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Abstract  Atrial fibrillation (AF) is a multivariable disease. Young patients with paroxysmal AF without structural cardiac abnormality (“lone AF”) likely have a primary electropathy with excellent results from radiofrequency ablation. However, with persistent AF with cardiac abnormalities, including left atrial enlargement and systolic ventricular dysfunction (ejection fraction percent), the electropathy is considered secondary and ablation results poor. We describe a case with persistent AF, depressed systolic function, and marked left atrial enlargement but without echo Doppler evidence of diastolic dysfunction. At electrophysiology study, findings were consistent with a primary electropathy, and the patient did well following ablation. [ABSTRACT FROM AUTHOR]

Married women have a higher risk of contracting human immunodeficiency virus (HIV) or develop acquired immune deficiency syndrome (AIDS) than men. Knowledge of HIV/AIDS contributes significantly to describing the prevalence and consequences of such virus/disease. The study aimed to investigate the level of HIV/AIDS knowledge and the socio-demographic variables that influence HIV/AIDS knowledge among married women in Bangladesh. We used three waves of Multiple Indicator Cluster Survey (MICS), which included 33,843, 20,727, and 29,724 married women from 2006, 2012, and 2019 MICS. A score was prepared through their interrogation to determine the level of knowledge and logistic regression models were used for analyzing the data. This study found that the prevalence of knowledge level of HIV/AIDS in different questions increased from 55.20% in 2006 to 58.69% in 2019. In our study, respondents having highest education had 4.03 (95% CI 3.50–4.64) times more chance to obtain "High Score" in 2019 MICS which is 5.30 times in 2012 MICS (95% CI 4.41–6.37) and 2.58 times in 2006 MICS (95% CI 2.28–2.93) compared to illiterate married women. Moreover, respondents from urban area were 1.13 times more likely to obtain "High Score" in 2019 MICS which is 1.14 times in 2012 MICS and 1.16 times in 2006 MICS, respectively than the rural married women. This study also found respondent's age, division, mass media access, and wealth status have played an important role in HIV/AIDS knowledge. Although a significant proportion of women had adequate knowledge of HIV/AIDS, more knowledge is still required to protect against such viruses/diseases. Thus, we advocate for the implementation of educational program in the curriculum, counselling, particularly in rural areas, and mass media access to ensure quality knowledge throughout the country. [ABSTRACT FROM AUTHOR]

The Nandus nandus (Hamilton, 1822) is a highly prized food fish that possesses significant nutritional and commercial worth. Bangladesh, India, Pakistan, Malaysia, Myanmar, Thailand and Viet Nam are the countries where it is endemic. The IUCN Bangladesh has classified this species as near endangered due to its current progressive decline. Hence, immediate actions are necessary to efficiently manage the fishery in this country. To address this issue, a comprehensive understanding of its life history parameters is required. This study aimed to examine the growth characteristics, recruitment length, sexual maturity, mortality, exploitation rate, and maximum sustainable production of N. nandus in Bangladesh's southern coastal waters. Samples were taken every month from January through December of 2021. Our study indicates that N. nandus grows in an isometric manner. The estimated asymptomatic length of this species is 18.0 cm in total length (TL), growing at a rate of 1.30 year−1. The growth performance index of this species was determined to be 2.62, and the projected lifespan was calculated to be 2.31 years. The initial length at recruitment was measured to be 9.5 cm TL, whie the size at first sexual maturity was recorded to be 9.4 cm TL. With the contributions of the natural mortality rate (2.26 year−1) and the fishing mortality rate (1.86 year−1) the total mortality rate was found to be 4.12 year−1. The exploitation rate, determined to be 0.45, surpasses the upper limit of sustainable yield criteria set at 0.37. Therefore, it is imperative to implement strategies to avoid excessive fishing and guarantee the long-term control of N. nandus populations.

The study was conducted to determine the inclusion effect of Spirulina platensis as a feed supplement on growth performance, feed efficiency, body composition, haematology, immune response, and gut microflora of the stinging catfish (Heteropneustes fossilis). Five iso-nitrogenous and iso-lipidic diets were prepared by replacing fish meal (FM) with S. platensis at a rate of 0, 2.5, 5, 7.5, and 10% and referred to as control, SP2.5, SP5, SP7.5, and SP10 diets, respectively. Three replicate groups of fish (average weight of 0.75 g) were reared in glass aquaria (180 L water capacity) and fed with each of the experimental diets up to satiation level twice a day, 7 days a week for 70 days. At termination, growth performance, carcass composition, immune parameters, and gut microflora were assessed. Moreover, ten fish from each aquarium were challenged with Aeromonas hydrophila and cumulative mortality was recorded for 15 days. Significantly (P < 0.05) higher weight gain, specific growth rate (SGR, % day−1), lower feed conversion ratio (FCR), and higher protein efficiency ratio (PER) were recorded in fish fed with SP7.5 and SP10 diets compared to control. Dietary S. platensis inclusion at 7.5–10% levels significantly (P < 0.05) boosted the whole-body protein and ash contents of stinging catfish, while decreasing the lipid and moisture contents compared to the control. Haematological parameters significantly (P < 0.05) improved in the S. platensis supplemented diet compared to the control. Serum lysozyme activity of fish fed with SP7.5 and SP10 diet was significantly (P < 0.05) higher compared to all other diets. Higher inclusion of S. platensis lowered post-challenge mortality and the lowest cumulative mortality (30%) was recorded in fish fed with the SP7.5 diet compared to the control (70%). Pseudomonas, Lactobacillus, and Lentibacillus were the prevalent genera in the gut microbiota found in the metagenomics study and the abundances of the above microbiota gradually increased with the level of dietary S. platensis inclusion. Based on the findings of the study, 7.5–10% inclusion of S. platensis was the most recommendable in stinging catfish diet to improve growth performance, feed utilization, body composition, haematology, immunological response, and gut microbiology. However, based on the regression analysis the optimum inclusion level of S. platensis as a feed supplement was calculated to be 9.3–9.9% in stinging catfish.

In this study, methyl orange (MO) was removed from solution using rice husk charcoal (RHC) and acid modified rice husk charcoal (AMRHC). In batch adsorption mode, contact time (1–240 min), pH (3–10), adsorbent dose (1–30 g/L), and initial MO concentration (10–100 mg/L) were investigated. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were used to characterize the adsorbent's surface morphology and chemistry. At equilibrium, the highest removal of MO by RHC and AMRHC were 89 and 99%, respectively. Removal efficiency increased with increasing adsorbent dose, while the opposite was observed for adsorption capacity because of the availability of unsaturated adsorption sites. RHC and AMRHC were best described by the Freundlich and Langmuir isotherm models, with maximum adsorption capacities of 4.57 and 11.53 mg/g, respectively. The pseudo-second-order kinetic model fitted well for both adsorption and chemisorption, and the process was controlled by multi-step diffusion. Thermodynamic measurements proved that dye adsorption is a spontaneous endothermic process. HIGHLIGHTS MO adsorption was studied using RHC and AMRHC.; About 89 and 99% of MO dye were removed by RHC and AMRHC, respectively.; The maximum adsorption capacities were 4.57 and 11.53 mg/g, for RHC and AMRHC, respectively.; Kinetic data followed pseudo-second-order kinetics for both adsorbents.; The adsorption potential of both adsorbents for the treatment of MO dye was compared with other adsorbents which is cost effective.;

Aims We sought to compare the predictive power and reproducibility between minimum and maximum left atrial (LA) volume for the development of first atrial fibrillation (AF)/flutter. Methods and results This prospective study included 574 adults, mean age 74 ± 6 years, in sinus rhythm, and had no history or evidence of prior atrial arrhythmias. During a mean follow-up of 1.9 ± 1.2 years, 30 (5.2%) developed first AF/flutter. The 3-year risk estimates of freedom from AF/flutter by tertiles of minimum and maximum LA volumes were, respectively, 97, 87, and 74% (P P = 0.03). Minimum LA volume was incremental to clinical and other echocardiographic parameters of AF/flutter prediction [per tertile, hazard ratio (HR) 2.4], as was maximum LA volume (per tertile, HR 1.8) in a separate model. When both volumes were entered into the same model and adjusting for covariates, minimum but not maximum LA volume retained significance. However, in terms of interobserver reproducibility, maximum LA volume compared more favourably (mean difference 3.1 ± 7.1 vs. 7.4 ± 7.3 mL/m2). Conclusion Minimal LA volume was an independent predictor of first AF/flutter. Although it was marginally superior to maximal LA volume in terms of predictive ability, the interobserver variability was greater. [ABSTRACT FROM AUTHOR]

Nutritional programming is the idea that early nutrient contributions can influence organismal structure or function and is documented in a variety of vertebrates, yet studies in fish are largely lacking. Tilapia are an important foodfish, with global production having increased rapidly since the 1990s. They exhibit high disease-resistance and grow well on formulated feeds which makes them an ideal aquaculture species, however incorporating high quality proteins into feeds can be costly. As feed constitutes 50-70% of total production costs in aquaculture, reducing protein content could curb these costs and increase revenue. Thus, we examined the effects of feeding Nile tilapia (O. niloticus) fry a restricted protein diet for the first 7-21 days on growth, gut microbial flora, and the intestinal transcriptome. Fish were fed either a 25% restricted or 48% control crude protein starter (ST) diet for up to 21 days and then switched to a 25% or 38% control crude protein growout (GO) diet. Fish fed a 25% ST diet for 14 days followed by a 38% GO diet had significantly higher lengths and weights and better feed efficiency than fish fed the control 48% ST and 38% GO diet after 56 days of culture. Growth of fry on the 25% ST, 7-day/38% GO and the 25% ST,7-day/25% GO diets did not differ from the those fed the control protein diets, while fish fed the 25% ST diet for 21 days had significantly lower growth and survival rates. We observed no significant differences in either alpha or beta diversity of the gut microbial flora between diets, however species richness (Shannon Index) was higher in fry fed the 25% protein ST diet regardless of the GO diet. Similarly, fish fed the 25% ST diet for 14 days followed by the 38% GO diet had minimal changes to the intestinal transcriptome relative to fish fed the control 48% ST and 38% GO diet. However, those fed 25% ST and GO diets for the entire 56 days exhibited substantial differences in the gut transcriptome from other groups showing gene expression profiles characteristic of detrimental changes to gut physiology, protein metabolism and immune function. Results suggest protein restriction for up to 14 days early in development leads to enhanced growth and feed efficiency with minimal effects on gut microbes or intestinal function. Protein restriction beyond this period appears detrimental to fish growth and health as underscored by expression of disease related genes and higher mortality rates.

Outbreaks of African filoviruses often have high mortality, including more than 11,000 deaths among 28,562 cases during the West Africa Ebola outbreak of 2014–2016. Numerous studies have investigated the factors that contributed to individual filovirus outbreaks, but there has been little quantitative synthesis of this work. In addition, the ways in which the typical causes of filovirus outbreaks differ from other zoonoses remain poorly described. In this study, we quantify factors associated with 45 outbreaks of African filoviruses (ebolaviruses and Marburg virus) using a rubric of 48 candidate causal drivers. For filovirus outbreaks, we reviewed >700 peer-reviewed and gray literature sources and developed a list of the factors reported to contribute to each outbreak (i.e., a "driver profile" for each outbreak). We compare and contrast the profiles of filovirus outbreaks to 200 background outbreaks, randomly selected from a global database of 4463 outbreaks of bacterial and viral zoonotic diseases. We also test whether the quantitative patterns that we observed were robust to the influences of six covariates, country-level factors such as gross domestic product, population density, and latitude that have been shown to bias global outbreak data. We find that, regardless of whether covariates are included or excluded from models, the driver profile of filovirus outbreaks differs from that of background outbreaks. Socioeconomic factors such as trade and travel, wild game consumption, failures of medical procedures, and deficiencies in human health infrastructure were more frequently reported in filovirus outbreaks than in the comparison group. Based on our results, we also present a review of drivers reported in at least 10% of filovirus outbreaks, with examples of each provided. [ABSTRACT FROM AUTHOR]

Biological features including sex ratio, length-frequency distributions (LFDs), size at sexual maturity, spawning season, length-weight relationships (LWRs) and condition factor of Chanda nama were studied in the Old Brahmaputra River, Bangladesh. There was no significant difference in sex ratio. LFDs indicated no significant differences in size between the sexes. Size at sexual maturity was estimated at ~3.0 cm standard length. Monthly variations in gonadosomatic index indicate that the main spawning season is from July to August. The LWRs showed isometric growth in males and positive allometric growth in females. Fulton’s condition factor varied in both sexes and was attributed to variations in GSI with maturity. The findings of this study will be helpful to formulate conservation and management strategies of C. nama population in the Old Brahmaputra River and surrounding ecosystems.

Abstract Spawning season, recruitment, and growth of the freshwater prawn Macrobrachium lamarrei were studied in a perennial wetland, northeastern Bangladesh during October 2016 to September 2017. Spawning season was estimated based on the monthly variations of percent ovigerous females. Recruitment and growth were estimated using the time series of the length-frequency distributions. We compared the von Bertalanffy growth function (VBGF) and the Pauly and Gaschütz growth function (PGGF) to identify any seasonal oscillation in growth rate. Ovigerous females occurred almost throughout the year, indicating a prolonged spawning season with two peaks between March-April (minor peak) and June-September (major peak). Both males and females with modal size ~ 8.0 mm carapace length first recruited in October, which synchronized with the major peak spawning season. There was seasonality in growth rate; hence, PGGF was adopted as the best-fitting model to describe the growth of both sexes. The estimated equations were Lt = 17.86 (1- exp [-2.432 (t/12 - 0.072) - (1.766/2π) sin {2π (t/12 - 0.982)}] for males and Lt = 23.18 (1- exp [-1.342 (t/12 + 0.106) - (0.388/2π) sin {2π (t/12 - 0.209)}] for females. Sexual dimorphism was found with larger size in females than males. Longevity was estimated to be ~ 14 months for both sexes. These findings can be useful to formulate management measures for this prawn.

Municipal solid waste (MSW) management is a major concern for Bangladesh, given its high population density and increasing waste production rate. Conventional waste management methods, such as landfilling, result in high carbon emissions for the environment. With over 70% of MSW being organic, hydrothermal carbonization (HTC) has emerged as a promising technology for recovering energy and nutrients from such heterogeneous waste streams. This study aimed to compare the environmental effects of HTC coupled with electricity generation (HTC-EG) from MSW with traditional landfilling using life cycle assessment in the context of Bangladesh. The HTC-EG scenario showed lower environmental impacts in three out of five impact categories, specifically reducing climate change, freshwater ecotoxicity, and photochemical ozone formation. For a functional unit of 6000-ton MSW, HTC-EG reduces the climate change impact by 7.7 × 10 6  kg CO 2 eq. Additionally, HTC-EG has 46.77% less impact on freshwater ecotoxicity compared to landfilling and reduces the photochemical ozone formation impact by 1.86 × 10 4 NMVOC eq. However, the HTC-EG scenario leads to increased particulate matter formation and marine water eutrophication due to SO 2 , SO 3 , and PM2.5 emissions during hydrochar combustion and nitrate release from the liquid stream of the HTC reactor, respectively. Addressing these challenges through appropriate post-processing of flue gas from hydrochar combustion and HTC liquid streams could make HTC-EG a viable alternative to landfilling for MSW management in Bangladesh., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Labour is a normal physiological process considered by a progressive rise in frequency, intensity, and duration of uterine contractions resulting in effacement and dilatation of the cervix with descent of the fetus over the birth canal. Spontaneous or Induced labour has a significant role in the eventual mode of delivery and neonatal outcome. This study aims to compare mean duration of labour and maternofoetal outcome of spontaneous versus induced labour among nulliparous women. This was a prospective observational study conducted in the Department of Obstetrics and Gynecology in Bangabandhu Sheikh Mujib Medical University (BSMMU) from October 2016 to September 2017. The study was conducted in nulliparous women coming at term (38-41) weeks in active phase of labour (with cervical dilatation at least 4cm) either spontaneous or induced, both group of labouring women were monitored using modified WHO partograph. Outcomes measures include requirement of augmentation of labour with oxytocin, mean duration of labour, eventual mode of delivery, and the maternofoetal outcome. A total of 160 women were enrolled in this study into two groups. There was no difference in mean age group, but BMI and gestational age were noted significant (p=0.001) More women had spontaneous normal vaginal delivery among those with spontaneous labour (86.25% vs. 78.75%). The mean duration of the second stage of labour was significantly more in induced (17.65 minutes) than in spontaneous labour (14.78 minutes) with a significant P-value (p=0.001). The mean Apgar score between the groups showed almost same. No statistically significant difference was found (p>0.05). This study prevailed that, requirement of oxytocin for augmentation of labour and mean duration of labour was less in spontaneous group and most of the patient delivered vaginally but in induced group rate of caesarean was higher and requirement of oxytocin for labour augmentation was also more than spontaneous group. We observed that induced labour can be a safe procedure among nulliparous women if labour is monitored by modified WHO partograph.

Objectives: The main goal of this research was to develop better tablet formulations by utilizing solid dispersions (SDs) and coprocessing excipients composite to achieve a better release rate of poor water-soluble gliclazide., Methods: The solvent evaporation method made SDs of gliclazide with different carriers carplex 67, carplex 80, and carplex FPS 500 (weight ratio, 1:1). The drug release patterns of the SDs were all evaluated and optimized. The SDs were illustrated by using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray powder diffraction (PXRD), and Fourier transform infrared spectroscopy (FTIR). Tablet batches FGC-1 to 8 were made using gliclazide-carplex 67 solid dispersions (GC67-SDs) and the co-processed composite of excipients, namely starch-MCC-povidone (SMP) and lactose-MCC-povidone-sodium starch glycolate (LMPS), prepared with coprocessing technology. We evaluated these batches by conducting physicochemical tests and comparing them to the existing commercial brand., Results: In a water medium, the release of gliclazide from SDs peaked within the first 30 min, showing a roughly 5∼6-fold increase compared to plain gliclazide. This quick dissolution rate may be due to the amorphization of the drug, which improved the specific surface area, and increased wettability caused by the hydrophilic properties of carplex particles. This has been confirmed through SEM, DSC, FTIR, and PXRD analysis. All FGC formulations had satisfactory pre-compression factor results, while the post-compression parameters indicated good mechanical strength and homogeneity across the blend. All produced tablets met the weight variation, friability, and disintegration time limit set by the compendia. Through in vitro drug release testing, it was discovered that all FGC tablet batches had consistent and nearly identical release results compared to SDs of gliclazide. However, the FGC-5 to 8 batches containing LMPS composites were determined to be the most effective formulations. In the first 30 min in a water medium, the percentage of drug generated from the FGC-8 tablets involving GC67-SDs and co-processed composite LMPS-4 is approximately 3.5 times higher than the average release of currently marketed products (MPs). After storing the selected FGC tablet batches for three months at 40 °C and 75 % RH, there were no noticeable alterations in the amount of drug and drug release profiles across the batches., Conclusion: Based on these findings, it appears that using the carplex silica-based SDs approach, along with gliclazide and co-processing excipients composite, could result in significant benefits compared to the current commercial brands. This approach could be effectively utilized to create solid dosage forms for drugs that have low solubility in water., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)

An analysis was conducted on both freshwater, coastal and marine fish species to evaluate the concentrations of heavy metals, with the aim of assessing their levels and examining the potential health risks for humans linked to the consumption of contaminated fish. This study estimate concentrations of Cr, Fe, Cu, As, Cd and Pb in 60 individuals belonging to 20 species (10 species for freshwater and another 10 for coastal and marine fishes) by using Atomic Absorption Spectrophotometer. Metal concentrations of Cr, Fe, and Pb in freshwater fishes and Cr, Fe, As, and Pb in marine fishes were exceeded the maximum allowable concentration (MAC). The Estimated Daily Intake (EDI), Average Pollution Load Index (APLI), Target Hazard Quotient (THQ), Hazard Index (HI) and Target Cancer Risk (TCR) of heavy metals were determined for the assessment of human health risk. Ranking order of the values of EDI for freshwater fishes, coastal and marine fishes were Cd > Fe > Pb > Cr > Cu > As and Cd > Fe > Pb > Cr > As > Cu. Highest APLI value of 8.14 ( Puntius ticto ) that is seriously polluted and 3.003 observed in Otolichthoides pama in freshwater and marine fishes, respectively. THQ Pb and THQ As for all the fish species were exceed the safe limit (THQ>1) suggesting potential health risk to consumers. The hazard index for both the fish samples were exceeded the USEPA (United States Environmental Protection Agency) permitted risk level (HI > 1). The target carcinogenic risk value for Cr and As were crossed the USEPA standard limit (TCR> 1E-04), which denotes that continuous consumption of studied fishes may cause health risk to the consumers. On the other hand, sensitivity analysis of freshwater, coastal and marine fishes indicates that all the metal concentrations were responsible factor for health risk., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors. Published by Elsevier Ltd.)

To assess the acceptability and efficacy immediate Postpartum Intrauterine Contraceptive Device (PPIUCD) among parturient at Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh; this prospective interventional analytical study was conducted from January 2013 to June 2013. Contraceptive counseling was given to 370 eligible parturient after delivery during their postpartum hospitalization. A pre-tested structured data collection sheet was administered to all participants. Women who accepted the PPIUCD during their postpartum care were inserted with the device before discharge (within 48 hours). These women were followed up at 6 weeks for complications. The acceptance rate of PPIUCD and the percentage of actual insertions were recorded. The reasons for both acceptances and decline were also recorded. Of the 370 women counseled, a total of 132(35.67%) were inserted with PPIUCD. Parturient who had a short duration from their last child birth (2-3) were significantly associated with greater acceptance of the PPIUCD. Preference of other methods of contraception mainly short acting methods and the need to discuss with their partners were the most common reasons for declining use of PPIUCD. More than half (51.51%) of the women whom PPIUCD was inserted did so due to its long term effect. Immediate PPIUCD was demonstrably safe due to its low rates of complications. The common complications at six weeks interval were expulsion (5.8%) and lost strings (2.5%) and pelvic infection (1.66%). Acceptance of PPIUCD was relatively high probably because of its 'newness' in the community. For these women, the best opportunity to receive information about contraception is during child birth when they are in contact with healthcare providers. It is also important to emphasize and educate women on long term methods of contraception as majority of the women preferred short term methods despite their future pregnancy desires of more than three years. Couple counseling should also be promoted. The government needs to develop strategies to increase public awareness of the PPIUCD through different media sources.

This study was done to find out the maternal risk factors associated with congenital anomaly. This cross-sectional observational study was carried out in the Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital, Dhaka, Bangladesh from January 2011 to December 2011. During this study period 78 patients had pregnancy with congenital anomaly and delivered in the Department of Obstetrics and Gynaecology. Women with ultrasound report of congenitally abnormal fetus irrespective of gestational age were included. Clinical evaluation of neonates was done by experienced neonatologist. The frequency of congenital anomaly was 3.46%. Most of the women belong to age <35 years (97.43%). Congenital anomalies more commonly were seen in the primiparas (64.10%). Most frequent associated risk factor was the history of abortions (35.89%). Maternal infections during antenatal period were also high (15.58%). There were 58 males (74.35%) and 20 females (25.64%). There was positive history of delivery of congenital abnormal babies in 6 cases (7.6%). Mothers of eight cases (10.25%) had history of drug ingestion during pregnancy. Four cases (5.12%) of mothers had hypothyroidism and 6 cases of mothers (7.69%) had diabetes mellitus respectively.