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357. [Neuroendocrine aspects of Parkinson's disease. Therapeutic/effect of a prolactin inhibitor].

Author

Agnoli A, Casacchia M, Carolei A, Meco G, Zamponi A, and Ruggieri S

Subjects
Aged, Drug Evaluation, Female, Humans, Middle Aged, Bromocriptine therapeutic use, Ergolines therapeutic use, Parkinson Disease drug therapy, Prolactin antagonists & inhibitors
Abstract

On the basis of a reassessment of the aetiopathogenetic problem and the neuroendocrine implications, the therapeutic effectiveness of a prolactin inhibitor, 2-alpha-Br-ergocryptine (CB 154), in Parkinson's disease is assessed. Five patients were treated for a total of two weeks using doses between 10 and 15 mg/die. CB 154 was found to act as a dopaminergic receptor agonist at nigro-striatal level, considerably improving tremor and rigidity and to a lesser extent bradykinesia and total disability.

Published
1976

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