236 results on '"Van Wezel, Annemarie P."'
Search Results
202. Interspecies comparison of metabolism of two novel prototype PFAS.
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Licul-Kucera, Viktória, Ragnarsdóttir, Oddný, Frömel, Tobias, van Wezel, Annemarie P., Knepper, Thomas P., Harrad, Stuart, and Abou-Elwafa Abdallah, Mohamed
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METABOLIC clearance rate , *FLUOROALKYL compounds , *METABOLISM , *LIVER enzymes , *PROTOTYPES , *PLANT metabolites , *CARBOXYLIC acids - Abstract
As a result of proposed global restrictions and regulations on current-use per-and polyfluoroalkyl substances (PFAS), research on possible alternatives is highly required. In this study, phase I in vitro metabolism of two novel prototype PFAS in human and rat was investigated. These prototype chemicals are intended to be safer-by-design and expected to mineralize completely, and thus be less persistent in the environment compared to the PFAS available on the market. Following incubation with rat liver S9 (RL-S9) fractions, two main metabolites per initial substance were produced, namely an alcohol and a short-chain carboxylic acid. While with human liver S9 (HL-S9) fractions, only the short-chain carboxylic acid was detected. Beyond these major metabolites, two and five additional metabolites were identified at very low levels by non-targeted screening for the ether- and thioether-linked prototype chemicals, respectively. Overall, complete mineralization during the in vitro hepatic metabolism of these novel PFAS by HL-S9 and RL-S9 fractions was not observed. The reaction kinetics of the surfactants was determined by using the metabolite formation, rather than the substrate depletion approach. With rat liver enzymes, the formation rates of primary metabolite alcohols were at least two orders of magnitude higher than those of secondary metabolite carboxylic acids. When incubating with human liver enzymes, the formation rates of single metabolite carboxylic acids, were similar or smaller than those experienced in rat. It also indicates that the overall metabolic rate and clearance of surfactants are significantly higher in rat liver than in human liver. The maximum formation rate of the thioether congener exceeded 10-fold that of the ether in humans but were similar in rats. Overall, the results suggest that metabolism of the prototype chemicals followed a similar trend to those reported in studies of fluorotelomer alcohols. [Display omitted] • Novel prototype chemicals were designed as alternatives to current PFAS. • Slow metabolism was observed by human and rat S9 fractions. • Main metabolites were alcohols and carboxylic acids with ≤3 fluorinated carbons. • Metabolism was faster in rat than in human. • S -linkage prototypes were metabolized faster than those with O-linkage. [ABSTRACT FROM AUTHOR]
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- 2024
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203. Occurrence of pesticides in Dutch drinking water sources.
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Sjerps, Rosa M.A., Kooij, Pascal J.F., van Loon, Arnaut, and Van Wezel, Annemarie P.
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PESTICIDES , *THIAMETHOXAM , *DRINKING water , *WATER utilities , *WATER table , *WATER , *WATER quality - Abstract
We determined pesticide occurrence in groundwater and surface water sources used for drinking water production in The Netherlands, using both routine monitoring data from Dutch drinking water companies and by studying the presence of newly authorized pesticides in drinking water sources. An analytical LC-MS/MS method was developed for 24 recently authorized pesticides, selected based on their mobility and persistence, and applied in a Dutch/Belgian ground- and surface water monitoring campaign. 15 of these pesticides were detected, including seven in concentrations above the water quality standard from the Water Framework Directive. Two neonicotinoids were detected in highest concentrations: acetamiprid (1.1 μg/L) and thiamethoxam (0.4 μg/L). The routine monitoring data was collected over 2010–2014 in The Netherlands, covering 408 pesticides and 52 metabolites. 63 pesticides and 6 metabolites were prioritized according to their presence in groundwater, surface water and drinking water. The vast majority of the pesticides in routine monitoring has not been detected or only in low concentrations. Overall, the study shows that pesticides are of major concern in drinking water sources across the Netherlands. In two third of the abstraction areas pesticides and/or metabolites have been detected. In one third of the abstraction areas pesticide and/or metabolites concentration exceeded water quality standards according to the Water Framework Directive. The results emphasize that monitoring should focus on priority pesticides, since the vast majority of the pesticides has a low priority. The occurrence of recently authorized pesticides in drinking water sources demonstrates the importance to keep routine monitoring methods up to date. • 15 out of 24 recently authorized pesticides were detected, including neonicotinoids. • Of 408 pesticides and 52 metabolites, 63 pesticides and 6 metabolites were prioritized. • In the majority of drinking water sources, pesticides and/or metabolites were detected. • Some prioritized pesticides were not earlier detected in large monitoring studies. [ABSTRACT FROM AUTHOR]
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- 2019
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204. Chemical and bioassay assessment of waters related to hydraulic fracturing at a tight gas production site.
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Faber, Ann-Hélène, Annevelink, Mark P.J.A., Schot, Paul P., Baken, Kirsten A., Schriks, Merijn, Emke, Erik, de Voogt, Pim, and van Wezel, Annemarie P.
- Abstract
Publicly available chemical assessments of hydraulic fracturing related waters are generally based on shale gas practices in the U.S. There is a lack of information on hydraulic fracturing related gas development from EU countries and more generally on other types of extractions. This research fills this knowledge gap by presenting chemical and bioassay assessments of hydraulic fracturing related waters from a tight gas development in the Netherlands. Fracturing fluid, flowback water and groundwater from surrounding aquifers before and after the actual fracturing were analysed by means of high resolution liquid chromatography tandem mass spectrometry, the Ames test and three chemical activated luciferase gene expression bioassays aimed at determining genotoxicity, oxidative stress response and polyaromatic hydrocarbon contamination. After sample enrichment a higher number of peaks can be found in both fracturing fluid and flowback samples. No clear differences in chemical composition were shown in the groundwater samples before and after hydraulic fracturing. Preliminary environmental fate data of the tentatively identified chemicals points towards persistence in water. Clear genotoxic and oxidative stress responses were found in the fracturing fluid and flowback samples. A preliminary suspect screening resulted in 25 and 36 matches in positive and negative ionisation respectively with the 338 possible suspect candidates on the list. Extensive measures relating to the handling, transport and treatment of hydraulic fracturing related waters are currently in place within the Dutch context. The results of the present study provide a scientific justification for such measures taken to avoid adverse environmental and human health impacts. Unlabelled Image • Lack of European hydraulic fracturing related water assessments • Chemical and bioassay assessment of Dutch hydraulic fracturing related water samples • Fracturing/flowback fluids potentially pose human and environmental health concerns. • Clear genotoxic and oxidative stress responses found for fracturing/flowback fluids • Measures justified to handle, transport and treat fracturing/flowback fluids. [ABSTRACT FROM AUTHOR]
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- 2019
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205. Prioritizing anthropogenic chemicals in drinking water and sources through combined use of mass spectrometry and ToxCast toxicity data.
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Brunner, Andrea M., Dingemans, Milou M.L., Baken, Kirsten A., and van Wezel, Annemarie P.
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CONTAMINATION of drinking water , *HEALTH risk assessment , *MASS spectrometry , *WATER sampling , *WATER purification - Abstract
Graphical abstract Highlights • Visualization of ToxCast data availability and density, including water relevant mechanisms of toxicity. • Efficient prioritization strategy for suspect screening data combining occurrence and hazard data. • High throughput approach allows automation. • Little overlap between exposure only and exposure/hazard ratio based prioritization. Abstract Advancements in high-resolution mass spectrometry based methods have enabled a shift from pure target analysis to target, suspect and non-target screening analyses to detect chemicals in water samples. The multitude of suspect chemicals thereby detected needs to be prioritized for further identification, prior to health risk assessment and potential inclusion into monitoring programs. Here, we compare prioritization of chemicals in Dutch water samples based on relative intensities only to prioritization including hazard information based on high-throughput in vitro toxicity data. Over 1000 suspects detected in sewage treatment plant effluent, surface water, groundwater and drinking water samples were ranked based on their relative intensities. Toxicity data availability and density in the ToxCast database were determined and visualized for these suspects, also in regard to water relevant mechanisms of toxicity. More than 500 suspects could be ranked using occurrence/hazard ratios based on more than 1000 different assay endpoints. The comparison showed that different prioritization strategies resulted in significantly different ranking, with only 2 suspects prioritized based on occurrence among the top 20 in the hazard ranking. We therefore propose a novel scheme that integrates both exposure and hazard data, and efficiently prioritizes which features need to be confidently identified first. [ABSTRACT FROM AUTHOR]
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- 2019
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206. Estimation of the water cycle related to shale gas production under high data uncertainties: Dutch perspective.
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Butkovskyi, Andrii, Cirkel, Gijsbert, Bozileva, Elvira, Bruning, Harry, Van Wezel, Annemarie P., and Rijnaarts, Huub H.M.
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SHALE gas , *HYDROLOGIC cycle , *SEWAGE disposal plants , *WASTE recycling , *FRACTURING fluids - Abstract
Abstract The potential water demand for fracturing fluids along with the possible flowback and produced water production is assessed for the Dutch Posidonia shale. Total water demand estimated for 25 years of the field development using historic data from the U.S. plays varies between 12.2 and 36.9 Mm3. The maximal annual water consumption of 0.95–2.88 Mm3 is expected in the peak years of shale gas production. These figures are much lower than the availability of any potential water sources, which include drinking water, fresh and brackish groundwater, river water, effluents of wastewater treatment plants (WWTP) and sea water. River water is considered the most promising water source for fracturing fluids in the Dutch Posidonia shale based on its availability (>6·104 Mm3/year) and quality (only bacterial composition needs to be controlled). Total wastewater production for the whole period of the field development is estimated between 6.6 and 48.0 Mm3. Wastewater recycling can cover significant part of the source water demand for fracturing fluid. However, high mineral content of the wastewater as well as temporal and spatial discrepancies between wastewater production and water demand will form obstacles for wastewater recycling. The assessment framework developed in this study may be applied for other shale gas fields with high uncertainties regarding subsurface properties, connate formation water characteristics and future legislative framework. Highlights • Estimated water demand for the Dutch Posidonia Shale development is 12.2–36.9 Mm3. • Water demand can be covered by any potentially available water source. • River water is the most promising water source regarding quantity and availability. • Wastewater recycling can cover significant part of fresh water demand. • The proposed assessment framework may be applicable for other formations. [ABSTRACT FROM AUTHOR]
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- 2019
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207. Finding a way out? Comprehensive biotransformation study of novel fluorinated surfactants.
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Licul-Kucera, Viktória, Frömel, Tobias, Kruså, Martin, van Wezel, Annemarie P., and Knepper, Thomas P.
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LIQUID chromatography-mass spectrometry , *SEMIVOLATILE organic compounds , *FLUOROSURFACTANTS , *CARBOXYLIC acids - Abstract
In this study the environmental fate of two novel trifluoromethoxy-substituted surfactants with respectively an ether or thioether linkage were investigated, of which the design aimed for less persistency and complete mineralization. Long-term microbial transformation studies under aerobic conditions in activated sludge-wastewater medium were performed for 126 days. A semi-closed experimental system with a trapping sorbent was selected to avoid losses of possible volatile transformation products (TPs). The changes in the concentration of the surfactants and their expected TPs were monitored by target analysis using liquid chromatography–tandem mass spectrometry. Significant decrease in the concentration of the surfactants was observed over the incubation period. The main detected TPs were short-chained carboxylic acids (CAs), including a CA with two fluorinated carbon atoms representing the last product prior to mineralization. High stability of these CAs and lack in the formation of inorganic fluoride over the incubation time was however observed. Consequently, unequivocal final mineralization of the investigated surfactants could not be confirmed. Regarding the mass balance, the total amount of detected substances achieved only 30–37% of the expected concentration at the end of the incubation time. The reason of the incomplete mass balance should be further investigated. [Display omitted] • Fluorinated surfactants were designed and synthesized with the goal of mineralization. • Degradability was tested in aerobic activated sludge over 126 days. • Main transformation products were carboxylic acids with ≤3 fluorinated carbon atoms. • No mineralization was proved. [ABSTRACT FROM AUTHOR]
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- 2023
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208. Toxicological risk assessment and prioritization of drinking water relevant contaminants of emerging concern.
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Baken, Kirsten A., Sjerps, Rosa M.a., Schriks, Merijn, and Van Wezel, Annemarie P.
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CONTAMINATION of drinking water , *HEALTH risk assessment , *DRINKING water composition , *TOXICITY testing , *HYDROLOGIC cycle - Abstract
Toxicological risk assessment of contaminants of emerging concern (CEC) in (sources of) drinking water is required to identify potential health risks and prioritize chemicals for abatement or monitoring. In such assessments, concentrations of chemicals in drinking water or sources are compared to either (i) health-based (statutory) drinking water guideline values, (ii) provisional guideline values based on recent toxicity data in absence of drinking water guidelines, or (iii) generic drinking water target values in absence of toxicity data. Here, we performed a toxicological risk assessment for 163 CEC that were selected as relevant for drinking water. This relevance was based on their presence in drinking water and/or groundwater and surface water sources in downstream parts of the Rhine and Meuse, in combination with concentration levels and physicochemical properties. Statutory and provisional drinking water guideline values could be derived from publically available toxicological information for 142 of the CEC. Based on measured concentrations it was concluded that the majority of substances do not occur in concentrations which individually pose an appreciable human health risk. A health concern could however not be excluded for vinylchloride, trichloroethene, bromodichloromethane, aniline, phenol, 2-chlorobenzenamine, mevinphos, 1,4-dioxane, and nitrolotriacetic acid. For part of the selected substances, toxicological risk assessment for drinking water could not be performed since either toxicity data (hazard) or drinking water concentrations (exposure) were lacking. In absence of toxicity data, the Threshold of Toxicological Concern (TTC) approach can be applied for screening level risk assessment. The toxicological information on the selected substances was used to evaluate whether drinking water target values based on existing TTC levels are sufficiently protective for drinking water relevant CEC. Generic drinking water target levels of 37 μg/L for Cramer class I substances and 4 μg/L for Cramer class III substances in drinking water were derived based on these CEC. These levels are in line with previously reported generic drinking water target levels based on original TTC values and are shown to be protective for health effects of the majority of contaminants of emerging concern evaluated in the present study. Since the human health impact of many chemicals appearing in the water cycle has been studied insufficiently, generic drinking water target levels are useful for early warning and prioritization of CEC with unknown toxicity in drinking water and its sources for future monitoring. [ABSTRACT FROM AUTHOR]
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- 2018
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209. Removal of organic compounds from shale gas flowback water.
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Butkovskyi, Andrii, Faber, Ann-Hélène, Wang, Yue, Grolle, Katja, Hofman-Caris, Roberta, Bruning, Harry, Van Wezel, Annemarie P., and Rijnaarts, Huub H.M.
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ORGANIC compounds & the environment , *SHALE gas , *FLOWBACK (Hydraulic fracturing) , *OZONIZATION , *ACTIVATED carbon , *CHEMICAL oxygen demand - Abstract
Ozonation, sorption to granular activated carbon and aerobic degradation were compared as potential treatment methods for removal of dissolved organic carbon (DOC) fractions and selected organic compounds from shale gas flowback water after pre-treatment in dissolved air flotation unit. Flowback water was characterised by high chemical oxygen demand and DOC. Low molecular weight (LMW) acids and neutral compounds were the most abundant organic fractions, corresponding to 47% and 35% of DOC respectively. Ozonation did not change distribution of organic carbon fractions and concentrations of detected individual organic compounds significantly. Sorption to activated carbon targeted removal of individual organic compounds with molecular weight >115 Da, whereas LMW compounds remained largely unaffected. Aerobic degradation was responsible for removal of LMW compounds and partial ammonium removal, whereas formation of intermediates with molecular weight of 200–350 Da was observed. Combination of aerobic degradation for LMW organics removal with adsorption to activated carbon for removal of non-biodegradable organics is proposed to be implemented between pre-treatment (dissolved air floatation) and desalination (thermal or membrane desalination) steps. [ABSTRACT FROM AUTHOR]
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- 2018
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210. Forever legacies? Profiling historical PFAS contamination and current influence on groundwater used for drinking water.
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Sadia, Mohammad, Kunz, Marlene, ter Laak, Thomas, De Jonge, Martin, Schriks, Merijn, and van Wezel, Annemarie P.
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- 2023
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211. European-wide spatial analysis of sewage treatment plants and the possible benefits to nature of advanced treatment to reduce pharmaceutical emissions.
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van Dijk, Joanke, Dekker, Stefan C., Kools, Stefan A.E., and van Wezel, Annemarie P.
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SEWAGE disposal plants , *WATER management , *NATURE conservation , *AQUATIC biodiversity , *WASTEWATER treatment - Abstract
• The potential of upgrading STPs to reduce pharmaceutical emissions is analysed with 3 scenarios. • Total EU emission load can be reduced from 48% to 69% when large STPs are updated with advanced treatment. • Not all pharmaceuticals are well removed in STPs, even by advanced techniques. • Some water bodies and nature areas might not be sufficiently protected in any scenario. • Results can be used to model emissions and prioritize STPs to install advanced treatment. Pharmaceuticals are known to widely occur in the environment and to affect the health of ecosystems. Sewage treatment plants (STPs) are main emission pathways for pharmaceuticals, which are often not sufficiently removed during wastewater treatment. In Europe, STP treatment requirements are specified under the Urban WasteWater Treatment Directive (UWWTD). The introduction of advanced treatment techniques, such as ozonation and activated carbon, under the UWWTD is expected to be an important option to reduce pharmaceutical emissions. In this study, we present a European-wide analysis of STPs reported under the UWWTD, their current treatment level and potential to remove a set of 58 prioritised pharmaceuticals. Three different scenarios were analysed to show 1) UWWTD present effectiveness, 2) the effectiveness at full UWWTD compliance, and 3) the effectiveness when advanced treatment is implemented at STPs with a treatment capacity of >100.000 person equivalents. Based on a literature study, the potential of individual STPs to reduce pharmaceutical emissions ranged from an average of 9% for STPs with primary treatment to 84% for STPs applying advanced treatment. Results of our calculations show that European-wide emission of pharmaceuticals can be reduced with 68% when large STPs are updated with advanced treatment, but spatial differences exist. We argue that adequate attention should also be paid with regards to preventing environmental impacts of STPs with a capacity <100.000 p.e. Circa 44% of total STP effluent is emitted near Natura2000 sites (EU nature protection areas). Of all surface waters receiving STP effluent for which the ecological status has been assessed under the Water Framework Directive, 77% have a status of less than good. Relatively often only primary treatment is applied to wastewater emitted into coastal waters. This analysis can be used to further model pharmaceutical concentrations in European surface waters, to identify STPs for which more advanced treatment might be required and to protect EU aquatic biodiversity. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2023
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212. Is there evidence for man-made nanoparticles in the Dutch environment?
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Bäuerlein, Patrick S., Emke, Erik, Tromp, Peter, Hofman, Jan A.M.H., Carboni, Andrea, Schooneman, Ferry, de Voogt, Pim, and van Wezel, Annemarie P.
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NANOPARTICLES , *NANOSTRUCTURED materials , *BUTYRIC acid , *FATTY acids , *BIOMACROMOLECULES - Abstract
Only very limited information is available on measured environmental concentrations of nanoparticles. In this study, several environmental compartments in The Netherlands were probed for the presence of nanoparticles. Different types of water were screened for the presence of inorganic (Ag, Au, TiO 2 ) and organic nanoparticles (C 60 , C 70 , [6,6]-phenyl-C 61 -butyric acid octyl ester, [6,6]-phenyl-C 61 -butyric acid butyl ester, [6,6]-phenyl-C 61 -butyric acid methyl ester, [6,6]-bis-phenyl-C 61 -butyric acid methyl ester, [6,6]-phenyl-C 71 -butyric acid methyl ester, [6,6]-thienyl-C 61 -butyric acid methyl ester). Air samples were analysed for the presence of nanoparticulate Mo, Ag, Ce, W, Pd, Pt, Rh, Zn, Ti, Si, B as well as Fe and Cu. ICP-MS, Orbitrap-HRMS, SEM and EDX were used for this survey. Water samples included dune and bank filtrates, surface waters and ground waters as well as influents, effluents and sludge of sewage treatment plants (STPs), and surface waters collected near airports and harbours. Air samples included both urban and rural samples. C 60 was detected in air, sewage treatment plants, influents, effluents and sludge, but in no other aqueous samples despite the low detection limit of 0.1 ng/L. C 70 and functionalised fullerenes were not detected at all. In STP sludge and influent the occurrence of Ag and Au nanoparticles was verified by SEM/EDX and ICP-MS. In air up to about 25 m% of certain metals was found in the nanosize fraction. Overall, between 1 and 6% of the total mass from metals in the air samples was found in the size fraction < 100 nm. [ABSTRACT FROM AUTHOR]
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- 2017
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213. Data-driven prioritization of chemicals for various water types using suspect screening LC-HRMS.
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Sjerps, Rosa M.A., Vughs, Dennis, van Leerdam, Jan A., ter Laak, Thomas L., and van Wezel, Annemarie P.
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WATER chemistry , *LIQUID chromatography-mass spectrometry , *EFFECT of human beings on climate change , *WATER sampling , *ECOLOGICAL risk assessment , *WATER quality - Abstract
For the prioritization of more than 5200 anthropogenic chemicals authorized on the European market, we use a large scale liquid chromatography-high resolution mass spectrometry (LC-HRMS) suspect screening study. The prioritization is based on occurrence in 151 water samples including effluent, surface water, ground water and drinking water. The suspect screening linked over 700 detected compounds with known accurate masses to one or multiple suspects. Using a prioritization threshold and removing false positives reduced this to 113 detected compounds linked to 174 suspects, 24 compounds reflect a confirmed structure by comparison with the pure reference standard. The prioritized compounds and suspects are relevant for detailed risk assessments after confirmation of their identity. Only one of the 174 prioritized compounds and suspects is mentioned in water quality regulations, and only 20% is mentioned on existing lists of potentially relevant chemicals. This shows the complementarity to commonly used target-based methods. The semi-quantitative total concentration, expressed as internal standard equivalents of detected compounds linked to suspects, in effluents is approximately 10 times higher than in surface waters, while ground waters and drinking waters show the lowest response. The average retention time, a measure for hydrophobicity, of the detected compounds per sample decreased from effluent to surface- and groundwater to drinking water, confirming the occurrence of more polar compounds in drinking water. The semi-quantitative total concentrations exceed the conservative and precautionary threshold of toxicological concern. Therefore, adverse effects of mixtures cannot be neglected without a more thorough risk assessment. [ABSTRACT FROM AUTHOR]
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- 2016
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214. Towards spatially smart abatement of human pharmaceuticals in surface waters: Defining impact of sewage treatment plants on susceptible functions.
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Coppens, Lieke J.C., van Gils, Jos A.G., ter Laak, Thomas L., Raterman, Bernard W., and van Wezel, Annemarie P.
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PHARMACEUTICAL industry , *SEWAGE purification , *SEWAGE disposal plants , *MATHEMATICAL functions , *WATER purification - Abstract
For human pharmaceuticals, sewage treatment plants (STPs) are a major point of entry to surface waters. The receiving waters provide vital functions. Modeling the impact of STPs on susceptible functions of the surface water system allows for a spatially smart implementation of abatement options at, or in the service area of, STPs. This study was performed on a nation-wide scale for the Netherlands. Point source emissions included were 345 Dutch STPs and nine rivers from neighboring countries. The Dutch surface waters were represented by 2511 surface water units. Modeling was performed for two extreme discharge conditions. Monitoring data of 7 locations along the rivers Rhine and Meuse fall mostly within the range of modeled concentrations. Half of the abstracted volumes of raw water for drinking water production, and a quarter of the Natura 2000 areas (European Union nature protection areas) hosted by the surface waters, are influenced by STPs at low discharge. The vast majority of the total impact of all Dutch STPs during both discharge conditions can be attributed to only 19% of the STPs with regard to the drinking water function, and to 39% of the STPs with regard to the Natura 2000 function. Attributing water treatment technologies to STPs as one of the possible measures to improve water quality and protect susceptible functions can be done in a spatially smart and cost-effective way, using consumption-based detailed hydrological and water quality modeling. [ABSTRACT FROM AUTHOR]
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- 2015
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215. Occurrence, hazard, and risk of psychopharmaceuticals and illicit drugs in European surface waters.
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Davey, Charlie J.E., Kraak, Michiel H.S., Praetorius, Antonia, ter Laak, Thomas L., and van Wezel, Annemarie P.
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DRUGS of abuse , *PSYCHIATRIC drugs , *SPECIES diversity , *SPECIES distribution , *HAZARDS - Abstract
• Psychopharmaceuticals have limited occurrence (49%) and ecotoxicity (15%) data. • Only for 87 (12%) compounds could risk be assessed, with 23 (3.3%) demonstrating risk. • Risk correlated with the amount and diversity of data available per compound. • This indicates there may be hidden risks for understudied compounds. • Risks could not be calculated for some commonly prescribed psychopharmaceuticals. This study aimed to provide insights into the risk posed by psychopharmaceuticals and illicit drugs in European surface waters, and to identify current knowledge gaps hampering this risk assessment. First, the availability and quality of data on the concentrations of psychopharmaceuticals and illicit drugs in surface waters (occurrence) and on the toxicity to aquatic organisms (hazard) were reviewed. If both occurrence and ecotoxicity data were available, risk quotients (risk) were calculated. Where abundant ecotoxicity data were available, a species sensitivity distribution (SSD) was constructed, from which the hazardous concentration for 5% of the species (HC 5) was derived, allowing to derive integrated multi-species risks. A total of 702 compounds were categorised as psychopharmaceuticals and illicit drugs based on a combination of all 502 anatomical therapeutic class (ATC) 'N' pharmaceuticals and a list of illicit drugs according to the Dutch Opium Act. Of these, 343 (49%) returned occurrence data, while only 105 (15%) returned ecotoxicity data. Moreover, many ecotoxicity tests used irrelevant endpoints for neurologically active compounds, such as mortality, which may underestimate the hazard of psychopharmaceuticals. Due to data limitations, risks could only be assessed for 87 (12%) compounds, with 23 (3.3%) compounds indicating a potential risk, and several highly prescribed drugs returned neither occurrence nor ecotoxicity data. Primary bottlenecks in risk calculation included the lack of ecotoxicity data, a lack of diversity of test species and ecotoxicological end points, and large disparities between well studied and understudied compounds for both occurrence and toxicity data. This study identified which compounds merit concern, as well as the many compounds that lack the data for any calculation of risk, driving research priorities. Despite the large knowledge gaps, we concluded that the presence of a substantial part (26%) of data-rich psychopharmaceuticals in surface waters present an ecological risk for aquatic non-target organisms. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2022
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216. Assessment of drinking water safety in the Netherlands using nationwide exposure and mortality data.
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Houthuijs, Danny, Breugelmans, Oscar R.P., Baken, Kirsten A., Sjerps, Rosa M.A., Schipper, Maarten, van der Aa, Monique, and van Wezel, Annemarie P.
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HEART disease related mortality , *DRINKING water quality , *DRINKING water , *AQUATIC sports safety measures , *WATER quality , *WATER hardness ,CARDIOVASCULAR disease related mortality - Abstract
[Display omitted] • Cohort of 7 million individuals: one of the largest studies in drinking water epidemiology. • Magnesium in drinking water associated with reduced risk for coronary heart disease mortality. • Calcium below 30 mg/L associated with elevated risk for coronary heart disease mortality. • No protective effect of calcium, magnesium, or hardness on cardiovascular disease mortality. • Nitrate in drinking water not related to mortality due to colorectal cancer. Although drinking water in the Netherlands is generally accepted as safe, public concern about health risks of long-term intake still exist. The aim was to explore associations between drinking water quality for nitrate, water hardness, calcium and magnesium and causes-of-death as related to cardiovascular diseases amongst which coronary heart disease and colorectal cancer. We used national administrative databases on cause-specific mortality, personal characteristics, residential history, social economic indicators, air quality and drinking water quality for parameters specified by the EU Drinking Water Directive. We put together a cohort of 6,998,623 persons who were at least 30 years old on January 1, 2008 and lived for at least five years on the same address. The average drinking water concentration over 2000–2010 at the production stations were used as exposure indicators. We applied age stratified Cox proportional hazards models. Magnesium was associated with a reduced risk for mortality due to coronary heart diseases: HR of 0.95 (95% CI: 0.90, 0.99) per 10 mg/L increase. For mortality due to cardiovascular diseases, a 100 mg/L increase in calcium was associated with a HR of 1.08 (95% CI: 1.03, 1.13) and an increase of 2.5 mmol/L of water hardness with a HR of 1.06 (95% CI: 1.01, 1.10). The results show an elevated risk for coronary heart disease mortality at calcium concentrations below 30 mg/L, but over the whole exposure range no exposure response relation was observed. For other combinations of drinking water quality parameters and cause-specific mortality studied, no statistical significant associations were identified. We identified in this explorative study a protective effect of magnesium for the risk of mortality to coronary heart disease. Also we found an increased risk of mortality due to cardiovascular disease associated with the concentration of calcium and the water hardness in drinking water. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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217. Safe and sustainable by design: A computer-based approach to redesign chemicals for reduced environmental hazards.
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van Dijk, Joanke, Flerlage, Hannah, Beijer, Steven, Slootweg, J. Chris, and van Wezel, Annemarie P.
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SUSTAINABLE design , *HAZARDS , *PERSISTENT pollutants , *FIREPROOFING agents , *POLLUTION , *BIODEGRADABLE nanoparticles , *ORGANOPHOSPHORUS compounds - Abstract
Persistency of chemicals in the environment is seen a pressing issue as it results in accumulation of chemicals over time. Persistent chemicals can be an asset in a well-functioning circular economy where products are more durable and can be reused or recycled. This objective can however not always be fulfilled as release of chemicals from products into the environment can be inherently coupled to their use. In these situations, chemicals should be designed for degradation. In this study, a systematic and computer-aided workflow was developed to facilitate the chemical redesign for reduced persistency. The approach includes elements of Essential Use, Alternatives Assessment and Green and Circular Chemistry and ties into goals recently formulated in the context of the EU Green Deal. The organophosphate chemical triisobutylphosphate (TiBP) was used as a case study for exploration of the approach, as its emission to the environment was expected to be inevitable when used as a flame retardant. Over 6.3 million alternative structures were created in silico and filtered based on QSAR outputs to remove potentially non-readily biodegradable structures. With a multi-criteria analysis based on predicted properties and synthesizability a top 500 of most desirable structures was identified. The target structure (di- n -butyl (2-hydroxyethyl) phosphate) was manually selected and synthesized. The approach can be expanded and further verified to reach its full potential in the mitigation of chemical pollution and to help enable a safe circular economy. [Display omitted] • A systematic approach for the design of Safe and Sustainable chemicals is developed. • The organophosphorus flame retardant TiBP was selected as a redesign example. • An exhaustive set of suggested alternative structures were generated in silico. • A final alternative was selected based on PBMT criteria and synthesizability. • The approach helps to enable a safe, circular economy. [ABSTRACT FROM AUTHOR]
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- 2022
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218. Trigger values for investigation of hormonal activity in drinking water and its sources using CALUX bioassays.
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Brand, Walter, de Jongh, Cindy M., van der Linden, Sander C., Mennes, Wim, Puijker, Leo M., van Leeuwen, Cornelis J., van Wezel, Annemarie P., Schriks, Merijn, and Heringa, Minne B.
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DRINKING water , *BIOLOGICAL assay , *ESTROGEN , *ANDROGENS , *PROGESTATIONAL hormones , *GLUCOCORTICOIDS , *HEALTH risk assessment , *PHARMACOKINETICS - Abstract
Abstract: To screen for hormonal activity in water samples, highly sensitive in vitro CALUX bioassays are available which allow detection of estrogenic (ERα), androgenic (AR), progestagenic (PR), and glucocorticoid (GR) activities. This paper presents trigger values for the ERα, AR, PR, and GR CALUX bioassays for agonistic hormonal activities in (drinking) water, which define a level above which human health risk cannot be waived a priori and additional examination of specific endocrine activity may be warranted. The trigger values are based on 1) acceptable or tolerable daily intake (ADI/TDI) values of specific compounds, 2) pharmacokinetic factors defining their bioavailability, 3) estimations of the bioavailability of unknown compounds with equivalent hormonal activity, 4) relative endocrine potencies, and 5) physiological, and drinking water allocation factors. As a result, trigger values of 3.8ng 17β-estradiol (E2)-equivalents (eq)/L, 11ng dihydrotestosterone (DHT)-eq/L, 21ng dexamethasone (DEX)-eq/L, and 333ng Org2058-eq/L were derived. Benchmark Quotient (BQ) values were derived by dividing hormonal activity in water samples by the derived trigger using the highest concentrations detected in a recent, limited screening of Dutch water samples, and were in the order of (value) AR (0.41)>ERα (0.13)>GR (0.06)>PR (0.04). The application of trigger values derived in the present study can help to judge measured agonistic hormonal activities in water samples using the CALUX bioassays and help to decide whether further examination of specific endocrine activity followed by a subsequent safety evaluation may be warranted, or whether concentrations of such activity are of low priority with respect to health concerns in the human population. For instance, at one specific drinking water production site ERα and AR (but no GR and PR) activities were detected in drinking water, however, these levels are at least a factor 83 smaller than the respective trigger values, and therefore no human health risks are to be expected from hormonal activity in Dutch drinking water from this site. [Copyright &y& Elsevier]
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- 2013
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219. Effect of combining in vitro estrogenicity data with kinetic characteristics of estrogenic compounds on the in vivo predictive value
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Punt, Ans, Brand, Walter, Murk, Albertinka J., van Wezel, Annemarie P., Schriks, Merijn, and Heringa, Minne B.
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- *
ESTROGEN receptors , *ESTRADIOL , *BIOLOGICAL assay , *GENISTEIN , *METABOLITES , *BISPHENOL A , *GLUCURONIC acid - Abstract
Abstract: With the ultimate aim of increasing the utility of in vitro assays for toxicological risk assessment, a method was developed to calculate in vivo estrogenic potencies from in vitro estrogenic potencies of compounds by taking into account systemic availability. In vitro estrogenic potencies of three model compounds (bisphenol A, genistein, and 4-nonylphenol) relative to ethinylestradiol (EE2), determined with the estrogen receptor alpha (ERα) transcriptional activation assay using hER-HeLa-9903 cells, were taken from literature and used to calculate the EE2 equivalent (EE2EQ) effect doses in the predominantly ERα-dependent rat uterotrophic assay. Compound-specific differences in hepatic clearance relative to the reference compound EE2 were determined in vitro to examine whether in vivo estrogenic potencies reported in literature could be more accurately estimated. The EE2EQ doses allowed to predict in vivo uterotrophic responses within a factor of 6-25 and the inclusion of the hepatic clearance further improved the prediction with a factor 1.6-2.1 for especially genistein and bisphenol A. Yet, the model compounds still were less potent in vivo than predicted based on their EE2 equivalent estrogenic potency and hepatic clearance. For further improvement of the in vitro to in vivo predictive value of in vitro assays, the relevance of other kinetic characteristics should be studied, including binding to carrier proteins, oral bioavailability and the formation of estrogenic metabolites. [Copyright &y& Elsevier]
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- 2013
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220. Wastewater-based epidemiology for illicit drugs: A critical review on global data.
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Huizer, Marit, ter Laak, Thomas L., de Voogt, Pim, and van Wezel, Annemarie P.
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DRUGS of abuse , *DRUG abuse , *METHAMPHETAMINE , *DRUG utilization , *EPIDEMIOLOGY , *DRUG monitoring - Abstract
• Overview and evaluation of available literature using WBE to detect illicit drugs. • The WBE approach shows an improvement in quality over the recent years. • High cocaine and methamphetamine consumption rates are found in the USA. • Relatively low illicit drug consumption is found in the continent of Asia. Illicit drug use is complex, hidden and often highly stigmatized behaviour, which brings a vast challenge for drug surveillance systems. Drug consumption can be estimated by measuring human excretion products in untreated wastewater, known as wastewater-based epidemiology (WBE). Over the last decade, the application of wastewater-based epidemiology to monitor illicit drug loads increased and WBE is currently applied on a global scale. Studies from over the globe are evaluated with regard to their sampling method, analytical accuracy and consumption calculation, aiming to further reduce relevant uncertainties in order to make reliable comparisons on a global level. Only a limited number is identified as high-quality studies, so further standardization of the WBE approach for illicit drugs is desired especially with regard to the sampling methodology. Only a fraction of the reviewed papers explicitly reports uncertainty ranges for their consumption data. Studies which had the highest reliability are recently published, indicating an improvement in reporting WBE data. Until now, WBE has not been used in large parts of Africa, nor in the Middle East and Russia. An overview of consumption data across the continents on commonly studied drugs (cocaine, MDMA, amphetamine and methamphetamine) is provided. Overall, high consumption rates are confirmed in the US, especially for cocaine and methamphetamine, while relatively low illicit drug consumption is reported in Asia. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2021
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221. Comparing conventional and green fracturing fluids by chemical characterisation and effect-based screening.
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Faber, Ann-Hélène, Brunner, Andrea M., Dingemans, Milou M.L., Baken, Kirsten A., Kools, Stefan A.E., Schot, Paul P., de Voogt, Pim, and van Wezel, Annemarie P.
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- 2021
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222. Towards 'one substance – one assessment': An analysis of EU chemical registration and aquatic risk assessment frameworks.
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van Dijk, Joanke, Gustavsson, Mikael, Dekker, Stefan C., and van Wezel, Annemarie P.
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- *
ANALYTICAL chemistry , *RISK assessment , *POLLUTION , *ENVIRONMENTAL protection , *AQUATIC exercises , *PESTICIDE pollution , *WATER pollution - Abstract
With the Green Deal the EU aims to achieve a circular economy, restore biodiversity and reduce environmental pollution. As a part of the Green Deal a 'one-substance one-assessment' (OS-OA) approach for chemicals has been proposed. The registration and risk assessment of chemicals on the European market is currently fragmented across different legal frameworks, dependent on the chemical's use. In this review, we analysed the five main European chemical registration frameworks and their risk assessment procedures for the freshwater environment, covering 1) medicines for human use, 2) veterinary medicines, 3) pesticides, 4) biocides and 5) industrial chemicals. Overall, the function of the current frameworks is similar, but important differences exist between the frameworks' environmental protection goals and risk assessment strategies. These differences result in inconsistent assessment outcomes for similar chemicals. Chemicals are also registered under multiple frameworks due to their multiple uses, and chemicals which are not approved under one framework are in some instances allowed on the market under other frameworks. In contrast, an OS-OA will require a uniform hazard assessment between all different frameworks. In addition, we show that across frameworks the industrial chemicals are the least hazardous for the freshwater environment (median PNEC of 2.60E-2 mg/L), whilst biocides are the most toxic following current regulatory assessment schemes (median PNEC of 1.82E-4 mg/L). Finally, in order to facilitate a successful move towards a OS-OA approach we recommend a) harmonisation of environmental protection goals and risk assessment strategies, b) that emission, use and production data should be made publicly available and that data sharing becomes a priority, and c) an alignment of the criteria used to classify problematic substances. • EU registration and assessment procedures for freshwater environments were analysed. • Chemicals can be registered under multiple frameworks due to their multiple uses. • Differences between frameworks result in incoherent assessments of similar chemicals. • Recommendations for a 'one substance – one assessment' approach are given. [ABSTRACT FROM AUTHOR]
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- 2021
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223. Shifting the imbalance: Intentional reuse of Dutch sewage effluent in sub-surface irrigation.
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Narain-Ford, Dominique M., Bartholomeus, Ruud P., Raterman, Bernard W., van Zaanen, Ian, ter Laak, Thomas T., van Wezel, Annemarie P., and Dekker, Stefan C.
- Abstract
Worldwide, agricultural irrigation currently accounts for 69% of freshwater withdrawal. Countries with a temperate climate, such as the Netherlands, experience periodic freshwater shortages in agriculture. The pressure on available freshwater will increase due to climate change and a growing demand for freshwater by e.g. industrial activities. Possible alternative water resources are considered in order to meet the current and future water demand. In this study we explore where, and how much, sewage treatment plant (STP) effluent can directly be reused in agricultural sub-surface irrigation (SSI) during an average and a dry season scenario, for all active (335) Dutch STPs. SSI systems may have a higher water demand as part of the STP effluent is transported with groundwater flow, although aboveground irrigation has a loss of water due to interception. Furthermore, such aboveground irrigation systems provide direct contact of crops with irrigation water. SSI systems provide a soil barrier which may function as a filter and buffer zone. In the Dutch situation, direct intentional reuse of STP effluent can fulfill up to 25% of croplands SSI water demand present within a five-kilometer transport buffer from the STPs during an average season and 17% during a dry season. Hereto, respectively, 78% and 84% of the total available Dutch STP effluent would be used. Thus, the intentional direct STP effluent reuse in agricultural SSI has the potential to satisfy a significant amount of the agricultural water demand at a national scale, presuming responsible reuse: safe applications for humans and environment and no limiting effects on water availability for other actors. Unlabelled Image • Possible alternative water resources are considered in order to meet the current and future water demand. • Direct intentional reuse of STP effluent can satisfy a significant amount of the Dutch agricultural water demand via SSI. • Prolonged SSI can elevate groundwater levels directly and indirectly via reduced groundwater abstraction. [ABSTRACT FROM AUTHOR]
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- 2021
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224. Bioturbation Affects Bioaccumulation: PFAS Uptake from Sediments by a Rooting Macrophyte and a Benthic Invertebrate.
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Gkika IS, Kraak MHS, van Gestel CAM, Ter Laak TL, van Wezel AP, Hardy R, Sadia M, and Vonk JA
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- Animals, Bioaccumulation, Fluorocarbons metabolism, Invertebrates metabolism, Plant Roots metabolism, Oligochaeta metabolism, Magnoliopsida metabolism, Geologic Sediments chemistry, Water Pollutants, Chemical metabolism
- Abstract
Despite the widespread presence of per- and polyfluoroalkyl substances (PFAS) in freshwater environments, only a few studies have addressed their bioaccumulation in macrophytes and benthic invertebrates. This study therefore aimed at investigating the presence of 40 PFAS in sediments, assessing their bioaccumulation in a rooting macrophyte ( Myriophyllum spicatum ) and a benthic invertebrate ( Lumbriculus variegatus ) and examining the effects of the presence and bioturbation activity of the invertebrate on PFAS bioaccumulation in the plants. The macrophytes were exposed to sediments originating from a reference and a PFAS-contaminated site. The worms were introduced in half of the replicates, and at the end of the experiment, PFAS were quantified in all environmental compartments. Numerous targeted PFAS were detected in both sediments and taken up by both organisms, with summed PFAS concentrations in organisms largely exceeding concentrations in the original sediments. Bioaccumulation differed between organisms and the two sediments. The presence of the worms significantly reduced the PFAS concentrations in the plant tissues, but for some compounds, root bioaccumulation increased in the presence of the worms. This effect was most prominent for the degradable PFAS precursors. It is concluded that organisms affect the environmental fate of PFAS, emphasizing that contaminant-macroinvertebrate interactions are two-sided.
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- 2024
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225. What if you eat nanoplastics? Simulating nanoplastics fate during gastrointestinal digestion.
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Hayder M, van Wezel AP, Gruter GM, and Astefanei A
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- Humans, Polymers chemistry, Plastics chemistry, Gastrointestinal Tract metabolism, Digestion, Nanoparticles chemistry, Particle Size
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Despite our growing awareness of micro-and nanoplastics presence in food and beverages, the fate of nanoplastics (NPs) in the human gastrointestinal tract (GIT) remains poorly investigated. Changes of nanoplastics size upon digestive conditions influence the potential of absorption through the intestine. In this study, polymer nanoparticles with different physicochemical properties (size, surface and chemistry) were submitted to gastrointestinal digestion (GID) simulated in vitro. Their agglomeration behaviour was measured with a unique set of analytical approaches, allowing to study NPs' interactions with the digestive enzymes. Smaller NPs agglomerated more, narrowing the overall particle size distribution of smaller and larger NPs. NPs of different polymers exhibited heteroagglomeration. Digestive enzymes interact with the NPs, forming large but fragile agglomerates. In presence of the enzymes, even acid-functionalized NPs, typically stable in harsh conditions, agglomerated similarly to the non-functionalized PS NPs. These results highlight the role of the GID in increasing the effective size of ingested NPs, potentially reducing their ability to pass through the cell membranes. Our findings address a critical knowledge gap in nanoplastics oral uptake potential, providing a solid technical foundation for their characterization., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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226. Exploring Perfluoroalkyl and Polyfluoroalkyl Substance Presence and Potential Leaching from Reverse Osmosis Membranes: Implications for Drinking Water Treatment.
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Sadia M, Ter Laak TL, Cornelissen ER, and van Wezel AP
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- Membranes, Artificial, Water Purification, Drinking Water chemistry, Osmosis, Water Pollutants, Chemical, Fluorocarbons analysis
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Reverse osmosis (RO) is increasingly used in drinking water production to effectively remove micropollutants, such as perfluoroalkyl and polyfluoroalkyl substances (PFAS). However, RO membranes themselves may contain PFAS, which can potentially leach into treated drinking water. Leaching experiments and direct total oxidizable precursor assays revealed the presence and leaching potential of PFOS (branched and linear), PFBA, PFHxA, PFNA, and PFOA in five selected commercial RO membranes. This resulted in the release of tens of milligrams of ΣPFAS per membrane element used in drinking water production. Depending on assumptions made regarding leaching kinetics and volume of produced water per membrane element, predicted concentrations of ΣPFAS in the produced water ranged from less than one up to hundreds of pg/L. These concentrations are two to four orders of magnitude lower than those currently observed in Dutch drinking waters. The origin of PFAS in the membranes remains unclear. Further research is needed to bridge the gap between the laboratory conditions as used in this study and the real-world conditions and for a full understanding of potential leaching scenarios. Such an understanding is critical for water producers using RO technologies to proactively manage and mitigate potential PFAS contamination.
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- 2024
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227. Research Priorities for the Environmental Risk Assessment of Per- and Polyfluorinated Substances.
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Gkika IS, Xie G, van Gestel CAM, Ter Laak TL, Vonk JA, van Wezel AP, and Kraak MHS
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- Animals, Invertebrates, Risk Assessment, Research, Ecotoxicology, Fluorocarbons toxicity
- Abstract
Per- and polyfluorinated substances (PFAS) are a group of thousands of ubiquitously applied persistent industrial chemicals. The field of PFAS environmental research is developing rapidly, but suffers from substantial biases toward specific compounds, environmental compartments, and organisms. The aim of our study was therefore to highlight current developments and to identify knowledge gaps and subsequent research needs that would contribute to a comprehensive environmental risk assessment for PFAS. To this end, we consulted the open literature and databases and found that knowledge of the environmental fate of PFAS is based on the analysis of <1% of the compounds categorized as PFAS. Moreover, soils and suspended particulate matter remain largely understudied. The bioavailability, bioaccumulation, and food web transfer studies of PFAS also focus on a very limited number of compounds and are biased toward aquatic biota, predominantly fish, and less frequently aquatic invertebrates and macrophytes. The available ecotoxicity data revealed that only a few PFAS have been well studied for their environmental hazards, and that PFAS ecotoxicity data are also strongly biased toward aquatic organisms. Ecotoxicity studies in the terrestrial environment are needed, as well as chronic, multigenerational, and community ecotoxicity research, in light of the persistency and bioaccumulation of PFAS. Finally, we identified an urgent need to unravel the relationships among sorption, bioaccumulation, and ecotoxicity on the one hand and molecular descriptors of PFAS chemical structures and physicochemical properties on the other, to allow predictions of exposure, bioaccumulation, and toxicity. Environ Toxicol Chem 2023;42:2302-2316. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC., (© 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.)
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- 2023
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228. Managing PMT/vPvM substances in consumer products through the concepts of essential-use and functional substitution: a case-study for cosmetics.
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van Dijk J, Figuière R, Dekker SC, van Wezel AP, and Cousins IT
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- Humans, Benzophenones, Cosmetics
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Measures are needed to protect water sources from substances that are mobile, persistent and toxic (PMT) or very persistent and very mobile (vPvM). PMT/vPvM substances are used in a diverse range of applications, including consumer products. The combined application of the essential-use and functional substitution concepts has been proposed to phase out substances of concern and support the transition to safer and more sustainable chemicals, a key goal of the European Commission's Chemicals Strategy for Sustainability. Here, we first identified the market share of PMT/vPvM containing cosmetic products. We found that 6.4% of cosmetic products available on the European market contain PMT or vPvM substances. PMT/vPvM substances were most often found in hair care products. Based on their high occurrence, the substances Allura red (CAS 25956-17-6), benzophenone-4 (CAS 4065-45-6) and climbazole (CAS 38083-17-9) were selected as case-studies for assessment of their functionality, availability of safer alternatives and essentiality. Following the functional substitution framework, we found that the technical function of Allura red was not necessary for the performance of some cosmetic products, making the use non-essential. For other applications of Allura red, as well as all applications of benzophenone-4 and climbazole, the technical function of the chemical was considered necessary for the performance. Via the alternative's assessment procedure, which used experimental and in silico data and three different multicriteria decision analysis (MCDA) strategies, safer alternatives were identified for all case-study chemicals. All assessed uses of PMT/vPvM substances were thus deemed non-essential and should consequently be phased out.
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- 2023
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229. Occurrence, Fate, and Related Health Risks of PFAS in Raw and Produced Drinking Water.
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Sadia M, Nollen I, Helmus R, Ter Laak TL, Béen F, Praetorius A, and van Wezel AP
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- Humans, Environmental Monitoring methods, Carboxylic Acids, Drinking Water analysis, Drinking Water chemistry, Water Pollutants, Chemical analysis, Groundwater chemistry, Fluorocarbons analysis, Alkanesulfonic Acids analysis
- Abstract
This study investigates human exposure to per- and polyfluoroalkyl substances (PFAS) via drinking water and evaluates human health risks. An analytical method for 56 target PFAS, including ultrashort-chain (C2-C3) and branched isomers, was developed. The limit of detection (LOD) ranged from 0.009 to 0.1 ng/L, except for trifluoroacetic-acid and perfluoropropanoic-acid with higher LODs of 35 and 0.24 ng/L, respectively. The method was applied to raw and produced drinking water from 18 Dutch locations, including groundwater or surface water as source, and applied various treatment processes. Ultrashort-chain (300 to 1100 ng/L) followed by the group of perfluoroalkyl-carboxylic-acids (PFCA, ≥C4) (0.4 to 95.1 ng/L) were dominant. PFCA and perfluoroalkyl-sulfonic-acid (≥C4), including precursors, showed significantly higher levels in drinking water produced from surface water. However, no significant difference was found for ultrashort PFAS, indicating the need for groundwater protection. Negative removal of PFAS occasionally observed for advanced treatment indicates desorption and/or degradation of precursors. The proportion of branched isomers was higher in raw and produced drinking water as compared to industrial production. Drinking water produced from surface water, except for a few locations, exceed non-binding provisional guideline values proposed; however, all produced drinking waters met the recent soon-to-be binding drinking-water-directive requirements.
- Published
- 2023
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230. ECORISK2050: An Innovative Training Network for predicting the effects of global change on the emission, fate, effects, and risks of chemicals in aquatic ecosystems.
- Author
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Welch SA, Lane T, Desrousseaux AOS, van Dijk J, Mangold-Döring A, Gajraj R, Hader JD, Hermann M, Parvathi Ayillyath Kutteyeri A, Mentzel S, Nagesh P, Polazzo F, Roth SK, Boxall ABA, Chefetz B, Dekker SC, Eitzinger J, Grung M, MacLeod M, Moe SJ, Rico A, Sobek A, van Wezel AP, and van den Brink P
- Abstract
By 2050, the global population is predicted to reach nine billion, with almost three quarters living in cities. The road to 2050 will be marked by changes in land use, climate, and the management of water and food across the world. These global changes (GCs) will likely affect the emissions, transport, and fate of chemicals, and thus the exposure of the natural environment to chemicals. ECORISK2050 is a Marie Skłodowska-Curie Innovative Training Network that brings together an interdisciplinary consortium of academic, industry and governmental partners to deliver a new generation of scientists, with the skills required to study and manage the effects of GCs on chemical risks to the aquatic environment. The research and training goals are to: (1) assess how inputs and behaviour of chemicals from agriculture and urban environments are affected by different environmental conditions, and how different GC scenarios will drive changes in chemical risks to human and ecosystem health; (2) identify short-to-medium term adaptation and mitigation strategies, to abate unacceptable increases to risks, and (3) develop tools for use by industry and policymakers for the assessment and management of the impacts of GC-related drivers on chemical risks. This project will deliver the next generation of scientists, consultants, and industry and governmental decision-makers who have the knowledge and skillsets required to address the changing pressures associated with chemicals emitted by agricultural and urban activities, on aquatic systems on the path to 2050 and beyond., Competing Interests: No competing interests were disclosed., (Copyright: © 2022 Welch SA et al.)
- Published
- 2022
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231. The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry.
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Mohammed Taha H, Aalizadeh R, Alygizakis N, Antignac JP, Arp HPH, Bade R, Baker N, Belova L, Bijlsma L, Bolton EE, Brack W, Celma A, Chen WL, Cheng T, Chirsir P, Čirka Ľ, D'Agostino LA, Djoumbou Feunang Y, Dulio V, Fischer S, Gago-Ferrero P, Galani A, Geueke B, Głowacka N, Glüge J, Groh K, Grosse S, Haglund P, Hakkinen PJ, Hale SE, Hernandez F, Janssen EM, Jonkers T, Kiefer K, Kirchner M, Koschorreck J, Krauss M, Krier J, Lamoree MH, Letzel M, Letzel T, Li Q, Little J, Liu Y, Lunderberg DM, Martin JW, McEachran AD, McLean JA, Meier C, Meijer J, Menger F, Merino C, Muncke J, Muschket M, Neumann M, Neveu V, Ng K, Oberacher H, O'Brien J, Oswald P, Oswaldova M, Picache JA, Postigo C, Ramirez N, Reemtsma T, Renaud J, Rostkowski P, Rüdel H, Salek RM, Samanipour S, Scheringer M, Schliebner I, Schulz W, Schulze T, Sengl M, Shoemaker BA, Sims K, Singer H, Singh RR, Sumarah M, Thiessen PA, Thomas KV, Torres S, Trier X, van Wezel AP, Vermeulen RCH, Vlaanderen JJ, von der Ohe PC, Wang Z, Williams AJ, Willighagen EL, Wishart DS, Zhang J, Thomaidis NS, Hollender J, Slobodnik J, and Schymanski EL
- Abstract
Background: The NORMAN Association (https://www.norman-network.com/) initiated the NORMAN Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/) in 2015, following the NORMAN collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange of information on chemicals that are expected to occur in the environment, along with the accompanying expert knowledge and references, has become a valuable knowledge base for "suspect screening" lists. The NORMAN-SLE now serves as a FAIR (Findable, Accessible, Interoperable, Reusable) chemical information resource worldwide., Results: The NORMAN-SLE contains 99 separate suspect list collections (as of May 2022) from over 70 contributors around the world, totalling over 100,000 unique substances. The substance classes include per- and polyfluoroalkyl substances (PFAS), pharmaceuticals, pesticides, natural toxins, high production volume substances covered under the European REACH regulation (EC: 1272/2008), priority contaminants of emerging concern (CECs) and regulatory lists from NORMAN partners. Several lists focus on transformation products (TPs) and complex features detected in the environment with various levels of provenance and structural information. Each list is available for separate download. The merged, curated collection is also available as the NORMAN Substance Database (NORMAN SusDat). Both the NORMAN-SLE and NORMAN SusDat are integrated within the NORMAN Database System (NDS). The individual NORMAN-SLE lists receive digital object identifiers (DOIs) and traceable versioning via a Zenodo community (https://zenodo.org/communities/norman-sle), with a total of > 40,000 unique views, > 50,000 unique downloads and 40 citations (May 2022). NORMAN-SLE content is progressively integrated into large open chemical databases such as PubChem (https://pubchem.ncbi.nlm.nih.gov/) and the US EPA's CompTox Chemicals Dashboard (https://comptox.epa.gov/dashboard/), enabling further access to these lists, along with the additional functionality and calculated properties these resources offer. PubChem has also integrated significant annotation content from the NORMAN-SLE, including a classification browser (https://pubchem.ncbi.nlm.nih.gov/classification/#hid=101)., Conclusions: The NORMAN-SLE offers a specialized service for hosting suspect screening lists of relevance for the environmental community in an open, FAIR manner that allows integration with other major chemical resources. These efforts foster the exchange of information between scientists and regulators, supporting the paradigm shift to the "one substance, one assessment" approach. New submissions are welcome via the contacts provided on the NORMAN-SLE website (https://www.norman-network.com/nds/SLE/)., Supplementary Information: The online version contains supplementary material available at 10.1186/s12302-022-00680-6., Competing Interests: Competing interestsThe authors declare that they have no competing interests., (© The Author(s) 2022.)
- Published
- 2022
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232. patRoon: open source software platform for environmental mass spectrometry based non-target screening.
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Helmus R, Ter Laak TL, van Wezel AP, de Voogt P, and Schymanski EL
- Abstract
Mass spectrometry based non-target analysis is increasingly adopted in environmental sciences to screen and identify numerous chemicals simultaneously in highly complex samples. However, current data processing software either lack functionality for environmental sciences, solve only part of the workflow, are not openly available and/or are restricted in input data formats. In this paper we present patRoon, a new R based open-source software platform, which provides comprehensive, fully tailored and straightforward non-target analysis workflows. This platform makes the use, evaluation and mixing of well-tested algorithms seamless by harmonizing various common (primarily open) software tools under a consistent interface. In addition, patRoon offers various functionality and strategies to simplify and perform automated processing of complex (environmental) data effectively. patRoon implements several effective optimization strategies to significantly reduce computational times. The ability of patRoon to perform time-efficient and automated non-target data annotation of environmental samples is demonstrated with a simple and reproducible workflow using open-access data of spiked samples from a drinking water treatment plant study. In addition, the ability to easily use, combine and evaluate different algorithms was demonstrated for three commonly used feature finding algorithms. This article, combined with already published works, demonstrate that patRoon helps make comprehensive (environmental) non-target analysis readily accessible to a wider community of researchers.
- Published
- 2021
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233. Natural Purification Through Soils: Risks and Opportunities of Sewage Effluent Reuse in Sub-surface Irrigation.
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Narain-Ford DM, Bartholomeus RP, Dekker SC, and van Wezel AP
- Subjects
- Agricultural Irrigation, Soil, Waste Disposal, Fluid, Wastewater, Sewage, Water Purification
- Published
- 2020
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234. Development and application of relevance and reliability criteria for water treatment removal efficiencies of chemicals of emerging concern.
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Fischer A, van Wezel AP, Hollender J, Cornelissen E, Hofman R, and van der Hoek JP
- Subjects
- Reproducibility of Results, Wastewater, Water, Water Pollutants, Chemical, Water Purification
- Abstract
With the growth in production and use of chemicals and the fact that many end up in the aquatic environment, there is an increasing need for advanced water treatment technologies that can remove chemicals of emerging concern (CECs) from water. The current lack of a homogenous approach for testing advanced water treatment technologies hampers the interpretation and evaluation of CEC removal efficiency data, and hinders informed decision making by stakeholders with regard to which treatment technology could satisfy their specific needs. Here a data evaluation framework is proposed to improve the use of current knowledge in the field of advanced water treatment technologies for drinking water and wastewater, consisting of a set of 9 relevance criteria and 51 reliability criteria. The two criteria sets underpin a thorough, unbiased and standardised method to select studies to evaluate and compare CEC removal efficiency of advanced water treatment technologies in a scientifically sound way. The relevance criteria set was applied to 244 papers on removal efficiency, of which only 20% fulfilled the criteria. The reliability criteria were applied to the remaining papers. In general these criteria were fulfilled with regards to information on the target compound, the water matrix and the treatment process conditions. However, there was a lack of information on data interpretation and statistics. In conclusion, a minority of the evaluated papers are suited for comparison across techniques, compounds and water matrixes. There is a clear need for more uniform reporting of water treatment studies for CEC removal. In the future this will benefit the selection of appropriate technologies., (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2019
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235. Impact of industrial waste water treatment plants on Dutch surface waters and drinking water sources.
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van Wezel AP, van den Hurk F, Sjerps RMA, Meijers EM, Roex EWM, and Ter Laak TL
- Abstract
Direct industrial discharges of Chemicals of Emerging Concern (CEC) to surface water via industrial wastewater treatment plants (IWTP) gained relatively little attention compared to discharges via municipal sewage water treatment plants. IWTP effluents may however seriously affect surface water quality. Here we modelled direct industrial emissions of all 182 Dutch IWTP from 19 different industrial classes, and derived their impact on Dutch surface water quality and drinking water production. We selected industrial chemicals relevant for drinking water production, however a lack of systematic information on concentrations in IWTP effluents for many chemicals of interest was found. Therefore, we used data from the European Pollutant Release and Transfer Register and data on Dutch IWTP as surrogate. We coupled these to a detailed hydrological model under two extreme river discharge conditions, and compared the predicted and measured concentrations. We derived relative impact factors for the IWTP based on their contribution to concentrations at surface water locations with a drinking water function. In total, a third of the abstracted water for drinking water production is influenced by the IWTP. From all Dutch 182 IWTP, only a limited number has - based on the model approach using surrogate parameters - a high impact on surface waters with a drinking water function. Mitigation measures can be taken cost-efficiently, by placing extra treatment technologies at the IWTP with high impact. Finally, we propose recommendations for licensing and controlling industrial aqueous emissions and give suggestions to fill the currently existing knowledge gaps and diminish uncertainties in the approach., (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
236. Risk analysis and technology assessment in support of technology development: Putting responsible innovation in practice in a case study for nanotechnology.
- Author
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van Wezel AP, van Lente H, van de Sandt JJ, Bouwmeester H, Vandeberg RL, and Sips AJ
- Subjects
- Environmental Policy, Environmental Pollutants, Industrial Development, Risk Assessment, Environmental Exposure statistics & numerical data, Nanoparticles, Nanotechnology trends
- Abstract
Governments invest in "key enabling technologies," such as nanotechnology, to solve societal challenges and boost the economy. At the same time, governmental agencies demand risk reduction to prohibit any often unknown adverse effects, and industrial parties demand smart approaches to reduce uncertainties. Responsible research and innovation (RRI) is therefore a central theme in policy making. Risk analysis and technology assessment, together referred to as "RATA," can provide a basis to assess human, environmental, and societal risks of new technological developments during the various stages of technological development. This assessment can help both governmental authorities and innovative industry to move forward in a sustainable manner. Here we describe the developed procedures and products and our experiences to bring RATA in practice within a large Dutch nanotechnology consortium. This is an example of how to put responsible innovation in practice as an integrated part of a research program, how to increase awareness of RATA, and how to help technology developers perform and use RATA. Integr Environ Assess Manag 2018;14:9-16. © 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC)., (© 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC).)
- Published
- 2018
- Full Text
- View/download PDF
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