10 dyads performed synchronized tapping and synchronized forearm oscillations, in two conditions: full (participants had full information about their partner), and digital (information was limited to discrete auditory signals). Results shows that whatever the task and the available information, synchronization was dominated by a discrete mutual adaptation. These results question the relevancy of the coordination dynamics perspective in interpersonal coordination. [ABSTRACT FROM AUTHOR]
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- 2021
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361. Biases in the Simulation and Analysis of Fractal Processes.
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Roume, Clément, Ezzina, Samar, Blain, Hubert, and Delignières, Didier
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FRACTAL analysis , *WHITE noise , *SPECTRAL energy distribution , *POWER density - Abstract
Fractal processes have recently received a growing interest, especially in the domain of rehabilitation. More precisely, the evolution of fractality with aging and disease, suggesting a loss of complexity, has inspired a number of studies that tried, for example, to entrain patients with fractal rhythms. This kind of study requires relevant methods for generating fractal signals and for assessing the fractality of the series produced by participants. In the present work, we engaged a cross validation of three methods of generation and three methods of analysis. We generated exact fractal series with the Davies–Harte (DH) algorithm, the spectral synthesis method (SSM), and the ARFIMA simulation method. The series were analyzed by detrended fluctuation analysis (DFA), power spectral density (PSD) method, and ARFIMA modeling. Results show that some methods of generation present systematic biases: DH presented a strong bias toward white noise in fBm series close to the 1/f boundary and SSM produced series with a larger variability around the expected exponent, as compared with other methods. In contrast, ARFIMA simulations provided quite accurate series, without major bias. Concerning the methods of analysis, DFA tended to systematically underestimate fBm series. In contrast, PSD yielded overestimates for fBm series. With DFA, the variability of estimates tended to increase for fGn series as they approached the 1/f boundary and reached unacceptable levels for fBm series. The highest levels of variability were produced by PSD. Finally, ARFIMA methods generated the best series and provided the most accurate and less variable estimates. [ABSTRACT FROM AUTHOR]
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- 2019
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362. Windowed detrended cross-correlation analysis of synchronization processes.
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Roume, C., Almurad, Z.M.H., Scotti, M., Ezzina, S., Blain, H., and Delignières, D.
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CROSS correlation , *SYNCHRONIZATION , *COMPUTATIONAL complexity , *INFORMATION processing , *COMPUTER simulation - Abstract
Abstract The aim of this paper was to propose a formal approach of the Windowed Detrended Cross-Correlation (WDCC) analysis, a method designed for identifying the processes that underlie intra- and interpersonal synchronization. We present the three main theoretical frameworks that have been proposed for accounting for synchronization processes, (1) the information-processing approach, (2) the coupled oscillators model and (3) the complexity matching effect. We formally derive the WDCC results that could be expected from each model. We show by simulation that each model allows generating series that fit the expected results. We also analyze experimental data sets collected in situations that were supposed to selectively elicit the synchronization processes depicted in the three theoretical frameworks. Our results show that the information-processing and the complexity matching processes are both present in each situation, but with a clear dominance of one of these processes on the other. Finally our results lead us to cast some doubts about the relevance of the coupled oscillators model in interpersonal synchronization. Highlights • We present a cross-correlational method (WDCC) for studying synchronization processes. • We derive the WDCC signatures expected from the most popular theoretical models. • We apply WDCC to a set of data collected during interpersonal synchronization. • A mix of asynchrony correction and complexity matching sustains synchronization. • Coupled oscillators model are not relevant in interpersonal synchronization. [ABSTRACT FROM AUTHOR]
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- 2018
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363. Molecular characterization of a cohort of 73 patients with infantile spasms syndrome.
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Boutry-Kryza, Nadia, Labalme, Audrey, Ville, Dorothee, de Bellescize, Julitta, Touraine, Renaud, Prieur, Fabienne, Dimassi, Sarra, Poulat, Anne-Lise, Till, Marianne, Rossi, Massimiliano, Bourel-Ponchel, Emilie, Delignières, Aline, Le Moing, Anne-Gaelle, Rivier, Clotilde, des Portes, Vincent, Edery, Patrick, Calender, Alain, Sanlaville, Damien, and Lesca, Gaetan
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COHORT analysis , *INFANTILE spasms , *PEOPLE with epilepsy , *ELECTROENCEPHALOGRAPHY , *ETIOLOGY of diseases , *PROGNOSTIC tests , *GENETIC testing - Abstract
Infantile Spasms syndrome (ISs) is a characterized by epileptic spasms occurring in clusters with an onset in the first year of life. West syndrome represents a subset of ISs that associates spasms in clusters, a hypsarrhythmia EEG pattern and a developmental arrest or regression. Aetiology of ISs is widely heterogeneous including many genetic causes. Many patients, however, remain without etiological diagnosis, which is critical for prognostic purpose and genetic counselling. In the present study, we performed genetic screening of 73 patients with different types of ISs by array-CGH and molecular analysis of 5 genes: CDKL5 , STXBP1 , KCNQ2 , and GRIN2A , whose mutations cause different types of epileptic encephalopathies, including ISs, as well as MAGI2 , which was suggested to be related to a subset of ISs. In total, we found a disease-causing mutation or CNV (Copy Number Variation) in 15% of the patients. These included 6 point mutations found in CDKL5 ( n = 3) and STXBP1 ( n = 3), 3 microdeletions (10 Mb in 2q24.3, 3.2 Mb in 5q14.3 including the region upstream to MEF2C , and 256 kb in 9q34 disrupting EHMT1 ), and 2 microduplications (671 kb in 2q24.3 encompassing SCN2A , and 11.93 Mb in Xq28). In addition, we discuss 3 CNVs as potential risk factors, including one 16p12.1 deletion, one intronic deletion of the NEDD4 gene, and one intronic deletion of CALN1 gene. The present findings highlight the efficacy of combined cytogenetic and targeted mutation screening to improve the diagnostic yield in patient with ISs. [ABSTRACT FROM AUTHOR]
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- 2015
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364. La restauration de la complexité de la marche pour la prévention de la chute chez les personnes âgées : l’appariement des complexités
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Ezzina, Samar, Euromov (EuroMov), Université de Montpellier (UM), Université Montpellier, Didier Delignières, and Hubert Blain
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Elderly ,Réhabilitation ,[SHS.EDU]Humanities and Social Sciences/Education ,Rehabilitation ,Fall ,Chute ,Appariement des complexités ,Complexity matching ,Personnes âgées ,Complexity ,Complexité - Abstract
Today, falling is a major health problem for aging population. It generates a cascade of health complications such as dependence, social isolation, death, depression, etc. This doctoral work aimed to treat falling via an innovative framework: the theory of complex systems. First, we focus on interpersonal synchronization, i.e. the interaction between two complex systems, and we propose a new methodology to analyze this phenomenon. Next, we show that the complexity matching effect could represent a suitable approach for the study of interpersonal interaction. Therefore, in a second step, we propose a walking rehabilitation protocol based on the phenomenon of complexity matching and allowing to restore the complexity of the locomotion system in the elderly. We show that a regular training of 3 weeks in synchronized walking (elderly subject + young guide) can restore the complexity of walking in seniors (up to 2 months post-protocol). In addition, this restoration of complexity results in a reduction in the fear of falling and an improvement in the overall health of seniors.; La chute constitue, aujourd’hui, une problématique de santé majeure chez la population vieillissante. Elle, engendre une cascade de complications sanitaires tel que la dépendance, l’isolement social, le décès, la dépression, etc. Par conséquent, ce travail doctoral a visé de traiter la chute via une méthodologie innovante : la théorie des système complexes. Dans un premier temps, nous nous sommes intéressés à la synchronisation interpersonnelle, donc, l’interaction entre deux systèmes complexes, et nous proposons une nouvelle méthodologie pour analyser ce phénomène. Ensuite, nous montrons que l’appariement des complexités pourrait constituer une approche adaptée pour l’étude de l’interaction interpersonnelle. De ce fait, dans un second temps, nous proposons un protocole de réhabilitation à la marche basé sur un phénomène d’appariement des complexités permettant de restaurer la complexité du système de locomotion des personnes âgées. Nous montrons qu’un entraînement régulier de 3 semaines à la marche synchronisée (sujet âgé + guide jeune), permet de restaurer la complexité de la marche chez les seniors de manière pérenne (jusqu’à 2 mois post-protocole). De plus, cette restauration de la complexité obtenue se traduit par une diminution de la peur de chuter et une amélioration de l’état de santé global des seniors.
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- 2020
365. Persistent coordination patterns in a complex task after 10 years delay: Subtitle: How validate the old saying “Once you have learned how to ride a bicycle, you never forget!”.
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Nourrit-Lucas, Déborah, Zelic, Grégory, Deschamps, Thibault, Hilpron, Michael, and Delignières, Didier
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BICYCLES , *MOTOR learning , *MOTOR ability , *PERFORMANCE evaluation , *ORDINARY differential equations - Abstract
Highlights: [•] We examined the long-term retention in a complex motor task on ski simulator. [•] The oscillations were modeled as oscillators obeying second ordinary differential equations. [•] We observed a decrease of performance variables (amplitude & frequency). [•] The coordination variables exhibited persistent values after a ten year lapse. [•] We argued that a valid assessment of learning had to consider coordination variables. [Copyright &y& Elsevier]
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- 2013
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366. Utilisation du lévétiracétam (LEV) dans le traitement des épilepsies réfractaires de l’enfant : expérience du service de neuropédiatrie du CHU d’Amiens en France
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Doumbia-Ouattara, M., Bourel-Ponchel, E., Le Moing, A.-G., Querne, L., Delignières, A., de Broca, A., and Berquin, P.
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CHILDHOOD epilepsy , *DRUG resistance , *ANTICONVULSANTS , *DRUG efficacy , *DRUG tolerance , *APPETITE loss , *DROWSINESS , *THERAPEUTICS - Abstract
Summary: Introduction: In young children presenting drug-resistant epilepsy, the number of approved antiepileptic drugs is limited. Levetiracetam (LEV) is one of the most recent antiepileptic drugs (AED) introduced on the market and data on its effectiveness and tolerance in children are scarce. Patients and methods: The objective of this retrospective study was to report our experience with the use of levetiracetam as an adjuvant therapy in a population of 42 children presenting a drug-resistant epilepsy. The study was conducted over a 5-year-period (from 1 January 2004 to 30 June 2007). Results: The patients’ mean age was 10.8 years (range, 2.1–19 years). The mean duration of epilepsy was 6.6 years (range, 1.5–19 years). After the administration of LEV, 10 patients (23.8%) became seizure-free and 16 (38.1%) had more than 50% seizure reduction. A reduction of less than 50% was observed in 13 patients (31%). Three patients (7.1%) presented an increase in seizure frequency. The effectiveness of LEV was similar in partial and generalized epilepsy. LEV was well tolerated by these patients. The main adverse effects were anorexia, asthenia, and behavioral disorders, and drowsiness was encountered in 17% of the patients. All persistent adverse events were noted. In children under 4 years of age, LEV was particularly well tolerated. Conclusion: This study confirms the effectiveness and tolerance of LEV used as an adjuvant therapy in children presenting drug-resistant epilepsy, particularly in the very young ones. [ABSTRACT FROM AUTHOR]
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- 2012
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367. Contemporary theories of 1/f noise in motor control
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Diniz, Ana, Wijnants, Maarten L., Torre, Kjerstin, Barreiros, João, Crato, Nuno, Bosman, Anna M.T., Hasselman, Fred, Cox, Ralf F.A., Van Orden, Guy C., and Delignières, Didier
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MOTOR ability , *HUMAN mechanics , *NOISE , *PSYCHOLOGICAL tests , *EXPERIMENTAL psychology , *STATISTICAL correlation , *MATHEMATICAL models , *TIME series analysis - Abstract
Abstract: 1/f noise has been discovered in a number of time series collected in psychological and behavioral experiments. This ubiquitous phenomenon has been ignored for a long time and classical models were not designed for accounting for these long-range correlations. The aim of this paper is to present and discuss contrasted theoretical perspectives on 1/f noise, in order to provide a comprehensive overview of current debates in this domain. In a first part, we propose a formal definition of the phenomenon of 1/f noise, and we present some commonly used methods for measuring long-range correlations in time series. In a second part, we develop a theoretical position that considers 1/f noise as the hallmark of system complexity. From this point of view, 1/f noise emerges from the coordination of the many elements that compose the system. In a third part, we present a theoretical counterpoint suggesting that 1/f noise could emerge from localized sources within the system. In conclusion, we try to draw some lines of reasoning for going beyond the opposition between these two approaches. [Copyright &y& Elsevier]
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- 2011
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368. Inter-limb coordination in swimming: Effect of speed and skill level
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Seifert, Ludovic, Leblanc, Hugues, Chollet, Didier, and Delignières, Didier
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MOTOR ability , *EXTREMITIES (Anatomy) , *BREASTSTROKE (Swimming) , *KNEE , *ELBOW , *BIOMECHANICS , *SWIMMERS , *UNDERWATER photography - Abstract
Abstract: The aim of this study was to examine the effects of swimming speed and skill level on inter-limb coordination and its intra-cyclic variability. The elbow–knee continuous relative phase (CRP) was used as the order parameter to analyze upper–lower limbs coupling during a complete breaststroke cycle. Twelve recreational and 12 competitive female swimmers swam 25m at a slow speed and 25m at maximal speed. Underwater and aerial side views were mixed and genlocked with an underwater frontal view. The angle, angular velocity, and phase were calculated for the knee and elbow by digitizing body marks on the side view. Three cycles were analyzed, filtered, averaged, and normalized in percentage of the total cycle duration. The competitive swimmers showed greater intra-cyclic CRP variability, indicating a combination of intermediate phase and in-phase knee–elbow coupling within a cycle. This characteristic was more marked at slow speed because more time was spent in the glide period of the stroke cycle, with the body completely extended. Conversely, because they spent less time in the glide, the recreational swimmers showed lower intra-cyclic CRP variability (which is mostly in the in-phase coordination mode), resulting in superposition of contradictory actions (propulsion of one limb during the recovery of the other limb). [Copyright &y& Elsevier]
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- 2010
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369. Nonlinear analysis of complex physiological control systems dynamics to assess performance and health in the connected human in an ecological environment
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Gilfriche, Pierre, Laboratoire de l'intégration, du matériau au système (IMS), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Université Sciences et Technologies - Bordeaux 1, Université de Bordeaux, Laurent Arsac, Arsac, Laurent, Deschodt-Arsac, Véronique, Temprado, Jean-Jacques, Delignières, Didier, Humeau, Anne, and STAR, ABES
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Analyse non linéaire ,IoT ,Entropie ,Physiology ,Entropy ,Complexity ,Complexité ,Nonlinear analysis ,Fractal ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,Physiologie ,[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing - Abstract
Maintaining a healthy state relies on many interactions between neural structures largely distributed in the organism and operating at different timescales. This structural complexity participates in the adaptiveness of physiological systems through a multi-level integration providing the control system with critical properties of flexibility, robustness and adaptability. This complexity in neurophysiological control systems can be evaluated through the analysis of their output signals: a complex signal is associated with a complex physiological network, and hence with an efficient control. Nonlinear analyses of physiological signals have proven their ability to characterize such complexity by introducing quantitative markers. These analyses bring new perspectives to the understanding of control strategies participating in health and performance in humans. Particularly, neurophysiological control distribution can be explored under different constraints to reveal adaptation strategies to numerous daily challenges. This way, studying the time course of heart rate, locomotor rhythms and postural sway is a way to explore control strategies contributing to health and performance in humans, in various contexts and under different constraints. In the present work, the frequency content, fractal fluctuations and entropy levels in time series generated by these systems are studied under different conditions. In a context of applied research, the experimental work has been conducted not only in the laboratory but also in ecological situations using connected devices (smartphone). For each situation, a methodological reflection is led to identify the most appropriate complexity analysis method for the control system studied, in line with the measurement devices used (connected devices or laboratory sensors)., Le maintien de conditions physiologiques compatibles avec une bonne santé repose sur de nombreuses interactions entre des structures nerveuses largement distribuées dans l’organisme et qui agissent selon différentes échelles de temps. Cette complexité structurelle permet aux systèmes physiologiques d’être adaptatifs via une intégration multi-niveaux offrant au système de contrôle la capacité d’être flexible, robuste et adaptable. La complexité des systèmes neurophysiologiques de contrôle peut être étudiée par le biais des signaux qu’ils émettent : un signal complexe est le signe d’une structure physiologique complexe et donc d’un contrôle performant. Les analyses non linéaires des signaux physiologiques ont prouvé leur capacité à caractériser cette complexité par l’introduction de marqueurs quantitatifs. Ces analyses apportent de nouvelles perspectives sur la compréhension des stratégies de contrôle qui participent à la santé et à la performance chez l’Homme. En particulier, la distribution du contrôle neurophysiologique peut être explorée sous différentes contraintes pour révéler les stratégies d’adaptation face à des situations auxquelles l’individu est confronté en permanence. Le rythme cardiaque, les rythmes locomoteurs et les oscillations du contrôle postural constituent des objets d’étude pour explorer ces stratégies dans des contextes variés, et sous différentes contraintes. Dans ce travail, les caractéristiques fréquentielles, fluctuations fractales et le niveau d’entropie présents dans les séries temporelles produites par ces systèmes sont étudiées dans différentes conditions. Dans un contexte de recherche appliquée, les expérimentations ont été menées en laboratoire mais aussi en situation écologique grâce à l’utilisation d’objets connectés (smartphone). Pour chaque situation, une réflexion méthodologique est menée pour identifier la méthode d’analyse de la complexité la plus adaptée au système de contrôle étudié, en adéquation avec les outils de mesures utilisés (objets connectés ou capteurs de laboratoire).
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- 2019
370. Human movement complexity : theoretical and practical aspects of the evaluation and the interaction of complexities at the service of rehabilitation
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Roume, Clément, Euromov (EuroMov), Université de Montpellier (UM), Université Montpellier, Didier Delignières, and Hubert Blain
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Fractals ,Synchronisation interpersonnelles ,Réhabilitation ,[SHS.EDU]Humanities and Social Sciences/Education ,Rehabilitation ,Interpersonal synchronization ,Complexity ,Fractales ,Compléxité - Abstract
Just look at our top athletes, their ability to adapt in record-breaking times during sudden changes in tactical phases, or the near-perfect coordination of Olympic-level synchronized swimmers to understand that human movement cannot be reduced to any model of excessive simplicity. Here we propose an application of the complexity sciences, and more particularly of fractal analysis methods aimed at giving a global picture of the complexity of human movement. In a first step, from the theoretical aspects, until their practical application, we show that the finest evaluation of the fractal exponents requires the combined use of a very specific fractal analysis and physiological task. Then, in a second step, we are interested in the coordination of two complex systems. Starting from several theoretical frameworks existing in the field of human movement sciences, we propose new methods to analyze this synchronization. Finally, all the works that we present are attached to rehabilitation goals and we show that despite a typical alteration of complexity with aging there are simple and effective ways to restore this complexity.; Il suffit d’observer nos athlètes de plus haut niveau, leur capacité à s’adapter dans des temps records lors de changements soudains dans les phases tactiques, ou encore la coordination quasi parfaite des nageuses synchronisées de niveau olympique, pour comprendre que le mouvement humain ne peut se réduire à quelconque modèle d’une simplicité excessive. Nous proposons ici une mise en application des sciences de la complexité, et plus particulièrement des méthodes d’analyse fractale ayant pour but de donner une image globale de la complexité du mouvement humain. Dans un premier temps, en partant des aspects théoriques, jusqu’à leur mise en application pratique, nous montrons que l’évaluation la plus fine des exposants fractals nécessite l’utilisation combinée d’une analyse fractale et d’une tâche physiologique bien spécifique. Puis, dans un deuxième temps, nous nous intéressons à la coordination de deux systèmes complexes. En partant de plusieurs cadres théoriques existant dans le champ des sciences du mouvement humain, nous proposons de nouvelles méthodes pour analyser cette synchronisation. Enfin, l’ensemble des travaux que nous présentons sont attachés à des buts de réhabilitation et nous montrons que malgré une altération typique de la complexité avec l’âge il existe des moyens simple et efficaces de rétablir cette complexité.
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- 2019
371. Processus d’appariement des complexités lors du couplage de deux systèmes biologiques : application à la rééducation de la marche chez les personnes âgées
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Al Murad, Zainy Mshco Hajy, Euromov (EuroMov), Université de Montpellier (UM), Université Montpellier, and Didier Delignières
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Aging ,Structure 1/f ,Restoration of complexity ,Coordination ,[SHS.EDU]Humanities and Social Sciences/Education ,1/f structure ,Complexity ,Complexité ,Vieillissement ,Multifractality ,Restauration de la complexité ,Multifractalité - Abstract
Several theoretical frameworks have attempted to account for interpersonal synchronization processes. Cognitive theories suggest that synchronization is achieved through discrete and mutual corrections of asynchronies between the two partners. The dynamic theories are based on the assumption of a continuous coupling between the two systems, conceived as self-sustained oscillators. Finally, the complexity matching model is based on the assumption of a multi-scale coordination between the two interacting systems. As a first step, we develop statistical tests in order to identify, in experimental data, the typical signatures of these three modes of coordination. In particular, we propose a multifractal signature, based on the analysis of correlations between the multifractal spectra characterizing the series produced by the two interacting systems. We also develop a windowed cross-correlation analysis, which aims at revealing the nature of the local synchronization processes. These studies allow us to revisit a number of previous works. We show that if the synchronization of discrete tasks such as tapping relies on discrete correction processes of asynchronies, the synchronization of continuous tasks such as pendulum oscillations is essentially based on the same principles of discrete correction, and not on a continuous coupling of effectors. Our results also indicate that synchronization could be sustained by hybrid mechanisms mixing notably asynchronies correction and complexity matching. Finally we highlight that synchronized walking is based on a dominant effect of complexity matching, especially when partners are closely coupled (arm-in-arm walking). We propose in a second step to exploit this result to test the possibility of a restoration of complexity in the elderly. Aging has indeed been characterized as a process of gradual loss of complexity, and this effect has been particularly documented in the field of locomotion. In particular, it has been shown that the loss of complexity correlates in older people with the propensity to fall. Complex matching theory assumes that two interacting systems tend to align their complexity levels. It also assumes that when two systems of different levels of complexity interact, the more complex system tends to attract the less complex, causing an increase in complexity in the second. We show, in a protocol in which older people are invited to walk arm-in-arm with a younger companion, that synchronization between the two partners is achieved through a complexity matching effect, and that prolonged training in such synchronized walking allows a restoration of the complexity of locomotion in the elderly. This effect persists during a post-test conducted two weeks after the end of the training sessions. This result, in addition to reinforcing one of the essential aspects of the theory of complexity matching, opens new avenues of research for the design of rehabilitation and fall prevention strategies.; Plusieurs cadres théoriques ont tenté de rendre compte des processus de synchronisation interpersonnelle. Les théories cognitivistes suggèrent que la synchronisation est réalisée par le biais d’une correction discrète et mutuelle des asynchronies entre les deux partenaires. Les théories dynamiques reposent sur l’hypothèse d’un couplage continu des deux systèmes, conçus comme oscillateurs auto-entretenus. Enfin le modèle du complexity matching repose sur l’hypothèse d’une coordination multi-échelle entre les deux systèmes en interaction. Dans un premier temps, nous développons des tests statistiques permettant de repérer dans les données expérimentales les signatures typiques de ces trois modes de coordination. Nous proposons notamment une signature multifractale, basée sur l’analyse des corrélations entre les spectres multifractals caractérisant les séries produites par les deux systèmes en interaction. Nous développons également une analyse de cross-corrélation fenêtrée, qui permet de dévoiler les processus locaux de synchronisation mis en œuvre. Ces études nous permettent de revisiter un certain nombre de travaux antérieurs. Nous montrons notamment que si la synchronisation de tâches discrètes telles que le tapping repose en effet sur des processus de correction discrète des asynchronies, la synchronisation de tâches continues telles que les oscillations de pendules est essentiellement basée sur les mêmes principes de correction discrète, et non sur un couplage continu des effecteurs. Nos résultats indiquent également que la synchronisation peut révéler des mécanismes hybrides mixant notamment correction des asynchronies et complexity matching. Enfin nous mettons en évidence que la marche synchronisée met en œuvre un effet dominant de complexity matching, d’autant plus prégnant que les deux partenaires sont étroitement couplés (marche bras-dessus-bras-dessous). Nous proposons dans un second temps d’exploiter ce résultat pour tester la possibilité d’une restauration de la complexité chez les personnes âgées. Le vieillissement a en effet été caractérisé comme un processus de perte graduelle de complexité, et cet effet a été notamment documenté dans le domaine de la locomotion. Il a notamment été montré que la perte de complexité corrélait avec la propension à la chute. La théorie du complexity matching suppose que deux systèmes en interaction tendent à aligner leurs niveaux de complexité. Elle suppose également que lorsque deux systèmes de niveaux différents de complexité interagissent, le système le plus complexe tend à attirer le moins complexe, engendrant un accroissement de la complexité chez le second. Nous montrons, dans un protocole au cours duquel des personnes âgées sont invitées à marcher bras-dessus-bras-dessous avec un accompagnant jeune, que la synchronisation entre les deux partenaires est réalisée au travers d’un effet d’appariement des complexités, et que l’entrainement prolongé en marche synchronisée permet une restauration de la complexité de la locomotion chez les personnes âgées. Cet effet perdure lors d’un post-test réalisé deux semaines après la fin de l’entraînement. Ce résultat, outre le fait qu’il conforte un des aspects essentiels de la théorie du complexity matching, ouvre de nouvelles voies de recherche pour la conception de stratégies de réhabilitation et de prévention de la chute.
- Published
- 2019
372. Complexity matching processes during the coupling of biological systems : application to rehabilitation in elderly
- Author
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Al Murad, Zainy Mshco Hajy, Euromov (EuroMov), Université de Montpellier (UM), Université Montpellier, and Didier Delignières
- Subjects
Aging ,Structure 1/f ,Restoration of complexity ,Coordination ,[SHS.EDU]Humanities and Social Sciences/Education ,1/f structure ,Complexity ,Complexité ,Vieillissement ,Multifractality ,Restauration de la complexité ,Multifractalité - Abstract
Several theoretical frameworks have attempted to account for interpersonal synchronization processes. Cognitive theories suggest that synchronization is achieved through discrete and mutual corrections of asynchronies between the two partners. The dynamic theories are based on the assumption of a continuous coupling between the two systems, conceived as self-sustained oscillators. Finally, the complexity matching model is based on the assumption of a multi-scale coordination between the two interacting systems. As a first step, we develop statistical tests in order to identify, in experimental data, the typical signatures of these three modes of coordination. In particular, we propose a multifractal signature, based on the analysis of correlations between the multifractal spectra characterizing the series produced by the two interacting systems. We also develop a windowed cross-correlation analysis, which aims at revealing the nature of the local synchronization processes. These studies allow us to revisit a number of previous works. We show that if the synchronization of discrete tasks such as tapping relies on discrete correction processes of asynchronies, the synchronization of continuous tasks such as pendulum oscillations is essentially based on the same principles of discrete correction, and not on a continuous coupling of effectors. Our results also indicate that synchronization could be sustained by hybrid mechanisms mixing notably asynchronies correction and complexity matching. Finally we highlight that synchronized walking is based on a dominant effect of complexity matching, especially when partners are closely coupled (arm-in-arm walking). We propose in a second step to exploit this result to test the possibility of a restoration of complexity in the elderly. Aging has indeed been characterized as a process of gradual loss of complexity, and this effect has been particularly documented in the field of locomotion. In particular, it has been shown that the loss of complexity correlates in older people with the propensity to fall. Complex matching theory assumes that two interacting systems tend to align their complexity levels. It also assumes that when two systems of different levels of complexity interact, the more complex system tends to attract the less complex, causing an increase in complexity in the second. We show, in a protocol in which older people are invited to walk arm-in-arm with a younger companion, that synchronization between the two partners is achieved through a complexity matching effect, and that prolonged training in such synchronized walking allows a restoration of the complexity of locomotion in the elderly. This effect persists during a post-test conducted two weeks after the end of the training sessions. This result, in addition to reinforcing one of the essential aspects of the theory of complexity matching, opens new avenues of research for the design of rehabilitation and fall prevention strategies.; Plusieurs cadres théoriques ont tenté de rendre compte des processus de synchronisation interpersonnelle. Les théories cognitivistes suggèrent que la synchronisation est réalisée par le biais d’une correction discrète et mutuelle des asynchronies entre les deux partenaires. Les théories dynamiques reposent sur l’hypothèse d’un couplage continu des deux systèmes, conçus comme oscillateurs auto-entretenus. Enfin le modèle du complexity matching repose sur l’hypothèse d’une coordination multi-échelle entre les deux systèmes en interaction. Dans un premier temps, nous développons des tests statistiques permettant de repérer dans les données expérimentales les signatures typiques de ces trois modes de coordination. Nous proposons notamment une signature multifractale, basée sur l’analyse des corrélations entre les spectres multifractals caractérisant les séries produites par les deux systèmes en interaction. Nous développons également une analyse de cross-corrélation fenêtrée, qui permet de dévoiler les processus locaux de synchronisation mis en œuvre. Ces études nous permettent de revisiter un certain nombre de travaux antérieurs. Nous montrons notamment que si la synchronisation de tâches discrètes telles que le tapping repose en effet sur des processus de correction discrète des asynchronies, la synchronisation de tâches continues telles que les oscillations de pendules est essentiellement basée sur les mêmes principes de correction discrète, et non sur un couplage continu des effecteurs. Nos résultats indiquent également que la synchronisation peut révéler des mécanismes hybrides mixant notamment correction des asynchronies et complexity matching. Enfin nous mettons en évidence que la marche synchronisée met en œuvre un effet dominant de complexity matching, d’autant plus prégnant que les deux partenaires sont étroitement couplés (marche bras-dessus-bras-dessous). Nous proposons dans un second temps d’exploiter ce résultat pour tester la possibilité d’une restauration de la complexité chez les personnes âgées. Le vieillissement a en effet été caractérisé comme un processus de perte graduelle de complexité, et cet effet a été notamment documenté dans le domaine de la locomotion. Il a notamment été montré que la perte de complexité corrélait avec la propension à la chute. La théorie du complexity matching suppose que deux systèmes en interaction tendent à aligner leurs niveaux de complexité. Elle suppose également que lorsque deux systèmes de niveaux différents de complexité interagissent, le système le plus complexe tend à attirer le moins complexe, engendrant un accroissement de la complexité chez le second. Nous montrons, dans un protocole au cours duquel des personnes âgées sont invitées à marcher bras-dessus-bras-dessous avec un accompagnant jeune, que la synchronisation entre les deux partenaires est réalisée au travers d’un effet d’appariement des complexités, et que l’entrainement prolongé en marche synchronisée permet une restauration de la complexité de la locomotion chez les personnes âgées. Cet effet perdure lors d’un post-test réalisé deux semaines après la fin de l’entraînement. Ce résultat, outre le fait qu’il conforte un des aspects essentiels de la théorie du complexity matching, ouvre de nouvelles voies de recherche pour la conception de stratégies de réhabilitation et de prévention de la chute.
- Published
- 2019
373. The dynamics of self-esteem and physical self: A new glance at variability and hierarchical model functioning
- Author
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Fortes-Bourbousson, Marina, Laboratoire \'Motricité, Interactions, Performance\' (EA4334), Motricité, interaction, performance EA 4334 (MIP), Le Mans Université (UM)-Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), Université de Nantes (UN)-Université de Nantes (UN)-Le Mans Université (UM)-Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), Université de Nantes (UN)-Université de Nantes (UN), Université Montpellier I, Didier Delignières & Grégory Ninot(didier.delignieres@univ-montp1.fr), Motricité, interactions, performance EA 4334 / Movement - Interactions - Performance (MIP), Le Mans Université (UM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), and Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Le Mans Université (UM)
- Subjects
self-esteem ,Dynamique ,séries temporelles ,variability ,variabilité ,soi physique ,physical self ,[SHS.PSY]Humanities and Social Sciences/Psychology ,estime de soi ,time series ,Dynamics - Abstract
This work aims at reassessing classical conceptions of personality traits and states as well as variability related to global self-esteem and physical self, from an idiographic and dynamic approach. This research emphasizes the iterative functioning for adults which corresponds to a simple exponential smoothing model thought as a dynamical adjustment. Moreover, time series are characterized by a fractal process (pink noise) which suggests that the self can be conceived as a complex dynamical system. These conclusions led us reinvestigating the hierarchical structure of global self-esteem and physical self, as well as its functioning using time series analysis. Surpassing recurrent limitations of classical approaches, the application of Dynamical Systems Theory allows providing new insights concerning the mechanisms by which dimensions are interconnected and especially the direction of the causal flow in the model. In conclusion, we provide a heuristic for theory construction, methodology perspectives and clinical applications.; A partir d'une approche idiographique et dynamique, nous avons revisité les conceptions classiques de trait, d'état de personnalité et de variabilité de l'estime globale de soi et du soi physique. Ce travail met en exergue, chez l'adulte, un fonctionnement itératif de moyenne mobile avec différenciation, conçu comme un ajustement dynamique. La mise en évidence de la nature fractale des séries temporelles suggère que le soi puisse être considéré comme un système dynamique complexe. Ces premières conclusions nous ont amené à réévaluer la structure hiérarchique de l'estime globale de soi et du soi physique, non plus dans une perspective nomothétique, mais à partir de séries temporelles individuelles. Dépassant certaines limites des approches classiques, l'utilisation de la théorie des systèmes dynamiques permet d'apporter des réponses quant aux processus d'influence qui gouvernent le fonctionnement de ce système : l'effet réciproque. Ce travail offre de nouvelles perspectives théoriques, méthodologiques et cliniques dans le champ de la psychologie sociale.
- Published
- 2003
374. Hypnosis for the management of COPD-related anxiety and dyspnoea in pulmonary rehabilitation: rationale and design for a cluster-randomised, active-control trial (HYPNOBPCO_2).
- Author
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Anlló H, Herer B, Delignières A, Ghergan A, Bocahu Y, Segundo I, Moulin C, and Larue F
- Abstract
Complementary psychological care is recommended for COPD, as it significantly reduces anxiety and boosts the pulmonary rehabilitation efficacy. In a precedent trial (HYPNOBPCO_1, ISRCTN10029862), administering a single hypnosis session was linked to reduced anxiety and improved breathing mechanics in intermediate and advanced COPD patients. However, whether hypnosis could improve self-management of anxiety and dyspnoea in COPD during pulmonary rehabilitation is yet to be investigated. This is the protocol for HYPNOBPCO_2, a 2-arm, cluster-randomised, statistician-blinded superiority monocentre trial (NCT04868357). Its aim is to assess the efficacy of hypnosis as a tool to manage anxiety and dyspnoea during a pulmonary rehabilitation programme (PRP). Clusters of COPD patients eligible for the conventional hospital-based PRP at the Centre Hospitalier de Bligny (CHB) will be randomised and evenly allocated into two parallel arms: "Hypnosis" (treatment) and "Relaxation" (active control). "Hypnosis" will consist of the CHB's conventional 4-week group PRP, supplemented by two educational sessions for teaching self-hypnosis. "Relaxation" will be identical, except standard relaxation exercises will be taught instead. Primary end-point will consist of assessing weekly changes in anxiety throughout the PRP, additional to total anxiety change after treatment completion. Anxiety will be determined by the six-item version of the State-Trait Anxiety Inventory (STAI-6). Secondary outcomes will include change in the 6-min walk test and the COPD assessment test (CAT). Further follow-up outcomes will include CAT and STAI-6 retests, re-hospitalisation rate, action plan use and persistence in self-hypnosis use, throughout the 12 weeks ensuing PRP completion., Competing Interests: Conflict of interest: The authors declare no conflicts of interest or competing interests., (Copyright ©The authors 2022.)
- Published
- 2021
- Full Text
- View/download PDF
375. Hypnosis for the Management of Anxiety and Dyspnea in COPD: A Randomized, Sham-Controlled Crossover Trial.
- Author
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Anlló H, Herer B, Delignières A, Bocahu Y, Segundo I, Mach Alingrin V, Gilbert M, and Larue F
- Subjects
- Anxiety diagnosis, Anxiety therapy, Bayes Theorem, Cross-Over Studies, Dyspnea diagnosis, Dyspnea etiology, Dyspnea therapy, Humans, Hypnosis, Pulmonary Disease, Chronic Obstructive diagnosis, Pulmonary Disease, Chronic Obstructive therapy
- Abstract
Background: Patients with chronic obstructive pulmonary disease (COPD) are prone to dyspnea, increased respiratory rate and other anxiety-inducing symptoms. Hypnosis constitutes a complementary procedure capable of improving subjective feelings of anxiety., Objective: Assessing the efficacy of a 15-minute hypnosis intervention for immediate improvement of anxiety in severe COPD patients., Methods: Twenty-one participants, COPD patients (mean FEV1 < 32.3%), were randomly assigned to two individual sessions in crossover (sham and hypnosis, 24-h washout period, arms: hypnosis-sham [n=11]/sham-hypnosis [n=10]). We tracked pre- and post-intervention anxiety (STAI-6 score) as primary endpoint., Results: Nineteen (90.5%) participants completed the study. Anxiety diminished significantly after hypnosis (STAI-6 scores -23.8% [SD = 18.4%] hypnosis vs -3.1% [32.8%] sham; χ
2 =8, P<0.01, Bayes Factor 5.5). Respiratory rate also decreased after hypnosis. Improvements in SpO2 and Borg exertion scores were registered after both conditions., Conclusion: A 15-minute hypnosis session improved participants' anxiety and lowered respiratory rate (as opposed to sham). Improvements in anxiety were correlated with an alleviation in respiratory strain. Results imply that hypnosis can contribute to the improvement of anxiety levels and breathing mechanics in severe COPD patients., Registration Id: ISRCTN10029862., Competing Interests: The authors declare no conflicts of interest, nor any competing interests., (© 2020 Anlló et al.)- Published
- 2020
- Full Text
- View/download PDF
376. Biallelic pathogenic variants in the lanosterol synthase gene LSS involved in the cholesterol biosynthesis cause alopecia with intellectual disability, a rare recessive neuroectodermal syndrome.
- Author
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Besnard T, Sloboda N, Goldenberg A, Küry S, Cogné B, Breheret F, Trochu E, Conrad S, Vincent M, Deb W, Balguerie X, Barbarot S, Baujat G, Ben-Omran T, Bursztejn AC, Carmignac V, Datta AN, Delignières A, Faivre L, Gardie B, Guéant JL, Kuentz P, Lenglet M, Nassogne MC, Ramaekers V, Schnur RE, Si Y, Torti E, Thevenon J, Vabres P, Van Maldergem L, Wand D, Wiedemann A, Cariou B, Redon R, Lamazière A, Bézieau S, Feillet F, and Isidor B
- Subjects
- Age of Onset, Alopecia complications, Alopecia pathology, Child, Child, Preschool, Cholesterol genetics, Developmental Disabilities complications, Developmental Disabilities pathology, Epilepsy complications, Epilepsy genetics, Epilepsy pathology, Female, Humans, Infant, Intellectual Disability complications, Intellectual Disability pathology, Lanosterol genetics, Lanosterol metabolism, Male, Mutation, Pedigree, Phenotype, Squalene analogs & derivatives, Squalene metabolism, Exome Sequencing, Alopecia genetics, Cholesterol metabolism, Developmental Disabilities genetics, Intellectual Disability genetics, Intramolecular Transferases genetics
- Abstract
Purpose: Lanosterol synthase (LSS) gene was initially described in families with extensive congenital cataracts. Recently, a study has highlighted LSS associated with hypotrichosis simplex. We expanded the phenotypic spectrum of LSS to a recessive neuroectodermal syndrome formerly named alopecia with mental retardation (APMR) syndrome. It is a rare autosomal recessive condition characterized by hypotrichosis and intellectual disability (ID) or developmental delay (DD), frequently associated with early-onset epilepsy and other dermatological features., Methods: Through a multicenter international collaborative study, we identified LSS pathogenic variants in APMR individuals either by exome sequencing or LSS Sanger sequencing. Splicing defects were assessed by transcript analysis and minigene assay., Results: We reported ten APMR individuals from six unrelated families with biallelic variants in LSS. We additionally identified one affected individual with a single rare variant in LSS and an allelic imbalance suggesting a second event. Among the identified variants, two were truncating, seven were missense, and two were splicing variants. Quantification of cholesterol and its precursors did not reveal noticeable imbalance., Conclusion: In the cholesterol biosynthesis pathway, lanosterol synthase leads to the cyclization of (S)-2,3-oxidosqualene into lanosterol. Our data suggest LSS as a major gene causing a rare recessive neuroectodermal syndrome.
- Published
- 2019
- Full Text
- View/download PDF
377. Non-invasive, multimodal analysis of cortical activity, blood volume and neurovascular coupling in infantile spasms using EEG-fNIRS monitoring.
- Author
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Bourel-Ponchel E, Mahmoudzadeh M, Delignières A, Berquin P, and Wallois F
- Subjects
- Cerebral Cortex diagnostic imaging, Electromyography, Female, Humans, Infant, Male, Multimodal Imaging, Spasms, Infantile diagnostic imaging, Cerebral Cortex physiopathology, Electroencephalography methods, Neurovascular Coupling physiology, Spasms, Infantile physiopathology, Spectroscopy, Near-Infrared methods
- Abstract
Although infantile spasms can be caused by a variety of etiologies, the clinical features are stereotypical. The neuronal and vascular mechanisms that contribute to the emergence of infantile spasms are not well understood. We performed a multimodal study by simultaneously recording electroencephalogram and functional Near-infrared spectroscopy in an intentionally heterogeneous population of six children with spasms in clusters. Regardless of the etiology, spasms were accompanied by two phases of hemodynamic changes; an initial change in the cerebral blood volume (simultaneously with each spasm) followed by a neurovascular coupling in all children except for the one with a large porencephalic cyst. Changes in cerebral blood volume, like the neurovascular coupling, occurred over frontal areas in all patients regardless of any brain damage suggesting a diffuse hemodynamic cortical response. The simultaneous motor activation and changes in cerebral blood volume might result from the involvement of the brainstem. The inconstant neurovascular coupling phase suggests a diffuse activation of the brain likely resulting too from the brainstem involvement that might trigger diffuse changes in cortical excitability.
- Published
- 2017
- Full Text
- View/download PDF
378. [Familial and non-familial benign infantile seizures: A homogeneous entity?].
- Author
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Bourel-Ponchel E, Le Moing AG, Delignières A, De Broca A, Wallois F, and Berquin P
- Subjects
- Anticonvulsants therapeutic use, Athetosis physiopathology, Disease Progression, Electroencephalography, Epilepsies, Partial physiopathology, Epilepsy, Benign Neonatal drug therapy, Epilepsy, Generalized physiopathology, Female, Genetic Predisposition to Disease, Humans, Infant, Infant, Newborn, Male, Neurologic Examination, Prognosis, Retrospective Studies, Seizures drug therapy, Seizures epidemiology, Seizures genetics, Treatment Outcome, Epilepsy, Benign Neonatal epidemiology, Epilepsy, Benign Neonatal genetics
- Abstract
Among the epileptic syndromes occurring during infancy, which are mostly non-idiopathic and associated with a poor prognosis, benign infantile convulsions are characterized by a favourable evolution. This work aims to analyse and compare the clinical, EEG and outcome characteristics of familial benign infantile convulsions (FBIC) and non-familial benign infantile convulsions (NFBIC). This is a retrospective study, conducted between 1988 and 2008, in 40 infants who presented benign infantile seizures during the two first years of life. All of them had no personal history, normal psychomotor development, normal neurological examinations, no abnormalities on biological and radiological investigations and a favourable outcome. In 14 cases, there was a familial history of familial benign infantile convulsions. However, among the 26 cases with non-familial benign infantile convulsions, 11 children had a familial history of other epileptic syndrome. That may suggest a genetic familial susceptibility. In the two groups, the clinical features and the electroencephalography were similar. The seizures had short duration and occurred most often in clusters. Twenty-nine children had secondarily generalized partial seizures and 11 infants had generalized seizures but a focal onset cannot be excluded. The antiepileptic drugs allowed rapid resolution of seizures. One child necessitated a prolonged antiepileptic treatment. In the other cases, seizures cured in the first year without recurrence of seizures after treatment discontinuation. The evolution was characterised in five children by a later occurrence of dystonia. This subgroup was described as infantile convulsion and choreoathetosis syndrome (ICCA). Benign infantile convulsions are probably an underestimated epileptic syndrome. The diagnosis is relatively easy in the familial forms with dominant autosomal transmission. In contrast, in sporadic forms, the diagnosis can be confirmed only by the evolution. The good prognosis must be tempered by the subsequent onset of dystonia consisted in the ICCA syndrome and justifies a prolonged follow-up., (Copyright © 2011 Elsevier Masson SAS. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
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