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4,897 results on '"Hoos, A."'

451. Complete Remission of Widely Metastatic Human Epidermal Growth Factor Receptor 2–Amplified Pancreatic Adenocarcinoma After Precision Immune and Targeted Therapy With Description of Sequencing and Organoid Correlates

Author

Daniel A. King, Amber R. Smith, Gino Pineda, Michitaka Nakano, Flavia Michelini, S. Peter Goedegebuure, Sheeno Thyparambil, Wei-Li Liao, Aaron McCormick, Jihang Ju, Michele Cioffi, Xiuli Zhang, Jasreet Hundal, Malachi Griffith, Carla Grandori, Maddy Pollastro, Rachele Rosati, Astrid Margossian, Payel Chatterjee, Trevor Ainge, Marta Flory, Paolo Ocampo, Lee-may Chen, George A. Poultsides, Ari D. Baron, Daniel T. Chang, Joseph M. Herman, William E. Gillanders, Haeseong Park, William A. Hoos, Mike Nichols, George A. Fisher, and Calvin J. Kuo

Subjects
Cancer Research, Oncology
Published
2023
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465. Algorithm Configuration in the Cloud: A Feasibility Study

Author

Geschwender, Daniel, Hutter, Frank, Kotthoff, Lars, Malitsky, Yuri, Hoos, Holger H., Leyton-Brown, Kevin, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Pardalos, Panos M., editor, Resende, Mauricio G.C., editor, Vogiatzis, Chrysafis, editor, and Walteros, Jose L., editor

Published
2014
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466. Evaluating Instance Generators by Configuration

Author

Bayless, Sam, Tompkins, Dave A. D., Hoos, Holger H., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Pardalos, Panos M., editor, Resende, Mauricio G.C., editor, Vogiatzis, Chrysafis, editor, and Walteros, Jose L., editor

Published
2014
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467. AClib: A Benchmark Library for Algorithm Configuration

Author

Hutter, Frank, López-Ibáñez, Manuel, Fawcett, Chris, Lindauer, Marius, Hoos, Holger H., Leyton-Brown, Kevin, Stützle, Thomas, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Pardalos, Panos M., editor, Resende, Mauricio G.C., editor, Vogiatzis, Chrysafis, editor, and Walteros, Jose L., editor

Published
2014
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469. VPint: value propagation-based spatial interpolation

Author

Laurens Arp, Mitra Baratchi, and Holger Hoos

Subjects
Computer Networks and Communications, Computer Science Applications, Information Systems
Abstract

Given the common problem of missing data in real-world applications from various fields, such as remote sensing, ecology and meteorology, the interpolation of missing spatial and spatio-temporal data can be of tremendous value. Existing methods for spatial interpolation, most notably Gaussian processes and spatial autoregressive models, tend to suffer from (a) a trade-off between modelling local or global spatial interaction, (b) the assumption there is only one possible path between two points, and (c) the assumption of homogeneity of intermediate locations between points. Addressing these issues, we propose a value propagation-based spatial interpolation method called VPint, inspired by Markov reward processes (MRPs), and introduce two variants thereof: (i) a static discount (SD-MRP) and (ii) a data-driven weight prediction (WP-MRP) variant. Both these interpolation variants operate locally, while implicitly accounting for global spatial relationships in the entire system through recursion. We evaluated our proposed methods by comparing the mean absolute error, root mean squared error, peak signal-to-noise ratio and structural similarity of interpolated grid cells to those of 8 common baselines. Our analysis involved detailed experiments on a synthetic and two real-world datasets, as well as experiments on convergence and scalability. Empirical results demonstrate the competitive advantage of VPint on randomly missing data, where it performed better than baselines in terms of mean absolute error and structural similarity, as well as spatially clustered missing data, where it performed best on 2 out of 3 datasets.

Published
2022
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471. Automating Data Science.

Author

DE BIE, TIJL, DE RAEDT, LUC, HERNÁNDEZ-ORALLO, JOSÉ, HOOS, HOLGER H., SMYTH, PADHRAIC, and WILLIAMS, CHRISTOPHER K. I.

Subjects
AUTOMATION, DATA science, COMPUTER simulation, MACHINE learning, DATA quality
Abstract

The article examines automation of data science processes including data engineering, model building, and data exploration. The automation of machine learning processes used by data scientists is described along with elements of data engineering including data organization, data quality, and data transformation and the automation of computer model maintenance and monitoring is called for.

Published
2022
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472. COVERING NEW GROUND.

Author

Duggan, Ginger Gregg and Fox, Judith Hoos

Subjects
EXHIBITIONS, RUGS, CARPETS
Published
2024

473. Industrializing engineered autologous T cells as medicines for solid tumours

Author

Britten, Cedrik M., Shalabi, Aiman, and Hoos, Axel

Abstract

Cell therapy is one of the fastest growing areas in the pharmaceutical industry, with considerable therapeutic potential. However, substantial challenges regarding the utility of these therapies will need to be addressed before they can become mainstream medicines with applicability similar to that of small molecules or monoclonal antibodies. Engineered T cells have achieved success in the treatment of blood cancers, with four chimeric antigen receptor (CAR)-T cell therapies now approved for the treatment of B cell malignancies based on their unprecedented efficacy in clinical trials. However, similar results have not yet been achieved in the treatment of the much larger patient population with solid tumours. For cell therapies to become mainstream medicines, they may need to offer transformational clinical effects for patients and be applicable in disease settings that remain unaddressed by simpler approaches. This Perspective provides an industry perspective on the progress achieved by engineered T cell therapies to date and the opportunities and current barriers for accessing broader patient populations, and discusses the solutions and new development strategies required to fully industrialize the therapeutic potential of engineered T cells as medicines.

Published
2024
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487. Risk Factors for Enteric Pathogen Exposure among Children in Black Belt Region of Alabama, USA.

Author

Capone, Drew, Bakare, Toheedat, Barker, Troy, Chatham, Amy Hutson, Clark, Ryan, Copperthwaite, Lauren, Flemister, Abeoseh, Geason, Riley, Hoos, Emery, Kim, Elizabeth, Manoj, Alka, Pomper, Sam, Samodal, Christina, Smith, Simrill, Poole, Claudette, and Brown, Joe

Abstract

We collected stool from 488 children from 352 households living in the Black Belt region of Alabama, USA, where sanitation infrastructure is lacking. We used quantitative reverse transcription PCR to measure key pathogens in stool that may be associated with water and sanitation, as an indicator of exposure. We detected genes associated with >1 targets in 26% of specimens, most frequently Clostridioides difficile (6.6%), atypical enteropathogenic Escherichia coli (6.1%), and enteroaggregative E. coli (3.9%). We used generalized estimating equations to as)sess reported risk factors for detecting >1 pathogen in stool. We found no association between lack of sanitation and pathogen detection (adjusted risk ratio 0.95 [95% CI 0.55–1.7]) compared with specimens from children served by sewerage. However, we did observe an increased risk for pathogen detection among children living in homes with well water (adjusted risk ratio 1.7 [95% CI 1.1–2.5]) over those reporting water utility service. [ABSTRACT FROM AUTHOR]

Published
2023
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488. Introducing the enterprise data marketplace: a platform for democratizing company data.

Author

Eichler, Rebecca, Gröger, Christoph, Hoos, Eva, Stach, Christoph, Schwarz, Holger, and Mitschang, Bernhard

Subjects
MARKETPLACES, BIG data, SCIENCE projects, BUSINESS models, BUSINESS enterprises, DATA science
Abstract

In this big data era, multitudes of data are generated and collected which contain the potential to gain new insights, e.g., for enhancing business models. To leverage this potential through, e.g., data science and analytics projects, the data must be made available. In this context, data marketplaces are used as platforms to facilitate the exchange and thus, the provisioning of data and data-related services. Data marketplaces are mainly studied for the exchange of data between organizations, i.e., as external data marketplaces. Yet, the data collected within a company also has the potential to provide valuable insights for this same company, for instance to optimize business processes. Studies indicate, however, that a significant amount of data within companies remains unused. In this sense, it is proposed to employ an Enterprise Data Marketplace, a platform to democratize data within a company among its employees. Specifics of the Enterprise Data Marketplace, how it can be implemented or how it makes data available throughout a variety of systems like data lakes has not been investigated in literature so far. Therefore, we present the characteristics and requirements of this kind of marketplace. We also distinguish it from other tools like data catalogs, provide a platform architecture and highlight how it integrates with the company's system landscape. The presented concepts are demonstrated through an Enterprise Data Marketplace prototype and an experiment reveals that this marketplace significantly improves the data consumer workflows in terms of efficiency and complexity. This paper is based on several interdisciplinary works combining comprehensive research with practical experience from an industrial perspective. We therefore present the Enterprise Data Marketplace as a distinct marketplace type and provide the basis for establishing it within a company. [ABSTRACT FROM AUTHOR]

Published
2023
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489. CCR Translation for the Article from Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria

Author

Wolchok, Jedd D., primary, Hoos, Axel, primary, O'Day, Steven, primary, Weber, Jeffrey S., primary, Hamid, Omid, primary, Lebbé, Celeste, primary, Maio, Michele, primary, Binder, Michael, primary, Bohnsack, Oliver, primary, Nichol, Geoffrey, primary, Humphrey, Rachel, primary, and Hodi, F. Stephen, primary

Published
2023
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490. Supplementary Data from The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD-1, PD-L1, and CTLA-4

Author

Liu, Li, primary, Mayes, Patrick A., primary, Eastman, Stephen, primary, Shi, Hong, primary, Yadavilli, Sapna, primary, Zhang, Tianqian, primary, Yang, Jingsong, primary, Seestaller-Wehr, Laura, primary, Zhang, Shu-Yun, primary, Hopson, Chris, primary, Tsvetkov, Lyuben, primary, Jing, Junping, primary, Zhang, Shu, primary, Smothers, James, primary, and Hoos, Axel, primary

Published
2023
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491. Supplementary figure 2 from The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD-1, PD-L1, and CTLA-4

Author

Liu, Li, primary, Mayes, Patrick A., primary, Eastman, Stephen, primary, Shi, Hong, primary, Yadavilli, Sapna, primary, Zhang, Tianqian, primary, Yang, Jingsong, primary, Seestaller-Wehr, Laura, primary, Zhang, Shu-Yun, primary, Hopson, Chris, primary, Tsvetkov, Lyuben, primary, Jing, Junping, primary, Zhang, Shu, primary, Smothers, James, primary, and Hoos, Axel, primary

Published
2023
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492. Figure S1 from Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma

Author

Peng, Weiyi, primary, Williams, Leila J., primary, Xu, Chunyu, primary, Melendez, Brenda, primary, McKenzie, Jodi A., primary, Chen, Yuan, primary, Jackson, Heather L., primary, Voo, Kui S., primary, Mbofung, Rina M., primary, Leahey, Sara Elizabeth, primary, Wang, Jian, primary, Lizee, Gregory, primary, Tawbi, Hussein A., primary, Davies, Michael A., primary, Hoos, Axel, primary, Smothers, James, primary, Srinivasan, Roopa, primary, Paul, Elaine M., primary, Yanamandra, Niranjan, primary, and Hwu, Patrick, primary

Published
2023
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493. Table S1 from Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma

Author

Peng, Weiyi, primary, Williams, Leila J., primary, Xu, Chunyu, primary, Melendez, Brenda, primary, McKenzie, Jodi A., primary, Chen, Yuan, primary, Jackson, Heather L., primary, Voo, Kui S., primary, Mbofung, Rina M., primary, Leahey, Sara Elizabeth, primary, Wang, Jian, primary, Lizee, Gregory, primary, Tawbi, Hussein A., primary, Davies, Michael A., primary, Hoos, Axel, primary, Smothers, James, primary, Srinivasan, Roopa, primary, Paul, Elaine M., primary, Yanamandra, Niranjan, primary, and Hwu, Patrick, primary

Published
2023
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494. Supplementary figure 1 from The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD-1, PD-L1, and CTLA-4

Author

Liu, Li, primary, Mayes, Patrick A., primary, Eastman, Stephen, primary, Shi, Hong, primary, Yadavilli, Sapna, primary, Zhang, Tianqian, primary, Yang, Jingsong, primary, Seestaller-Wehr, Laura, primary, Zhang, Shu-Yun, primary, Hopson, Chris, primary, Tsvetkov, Lyuben, primary, Jing, Junping, primary, Zhang, Shu, primary, Smothers, James, primary, and Hoos, Axel, primary

Published
2023
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495. Supplementary tables S1-S6 from The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD-1, PD-L1, and CTLA-4

Author

Liu, Li, primary, Mayes, Patrick A., primary, Eastman, Stephen, primary, Shi, Hong, primary, Yadavilli, Sapna, primary, Zhang, Tianqian, primary, Yang, Jingsong, primary, Seestaller-Wehr, Laura, primary, Zhang, Shu-Yun, primary, Hopson, Chris, primary, Tsvetkov, Lyuben, primary, Jing, Junping, primary, Zhang, Shu, primary, Smothers, James, primary, and Hoos, Axel, primary

Published
2023
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496. Supplementary Figure legends from Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma

Author

Peng, Weiyi, primary, Williams, Leila J., primary, Xu, Chunyu, primary, Melendez, Brenda, primary, McKenzie, Jodi A., primary, Chen, Yuan, primary, Jackson, Heather L., primary, Voo, Kui S., primary, Mbofung, Rina M., primary, Leahey, Sara Elizabeth, primary, Wang, Jian, primary, Lizee, Gregory, primary, Tawbi, Hussein A., primary, Davies, Michael A., primary, Hoos, Axel, primary, Smothers, James, primary, Srinivasan, Roopa, primary, Paul, Elaine M., primary, Yanamandra, Niranjan, primary, and Hwu, Patrick, primary

Published
2023
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