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A series of 4-aryl-3,5-dicyano-2,6-di(3′-indolyl)pyridine derivatives were synthesized via a one-pot multicomponent reaction of aromatic aldehydes, 3-cyanoacetyl indoles, and ammonium acetate under microwave irradiation. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time, and straightforward procedure.

It is described that indium-mediated allylation of trichloromethyl ketones could afford the corresponding homoallylic alcohols smoothly in aqueous media.

3-(2-Furanyl)indoles were firstly synthesized in a one-pot procedure by the reaction of 3-cyanoacetyl indole, aromatic aldehydes and isocyanides in ethanol in the presence of ammonium acetate.

A mild, efficient, and novel synthesis of 2-aryl-2H-indazoles via cyclization of 2-nitrobenzylamines promoted by SnCl 2 ·2H 2 O has been described. This method applies to a wide scope of substrates containing electron-donating and electron-withdrawing substituents.

A short and efficient synthesis of substituted pyrroles was accomplished in good yields via the novel coupling cyclization reaction of 1,3-diketones with imines promoted by low-valent titanium reagent. High regioselectivity was achieved and the structures of two of the products were confirmed by X-ray diffraction studies.

A facile synthetic method using low-valent titanium reagent (TiCl 4 /Zn system) to promote the novel reductive cyclization of 2-nitrobenzamides and triphosgene is described. Sequentially, a series of quinazoline-2,4-diones were synthesized in good yields.

The reaction of xanthene derivatives with indoles and pyrrole catalyzed by CAN in methanol through S N 1 reaction of -pyrillium with a nucleophilic reagent afforded the corresponding -indole- and pyrrole-substituted xanthene derivatives in high yields, respectively.

A simple and efficient one-pot three-component synthesis of the biologically important spirooxindoles scaffold was carried out by the reaction of isatin, activated methylene reagent, and 1,3-dicarbonyl compounds in aqueous medium. This method is of great value because of its environmentally benign character, high yield processing, and easy handling.

N-(α-Alkoxyalkyl)benzotriazoles were synthesized via the condensation of benzotriazole with various aldehydes and alcohols catalyzed by acidic ionic liquid [hmim]HSO4 at room temperature. The yield was up to 99%. This novel method was effective when triethoxymethane was utilized instead of alcohols. Moreover, acidic ionic liquid could be reused easily with no significant degradation of its catalytic activity.

A series of new, N-substituted azapodophyllotoxin derivatives were synthesized via a three-component reaction of an aldehyde, an enaminone and tetronic acid in glacial acetic acid, under microwave irradiation, without a catalyst. This new protocol has the advantages of shorter time, higher yields, lower cost and broader substrate scope, as well as easier operation.

4-Aza-podophyllotoxin derivatives were synthesized via the three-component reaction of an aldehyde, an aromatic amine, and either tetronic acid or 1,3-indanedione in water under microwave irradiation conditions. This new protocol has the advantages of higher yield, lower cost, reduced environmental impact, and convenient procedure.

An indium complex of chiral pyridine bis(oxazoline) (PYBOX) has been applied to the catalytic asymmetric allylation of ketones. It has been found that this chiral indium complex is strong enough to promote the reaction of ketones with allyltributylstannane smoothly. The products were obtained in moderate yields with low to moderate enantioselectivities.

A highly efficient regio- and enantioselective catalytic asymmetric addition of Grignard regeants to α,β-unsaturated esters promoted by the CuI-Tol-BINAP system is described.

Invited for the cover of this issue is the group of Shun-Jun Ji and co-workers at Soochow University, (China). The image depicts a cheaper, low-toxic, eco-friendly benign and metal-free methodology incorporating the both aryl and trifyl sulfonyl functionality from allylic alcohols. Read the full text of the article at 10.1002/chem.201500469.

An indium complex of chiral PYBOX was applied in the catalytic asymmetric allylation of ketones in the ionic liquid. It was found that this chiral indium complex was strong enough to promote the reaction of ketones with allyltributylstannane smoothly. The products were obtained in moderate to high enantioselectivities, and the chiral catalyst immobilized in the ionic liquid could be reused with comparable enantioselectivities and yields.

This article describes a fast, efficient, economical, and environmentally friendly method for the preparation of a series of ferrocenyl‐substituted 1,5‐diketone compounds via Michael addition of ferrocenyl‐substituted chalcones with deoxybenzoin or dibenzyl ketone under solvent‐free conditions, and affords the corresponding Michael adducts with excellent yields of 77–93%.

Green, mild and efficient electrophilic substitution reactions of indoles with various aldehydes were carried out using task-specific ionic liquids to afford the corresponding bis(indolyl)methanes in excellent yields.

Mukaiyama aldol and Mukaiyama–Michael reactions can proceed smoothly in the presence of a catalytic amount of DBU (20% mmol), to afford the corresponding products in moderate to good yields. This solvent- and metal-free approach provides an environmentally friendly procedure for Mukaiyama reactions.

In the presence of chiral catalytic complexes prepared from In(OTf)3 and chiral PYBOX ligands, allytributylstannane reacted with aldehydes in ionic liquids to afford the corresponding homoallylic alcohols in high enantioselectivities (86–94% ee) and good yields (68–89%); the chiral catalysts immobilized in ionic liquids could be reused with comparable enantioselectivities and yields.

In the presence of 20 mol% of a chiral catalytic complex prepared from In(OTf)(3) and chiral PYBOX, allyltributylstannane reacted with aldehydes to afford the corresponding homoallylic alcohols in moderate to high enantioselectivities (60-93% ee).

A chiral indium(III)-PYBOX complex prepared from indium triflate and chiral PYBOX has been discovered to effect high enantioselectivities in the addition of allyltributyl stannane to aldehydes. The allylation of a variety of aromatic, alpha,beta-unsaturated, and aliphatic aldehydes resulted in good yields and high enantioselectivities (up to 94% ee).

The reaction of aryldiazoacetates with enamines catalyzed by copper and rhodium complexes provided γ-ketoesters in good yields. Careful analysis of the crude reaction mixture revealed a substituted enamine as the primary product, which was hydrolyzed over silica gel to give a γ-ketoester as the final product. A reaction mechanism involving nucleophilic addition of an enamine to a metal carbene and subsequent hydrogen transfer was proposed.

A one-pot indium trichloride-catalyzed indium-mediated allylation of dihydropyrans and dihyfrofurans has been found to be feasible. This catalytic system afforded the allylated diols in moderate to high yields.

Efficient electrophilic substitution reactions of indoles with various aromatic aldehydes were carried out using a catalytic amount of I 2 under solvent-free conditions to afford the corresponding bis(indolyl)methanes in excellent yields.

This paper described alkynylation of ethynylbenzene to ketones catalyzed by potassium tert-butoxide under solvent-free conditions in the presence of ultrasound irradiation.

Solid phase coordination reaction of Sm3+ and the resultant of the imidization of polycondensor of polycondensation and imidization of benzoguanamine(BGA) and 2, 4-tolylenediisocyanate (TDI) and pyromellitic dianhydride (PMIDA) under microwave irradiation were synthesized and studied. The effect of microwave irradiation time (power), the composition of reactants and the reaction temperature on the yield and Sm content in complexes were studied. The complex was determined by Fourier transform infrared absorption (FTIR), Fourier transform Roman spectrum (FTRS), scanning electric minor (SEM), 13C solid state nuclear magnetic resonance spectrometry and X-ray powder diffraction. The fluorescence intensity was measured by fluorescent emission spectrum and compared with thermal coordination. The magnetic susceptibilities were measured by magnetic curve. The results showed that the complex had not characteristic fluorescence of Sm3+, which illustrated that the first excitation level of Sm3+ and polymer could not match at all. But the complex showed good magnetic property of the ion.

Microwave-assisted oxidative coupling of 2-naphthols at solid state gave the corresponding coupling products in high yields, which provides a simple, rapid and efficient approach to the preparation of binaphthols.

A metal-free method for direct C(sp3)–H bond functionalization of simple ethers with α,α-diaryl allylic alcohols is described. The established protocol provides facile access to α-aryl-β-oxyalkylated carbonyl ketones via radical addition and a 1,2-aryl migration cascade process. An application of the product has been demonstrated in the synthesis of a serotonin antagonist.

A transition-metal-free process for the synthesis of 1,4-dihydroquinoline derivatives starting from simple enaminones with aldehydes via intermolecular cascade cyclization in a one-pot protocol is developed. This methodology affords a variety of products in moderate to good yields. Particularly, the use of the enaminone fragment in 1,4-dihydroquinoline derivatives 3 as a leaving group for further diverse applications with C-nucleophiles is proved to be feasible.

An efficient method for the construction of 6-alkyl phenanthridines by tert-butyl peroxybenzoate (TBPB)-mediated 2-isocyanobiaryl insertion with 1,4-dioxane was established. Two new C-C bonds were formed in this reaction via a sequential C(sp(3))-H/C(sp(2))-H bond functionalization under metal-free conditions.

Organocatalyzed asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media has been developed. The reactions proceeded efficiently in the presence of the MacMillan catalyst to give the desired products in good to excellent yields with moderate diastereoselectivities and excellent enantioselectivities.

A novel C3-benzylation of indoles through C–O bond activation of benzyl alcohols catalyzed by In(OTf)3 in water has been developed. The reactions proceed smoothly in presence of In(OTf)3 as the catalyst without the use of any bases, ligands or other additives to perform the desired product in moderate to excellent yields.