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935 results on '"Hirano, Toshio"'

467. NetPath: a public resource of curated signal transduction pathways

Author

Kandasamy, Kumaran, Mohan, S Sujatha, Raju, Rajesh, Keerthikumar, Shivakumar, Kumar, Ghantasala, Venugopal, Abhilash, Telikicherla, Deepthi, Navarro, J Daniel, Mathivanan, Suresh, Pecquet, Christian, Gollapudi, Sashi, Tattikota, Sudhir, Mohan, Shyam, Padhukasahasram, Hariprasad, Subbannayya, Yashwanth, Goel, Renu, Jacob, Harrys, Zhong, Jun, Sekhar, Raja, Nanjappa, Vishalakshi, Balakrishnan, Lavanya, Subbaiah, Roopashree, Ramachandra, YL, Rahiman, B Abdul, Prasad, TS Keshava, Lin, Jian-Xin, Houtman, Jon, Desiderio, Stephen, Renauld, Jean-Christophe, Constantinescu, Stefan, Ohara, Osamu, Hirano, Toshio, Kubo, Masato, Singh, Sujay, Khatri, Purvesh, Draghici, Sorin, Bader, Gary, Sander, Chris, Leonard, Warren, and Pandey, Akhilesh

Abstract

We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.

Published
2010
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468. Enhanced Expression of Interleukin-6 in Primary Human Renal Cell Carcinomas

Author

Takenawa, Jun, Kaneko, Yoshiyuki, Fukumoto, Manabu, Fukatsu, Atsushi, Hirano, Toshio, Fukuyama, Hidenao, Nakayama, Hiroki, Fujita, Jun, and Yoshida, Osamu

Abstract

We have demonstrated interIeukin-6 (IL-6) production by human renal carcinoma cells. The IL-6 gene expression was detected by Northern blot analysis in 22 of 43 primary renal cell carcinoma tissues and in five of seven renal cell carcinoma cell lines. Immunohistochemical analysis confirmed the expression of IL-6 by the tumor cells. Patients with a high-level expression of IL-6 had significantly greater incidences of lymph node metastasis and a larger increase in serum C-reactive protein than those without it. We have also probed for the presence of IL-6 receptor by Northern blot analysis; we detected this receptor in 11 of the 43 primary renal cell carcinoma tissues but in none of the seven renal cell carcinoma cell lines. However, by use of the complementary DNA-polymerase chain reaction, the IL-6 receptor transcript was detected in all specimens, including the seven cell lines. No expression of the in-terleukin-3 (IL-3) gene was identified in any of the 43 primary renal cell tumors. These data provide evidence that IL-6 and its receptor may play a role in promoting the transformation and/or proliferation of renal cell carcinomas as well as in the development of symptoms. [J Natl Cancer Inst 83:1668-1672, 1991]

Published
1991
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469. Gab11 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation.

Author

Ti Cai, Nishida, Keigo, Hirano, Toshio, and Khavari, Paul A.

Subjects
*EPIDERMAL growth factor, *RENIN-angiotensin system, *CELL differentiation
Abstract

Investigates the promotion of Ras/MAPK regulation of epidermal growth and differentiation using Gab1 and SHP-2. Reduction of active level of basal levels active Ras and downstream MAPK proteins; Demonstration of hypoplasia; Enhancement of differentiation.

Published
2002
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470. Activation of Stat3 by v-Src Is through a Ras-Independent Pathway.

Author

Jan-Jan Liu, Nakajima, Koichi, Hirano, Toshio, and Hsin-Fang Yang-Yen

Subjects
*ONCOGENES, *TYROSINE, *PHOSPHORYLATION, *PROTEINS, *PROTEIN-tyrosine kinases
Abstract

V-Src induces tyrosine phosphorylation of various cellular proteins and activates a number of signaling molecules including the Jak family of proteins tyrosine kinases and Stat (signal transducers and activators of transcription) proteins. Many cellular effects elicited by v-Src are mediated through Ras, a molecular switch linking growth factor receptors and non-receptor tyrosine kinases to many downstream effectors. In this report, we demonstrated that v-H-Ras and v-Src both induced cellular transformation. However, the activation of Jak1 and Stat3 were only observed in v-Src transformed cells. Using reporter gene assays, we further showed that activation of Stat3 and possibly of Jak1 by v-Src were mediated through a Ras-independent pathway. As Stat3 activation has recently been shown to be required for cellular transformation by v-Src, our results suggest that activation of the Jak-Stat pathway may serve as a modulator in some but not all transformation processes. [ABSTRACT FROM AUTHOR]

Published
1998
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