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458. Synthesis, Characterization and Device Simulation of the Thin Films of CH3NH3PbI3 Perovskite Absorber and Cds Buffer Layer.

Author

Parrey, Khursheed Ahmad, Nisha, Aziz, Anver, Ansari, S. G., and Niazi, Asad

Subjects
PEROVSKITE, THIN film devices, BUFFER layers, OPEN-circuit voltage, SOLAR cells, ELECTRON transport
Abstract

Here we synthesized halide perovskite absorber CH3NH3PbI3 and CdS as charge transporting layer for perovskite photovoltaic device. Perovskite absorber and CdS were characterized by X-ray diffraction, UV-Visible spectrophotometry and SEM. The energy gap and structure of CH3NH3PbI3 and CdS were found to be suitable for use as absorber and electron transporting layer in perovskite solar cell device respectively. Numerical simulation of CH3NH3PbI3 perovskite solar cells was then carried out using the SCAPS-1D solar cell capacitance simulator software. A perovskite solar cell was simulated for best efficiency by replacing the traditional compact TiO2 layer with CdS (i.e., a hole-blocking layer) because CdS layers possess a greater photostability than TiO2 with continuous illumination of sunlight. We investigated the effect of layer parameters like absorber thickness, bulk defects, and interface defects on the device performance of CdS based perovskite photovoltaic device. It was observed that these parameters have strong impact on open circuit voltage Voc, short circuit current Isc, fillfactor (FF) and the power conversion efficiency. The device characteristics and optimization of the solar photovoltaic device was recorded and presented in paper. [ABSTRACT FROM AUTHOR]

Published
2019
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459. Growth and morphological study of zinc oxide nanoneedles grown on the annealed titanate nanotubes using hydrothermal method.

Author

Kim, G. S., Ansari, S. G., Seo, H. K., Kim, Y. S., and Shin, H. S.

Subjects
*ZINC oxide, *TITANATES, *NANOTUBES, *ANNEALING of metals, *HYDROTHERMAL alteration
Abstract

Hydrothermal growth of ZnO on the annealed titanate nanotube films results in the oriented hexagonal-needlelike structures. The size, shape, density, and alignment of ZnO film are significantly affected by annealing temperature and orientation of the beneath titanate layer. It is believed that oxygen and hydrogen vacancies, generated due to dehydration of interlayered OH groups while annealing of the titanate, are responsible for the changes in the morphology of the ZnO. Microscopic observations clearly resolved nanoneedles with the base diameter of ∼150 nm and length of ∼5 μm with lattice spacing of 0.52 nm, indicating single crystalline ZnO and grown along the (0001) direction. A growth model is presented based on the layer-by-layer growth (three-step growth) as a function of growth time (2–6 h). Thicknesses of these three steps were found increasing with growth time. The second step (II) of growth exhibits the same feature as that of the first step (I), i.e., bounded with six crystallographic, lower surface energy facets of {0110} surfaces and capped with {0111} planes, but with higher step thickness and sharper tip. Finally, the obtained ZnO nanoneedles exhibit {0111} facets, the third step (III), with sharp tip in the [0001] direction. [ABSTRACT FROM AUTHOR]

Published
2007
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460. Low temperature deposition and effect of plasma power on tin oxide thin films prepared by modified plasma enhanced chemical vapor deposition.

Author

Ansari, S. G., Dar, M. A., Dhage, M. S., Kim, Young Soon, Shin, Hyung-Shik, and Ansari, Z. A.

Subjects
*CHEMICAL vapor deposition, *THIN films, *RADIO frequency, *LOW temperatures, *TIN compounds
Abstract

This work presents low temperature (200 and 300 °C) thin film deposition of tin oxide (SnO2) using modified plasma enhanced chemical vapor deposition as a function of radio frequency power (100 – 500 W). Stannic chloride (SnCl4) was used as precursor and oxygen (O2, 300 SCCM) as reactant gas. Fine granular morphology was observed with tetragonal rutile structure grown along the [110] direction, at all the deposition conditions. Higher plasma power resulted in smoother morphology, improved crystallinity, and enhanced conductivity. Electrical resistivity value of as low as ∼0.01 Ω cm was obtained at the deposition temperature of 300 °C and 250 W of plasma power. [ABSTRACT FROM AUTHOR]

Published
2007
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461. Effect of annealing temperature on structural and bonded states of titanate nanotube films.

Author

Kim, Gil-Sung, Ansari, S. G., Seo, Hyung-Kee, Kim, Young-Soon, and Shin, Hyung-Shik

Subjects
*NANOPARTICLES, *NANOTUBES, *METHODOLOGY, *ELECTROPHORETIC deposition, *ELECTROPHORESIS, *SODIUM, *TEMPERATURE, *THERMAL properties, *TITANATES
Abstract

A conversion from commercial titania (TiO2) nanoparticles to nanotubes was achieved by a hydrothermal method. The titanate nanotube (titanate) film was then deposited on a Si (001) substrate using an electrophoretic deposition (EPD) technique. The post hydrothermal treatment was then carried out by annealing the films at 300–1000 °C for 30 min in the static air. A major amount of intercalated sodium (Na) in as-synthesized titanate nanotubes was removed during the electrodeposition process. The collapse of the tubular structure can be seen clearly when annealed above 500 °C. X-ray diffraction data indicate a significant increase in the anatase phase peak intensity with annealing temperature. O 1s peak is found to be built up of subpeaks of H2O, -OH, and Ti–O. Annealing results in an increase of the Ti–O peak intensity while other peaks disappear. Clear changes in the O 1s peak positions, symmetry, and shift towards lower energy (0.8 eV) are evident with the increasing annealing temperature. The doublet spectral lines of Ti 2p were found separated by an energy of 5.6 eV. Photoelectron spectroscopy show that during the annealing treatment, the chemical bonds such as H2O and -OH are removed from the titanate films as well as converting the bonded states of titanate to that of titania. [ABSTRACT FROM AUTHOR]

Published
2007
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462. Rotational and vibrational state distributions of H2 activated on a heated tungsten filament.

Author

Umemoto, Hironobu, Ansari, S. G., and Matsumura, Hideki

Subjects
*TUNGSTEN, *ROTATIONAL motion, *MATERIALS science, *THIN films, *STOKES equations, *SCATTERING (Physics)
Abstract

The rotational and vibrational state distributions of H2 activated on a heated tungsten filament were determined by employing a coherent anti-Stokes Raman scattering technique to examine the contribution to the catalytic chemical vapor deposition process. The rotational excitation could be confirmed and the distribution was Boltzmann-like. When the filament temperature was 2700 K and the H2 pressure was over 1.3 kPa, the rotational temperature monitored 5 cm under the filament was around 1200 K; it showed a sharp decrease below 670 Pa and it was 700 K at 67 Pa. This decrease in the rotational temperature suggests the importance of relaxation processes on the chamber walls. The first vibrationally excited H2 molecules could also be identified at pressures over 670 Pa and the vibrational temperature was not much different from the rotational one. This vibrational temperature is much lower than those in typical H2 plasma, showing that the direct vibrational excitation of H2 on hot filaments is inefficient compared to its dissociation to two H atoms. [ABSTRACT FROM AUTHOR]

Published
2006
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465. A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics

Author

Nasajpour, A, Nasajpour, A, Ansari, S, Rinoldi, C, Rad, AS, Aghaloo, T, Shin, SR, Mishra, YK, Adelung, R, Swieszkowski, W, Annabi, N, Khademhosseini, A, Moshaverinia, A, Tamayol, A, Nasajpour, A, Nasajpour, A, Ansari, S, Rinoldi, C, Rad, AS, Aghaloo, T, Shin, SR, Mishra, YK, Adelung, R, Swieszkowski, W, Annabi, N, Khademhosseini, A, Moshaverinia, A, and Tamayol, A

Abstract

Periodontitis is a prevalent chronic, destructive inflammatory disease affecting tooth-supporting tissues in humans. Guided tissue regeneration strategies are widely utilized for periodontal tissue regeneration generally by using a periodontal membrane. The main role of these membranes is to establish a mechanical barrier that prevents the apical migration of the gingival epithelium and hence allowing the growth of periodontal ligament and bone tissue to selectively repopulate the root surface. Currently available membranes have limited bioactivity and regeneration potential. To address such challenges, an osteoconductive, antibacterial, and flexible poly(caprolactone) (PCL) composite membrane containing zinc oxide (ZnO) nanoparticles is developed. The membranes are fabricated through electrospinning of PCL and ZnO particles. The physical properties, mechanical characteristics, and in vitro degradation of the engineered membrane are studied in detail. Also, the osteoconductivity and antibacterial properties of the developed membrane are analyzed in vitro. Moreover, the functionality of the membrane is evaluated with a rat periodontal defect model. The results confirmed that the engineered membrane exerts both osteoconductive and antibacterial properties, demonstrating its great potential for periodontal tissue engineering.

Published
2018

466. Use of cell surface protein typing for genotyping of azole-resistant and -susceptible Aspergillus fumigatus isolates in Iran

Author

Falahatinejad, M., Vaezi, A., Fakhim, H., Abastabar, M., Shokohi, T., Zahedi, N., Ansari, S., Meis, J.F.G.M., Badali, H., Falahatinejad, M., Vaezi, A., Fakhim, H., Abastabar, M., Shokohi, T., Zahedi, N., Ansari, S., Meis, J.F.G.M., and Badali, H.

Abstract

Item does not contain fulltext, Aspergillus fumigatus is the leading cause of mortality in severely immunocompromised individuals. Understanding pathogen dispersion and relatedness is essential for determining the epidemiology of nosocomial infections. Therefore, the aim of this study was to investigate the diversity and putative origins of clinical and environmental azole-susceptible and -resistant A. fumigatus isolates from Iran. In all, 79 isolates, including 64 azole-susceptible and 15 -resistant isolates, were genotyped using the cell surface protein (CSP) gene. Seven distinct repeat types (r01, r02, r03, r04, r05, r06 and r07) and 11 different CSP variants (t01, t02, t03, t04A, t06A, t06B, t08, t10, t18A, t18B and t22) were observed. Interestingly, t06B, t18A and t18B were exclusively present in azole-resistant isolates. The Simpson's index of diversity (D) was calculated at 0.78. Resistant isolates were genetically less diverse than azole-susceptible isolates. However, azole-resistant A. fumigatus without TR34 /L98H were more diverse than with TR34 /L98H. The limited CSP type diversity of the TR34 /L98H isolates versus azole-susceptible isolates suggests that repeated independent emergence of the TR34 /L98H mechanism is unlikely. It has been suggested that CSP types might have a common ancestor that developed locally and subsequently migrated worldwide.

Published
2018

467. Molecular epidemiology of environmental Cryptococcus species isolates based on amplified fragment length polymorphism

Author

Pakshir, K., Fakhim, H., Vaezi, A., Meis, J.F.G.M., Mahmoodi, M., Zomorodian, K., Javidnia, J., Ansari, S., Hagen, F., Badali, H., Pakshir, K., Fakhim, H., Vaezi, A., Meis, J.F.G.M., Mahmoodi, M., Zomorodian, K., Javidnia, J., Ansari, S., Hagen, F., and Badali, H.

Abstract

Item does not contain fulltext, OBJECTIVE: Cryptococcosis is a major opportunistic fungal infection caused by members of the genus Cryptococcus, mainly those belonging to the Cryptococcus neoformans/Cryptococcus gattii species complexes. Here, we report a comprehensive molecular epidemiological study of the environmental distribution of Cryptococcus isolates in Shiraz, Iran with review of litreature. METHOD: A total of 406 samples were obtained from Eucalyptus trees and 139 samples from pigeon droppings. Cryptococcus species identification and genotyping were performed by amplified fragment length polymorphism (AFLP) fingerprinting sequencing and sequencing of the ITS rDNA region. RESULTS: Majority of the isolates belonged to the Naganishia taxon (n=69) including N. albida (formerly C. albidus, n=62), N. globosa (formerly C. saitoi, n=4), N. adeliensis (formerly C. adeliensis, n=2), N. diffluens (formerly C. diffluens, n=1), and the identified C. neoformans isolates (n=25) belonged to genotype AFLP1/VNI (n=22) and AFLP1B/VNII (n=3). CONCLUSION: More research efforts should be employed to isolate C. gattii species complex from environmental niches in Iran and provide additional evidence related to novel molecular types.

Published
2018

470. Investigating the Use of Translation Apps and Websites in Health Care Settings: Study Protocol

Author

Ansari, S, Harris-Roxas, B, Woodland, L, Corcoran, J, Lloyd, J, Harris, MF, Ansari, S, Harris-Roxas, B, Woodland, L, Corcoran, J, Lloyd, J, and Harris, MF

Abstract

Context and aims: NSW Health revised its policy on interpretation in December 2017 to prohibit the use of non-professional translation in health care settings. This change was informed by the findings of a question in a recent staff survey by South Eastern Sydney Local Health District which revealed that participants had experience of using translation apps and websites during clinical encounters. There is a lack of evidence regarding the nature and extent of such use in health care settings, with most prior research focusing on the accuracy of translation. This study aims to: i) understand the nature and extent of use of translation apps in health care settings, ii) identify potential risks and benefits and iii) identify potential responses by health services and health systems.Methods: Data is being collected via a cross-sectional online survey of health care providers from partner LHDs within NSW. Up to 20 semi-structured interviews are being conducted with health care providers as well as key stakeholders from the LHDs and NSW Health. Quantitative data will be analysed using bivariate statistical analysis; qualitative data will be thematically analysed using an Interpretive Description approach.Contribution to policy, practice and/or research: Findings from this study will provide an insight into the circumstances under which translation apps and websites are used in health care settings. The study will inform potential worker, service and system responses regarding use of such translation. The study will also contribute to the limited body of evidence investigating patterns of this use in health care.

Published
2018

471. Molecular epidemiology of environmental Cryptococcus species isolates based on amplified fragment length polymorphism

Author

Pakshir, K, Fakhim, H, Vaezi, A, Meis, J F, Mahmoodi, M, Zomorodian, K, Javidnia, J, Ansari, S, Hagen, F, Badali, H, Pakshir, K, Fakhim, H, Vaezi, A, Meis, J F, Mahmoodi, M, Zomorodian, K, Javidnia, J, Ansari, S, Hagen, F, and Badali, H

Abstract

OBJECTIVE: Cryptococcosis is a major opportunistic fungal infection caused by members of the genus Cryptococcus, mainly those belonging to the Cryptococcus neoformans/Cryptococcus gattii species complexes. Here, we report a comprehensive molecular epidemiological study of the environmental distribution of Cryptococcus isolates in Shiraz, Iran with review of litreature.METHOD: A total of 406 samples were obtained from Eucalyptus trees and 139 samples from pigeon droppings. Cryptococcus species identification and genotyping were performed by amplified fragment length polymorphism (AFLP) fingerprinting sequencing and sequencing of the ITS rDNA region.RESULTS: Majority of the isolates belonged to the Naganishia taxon (n=69) including N. albida (formerly C. albidus, n=62), N. globosa (formerly C. saitoi, n=4), N. adeliensis (formerly C. adeliensis, n=2), N. diffluens (formerly C. diffluens, n=1), and the identified C. neoformans isolates (n=25) belonged to genotype AFLP1/VNI (n=22) and AFLP1B/VNII (n=3).CONCLUSION: More research efforts should be employed to isolate C. gattii species complex from environmental niches in Iran and provide additional evidence related to novel molecular types.

Published
2018

472. Incidence of Hepatocellular Carcinoma in Patients with Thalassemia Who Had Hepatitis C

Author

Ansari, S., Azita Azarkeivan, and Halagi, F.

Subjects
Hepatitis C Virus, lcsh:R5-920, Iron Overload, Cirrhosis, Thalassemia, Hepatocellular Carcinoma, Hepatitis B Virus, lcsh:Medicine (General), Chelating Agents
Abstract

Hepatitis is the infections of a common cause disease among poly transfused patients. Hepatitis C is slowed progression and inducing HCC. This study assessed HCC incidences, the role of iron and possible antitumor activity of chelators in 170 thalassemia patients using deferoxamine (DFO) therapy. They are diagnosed with Hepatitis C due to positive PCR-RNA. They are Treated with IFN. The follow up program including tests every 3 Months and PCR-RNA, AFP and liver US every 6 months. Whenever there was suspicion of liver malignancy, Biopsy was performed. From the total of 170 patients, 59.4% were male, and 40.6% were female. Mean age of thalassemia diagnosis was 2.69±5.403 (1-41) years and mean Age of hepatitis diagnosis was 17.37±7.263 (3-51) years. 92.4 % of Patient's MT, 0.6 % SS, 2.9% TI. the viral genome was 1a3a. 73.5% of patients had first course of therapy. The frequency of AFP greater than 10 was 5.9%. And the incidence of HCC was 0.6 %(1/170) with a 95% confidence interval. The main risk factor for HCC was HCV infection in TM patients, but it was iron activity in TI patients. Iron chelation with DFO appeared to play a Protective role.

Published
2013

476. The Mark-J Vertex Detector

Author

Anderhub, H., Anders, H., Ansari, S., Boehm, A., Bourquin, M., Burger, J., Chen, M., Commichau, V., Deutschmann, M., Dhina, M., Draheim, K. J., Fehlmann, J., Fong, D., Friebel, W., Gessner, U., Hangarter, K., Hausammann, R., Herten, U., Hofer, H., Hofmann, K., Ilyas, M. M., Krause, B., Leiste, R., Li, Q. Z., Linnhoefer, D., Lue, X., Masson, S., Nusbaumer, M., Nierobisch, H., Nowak, W. D., Pohl, M., Rau, R. R., Ren, D., Roderburg, E., Rohde, M., Schreiber, H. J., Schug, J., Stoehr, B., Ting, S. C. C., Tonutti, M., Viertel, G., Wu, S. X., Wyne, M. F., Wyslouch, B., Zichichi, Antonino, editor, and Villa, Francesco, editor

Published
1988
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477. A revised B(E2; 2$^{+}_{1} \to 0^{+}_{1}$) value in the semi-magic nucleus $^{210}$Po

Author

Kocheva , D., Rainovski , G., Jolie , J., Pietralla , N., Blazhev , A., Astier , A., Altenkirch , R., Ansari , S., Braunroth , Th., Cortés , M.L., Dewald , A., Diel , F., Djongolov , M., Fransen , C., Gladnishki , K., Hennig , A., Karayonchev , V., Keatings , J.M., Kluge , E., Litzinger , J., Müller-Gatermann , C., Petkov , P., Rudigier , M., Scheck , M., Scholz , Ph., Spagnoletti , P., Spieker , M., Stahl , C., Stegmann , R., Stoyanova , M., Thöle , P., Warr , N., Werner , V., Zell , K.O., Van Isacker , P., Ponomarev , V.Yu., Wölk , D., Witt , W., Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière ( CSNSM ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Grand Accélérateur National d'Ions Lourds ( GANIL ), and Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
Nuclear Theory, [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], 25.45.Hi, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 190 ≤ A ≤ 219, Random-phase approximations, 27.80.+w, Nuclear Theory (nucl-th), Electromagnetic transitions, Transfer reactions, 21.60.Jz, 21.10.Tg, 23.20.-g, [ PHYS.NEXP ] Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment (nucl-ex), Nuclear Experiment, [ PHYS.NUCL ] Physics [physics]/Nuclear Theory [nucl-th]
Abstract

International audience; The lifetimes of the $ 2^+_1$ , the $ 2^+_2$ and the $ 3^-_1$ states of$^{210}$Po have been measured in the$^{208}$Pb($^{12}$C,$^{10}$Be)$^{210}$Po transfer reaction by the Doppler-shift attenuation method. The result for the lifetime of the $ 2^+_1$ state is about three times shorter than the adopted value. However, the new value still does not allow for a consistent description of the properties of the yrast $ 2^+_1$ , $ 4^+_1$ , $ 6^+_1$ , and $ 8^+_1$ states of$^{210}$Po in the framework of nuclear shell models. Quasi-particle Phonon Model (QPM) calculations also cannot overcome this problem thus indicating the existence of a peculiarity which is neglected in both theoretical approaches.

Published
2017
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478. Understanding 'Failed' Markets: Conflicting Logics and Dissonance in Attempts to Price the Priceless Child

Author

Vermeulen, P.A.M., Ansari, S., Lounsbury, M., Gehman, J., Greenwood, R., Gehman, J., Lounsbury, M., and Greenwood, R.

Subjects
050402 sociology, Research in the Sociology of Organizations, media_common.quotation_subject, Field (Bourdieu), 05 social sciences, Perspective (graphical), Resistance (psychoanalysis), Ambivalence, 0504 sociology, State (polity), Political science, 0502 economics and business, Cognitive dissonance, Marketization, Positive economics, Construct (philosophy), Social psychology, Institute for Management Research, 050203 business & management, media_common
Abstract

Contains fulltext : 167414.pdf (Publisher’s version ) (Closed access) While scholars have developed increasingly well-developed accounts of institutional change, little attention has been paid to how change is resisted and, in particular, how efforts to marketize fail. We draw on the institutional logics perspective to guide analysis of an empirical case of the failed attempt by the Dutch state to marketize childcare organizations and create a market for childcare. We document that even though the existence of logics that were antithetical to the market logic did not catalyze organized collective resistance to marketization, the market logic never took root, and marketization has even been rolled back. We argue that the failure to create a childcare market in the Netherlands was caused by individual-level cognitive dissonance that cumulated into profound field-level ambivalence that undermined efforts to implement market practices. We develop several propositions that could usefully guide future research on how cognitive dissonance might underlie the failure to construct markets. By theorizing failure to change a field, we contribute to the limited body of work that has looked at failed attempts to change institutions, arguing for more attention to individual-field cross-level dynamics.

Published
2017

479. Low collectivity of the ${2}_{1}^{+}$ state of $^{212}\mathrm{Po}$

Author

Kocheva, D., Rainovski, G., Jolie, J., Pietralla, N., Blazhev, A., Altenkirch, R., Ansari, S., Astier, A., Bast, M., Beckers, M., Braunroth, Th., Cappellazzo, M., Dewald, A., Diel, F., Djongolov, M., Fransen, C., Gladnishki, K., Goldkuhle, A., Hennig, A., Karayonchev, V., Keatings, J.M., Kluge, E., Kröll, Th., Litzinger, J., Moschner, K., Müller-Gatermann, C., Petkov, P., Scheck, M., Scholz, Ph., Schmidt, T., Spagnoletti, P., Stahl, C., Stegmann, R., Stolz, A., Vogt, A., Warr, N., Werner, V., Wölk, D., Zamora, J.C., Zell, K.O., Ponomarev, V.Yu., Van Isacker, P., Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]
Abstract

International audience; The lifetime of the $2^+_1$ state of $^{212}$Po was measured in the $^{208}$Pb($^{12}$C,$^{8}$Be)$^{212}$Po transfer reaction by γ -ray spectroscopy employing the recoil distance Doppler shift (RDDS) method. The derived absolute B(E2) value of 2.6(3)W.u. indicates a low collectivity and contradicts previous claims of α-cluster components in the structure of the $2^+_1$ state. It is demonstrated that a consistent description of the properties of the $2^+_1$−$4^+_1$−$6^+_1$−$8^+_1$ sequence in $^{212}$Po cannot be achieved in the framework of a single-j shell-model calculation, either. This puzzle is traced to the properties of the seniority-2 configurations in $^{210}$Pb and $^{210}$Po.

Published
2017
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480. The Relationship of Polymorphism of RFC-I Gene on Methotrexate Serum Level and Related Toxicity in Pediatric Acute Lymphoblastic Leukemia

Author

Sharafi H, Ansari S, Toosi B, Sayadi M, and Zaker F

Subjects
Drug, Chemotherapy, medicine.medical_specialty, business.industry, media_common.quotation_subject, medicine.medical_treatment, Common Terminology Criteria for Adverse Events, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Toxicity, Genotype, medicine, Methotrexate, Allele, business, Gene, 030215 immunology, media_common, medicine.drug
Abstract

Introduction: Methotrexate is one of the most effective agents in chemotherapy regimens for childhood ALL. However, methotrexate has remarkable side effects, which causes complications in various tissues and organs of some patients under treatment of this drug. It is proved that genetic factors can determine methotrexate toxicity. The aim of this study is to evaluate the effect of RFC-I A80G polymorphism on toxicity and serum level of methotrexate in children affected by acute lymphoblastic leukemia. Methods: A80G polymorphism of RFC-I was genotyped with PCR-RFLP method in 69 ALL patients treated with methotrexate. The relation between RFC-I genotypes and serum level of methotrexate and toxicity were evaluated using HPLC method and common terminology criteria for adverse events (CTCAE) respectively. Results: In this study, frequency of allele A for A80G polymorphism was 42.8% in patients who were studied. In consolidation phase, allele A frequency in patients with hepatotoxicity was higher than patients with no hepatic event (P=0.03, OR=2.32, 95% CI=1.10-4.98). Nevertheless, there were not any association between the other types of toxicity and RFC-I genotypes. Also, there was no association between A80G genotypes and the serum level of methotrexate. Conclusion: Based on the obtained results, we concluded that allele A of A80G polymorphism of RFC-I gene is a risk factor for methotrexate hepatotoxicity in consolidation phase and the A80G polymorphism can be utilized for prediction of methotrexate toxicity and dose adjustment.

Published
2017
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481. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author

Sartelli, M. Kluger, Y. Ansaloni, L. Carlet, J. Brink, A. Hardcastle, T.C. Khanna, A. Chicom-Mefire, A. Rodríguez-Baño, J. Nathwani, D. Mendelson, M. Watkins, R.R. Pulcini, C. Beović, B. May, A.K. Itani, K.M.F. Mazuski, J.E. Fry, D.E. Coccolini, F. Rasxa, K. Montravers, P. Eckmann, C. Abbo, L.M. Abubakar, S. Abu-Zidan, F.M. Adesunkanmi, A.K. Al-Hasan, M.N. Althani, A.A. Ticas, J.E.A. Ansari, S. Ansumana, R. Da Silva, A.R.A. Augustin, G. Bala, M. Balogh, Z.J. Baraket, O. Bassetti, M. Bellanova, G. Beltran, M.A. Ben-Ishay, O. Biffl, W.L. Boermeester, M.A. Brecher, S.M. Bueno, J. Cainzos, M.A. Cairns, K. Camacho-Ortiz, A. Ceresoli, M. Chandy, S.J. Cherry-Bukowiec, J.R. Cirocchi, R. Colak, E. Corcione, A. Cornely, O.A. Cortese, F. Cui, Y. Curcio, D. Damaskos, D. Dasx, K. Delibegovic, S. Demetrashvili, Z. De Simone, B. De Souza, H.P. De Waele, J. Dhingra, S. Diaz, J.J. Di Carlo, I. Di Marzo, F. Di Saverio, S. Dogjani, A. Dorj, G. Dortet, L. Duane, T.M. Dupont, H. Egiev, V.N. Eid, H.O. Elmangory, M. El-Sayed Marei, H. Enani, M.A. Escandón-Vargas, K. Faro, M.P., Jr. Ferrada, P. Foghetti, D. Foianini, E. Fraga, G.P. Frattima, S. Gandhi, C. Gattuso, G. Giamarellou, E. Ghnnam, W. Gkiokas, G. Girardis, M. Goff, D.A. Gomes, C.A. Gomi, H. Gronerth, R.I.G. Guirao, X. Guzman-Blanco, M. Haque, M. Hecker, A. Hell, M. Herzog, T. Hicks, L. Kafka-Ritsch, R. Kao, L.S. Kanj, S.S. Kaplan, L.J. Kapoor, G. Karamarkovic, A. Kashuk, J. Kenig, J. Khamis, F. Khokha, V. Kiguba, R. Kirkpatrick, A.W. Kørner, H. Koike, K. Kok, K.Y.Y. Kon, K. Kong, V. Inaba, K. Ioannidis, O. Isik, A. Iskandar, K. Labbate, M. Labricciosa, F.M. Lagrou, K. Lagunes, L. Latifi, R. Lasithiotakis, K. Laxminarayan, R. Lee, J.G. Leone, M. Leppäniemi, A. Li, Y. Liang, S.Y. Liau, K.-H. Litvin, A. Loho, T. Lowman, W. Machain, G.M. Maier, R.V. Manzano-Nunez, R. Marinis, A. Marmorale, C. Martin-Loeches, I. Marwah, S. Maseda, E. McFarlane, M. De Melo, R.B. Melotti, M.R. Memish, Z. Mertz, D. Mesina, C. Menichetti, F. Mishra, S.K. Montori, G. Moore, E.E. Moore, F.A. Naidoo, N. Napolitano, L. Negoi, I. Nicolau, D.P. Nikolopoulos, I. Nord, C.E. Ofori-Asenso, R. Olaoye, I. Omari, A.H. Ordoñez, C.A. Ouadii, M. Ouedraogo, A.-S. Pagani, L. Paiva, J.A. Parreira, J.G. Pata, F. Pereira, J. Pereira, N.R. Petrosillo, N. Picetti, E. Pintar, T. Ponce-De-Leon, A. Popovski, Z. Poulakou, G. Preller, J. Guerrero, A.P. Pupelis, G. Quiodettis, M. Rawson, T.M. Reichert, M. Reinhart, K. Rems, M. Rello, J. Rizoli, S. Roberts, J. Rubio-Perez, I. Ruppé, E. Sakakushev, B. Sall, I. Kafil, H.S. Sanders, J. Sato, N. Sawyer, R.G. Scalea, T. Scibé, R. Scudeller, L. Lohse, H.S. Sganga, G. Shafiq, N. Shah, J.N. Spigaglia, P. Suroowan, S. Tsioutis, C. Sifri, C.D. Siribumrungwong, B. Sugrue, M. Talving, P. Tan, B.K. Tarasconi, A. Tascini, C. Tilsed, J. Timsit, J.-F. Tumbarello, M. Trung, N.T. Ulrych, J. Uranues, S. Velmahos, G. Vereczkei, A.G. Viale, P. Estape, J.V. Viscoli, C. Wagenlehner, F. Wright, B.J. Xiao, Y. Yuan, K.-C. Zachariah, S.K. Zahar, J.R. Mergulhão, P. Catena, F.

Abstract

This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages. © Copyright 2017, Mary Ann Liebert, Inc.

Published
2017

482. Experimental study of the lifetime and phase transition in neutron-rich $^{98,100,102}\mathrm{Zr}$

Author

Ansari, S, Régis, J.-M., Jolie, J., Saed-Samii, N., Warr, N., Korten, W., Zielinska, M., Salsac, M.-D., Blanc, A., Jentschel, M., Köster, U., Mutti, P., Soldner, T., Simpson, G.S., Drouet, F., Vancraeyenest, A., de France, G., Clément, E., Stezowski, O., Ur, C.A., Urban, W., Regan, P.H., Podolyák, Zs., Larijani, C., Townsley, C., Carroll, R., Wilson, E., Mach, H., Fraile, L.M., Paziy, V., Olaizola, B., Vedia, V., Bruce, A.M., Roberts, O.J., Smith, J.F., Scheck, M., Kröll, T., Hartig, A.-L., Ignatov, A., Ilieva, S., Lalkovski, S., Marginean, N., Otsuka, T., Shimizu, N., Togashi, T., Tsunoda, Y., Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Laue-Langevin (ILL), ILL, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])

Subjects
Nuclear Theory, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment
Abstract

International audience; Rapid shape changes are observed for neutron-rich nuclei with A around 100. In particular, a sudden onset of ground-state deformation is observed in the Zr and Sr isotopic chains at N = 60: Low-lying states in N 58 nuclei are nearly spherical, while those with N 60 have a rotational character. Nuclear lifetimes as short as a few picoseconds can be measured using fast-timing techniques with LaBr3(Ce) scintillators, yielding a key ingredient in the systematic study of the shape evolution in this region.We used neutron-induced fission of 241Pu and 235U to study lifetimes of excited states in fission fragments in the A ∼ 100 region with the EXILL-FATIMA array located at the PF1B cold neutron beam line at the Institut Laue-Langevin. In particular, we applied the generalized centroid difference method to deduce lifetimes of low-lying states for the nuclei 98Zr (N = 58), 100Zr,and 102Zr (N 60). The results are discussed in the context of the presumed phase transition in the Zr chain by comparing the experimental transition strengths with the theoretical calculations using the interacting boson model and the Monte Carlo shell model.

Published
2017
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483. Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y

Author

Sartelli, M. Weber, D.G. Ruppé, E. Bassetti, M. Wright, B.J. Ansaloni, L. Catena, F. Coccolini, F. Abu-Zidan, F.M. Coimbra, R. Moore, E.E. Moore, F.A. Maier, R.V. De Waele, J.J. Kirkpatrick, A.W. Griffiths, E.A. Eckmann, C. Brink, A.J. Mazuski, J.E. May, A.K. Sawyer, R.G. Mertz, D. Montravers, P. Kumar, A. Roberts, J.A. Vincent, J.L. Watkins, R.R. Lowman, W. Spellberg, B. Abbott, I.J. Adesunkanmi, A.K. Al-Dahir, S. Al-Hasan, M.N. Agresta, F. Althani, A.A. Ansari, S. Ansumana, R. Augustin, G. Bala, M. Balogh, Z.J. Baraket, O. Bhangu, A. Beltrán, M.A. Bernhard, M. Biffl, W.L. Boermeester, M.A. Brecher, S.M. Cherry-Bukowiec, J.R. Buyne, O.R. Cainzos, M.A. Cairns, K.A. Camacho-Ortiz, A. Chandy, S.J. Che Jusoh, A. Chichom-Mefire, A. Colijn, C. Corcione, F. Cui, Y. Curcio, D. Delibegovic, S. Demetrashvili, Z. De Simone, B. Dhingra, S. Diaz, J.J. Di Carlo, I. Dillip, A. Di Saverio, S. Doyle, M.P. Dorj, G. Dogjani, A. Dupont, H. Eachempati, S.R. Enani, M.A. Egiev, V.N. Elmangory, M.M. Ferrada, P. Fitchett, J.R. Fraga, G.P. Guessennd, N. Giamarellou, H. Ghnnam, W. Gkiokas, G. Goldberg, S.R. Gomes, C.A. Gomi, H. Guzmán-Blanco, M. Haque, M. Hansen, S. Hecker, A. Heizmann, W.R. Herzog, T. Hodonou, A.M. Hong, S.K. Kafka-Ritsch, R. Kaplan, L.J. Kapoor, G. Karamarkovic, A. Kees, M.G. Kenig, J. Kiguba, R. Kim, P.K. Kluger, Y. Khokha, V. Koike, K. Kok, K.Y. Kong, V. Knox, M.C. Inaba, K. Isik, A. Iskandar, K. Ivatury, R.R. Labbate, M. Labricciosa, F.M. Laterre, P.F. Latifi, R. Lee, J.G. Lee, Y.R. Leone, M. Leppaniemi, A. Li, Y. Liang, S.Y. Loho, T. Maegele, M. Malama, S. Marei, H.E. Martin-Loeches, I. Marwah, S. Massele, A. McFarlane, M. Melo, R.B. Negoi, I. Nicolau, D.P. Nord, C.E. Ofori-Asenso, R. Omari, A.H. Ordonez, C.A. Ouadii, M. Pereira Júnior, G.A. Piazza, D. Pupelis, G. Rawson, T.M. Rems, M. Rizoli, S. Rocha, C. Sakakushev, B. Sanchez-Garcia, M. Sato, N. Segovia Lohse, H.A. Sganga, G. Siribumrungwong, B. Shelat, V.G. Soreide, K. Soto, R. Talving, P. Tilsed, J.V. Timsit, J.F. Trueba, G. Trung, N.T. Ulrych, J. van Goor, H. Vereczkei, A. Vohra, R.S. Wani, I. Uhl, W. Xiao, Y. Yuan, K.C. Zachariah, S.K. Zahar, J.R. Zakrison, T.L. Corcione, A. Melotti, R.M. Viscoli, C. Viale, P.

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

The original article [1] contains an error whereby a co-author, Boris Sakakushev has their family name spelt incorrectly as 'Sakakhushev'. The authors would therefore like it known that the correct spelling of the family name is 'Sakakushev'. © The Author(s).

Published
2017

484. Hyperparathyroidism complicating pregnancy: a diagnostic challenge?

Author

Jibhkate, S., Valand, A., Ansari, S., and Bharambe, B.

Subjects
Diagnosis, Case studies, Reports, Pregnancy complications -- Diagnosis -- Case studies -- Reports, Hyperparathyroidism -- Diagnosis -- Case studies -- Reports, Pregnancy, Complications of -- Diagnosis -- Case studies -- Reports
Published
2014

485. Training Guidelines for Endovascular Stroke Intervention: An International Multi-Society Consensus Document

Author

Lavine, S D, Cockroft, K, Hoh, B, Bambakidis, N, Khalessi, A A, Woo, H, Riina, H, Siddiqui, A, Hirsch, J A, Chong, W, Rice, H, Wenderoth, J, Mitchell, P, Coulthard, A, Signh, T J, Phatorous, C, Khangure, M, Klurfan, P, Ter Brugge, K, Iancu, D, Gunnarsson, T, Jansen, O, Muto, M, Szikora, I, Pierot, L, Brouwer, P, Gralla, Jan, Renowden, S, Andersson, T, Fiehler, J, Turjman, F, White, P, Januel, A C, Spelle, L, Kulcsar, Z, Chapot, R, Biondi, A, Dima, S, Taschner, C, Szajner, M, Krajina, A, Sakai, N, Matsumaru, Y, Yoshimura, S, Diaz, O, Lylyk, P, Jayaraman, M V, Patsalides, A, Gandhi, C D, Lee, S K, Abruzzo, T, Albani, B, Ansari, S A, Arthur, A S, Baxter, B W, Bulsara, K R, Chen, M, Almandoz, J E Delgado, Fraser, J F, Heck, D V, Hetts, S W, Hussain, M S, Klucznik, R P, Leslie-Mawzi, T M, Mack, W J, McTaggart, R A, Meyers, P M, Mocco, J, Prestigiacomo, C J, Pride, G L, Rasmussen, P A, Starke, R M, Sunenshine, P J, Tarr, R W, Frei, D F, Ribo, M, Nogueira, R G, Zaidat, O O, Jovin, T, Linfante, I, Yavagal, D, Liebeskind, D, Novakovic, R, Pongpech, S, Rodesch, G, Soderman, M, Taylor, A, Krings, T, Orbach, D, Picard, L, Suh, D C, Tanaka, M, and Zhang, H Q

Subjects
Consensus Article, education, 610 Medicine & health, Surgery, Neurology (clinical), Cardiology and Cardiovascular Medicine, health care economics and organizations, humanities
Published
2016
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486. Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author

Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, and Kiguba, R

Subjects
Anti-Infective Agents, International Cooperation, Humans, Intraabdominal Infections, Surgery, Drug Resistance, Microbial, Microbial Sensitivity Tests, Prognosis
Abstract

© 2016 The Author(s). Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Published
2016

494. Business Centre Development Model of Airport Area in Supporting Airport Sustainability in Indonesia

Author

Setiawan, MI, primary, Surjokusumo, S, additional, Ma’soem, DM, additional, Johan, J, additional, Hasyim, C, additional, Kurniasih, N, additional, Sukoco, A, additional, Dhaniarti, I, additional, Suyono, J, additional, Sudapet, IN, additional, Nasihien, RD, additional, Mudjanarko, SW, additional, Wulandari, A, additional, Ahmar, Ansari S, additional, and Wajdi, MBN, additional

Published
2018
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496. Lifetime measurement in neutron-rich A~100 nuclei

Author

Ansari, S., primary, Régis, J-M., additional, Jolie, J., additional, Saed-Samii, N., additional, Warr, N., additional, Korten, W., additional, Zielińska, M., additional, Salsac, M.-D., additional, Blanc, A., additional, Jentschel, M., additional, Köster, U., additional, Mutti, P., additional, Soldner, T., additional, Simpson, G.S., additional, Drouet, F., additional, Vancraeyenest, A., additional, de France, G., additional, Clément, E., additional, Stezowski, O., additional, Ur, C.A., additional, Urban, W., additional, Regan, P.H., additional, Podolyák, Zs., additional, Larijani, C., additional, Townsley, C., additional, Carroll, R., additional, Wilson, E., additional, Mach, H., additional, Fraile, L.M., additional, Paziy, V., additional, Olaizola, B., additional, Vedia, V., additional, Bruce, A.M., additional, Roberts, O.J., additional, Smith, J.F., additional, Scheck, M., additional, Kröll, T., additional, Hartig, A.-L., additional, Ignatov, A., additional, Ilieva, S., additional, Lalkovski, S., additional, Mărginean, N., additional, Otsuka, T., additional, Shimizu, N., additional, Togashi, T., additional, and Tsunoda, Y., additional

Published
2018
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497. Characterization of Molecular Mimicry Between UL18 Glycoprotein of Human Cytomegalovirus [HCMV] and Class-I MHC Molecule through Pattern-based Analysis: An In-silico Approach

Author

Ansari S, Chakraborty N, Sarkar A, and Chatterjee A

Subjects
0301 basic medicine, biology, Protein domain, Computational biology, Major histocompatibility complex, Bioinformatics, medicine.disease_cause, Protein tertiary structure, 03 medical and health sciences, Open reading frame, Transmembrane domain, Molecular mimicry, 030104 developmental biology, Viral replication, MHC class I, biology.protein, medicine
Abstract

Viral replication occurs using the host cell synthesis mechanisms and they are able to exploit the mechanisms of nucleic acid replication and protein translation machinery. Viral proteins require a target to fit subcellular compartments of the host cell and localized in different cellular compartments including the nucleus. Human Cytomegalovirus downregulates expression of traditional class-I MHC [Major Histocompatibility Complex] molecules at the infected cell surface and allows the infected cells to avoid acknowledgment by cytotoxic T-cells. In the present study, we have focused on generally accessible online and offline computational tools to examine practical and fundamental characteristics of the most conserved domain [CD] of UL18 gene along with the viral class-I MHC molecule. Six open reading frames [ORF] were reanalyzed by selecting start codon. Site-specific homology was determined to the MHC class-I molecule [19 to 197 residual position; ID: pfam00129, E-value: 3.26e-14]. The predicted protein architecture contained about 28.90% helices [107 residues] and 10.32% strands [38 residues]. The tertiary structure represented that 276 residues [75% of sequence] were modeled by the single highest scoring template with 100% confidence and the structure represents a peptide-binding viral MHC mimic, apprenticed to a host inhibitory receptor [pdb code-3d2u]. Thus, our analysis suggests that the homologous sequence corresponding to MHC class-I gene is situated between 19 and 200th residues of UL18 ORF and the recognition domain was identified with significant E-value. Our study also demonstrated that the ORF18 is homologous to the Ig-superfamily in 229-289th position. Therefore, these domains were found to date homologous in HCMV proteins suggesting a particular functional role during infection. In light of the above, further experimental steps are needed to elucidate the exact role of the UL18 during infections.

Published
2016
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498. Vehicular Safety Application Identifier algorithm for LTE VANET server

Author

Ansari, S., Boutaleb, T., Gamio, C., Sinanovic, S., Krikidis, Ioannis A., Sanchez, M., and Krikidis, Ioannis A. [0000-0003-4036-1364]

Subjects
Vehicular communication systems, Vehicular ad hoc network, Network packet, Computer science, business.industry, Goodput, Quality of service, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Real-time computing, Core network, 020302 automobile design & engineering, 020206 networking & telecommunications, 02 engineering and technology, 0203 mechanical engineering, Telecommunications link, 0202 electrical engineering, electronic engineering, information engineering, business, Algorithm, Multipath propagation, Computer network
Abstract

Vehicular communications have been an incentive for driver safety and ultimately autonomous smart vehicles. These vehicular networks have strict requirements with transmission frequency, range, and delay. From previous contributions, Long Term Evolution (LTE) has been found to meet the requirements for vehicular networks. Extensive realistic system level simulations, including multipath and multi cell environments, have been carried out to evaluate the performance of LTE networks for vehicular communications. This paper improves upon previously contributed simulations by introducing Safety Application Identifier along with an algorithm that implements differentiated Quality of Service (QoS) for different safety applications that are handled by the vehicular server located within the LTE core network. Results show that the probability of end-to-end delay below 100 ms increases by 20%, downlink goodput of the system improves reducing the amount of vehicular application traffic, and eventually the number of downlink flows is reduced by 60%; improving network capacity. Moreover, with the implementation of the proposed algorithm, high QoS can be achieved for vehicular safety applications in terms of delay and packet delivery.

Published
2016

499. Surrogate Markers for Facial Nerve Dehiscence in Cholesteatoma Surgery

Author

Iyer A, Orr J, Crosbie R, and Ansari S

Subjects
medicine.medical_specialty, Ossicular chain, business.industry, Cholesteatoma, Dehiscence, medicine.disease, Positive correlation, Facial nerve, Facial paralysis, Surgery, medicine.anatomical_structure, otorhinolaryngologic diseases, medicine, Middle ear, Otologic Surgical Procedures, business
Abstract

Background: Lateral semi-circular canal dehiscence (LSCCD) and facial nerve dehiscence (FND) may increase the risk of dead ear and facial paralysis in cholesteatoma surgery. While CT scanning may show LSCCD, disease extent and ossicular erosion, FND is difficult to assess via this modality. Our study aims to establish the correlation between the factors which can be assessed on CT and FND. We compared social deprivation levels to determine any predictive value on FND. Methods: Consecutive patients undergoing surgery for cholesteatoma by one otologist from 2009 to 2014 were included. Results: Of 132 patients included in the study, FND was noted in 29 (22%). There was positive correlation between FND and ossicular chain erosion, Pearson correlation=0.289(p=0.001), LSCCD 0.087 (p=0.322) and extent of cholesteatoma 0.077 (p=0.382). Deprivation index scores followed normal distributions. Conclusions: There is positive correlation between FND and cholesteatoma extent, LSCCD and ossicular erosion. The correlation with ossicular erosion is statistically significant thus helping to predict FND with pre-operative CT scans. Socioeconomic status does not predict FND.

Published
2016
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500. A Review of Hydrogels in Droplet-based Bio-Fabrication Techniques

Author

Ansari, S, Date, M, Simhambhatla, S, and Rath, Subha Narayan

Subjects
Biomedical Engineering
Abstract

The Rapid Prototyping (RP) technologies with hydrogels as biomaterials have gained tremendous popularity in Tissue Engineering applications for scaffold development, especially for the soft scaffold developments. Droplet-based RP technologies which use hydrogels as printing materials have seen growing acceptance in past decade, as they facilitate the encapsulation of living cells and improvement of cell seeding efficiency. In this review different droplet-based RP techniques have been briefly reviewed along with various natural hydrogels used for the fabricating the scaffolds.

Published
2016

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