434 results on '"Boolean logic"'
Search Results
402. The arbitration-extension hypothesis : A hierarchical interpretation of the functional organization of the basal ganglia
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Kamali Sarvestani, Iman, Lindahl, Mikael, Hellgren Kotaleski, Jeanette, Ekeberg, Örjan, Kamali Sarvestani, Iman, Lindahl, Mikael, Hellgren Kotaleski, Jeanette, and Ekeberg, Örjan
- Abstract
Based on known anatomy and physiology, we present a hypothesis where the basal ganglia motor loop is hierarchically organized in two main subsystems: the arbitration system and the extension system. The arbitration system, comprised of the subthalamic nucleus, globus pallidus, and pedunculopontine nucleus, serves the role of selecting one out of several candidate actions as they are ascending from various brain stem motor regions and aggregated in the centromedian thalamus or descending from the extension system or from the cerebral cortex. This system is an action-input/action-output system whose winner-take-all mechanism finds the strongest response among several candidates to execute. This decision is communicated back to the brain stem by facilitating the desired action via cholinergic/glutamatergic projections and suppressing conflicting alternatives via GABAergic connections. The extension system, comprised of the striatum and, again, globus pallidus, can extend the repertoire of responses by learning to associate novel complex states to certain actions. This system is a state-input/action-output system, whose organization enables it to encode arbitrarily complex Boolean logic rules using striatal neurons that only fire given specific constellations of inputs (Boolean AND) and pallidal neurons that are silenced by any striatal input (Boolean OR). We demonstrate the capabilities of this hierarchical system by a computational model where a simulated generic "animal" interacts with an environment by selecting direction of movement based on combinations of sensory stimuli, some being appetitive, others aversive or neutral. While the arbitration system can autonomously handle conflicting actions proposed by brain stem motor nuclei, the extension system is required to execute learned actions not suggested by external motor centers. Being precise in the functional role of each component of the system, this hypothesis generates several readily testable predictions., QC 20111004
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- 2011
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403. Sistema de inferencia difusa basado en relaciones booleanas
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Espitia Cuchango, Helbert Eduardo, Soriano Méndez, José Jairo, Espitia Cuchango, Helbert Eduardo, and Soriano Méndez, José Jairo
- Abstract
Este documento describe la estructura de un sistema de inferencia difusa basado en relaciones booleanas. La teoría relacionada con lógica y conjuntos booleanos es una buena herramienta para el diseño de automatismos y sistemas digitales. Una variación con la cual se busca mejorar los sistemas basados en automatismos consiste en emplear conjuntos difusos en lugar de booleanos. Lo anterior se realiza con el objetivo de tener una acción continua en el actuador del automatismo. Al realizar esta variación y al aplicar la metodología de diseño de los sistemas de automatismos, aparecen los sistemas de inferencia difusa basados en relaciones booleanas. Aunque inicialmente esta propuesta se realizó considerando sistemas de automatismos, se observa que es posible extenderla a sistemas de inferencia difusa., This paper describes a fuzzy-inference system that is based on Boolean relations. Boolean logic is recognized as a useful tool for automata and digital systems design. An alternative to improve automata systems consists in smoothing the crisp sets into fuzzy sets. The purpose to perform a continuous action on the actuator; by making this change, a new fuzzy inference system based on Boolean relations arises. Although the original proposal was formulated so as to consider automata systems, it is clear that this approach can be extended to more general fuzzy inference systems.
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- 2010
404. Deducibility Theorems in Boolean Logic
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Smarandache, Florentin
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Boolean Logic ,TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES ,General Mathematics (math.GM) ,TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS ,Computer Science::Logic in Computer Science ,FOS: Mathematics ,axiom ,Mathematics - General Mathematics ,Hardware_LOGICDESIGN ,03E40 - Abstract
In this paper we give two theorems from the Propositional Calculus of the Boolean Logic with their consequences and applications and we prove them axiomatically., Comment: 4 pages
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- 2006
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405. Enhanced Specification and Verification for Timed Planning
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NATIONAL UNIV OF SINGAPORE, Dong, Jin S., Zhang, Xian, Sun, Jun, NATIONAL UNIV OF SINGAPORE, Dong, Jin S., Zhang, Xian, and Sun, Jun
- Abstract
In this project, the PI introduced a specification language named Timed Planning, which is an extension of Timed CSP with the capability of stating more complicated timing behaviors for processes and events. They also developed a reasoning mechanism for Timed Planning based on Constraint Logic Programming. They model the Pearl Harbor Attack plan to demonstrate the capability of their approach for modeling time based military plans with critical timing constraints. Their approach is capable to handle the extended job-shop scheduling problems. In their work, the job shop scheduling problems with extensions can be naturally modeled as Timed Planning processes, whose complete executions correspond to feasible schedules. By using CLP based reasoning mechanism, the optimal scheduler which is an execution with the minimum execution time, can be found.
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- 2009
406. A comprehensive multi-criteria decision making-based land capability assessment for municipal solid waste landfill sitting.
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Soroudi M, Omrani G, Moataar F, and Jozi SA
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- Cities, Iran, Decision Making, Solid Waste analysis, Waste Disposal Facilities standards
- Abstract
The municipal waste management has always been one of the most challenging environmental concerns. Today, although different strategies have been developed, sanitary disposal of municipal waste is still considered as one of the most widely used alternatives, especially in developing countries such as Iran. To investigate the land capability of Pishva, for landfill sitting, the important criteria were categorized in two groups of ecological and socioeconomic and then a multi-criteria decision-making model was used with decision-making trial and evaluation decision-making trial and evaluation (DEMATEL)-analytical network process (ANP) approach. First and foremost, the interaction of criteria was determined implementing DEMATEL. It was found that the soil depth criterion not only is the most effective but also is the most influenced one. Moreover, ANP structure was developed to weigh the criteria. In comparison to socioeconomic criteria, ecological ones play a more significant role. Afterwards, factor maps and constraints were standardized using fuzzy and Boolean logic, respectively, and all layers were combined to generate the final capability map of Pishva applying WLC method. The capability map showed that 71% of the area is not capable of landfilling, and only 5% of Pishva has a high capability. The results proved the great effectiveness of the methods proposed in this study.
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- 2018
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407. Modeling Rho GTPase Dynamics Using Boolean Logic.
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Hetmanski JHR, Schwartz JM, and Caswell PT
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- Animals, Humans, Computer Simulation, Models, Biological, Signal Transduction physiology, Software, rac1 GTP-Binding Protein metabolism, rhoA GTP-Binding Protein metabolism
- Abstract
Rho GTPases such as the canonical Rac1 and RhoA are embedded within complex networks requiring the precise spatiotemporal balance of GEFs, GAPs, upstream regulators, growth factors, and downstream effectors. A modeling approach based on Boolean logical networks is becoming an increasingly relied-upon tool to harness this complexity and elucidate further details regarding Rho GTPase signaling. In this methods chapter we describe how to initially create appropriately sized networks based on literature evidence; formalize these networks with reactions based on Boolean logical operators; implement the network into appropriate simulation software (CellNetAnalyzer); and finally perform simulations and make novel, testable predictions via in silico knockouts. Given this predictive power, the Boolean approach may ultimately help to highlight potential future avenues of experimental research.
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- 2018
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408. On a natural fuzzification of Boolean logic
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Bisdorff, Raymond
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Fuzzy logic ,Mathematics [G03] [Physical, chemical, mathematical & earth Sciences] ,Mathématiques [G03] [Physique, chimie, mathématiques & sciences de la terre] ,Fuzzy set theory ,Boolean logic - Abstract
In this communication we propose two logically sound fuzzification and defuzzifi- cation techniques for implementing a credibility calculus on a set of propositional expressions. Both rely on a credibility evaluation domain using the rational in- terval [−1, 1] where the sign carries a split truth/falseness denotation. The first technique implements the classic min and max operators where as the second technique implements Bochvar-like operators. Main interest in the communica- tion is given to the concept of natural fuzzification of a propositional calculus. A formal definition is proposed and the demonstration that both fuzzification techniques indeed verify this definition is provided.
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- 2004
409. Determination of precedence hypergraphs for assembly line design and assembly line balancing
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Relange, Laurent, Laboratoire d'automatique de Besançon (LAB), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Franche-Comté, Jean-Michel Henrioud(jean-michel.henrioud@ens2m.fr), and Azema, Martine
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[SPI.AUTO] Engineering Sciences [physics]/Automatic ,boolean logic ,Assembly ,Assemblage ,graphe de précédence ,hypergraph ,logique ,precedence graph ,hypergrahe ,[SPI.AUTO]Engineering Sciences [physics]/Automatic - Abstract
After a short introduction to the assembly systems and different representations of assembly process, this work presents three types of models : assembly graphs, precedence graphs and ASTD. The precedence graphs being currently used by assembly line balancing methods in order to assembly systems determination, the objective of this work is to propose an easy and effective method of precedence graphs generation from a set of assembly sequences. Two methods of generation of precedence graphs are presented here : the first one based on graph transformations and the second one based directly boolean logic. The graph transformation method gives a precedence graph if the set of the assembly sequences can be represented by one and only one precedence graph. In the opposite cas, with some ameliorations, it is possible to obtain either a set of precedence graphs or a single precedence hypergraph. With the second method, we can obtain directly a set of precedence graphs or of precedence hypergraphs depending upon the set of assembly sequences. The evaluation of complexity of respective algorithms allows to say that they are polynomial., Après une rapide présentation des systèmes d'assemblage et des différentes représentations des processus d'assemblage, ce travail de recherche présente plus précisément trois grands types de modélisation : les graphes d'assemblage, les graphes de précédence et les ASTD. Les graphes de précédence étant très utilisés avec les méthodes d'équilibrage ou de conception des lignes d'assemblage, l'objectif de ce travail est de proposer une méthode de génération des graphes de précédence simple et efficace à partir d'un ensemble de graphes d'assemblage préalablement établis. Deux méthodes de génération de graphe de précédence sont proposées dans ce travail : une par transformation de graphes et une directement basée sur la logique booléenne. La méthode par transformation de graphes permet d'obtenir un graphe de précédence si l'ensemble des séquences d'enchaînement peut être représenté par un unique graphe de précédence. Dans le cas contraire, avec les améliorations apportées à la méthode, il est possible d'obtenir soit un ensemble de graphes de précédence soit un hypergraphe de précédence. La deuxième de ces méthodes permet d'obtenir directement un ensembl e de graphes de précédence ou d'hypergraphes de précédence selon le niveau de complexité du problème. Un calcul des complexités des algorithmes respectifs montre qu'ils sont polynomiaux.
- Published
- 2002
410. Lotfi Zadeh, Fuzzy Logic Incorporating Real-World Vagueness. CSISS Classics
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Agarwal, Pragya
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fuzzy sets ,semantic concepts ,Engineering ,linguistic variables ,Physical Sciences and Mathematics ,regions ,Social and Behavioral Sciences ,complex systems ,boundaries ,multi-valued logic ,decision making ,infinite-valued logic ,Boolean logic - Abstract
Zadeh's paper on fuzzy sets introduced the concept of a class with unsharp boundaries and provided a new qualitative approach to the analysis of complex systems in which linguistic rather than numerical variables are employed to describe system behavior and performance.
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- 2002
411. Boolean logic and character state identity: pitfalls of character coding in metazoan cladistics
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Ronald A. Jenner and Naturalis journals & series
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Theoretical computer science ,Phylogenetic tree ,nonadditive binary coding ,Metazoa ,Morphological variation ,metazoan cladistics ,Biology ,character state identity ,absence/presence coding ,Cladistics ,Boolean logic ,Animal Science and Zoology ,Character coding ,Ecology, Evolution, Behavior and Systematics ,character coding ,Coding (social sciences) - Abstract
A critical study of the morphological data sets used for the most recent analyses of metazoan cladistics exposes a rather cavalier attitude towards character coding. Binary absence/presence coding is ubiquitous, but without any explicit justification. This uncompromising application of Boolean logic in character coding is remarkable since several recent investigations have nominated absence/presence coding as the most problematic coding method available for standard cladistic analysis. Moreover, the prevalence of unspecified “absence” character states in the published data sets introduces a discrepancy between the theoretical foundations of phylogenetic parsimony and current practices in metazoan cladistics. Because phylogenetic parsimony assumes transformation of character states, its effective operation breaks down when not all character states are carefully delimited. Examples of resulting meaningless character state transformations are discussed in two categories: 1) when unspecified “absence” states are plesiomorphic; and 2) when unspecified “absence” states are apomorphic (character reversals). To facilitate future progress in metazoan cladistics, the mandatory link between comparative morphology and character coding needs to be reestablished through a more explicit study of morphological variation prior to character coding, and through a more explicitly experimental approach to character coding.
- Published
- 2002
412. QuBE: A System for Deciding Quantified Boolean Formulas Satisfiability
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Enrico Giunchiglia, Armando Tacchella, and Massimo Narizzano
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Discrete mathematics ,Automated Reasoning ,Decision Procedures ,Boolean Logic ,TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES ,Theoretical computer science ,Computer science ,True quantified Boolean formula ,Maximum satisfiability problem ,Monotonic function ,Satisfiability - Abstract
Deciding the satisfiability of a Quantified Boolean Formula (QBF) is an important research issue in Artificial Intelligence. Many reasoning tasks involving planning [1], abduction, reasoning about knowledge, non monotonic reasoning [2], can be directly mapped into the problem of deciding the satisfiability of a QBF. In this paper we present QuBE, a system for deciding QBFs satisfiability.
- Published
- 2001
413. Under the Sign of Boole
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Marcus, Solomon
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language and algebra ,Boolean logic ,thought - Abstract
The note presents some personal thoughts on Professor S. Rudeanu's scientific and human personality. 1 C.S.Calude and G.Stefanescu (eds.). Automata, Logic, and Computability. Special issue dedicated to Professor Sergiu Rudeanu Festschrift.
- Published
- 2000
414. Boolean logic and character state identity: pitfalls of character coding in metazoan cladistics
- Author
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Jenner, (Ronald A.) and Jenner, (Ronald A.)
- Abstract
A critical study of the morphological data sets used for the most recent analyses of metazoan cladistics exposes a rather cavalier attitude towards character coding. Binary absence/presence coding is ubiquitous, but without any explicit justification. This uncompromising application of Boolean logic in character coding is remarkable since several recent investigations have nominated absence/presence coding as the most problematic coding method available for standard cladistic analysis. Moreover, the prevalence of unspecified “absence” character states in the published data sets introduces a discrepancy between the theoretical foundations of phylogenetic parsimony and current practices in metazoan cladistics. Because phylogenetic parsimony assumes transformation of character states, its effective operation breaks down when not all character states are carefully delimited. Examples of resulting meaningless character state transformations are discussed in two categories: 1) when unspecified “absence” states are plesiomorphic; and 2) when unspecified “absence” states are apomorphic (character reversals). To facilitate future progress in metazoan cladistics, the mandatory link between comparative morphology and character coding needs to be reestablished through a more explicit study of morphological variation prior to character coding, and through a more explicitly experimental approach to character coding.
- Published
- 2002
415. Neural logic : theory and implementation
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Bohossian, Vasken Z.
- Subjects
threshold logic ,threshold circuits ,boolean circuits ,neural networks ,neuromorphic engineering ,Computation and Neural Systems ,circuit complexity ,boolean logic - Abstract
NOTE: Text or symbols not renderable in plain ASCII are indicated by [...]. Abstract is included in .pdf document. Human brains are by far superior to computers in solving hard problems like combinatorial optimization and image and speech recognition, although their basic building blocks are several orders of magnitude slower. This observation has boosted interest in the field of artificial networks [20], [37]. The latter are built by interconnecting artificial neurons whose behavior is inspired by that of biological neurons. In this thesis we consider the Boolean version of an artificial neuron, namely, a Linear Threshold (LT) element, which computes a neural-like Boolean function of n binary inputs [32]. An LT element outputs the sign of a weighted sum of its Boolean inputs. The main issues in the study of networks (circuits) consisting of LT elements, called LT circuits, include the estimation of their computational capabilities and limitations and the comparison of their properties with those of traditional Boolean logic circuits based on AND, OR and NOT gates (called AON circuits). For example, there is a strong evidence that LT circuits are more efficient than AON circuits in implementing a number of important functions including the addition, product and division of integers [44], [45]. It is easy to see that an LT element is more powerful than an AON gate, simply because of the freedom one has in selecting the weights. Indeed, different choices of weights produce different Boolean functions. As a matter of fact, the number of n-input Boolean functions that can be implemented by a single LT element is of the order of […], [42], [22]. That additional power comes at the cost of added complexity. Some LT functions require weights that are very different in magnitude, potentially rendering difficult hardware or software implementations of the corresponding LT elements. For that reason, theoretical research in the field of LT circuits has focused on the weights, in particular the power of LT elements with restricted weights. As early as 1971, Muroga, [32], proved that any linear threshold element can be implemented with integer weights. That is, by restricting the magnitudes of the weights to natural numbers, one does not lose any power of the original LT element. We generalize this result to arbitrary subsets of the set of real numbers. For example, we show that one can restrict the weights to be the square of integers, and still be able to realize all LT functions. We ask the following question. What are the conditions on the subset […] which guarantee that all LT functions can be implemented with weights drawn from it? Another aspect of the complexity of the weights is their growth as the number of inputs increases. It has been shown [17], [33], [38], [43] that there exist linear threshold functions that can be implemented by a single threshold element with exponentially growing weights, but cannot be implemented by a threshold element with smaller polynomialy growing weights. In light of that result the above question was dealt with by defining a class, called […], within the set of linear threshold functions: the class of functions with "small" (i.e. polynomialy growing) weights [43]. We focus on a single LT element. Our contribution consists in two novel methods for constructing threshold functions with minimal weights, which allow us to fill up the gap between polynomial and exponential weight growth by further refining the separation. Namely, we prove that the class of linear threshold functions with polynomial-size weights can be divided into subclasses […], according to the degree, d, of the polynomial. In fact, we prove a more general result-—that there exists a linear threshold function for any arbitrary number of inputs and any weight size. Even though some LT functions require weights that grow exponentially with the number of input variables, it has been shown recently, in [13], [18], that such functions can be replaced by a two-layer circuit composed of LT gates with polynomially growing, i.e., small weights. We improve the best known bound on the size of that circuit, presented in [18] by focusing on a particular function with large coefficients. We also derive explicit two-layer circuits. Two layer LT circuits are in general composed of different linear threshold elements, but for some useful Boolean functions, such as parity, addition and product, the gates of the first layer are almost identical. To take advantage of this fact we introduce a new Boolean computing element. Instead of the sign function, it computes an arbitrary (with polynomialy many transitions) Boolean function of the weighted sum of its inputs. We call the new computing element an LTM element, which stands for Linear Threshold with Multiple transitions. The advantages of LTM become apparent in the context of VLSI implementation. Indeed, this new model reduces the layout area of the corresponding symmetric function from […] to O(n). We present a VLSI implementations of both LT and LTM elements. Two kinds of elements were fabricated, programmable and hardwired. The programmable elements use the charge on a floating gate in order to store the values of the weights. For many years, the topic of linear threshold logic, has been approached in two different ways, theory, i.e. computational circuit complexity, [38], [56], and hardware implementation, [48], [40]. Surprisingly, there has been very little interaction between those two approaches. As a whole, the present thesis is one step towards establishing a connection between the theory and implementation of threshold circuits. Its contributions are at three levels. At the theoretical level, new classes of functions such as […] and LTM are defined and their computational power is estimated. At the algorithmic level, we show how to convert real weights to weights drawn from arbitrary subset of the real numbers, e.g., integer weights, we also show how to construct LT functions with minimal weights, and finally we present an algorithm that produces an […] circuit (circuit composed of gates with small weights), that computes the comparison function, COMP. We also present LTM circuits computing useful functions, such as XOR, ADD, PRODUCT. At the implementation level, we show the design, layout and testing of the VLSI implementation of LT and LTM. Establishing a connection between the theoretical and practical aspects of threshold logic will profit both domains by providing solutions for practical problems and by defining new theoretical questions inspired by implementation issues.
- Published
- 1998
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416. Editors' Introduction.
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Barr, Pamela S. and Robinson, Sandra
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MANAGEMENT science ,ORGANIZATIONAL behavior ,MANAGEMENT ,QUALITATIVE research ,CASE method (Teaching) - Abstract
In this article, the authors focus on several issues related to management science. Qualitative methods, cross-case comparisons in particular, have proven to be valuable approaches to research in management. Significant insights into management theory have been gained from the careful comparison of detailed studies of management practices and organizational phenomena. Making sense of hundreds of pages of transcripts, field notes, and other information, and trying to develop an understanding of the complex phenomena revealed in the cases, is an often overwhelming task that researchers face with little formal methodological guidance. The major contribution of this article is in highlighting the potential benefits to be gained by formalizing some aspects of qualitative analysis. It has been argued elsewhere that the lack of formal structured analysis procedures in most qualitative methods, including cross-case comparisons, is what allows the researcher to gain new theoretical insights.
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- 2004
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417. Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate
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Beata Hat, Marek Kochańczyk, Marta N. Bogdał, and Tomasz Lipniacki
- Subjects
Bistability ,Logic ,Systems biology ,Regulator ,bcl-X Protein ,Bcl-xL ,Apoptosis ,Models, Biological ,Cell survival ,Computers, Molecular ,Bcl-2 family ,Structural Biology ,Modelling and Simulation ,Protein kinase B ,Molecular Biology ,biology ,Signaling pathway ,Applied Mathematics ,Computer Science Applications ,Cell biology ,Boolean logic ,Modeling and Simulation ,Logic gate ,biology.protein ,bcl-Associated Death Protein ,Signal transduction ,Ordinary differential equations ,Research Article ,Signal Transduction - Abstract
Background Apoptosis is a tightly regulated process: cellular survive-or-die decisions cannot be accidental and must be unambiguous. Since the suicide program may be initiated in response to numerous stress stimuli, signals transmitted through a number of checkpoints have to be eventually integrated. Results In order to analyze possible mechanisms of the integration of multiple pro-apoptotic signals, we constructed a simple model of the Bcl-2 family regulatory module. The module collects upstream signals and processes them into life-or-death decisions by employing interactions between proteins from three subgroups of the Bcl-2 family: pro-apoptotic multidomain effectors, pro-survival multidomain restrainers, and pro-apoptotic single domain BH3-only proteins. Although the model is based on ordinary differential equations (ODEs), it demonstrates that the Bcl-2 family module behaves akin to a Boolean logic gate of the type dependent on levels of BH3-only proteins (represented by Bad) and restrainers (represented by Bcl-xL). A low level of pro-apoptotic Bad or a high level of pro-survival Bcl-xL implies gate AND, which allows for the initiation of apoptosis only when two stress stimuli are simultaneously present: the rise of the p53 killer level and dephosphorylation of kinase Akt. In turn, a high level of Bad or a low level of Bcl-xL implies gate OR, for which any of these stimuli suffices for apoptosis. Conclusions Our study sheds light on possible signal integration mechanisms in cells, and spans a bridge between modeling approaches based on ODEs and on Boolean logic. In the proposed scheme, logic gates switching results from the change of relative abundances of interacting proteins in response to signals and involves system bistability. Consequently, the regulatory system may process two analogous inputs into a digital survive-or-die decision.
- Published
- 2013
418. Realization of Functional Complete Stateful Boolean Logic in Memristive Crossbar.
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Li Y, Zhou YX, Xu L, Lu K, Wang ZR, Duan N, Jiang L, Cheng L, Chang TC, Chang KC, Sun HJ, Xue KH, and Miao XS
- Abstract
Nonvolatile stateful logic computing in memristors is a promising paradigm with which to realize the unity of information storage and processing in the same physical location that has shown great feasibility for breaking the von Neumann bottleneck in traditional computing architecture. How to reduce the computational complexity of memristor-based logic functions is a matter of concern. Here, based on a general logic expression, we proposed a method to implement the arbitrary logic of complete 16 Boolean logic in two steps with one memristor in the crossbar architecture. A representative functional complete NAND logic is successfully experimentally demonstrated in the filamentary Ag-AgGeTe-Ta memristors to prove the validity of our method. We believe our work may promote the development of the revolutionary logic in memory architectures.
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- 2016
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419. Modelling GTPase dynamics to understand RhoA-driven cancer cell invasion.
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Hetmanski JH, Schwartz JM, and Caswell PT
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- ErbB Receptors metabolism, Extracellular Matrix metabolism, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms pathology, Pseudopodia metabolism, Signal Transduction, Cell Movement, Models, Biological, Neoplasms metabolism, rho GTP-Binding Proteins metabolism, rhoA GTP-Binding Protein metabolism
- Abstract
Metastasis, initially driven by cells migrating and invading through the local environment, leads to most cancer-associated deaths. Cells can use a variety of modes to move in vitro, all of which depend on Rho GTPases at some level. While traditionally it was thought that Rac1 activity drives protrusive lamellipodia at the leading edge of a polarised cell while RhoA drives rear retraction, more recent work in 3D microenvironments has revealed a much more complicated picture of GTPase dynamics. In particular, RhoA activity can dominate the leading edge polymerisation of actin to form filopodial actin-spike protrusions that drive more invasive cell migration. We recently described a potential mechanism to abrogate this pro-invasive localised leading edge Rac1 to RhoA switch via manipulation of a negative feedback loop that was revealed by adopting a logical modelling approach. Both challenging dogma and taking a formal, mathematical approach to understanding signalling involved in motility may be vital to harnessing harmful cell migration and preventing metastasis in future research., (© 2016 The Author(s).)
- Published
- 2016
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420. Optical Logic and Signal Processing Using a Semiconductor Laser Diode-Based Optical Bistability Device
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NATIONAL AIR INTELLIGENCE CENTER WRIGHT-PATTERSON AFB OH, Zhang, Yuancheng, Song, Qian, He, Shaowei, NATIONAL AIR INTELLIGENCE CENTER WRIGHT-PATTERSON AFB OH, Zhang, Yuancheng, Song, Qian, and He, Shaowei
- Abstract
Using an optical fibre-coupled semiconductor laser diode OBD with output feedback pumping operation in 5 modes (differential gain, bistability, zero-bias, inverted differential gain, and inverted bistability) has been realized respectively, and 5 elementary optical logic functions (AND, OR, NOT, NAND, and NOR) and some optical signal processing such as limiting, reshaping, and triggering have been implemented. (MM), Trans. of Jiguang Zazhi (China) v13 n1 Feb 92.
- Published
- 1995
421. Logic motif of combinatorial control in transcriptional networks
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Wu, Xuebing, Sun, Zhirong, and Jiang, Rui
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- 2008
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422. Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation.
- Author
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Honigberg SM
- Abstract
Diploid budding yeast ( Saccharomyces cerevisiae ) can adopt one of several alternative differentiation fates in response to nutrient limitation, and each of these fates provides distinct biological functions. When different strain backgrounds are taken into account, these various fates occur in response to similar environmental cues, are regulated by the same signal transduction pathways, and share many of the same master regulators. I propose that the relationships between fate choice, environmental cues and signaling pathways are not Boolean, but involve graded levels of signals, pathway activation and master-regulator activity. In the absence of large differences between environmental cues, small differences in the concentration of cues may be reinforced by cell-to-cell signals. These signals are particularly essential for fate determination within communities, such as colonies and biofilms, where fate choice varies dramatically from one region of the community to another. The lack of Boolean relationships between cues, signaling pathways, master regulators and cell fates may allow yeast communities to respond appropriately to the wide range of environments they encounter in nature.
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- 2016
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423. Unlimited multistability and Boolean logic in microbial signalling.
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Kothamachu VB, Feliu E, Cardelli L, and Soyer OS
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- Bacteria genetics, Bacterial Proteins genetics, Histidine Kinase, Protein Kinases genetics, Bacteria enzymology, Bacterial Proteins metabolism, Models, Biological, Protein Kinases metabolism, Signal Transduction physiology
- Abstract
The ability to map environmental signals onto distinct internal physiological states or programmes is critical for single-celled microbes. A crucial systems dynamics feature underpinning such ability is multistability. While unlimited multistability is known to arise from multi-site phosphorylation seen in the signalling networks of eukaryotic cells, a similarly universal mechanism has not been identified in microbial signalling systems. These systems are generally known as two-component systems comprising histidine kinase (HK) receptors and response regulator proteins engaging in phosphotransfer reactions. We develop a mathematical framework for analysing microbial systems with multi-domain HK receptors known as hybrid and unorthodox HKs. We show that these systems embed a simple core network that exhibits multistability, thereby unveiling a novel biochemical mechanism for multistability. We further prove that sharing of downstream components allows a system with n multi-domain hybrid HKs to attain 3n steady states. We find that such systems, when sensing distinct signals, can readily implement Boolean logic functions on these signals. Using two experimentally studied examples of two-component systems implementing hybrid HKs, we show that bistability and implementation of logic functions are possible under biologically feasible reaction rates. Furthermore, we show that all sequenced microbial genomes contain significant numbers of hybrid and unorthodox HKs, and some genomes have a larger fraction of these proteins compared with regular HKs. Microbial cells are thus theoretically unbounded in mapping distinct environmental signals onto distinct physiological states and perform complex computations on them. These findings facilitate the understanding of natural two-component systems and allow their engineering through synthetic biology.
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- 2015
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424. Signal-to-Noise Ratio Measures Efficacy of Biological Computing Devices and Circuits.
- Author
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Beal J
- Abstract
Engineering biological cells to perform computations has a broad range of important potential applications, including precision medical therapies, biosynthesis process control, and environmental sensing. Implementing predictable and effective computation, however, has been extremely difficult to date, due to a combination of poor composability of available parts and of insufficient characterization of parts and their interactions with the complex environment in which they operate. In this paper, the author argues that this situation can be improved by quantitative signal-to-noise analysis of the relationship between computational abstractions and the variation and uncertainty endemic in biological organisms. This analysis takes the form of a ΔSNRdB function for each computational device, which can be computed from measurements of a device's input/output curve and expression noise. These functions can then be combined to predict how well a circuit will implement an intended computation, as well as evaluating the general suitability of biological devices for engineering computational circuits. Applying signal-to-noise analysis to current repressor libraries shows that no library is currently sufficient for general circuit engineering, but also indicates key targets to remedy this situation and vastly improve the range of computations that can be used effectively in the implementation of biological applications.
- Published
- 2015
- Full Text
- View/download PDF
425. Excitonic AND Logic Gates on DNA Brick Nanobreadboards.
- Author
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Cannon BL, Kellis DL, Davis PH, Lee J, Kuang W, Hughes WL, Graugnard E, Yurke B, and Knowlton WB
- Abstract
A promising application of DNA self-assembly is the fabrication of chromophore-based excitonic devices. DNA brick assembly is a compelling method for creating programmable nanobreadboards on which chromophores may be rapidly and easily repositioned to prototype new excitonic devices, optimize device operation, and induce reversible switching. Using DNA nanobreadboards, we have demonstrated each of these functions through the construction and operation of two different excitonic AND logic gates. The modularity and high chromophore density achievable via this brick-based approach provide a viable path toward developing information processing and storage systems.
- Published
- 2015
- Full Text
- View/download PDF
426. Teaching Boolean Logic through Game Rule Tuning.
- Author
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Weng, Jui-Feng, Tseng, Shian-Shyong, and Lee, Tsung-Ju
- Abstract
The Boolean logic is a tool to model the algebra of truth values. It is an essential subject in Computer Programming and Digital Electronics. While teaching the Boolean logic, teacher usually gives examples to elaborate the Boolean logic formulation. However, the physical meaning of the Boolean logic is difficult for students to imagine without the realization to real-world case. The classical Pac-Man game which has clear Boolean logic game rules and simple game scenario is chosen as the teaching aid. Accordingly, two learning activities, the Boolean logic realization activity and game scenario formulation activity, are proposed. Our idea is that through game rule tuning in the learning activities, the students can comprehend how the changing of game rule (Boolean logic) affects the game scenario. To manipulate the game scenario for teaching specific learning objectives of Boolean logic, the Game Rule of the original Pac-Man game is defined and seven versions of modified game scenarios provided as illustrations are appropriately organized for students to practice one Boolean logic concept each time. The experimental results showed the proposed activity can have higher learning achievements compared to the traditional lecturing. [ABSTRACT FROM PUBLISHER]
- Published
- 2010
- Full Text
- View/download PDF
427. Logic computation in phase change materials by threshold and memory switching.
- Author
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Cassinerio M, Ciocchini N, and Ielmini D
- Subjects
- Crystallization, Logic, Transistors, Electronic
- Abstract
Memristors, namely hysteretic devices capable of changing their resistance in response to applied electrical stimuli, may provide new opportunities for future memory and computation, thanks to their scalable size, low switching energy and nonvolatile nature. We have developed a functionally complete set of logic functions including NOR, NAND and NOT gates, each utilizing a single phase-change memristor (PCM) where resistance switching is due to the phase transformation of an active chalcogenide material. The logic operations are enabled by the high functionality of nanoscale phase change, featuring voltage comparison, additive crystallization and pulse-induced amorphization. The nonvolatile nature of memristive states provides the basis for developing reconfigurable hybrid logic/memory circuits featuring low-power and high-speed switching., (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2013
- Full Text
- View/download PDF
428. The arbitration-extension hypothesis: a hierarchical interpretation of the functional organization of the Basal Ganglia.
- Author
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Kamali Sarvestani I, Lindahl M, Hellgren-Kotaleski J, and Ekeberg O
- Abstract
Based on known anatomy and physiology, we present a hypothesis where the basal ganglia motor loop is hierarchically organized in two main subsystems: the arbitration system and the extension system. The arbitration system, comprised of the subthalamic nucleus, globus pallidus, and pedunculopontine nucleus, serves the role of selecting one out of several candidate actions as they are ascending from various brain stem motor regions and aggregated in the centromedian thalamus or descending from the extension system or from the cerebral cortex. This system is an action-input/action-output system whose winner-take-all mechanism finds the strongest response among several candidates to execute. This decision is communicated back to the brain stem by facilitating the desired action via cholinergic/glutamatergic projections and suppressing conflicting alternatives via GABAergic connections. The extension system, comprised of the striatum and, again, globus pallidus, can extend the repertoire of responses by learning to associate novel complex states to certain actions. This system is a state-input/action-output system, whose organization enables it to encode arbitrarily complex Boolean logic rules using striatal neurons that only fire given specific constellations of inputs (Boolean AND) and pallidal neurons that are silenced by any striatal input (Boolean OR). We demonstrate the capabilities of this hierarchical system by a computational model where a simulated generic "animal" interacts with an environment by selecting direction of movement based on combinations of sensory stimuli, some being appetitive, others aversive or neutral. While the arbitration system can autonomously handle conflicting actions proposed by brain stem motor nuclei, the extension system is required to execute learned actions not suggested by external motor centers. Being precise in the functional role of each component of the system, this hypothesis generates several readily testable predictions.
- Published
- 2011
- Full Text
- View/download PDF
429. Mechanical Intelligence: Research and Applications
- Author
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SRI INTERNATIONAL MENLO PARK CA, Sacerdoti, Earl D, Fikes, Richard E, Hendrix, Gary G, Morris, Paul, Sagalowicz, Daniel, Slocum, Jonathan, SRI INTERNATIONAL MENLO PARK CA, Sacerdoti, Earl D, Fikes, Richard E, Hendrix, Gary G, Morris, Paul, Sagalowicz, Daniel, and Slocum, Jonathan
- Abstract
This report summarizes the results of a research project whose goal is to develop computer systems that can provide easy access for nontechnicians to large, distributed data bases of information. Our goal has been to develop mechanisms for automating many of the detailed tasks that today are normally performed by a decision maker's technical staff. These include accepting a question, in natural (not necessarily grammatical) English, in the decision maker's own terms; planning a sequence of queries to various files to gather the requested information; developing the plan into a computer program or programs in the language of the data base management system on which the data resides; transmitting the retrieval programs, and monitoring their execution; and composing the information retrieved into a suitable output format. We have focused our efforts along two mutually supporting lines of research. First, we have created a performance system, called LADDER (for Language Access to Distributed Data with Error Recovery), that carries out all of the functions listed above in at least rudimentary form. Our second line of research focuses on longer-term efforts to develop the techniques required to satisfy more fully the needs of decision makers.
- Published
- 1977
430. IDA: An Intelligent Data Access Program
- Author
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SRI INTERNATIONAL MENLO PARK CA ARTIFICIAL INTELLIGENCE CENTER, Sagalowicz, Daniel, SRI INTERNATIONAL MENLO PARK CA ARTIFICIAL INTELLIGENCE CENTER, and Sagalowicz, Daniel
- Abstract
This paper is concerned with one of the components of LADDER (Language Access to Distributed Data with Error Recovery), a database access system currently being developed at SRI. The ultimate goal of this system is to provide decision makers with easy access to information stored in multiple computers, under various database management systems (DBMSs). The particular application for LADDER is as an aid to Navy decision makers, but the techniques being developed are likely to be applicable to a wide range of decision-making activities. The first component of LADDER is INLAND (Informal Natural Language Access to Navy Data), which allows the user to ask questions in English about information contained in databases similar to those currently used by the Navy. It translates the query into a formal high-level query that contains no mention of the database structure. This query is then passed to the next component of the system: Intelligent Data Access (IDA). IDA was developed at SRI to allow a casual user to retrieve information from a database knowing the fields present in the database, but not the structure of the database itself. IDA's input is a very simple, formal query language that is essentially a list of restrictions on fields and queries about fields, with no mention of database structure. It produces a series of DBMS queries that are transmitted over the ARPA network. The results of these queries are combined by IDA to provide the answer to the user's query. In this paper, the author defines the input language, and give examples of IDA's behavior. He also presents his representation of the "structural schema," which is the information needed by IDA to know how the database is actually organized. He gives an idea of some of the heuristics that are used to produce a program in the language of the DBMS. Finally, he discusses the limitations of this approach, as well as future research areas., Sponsored in part by the Advanced Research Projects Agency (ARPA). Technical Note 145.
- Published
- 1977
431. An Overview of the Penman Text Generation System.
- Author
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UNIVERSITY OF SOUTHERN CALIFORNIA MARINA DEL REY INFORMATION SCIENCES INST, Mann,William C, UNIVERSITY OF SOUTHERN CALIFORNIA MARINA DEL REY INFORMATION SCIENCES INST, and Mann,William C
- Abstract
The problem of programming computers to produce natural language explanations and other texts on demand is an active research area in artifical intelligence. In the past, research systems designed for this purpose have been limited by the weakness of their linguistic bases, especially their grammars, and their techniques often cannot be transferred to new knowledge domains. A new text generation system, Penman, is designed to overcome these problems and produce fluent multiparagraph text in English in response to a goal presented to the system. Penman consists of four major modules: a knowledge acquisition module which can perform domain-specific searches for knowledge relevant to a given communication goal; a text planning module which can organize the relevant information, decide what portion to present, and decide how to lead the reader's attention and knowledge through the content; a sentence generation module based on a large systemic grammar of English; and an evaluation and plan-perturbation module which revises text plans based on evaluation of text produced. Development of Penman has included implementation of the largest systemic grammar of English in a single notation. A new semantic notation has been added to the systemic framework, and the semantics of nearly the entire grammar has been defined. The semantics is designed to be independent of the system's knowledge notation, so that it is usable with widely differing knowledge representtions, including both frame-based and predicate-calculus-based approaches. (Author)
- Published
- 1983
432. Two Person Information Structure. Part I: Information Structure: Common and Private. Part II: Private Information Structures of A with Respect to B.
- Author
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HARVARD UNIV CAMBRIDGE MASS DIV OF ENGINEERING AND APPLIED PHYSICS, Ho,Y. C., Hexner,G., Martin,C., HARVARD UNIV CAMBRIDGE MASS DIV OF ENGINEERING AND APPLIED PHYSICS, Ho,Y. C., Hexner,G., and Martin,C.
- Abstract
New definitions are introduced for the common and private information structures between two decision makers and show that they satisfy various reasonable properties.
- Published
- 1976
433. Two neural network construction methods
- Author
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Thimm, Georg and Fiesler, Emile
- Subjects
learning ,ontogenic neural network ,Computer Science::Neural and Evolutionary Computation ,high order perceptron ,connectionism ,neuron ,high order neural network ,Boolean logic - Abstract
Two low complexity methods for neural network construction, that are applicable to various neural network models, are introduced and evaluated for high order perceptrons. The methods are based on a Boolean approximation of real-valued data. This approximation is used to construct an initial neural network topology which is subsequently trained on the original (real-valued) data. The methods are evaluated for their effectiveness in reducing the network size and increasing the network's generalization capabilities in comparison to fully connected high order perceptrons.
434. Logic Regression
- Author
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Ruczinski, Ingo, Kooperberg, Charles, and LeBlanc, Michael
- Published
- 2003
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