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Broadleaf forests are critical habitats for biodiversity and this biodiversity is in turn essential for their proper functioning. Mites (Acari) are a numerous and functionally essential component of these forests. We report the diversity of two important groups, Oribatida and Mesostigmata, in a broadleaf forest in Eastern Norway which is considered to be a biodiversity hotspot. Eighteen samples, each 500 cm3, were collected from diverse microhabitats (moss on ground, lichens on tree twigs lying on ground, moss on tree trunks at ground level, moss on tree trunks 1.5 m above ground, moss on decaying stump, moss on decaying log, and decaying wood from trees) from which 10,843 specimens and 95 species from 32 families of Oribatida, and 655 specimens of 34 species from 14 families of Mesostigmata were found. Only 30% of the species were previously recorded in broadleaf forests in Western Norway. Oribatid communities on decaying stump and in lichens were distinct from the other communities, while mesostigmatid communities on tree trunks (both at ground level and 1.5 m above ground) and in lichens differed most from other communities. Over 30% of the species were found in only a single microhabitat. Twenty-three species and the genus Zerconopsis are reported from Norway for the first time. Six records are also new to Fennoscandia, including (Oribatida) Coronoquadroppia monstruosa, Eueremaeus valkanovi, Ramusella furcata, and (Mesostigmata) Dendrolaelaps rectus, D. multidentatus, and D. tenuipilus. In addition, several rare species were detected, e.g., Achipteria magna, Oribotritia berlesei, and Subiasella quadrimaculata, and two were found in their northernmost locality (O. berlesei, E. valkanovi). These results confirm the unique character and high conservation value of the studied forest in Norway, Fennoscandia and at a European scale. [ABSTRACT FROM AUTHOR]

(1) We document the invertebrate fauna collected from 24 oak canopies in east and west Norway as a contribution to the Norwegian Biodiversity Information Centre's 'The Norwegian Taxonomy Initiative'. (2) A snap-shot inventory of the canopies was recorded by means of emitting a mist of natural pyrethrum into the canopies at night using a petrol-driven fogger and collecting the specimens in butterfly nets spread on the ground under the canopy. (3) Almost the entire catch of more than 6800 specimens was identified to 722 species. Out of 92 species new to the Norwegian fauna, 21 were new to science and, additionally, 15 were new to the Nordic fauna. Diptera alone constituted nearly half of the species represented, with 61 new records (18 new species). Additionally, 24 Hymenoptera (one new species), six oribatid mites (two new species) and one Thysanoptera were new to the Norwegian fauna. (4) Our study emphasizes the importance of the oak tree as a habitat both for a specific fauna and occasional visitors, and it demonstrates that the canopy fogging technique is an efficient way to find the 'hidden fauna' of Norwegian forests. The low number of red listed species found reflects how poor the Norwegian insect fauna is still studied. Moreover, the implication of the IUCN red list criteria for newly described or newly observed species is discussed. [ABSTRACT FROM AUTHOR]

In reviewing the Great Reset, an initiative launched by the World Economic Forum (WEF) in response to the global coronavirus crisis, this perspective article considers the scenario of an epochal transition from capitalism to "restorism". To facilitate the observation of underlying trends and assumptions, a systems-theoretical framework is developed for the observation of both this Great Reset scenario and those scenarios that are by implication excluded by the WEF vision. It is thus shown that the "shared goals" advocated by the WEF would converge to a transition from a modern pluralist to a "new-normative" order stratified to the primacy of individual, institutional, and planetary health. In discussing sociological implications of this transition, a vision emerges of a new digitally enhanced medieval era where health plays the role once played by religion. In this restorist scenario of a neo-medieval world health society, the emergence of new social strata corresponding to different levels of purity, infection, or pollution would be a probable consequence. The paper concludes that idea of deliberately caused great resets and other control illusions nurtured by the WEF initiative are barely smarter than and spur what the UN Secretary-General refers to as "wild conspiracy theories". [ABSTRACT FROM AUTHOR]

For release of parenteral drug products, bacterial endotoxin testing is one of a panel of necessary tests. In order to ensure the validity of such tests, various controls are performed, including demonstration of compendial method suitability or method qualification. In addition to compendial suitability testing, quality control (QC) sample hold-time studies are requested by authorities like the Food and Drug Administration (FDA) as described in "Guidance for Industry: Pyrogen and Endotoxins Testing." It is requested to be determine whether the ability to detect endotoxins can be affected by storage and handling of the sample to be tested. To accomplish these studies, endotoxin is introduced or spiked into the undiluted product and held for a certain period of time in process-representative containers. This time period reflects procedural maximum QC sample hold time from sampling until analysis. Inadequate detection of endotoxin can be caused by adsorption of endotoxin to container surfaces or molecular masking effects, in which the binding sites on the endotoxin molecules are prevented from triggering the enzymatic cascade necessary in the assay, are obscured. The endotoxin may form macromolecular structures, such as sheets or blebs, or the binding sites may otherwise be rendered unavailable due to the sample matrix composition. In either case, the endotoxin assay may yield falsely low results if and when masking occurs. In this work, the QC sample hold times of different in-process controls within the production process of a biopharmaceutical product were analyzed. One out of eight different samples showed a strong masking of endotoxin. Analysis of the sample composition revealed that either kifunensine, mycophenolic acid (MPA), or lauryl-N, N-dimethylamine oxide (LDAO) was responsible for masking. Further analysis clearly identified LDAO as the root cause for masking. A novel one-step mechanism for LDAO-induced endotoxin masking is proposed. The principle is similar to an already-proposed two-step mechanism for endotoxin masking, but the LDAO case combines these two steps: the disturbance of the salt bridges and hydrophobic interactions with LPS in one molecule. These molecular interactions occur quickly when both endotoxin and LDAO are present in the same matrix. Thus, depending on the masking agents, low endotoxin recovery (LER) can occur regardless of the QC sample hold duration. [ABSTRACT FROM AUTHOR]

At the core of ecological economics is the image of the economy as an open system embedded in the natural environment whose carrying capacity is limited. The present paper revisits this image by drawing upon the constructivist implications of Luhmann's social systems theory. To Luhmann, the modern society consists of a multitude of social systems each bringing forth and observing their own environments. If the Luhmannian vision is accepted, then ecological economics can be said to privilege the observational perspective of natural sciences. The unfortunate consequence of this privileging is the underestimation of a broad range of multidimensional sustainability risks which are foregrounded by the numerous alternative observational perspectives which are just as legitimate. It is argued that, rather than relativizing the sustainability concerns of the modern ecological economics, the Luhmannian perspective generalizes and radicalizes them. In doing so, the latter perspective opens new possibilities not only for navigating these risks but also for envisioning new resources and solutions. [ABSTRACT FROM AUTHOR]

• The digital transformation is fundamentally changing research contexts and conditions in the social sciences and humanities. • The vast majority of social theorists are computer illiterates. • Computer illiterate social theorists produce analogue theories of digital societies. • A research agenda on the threats and opportunities of a digital transformation of social theory is required. ICT and the increasing availability of digital data are dramatically changing the processes of research and knowledge production in the social sciences and humanities (SSH). Whereas the methodological momentum in digital humanities and computational social sciences is already immense, theory development in the SSH is much less dynamic and consists mainly of digital resurrections of the classics of our fields. The contributions to this virtual special issue of Technological Forecasting and Social Change do, therefore, not constitute efforts at presenting new social theories of the digital transformation, but rather, efforts at digitally transforming social theory. This introduction presents an overview of the topic and the contributions and outlines key elements of a research agenda on the digital transformation of social theory. [ABSTRACT FROM AUTHOR]

• Dominant theories of society are grounded on strong assumptions about the capitalist nature of the modern society. • Results from this advanced replication of Roth et al. (2017) confirm doubts that society has been capitalist. • Popular conceptions ought to undergo regular routine checks. • Social theories which are no longer by default geared primarily to political and economic issues are required in the future. Seeking to advance a big data approach to social theory, Roth et al. (2017) applied the Google Ngram Viewer to explore the way the evolution of the function systems of the modern society is reflected in the Google Books corpus. The authors produced a highly counterintuitive finding that the modern Western societies cannot be adequately described as capitalist. In order to respond to the controversies raised by this finding, the present article replicates Roth et al. (2017) study while using a superior plotting software that allows to control the risk that keyword strength can be biased due to the neglect of keyword quantity. Covering the English-, French-, and German-language corpora, the present replication effort has confirmed the existence of distinct trends exhibited by the individual function systems, such as secularization, the persistent dominance of the political system, and the relatively lesser role of the economic system. These results are largely consistent with those of Roth et al. (2017) and thus lend credence to the authors' sceptical assessment of the validity of the capitalist semantics. The article concludes by pleading for the routinization of big data-driven checks of the modern social theories. [ABSTRACT FROM AUTHOR]

All 100+ bedbug species (Cimicidae) are obligate blood-sucking parasites [ 1, 2 ]. In general, blood sucking (hematophagy) is thought to have evolved in generalist feeders adventitiously taking blood meals [ 3, 4 ], but those cimicid taxa currently considered ancestral are putative host specialists [ 1, 5 ]. Bats are believed to be the ancestral hosts of cimicids [ 1 ], but a cimicid fossil [ 6 ] predates the oldest known bat fossil [ 7 ] by >30 million years (Ma). The bedbugs that parasitize humans [ 1, 8 ] are host generalists, so their evolution from specialist ancestors is incompatible with the "resource efficiency" hypothesis and only partially consistent with the "oscillation" hypothesis [ 9–16 ]. Because quantifying host shift frequencies of hematophagous specialists and generalists may help to predict host associations when vertebrate ranges expand by climate change [ 17 ], livestock, and pet trade in general and because of the previously proposed role of human pre-history in parasite speciation [ 18–20 ], we constructed a fossil-dated, molecular phylogeny of the Cimicidae. This phylogeny places ancestral Cimicidae to 115 mya as hematophagous specialists with lineages that later frequently populated bat and bird lineages. We also found that the clades, including the two major current urban pests, Cimex lectularius and C. hemipterus , separated 47 mya, rejecting the notion that the evolutionary trajectories of Homo caused their divergence [ 18–21 ]. • Bedbugs arose 115 mya, 30+ Ma before their assumed host, bats • From unknown ancestral hosts, several bat and bird host lineages evolved • Humans became hosts three times by host extension of specialists, not host switching • Two urban pests, common and tropical bedbug, split ca. 40 Ma before Homo speciation Using a fossil-dated phylogeny, Roth et al. show the bedbug family evolved 30+ Ma before bats, their previously assumed hosts. Bats, birds, and humans were each colonized several times. The tropical and common bedbug split 47 mya, rejecting Ashford's hypothesis of their independent evolution on Homo erectus and H. sapiens. [ABSTRACT FROM AUTHOR]

An introduction is presented in which the editors discuss various reports within the issue on topics including the role of plays and games in creativity, the role of game in innovation management, and the function of design thinking in product development.

Besides humans, the common bed bug Cimex lectularius uses bats as hosts, but no such records were available from the Southern Caucasus. Here, we record the greater horseshoe bat (Rhinolophus ferrumequinum) and the lesser mouse-eared bat (Myotis blythii) as hosts of C. lectularius from two Georgian and one Armenian sites. A summary of all known published records of bat-associated populations of C. lectularius shows they are both scattered and restricted to the Palearctic only. Observations of C. lectularius from bat colonies in Georgia and Armenia were made in old buildings or ruins, like churches or monasteries, but not in caves, despite a specific search. This supports previous studies suggesting that 1) bat-associations of common bed bugs are very rare outside Central Europe and 2) almost never occur in caves. We discuss climatic conditions and host preferences as possible factors for these findings and the implications for the origin of the human bed bug interaction. [ABSTRACT FROM AUTHOR]

Rapid genitalia evolution is believed to be mainly driven by sexual selection. Recently, noncopulatory genital functions have been suggested to exert stronger selection pressure on female genitalia than copulatory functions. In bedbugs (Cimicidae), the impact of the copulatory function can be isolated from the noncopulatory impact. Unlike in other taxa, female copulatory organs have no function in egg-laying or waste-product expulsion. Males perform traumatic mating by piercing the female integument, thereby imposing antagonistic selection on females and suspending selection to morphologically match female genitalia. We found the location of the copulatory organ evolved rapidly, changing twice between dorsal and ventral sides, and several times along the anteroposterior and the left-right axes. Male genital length and shape varied much less, did not appear to follow the positional changes seen in females, and showed no evidence for coevolution. Female genitalia position evolved 1.5 times faster than male genital length and shape and showed little neutral or geographic signals. Instead, we propose that nonmorphological male traits, such as mating behavior, may drive female genitalia morphology in this taxon. Models of genitalia evolution may benefit from considering morphological genital responses to nonmorphological stimuli, such as male mating behavior or copulatory position., (© The Author(s) 2023. Published by Oxford University Press on behalf of The Society for the Study of Evolution (SSE).)

The bed bug family Cimicidae (Hemiptera: Heteroptera) constitutes a group of specialized haematophagous ectoparasitic insects with about 110 species worldwide and 13 species in the Neotropics. Here we provide biological and faunistic observations for 4 out of the 8 species recorded in Argentina. Propicimex tucmatiani (Wygodzinsky, 1951) was recorded for the first time in the Province of Santa Fe and we provide the first barcode sequence for this species. Acanthocrios furnarii (Cordero & Vogelsang, 1928), a mainly ornithophilic species, has been found in a human apartment in Buenos Aires and was probably attacking humans. Bertilia valdiviana (Philippi, 1865) had been reported in 1950 in the Province of Ro Negro, we discuss its potential habitat and host association after visiting the only location where this species had been recorded so far in Argentina. Moreover, we provide some natural history data, i.e. developmental stages, sex ratio and feeding habit of the parrot parasite Cyanolicimex patagonicus Carpintero, Di Iorio, Masello & Turienzo, 2010 from a colony in El Condor (Province of Ro Negro).

On the occasion of a growing popularity of paradox theory in management and organisation research, this article provides an introduction to the paradox of true distinctions, reports on its relevance to theory building, and presents a strategy to contain the paradox without resolving it. To this end, I draw on works by George Spencer Brown and Niklas Luhmann to contextualize theory within the paradox of observation in general and the paradox of scientific observation in particular. A special case of the paradox of scientific communication, paradox theory is then redefined as a scientific programme fascinated with the paradoxical nature of the basic operation of science. I conclude that further development work on the "source code" of science will provide "critical updates" on the opportunities and limits to metatheoretical extensions of theories of management, organisation, and society, including their digital transformation., Competing Interests: Competing InterestThe author has no relevant financial or non-financial interests to disclose., (© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)

In Niklas Luhmann's vision of the modern functionally differentiated society, health presents one of the essential function systems, along with politics, law, economy and science. While he devoted much effort to elaborating the theoretical foundations of the latter function systems, his work on the health system was relatively sparse. This research gap has been rendered particularly acute by the recent COVID-19 crisis. In reconstructing and updating the Luhmannian analysis of this system, this article presents a three-dimensional concept of organic, psychic and social health and highlights the risks raised by a potential overexpansion of the health concept to the planetary level. The most important of these risks is shown to be the potential rise of totalitarian social control that exceeds classical forms of medical social control. The proposed argument not only contributes to the public criticism of the political responses to the COVID-19 crisis but also fills in some missing pieces of Luhmann's seminal elaboration of the health system., (© 2022 Foundation for the Sociology of Health & Illness.)

Natural product methyltransferases (NPMTs) represent an emerging class of enzymes that can be of great use for the structural and functional diversification of bioactive compounds, such as the strategic modification of C-, N-, O- and S-moieties. To assess the activity and the substrate scope of the ever-expanding repertoire of NPMTs, a simple, fast, and robust assay is needed. Here, we report a continuous spectroscopic assay, in which S-adenosyl-L-methionine-dependent methylation is linked to NADH oxidation through the coupled activities of S-adenosyl-L-homocysteine (SAH) deaminase and glutamate dehydrogenase. The assay is highly suitable for a high-throughput evaluation of small molecule methylation and for determining the catalytic parameters of NPMTs under conditions that remove the potent inhibition by SAH. Through the modular design, the assay can be extended to match the needs of different aspects of methyltransferase cascade reactions and respective applications., (© 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH.)

Wolbachia bacteria, vertically transmitted intracellular endosymbionts, are associated with two major host taxa in which they show strikingly different symbiotic modes. In some taxa of filarial nematodes, where Wolbachia are strictly obligately beneficial to the host, they show complete within- and among-species prevalence as well as co-phylogeny with their hosts. In arthropods, Wolbachia usually are parasitic; if beneficial effects occurs, they can be facultative or obligate, related to host reproduction. In arthropods, the prevalence of Wolbachia varies within and among taxa, and no co-speciation events are known. However, one arthropod species, the common bedbug Cimex lectularius was recently found to be dependent on the provision of biotin and riboflavin by Wolbachia, representing a unique case of Wolbachia providing nutritional and obligate benefits to an arthropod host, perhaps even in a mutualistic manner. Using the presence of presumably functional biotin gene copies, our study demonstrates that the obligate relationship is maintained at least in 10 out of 15 species of the genera Cimex and Paracimex. The remaining five species harboured Wolbachia as well, demonstrating the first known case of 100% prevalence of Wolbachia among higher arthropod taxa. Moreover, we show the predicted co-cladogenesis between Wolbachia and their bedbug hosts, also as the first described case of Wolbachia co-speciation in arthropods.

Background: The in vivo developing embryo is naturally exposed to constant vibrations of around 6 Hz, increasing to 20 Hz when the oviductal fluid is mechanically agitated by the cilia. This study examines the effects on viability of subjecting human pronuclear oocytes and embryos to mechanical agitation during their in vitro culture before transplantation., Methods: Metaphase-II oocytes were ICSI/IVF with morphologically normal spermatozoa and then divided into two groups according to whether the cells underwent mechanical agitation (20 Hz over 5 seconds once per hour) of the culture medium (Group 2, n=23) or were cultured without mechanical agitation (Group 1, n=23). The fertilization rate of oocytes was recorded 18 hours later. Embryo development was monitored every day during the whole period of in vitro culture up to the embryo transfer on day 3, 4 or 5., Results: Pregnancy rates after the transfer of 3 Day embryos in Group 1 and Group 2 were 50% and 80%, and of 5 Day embryos in Group 1 and Group 2 were 36% and 73%, respectively., Conclusions: The in vitro culture of human embryos in a medium subjected to regular short bursts of mechanical agitation drastically increases their development rate.