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1. Preferential and persistent impact of acute HIV-1 infection on CD4⁺ iNKT cells in colonic mucosa

Author

RV217, RV254/SEARCH010, RV304/SEARCH013 StudyGroup, Paquin-Proulx, Dominic, Lal, Kerri G., Phuang-Ngern, Yuwadee, Creegan, Matthew, Tokarev, Andrey, Suhkumvittay, Suchada, Alrubayyi, Aljawharah, Kroon, Eugène, Pinyakorn, Suteeraporn, Slike, Bonnie M., Bolton, Diane L., Krebs, Shelly J., Eller, Leigh Anne, Sajjaweerawan, Chayada, Pagliuzza, Amélie, Chomont, Nicolas, Rerknimitr, Rungsun, Chomchey, Nitiya, Phanuphak, Nittaya, de Souza, Mark S., Michael, Nelson L., Robb, Merlin L., Ananworanich, Jintanat, Sandberg, Johan K., Eller, Michael A., and Schuetz, Alexandra

Published
2021

2. Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial

Author

Ake, Julie A., Akapirat, Siriwat, Bose, Meera, Cale, Evan, Chan, Phillip, Chanthaburanun, Sararut, Churikanont, Nampueng, Dawson, Peter, Dumrongpisutikul, Netsiri, Getchalarat, Saowanit, Jongrakthaitae, Surat, Jongsakul, Krisada, Lerdlum, Sukalaya, Manasnayakorn, Sopark, McCullough, Corinne, Milazzo, Mark, Nuntapinit, Bessara, On, Kier, Ouellette, Madelaine, Phanuphak, Praphan, Sanders-Buell, Eric, Sangnoi, Nongluck, Shangguan, Shida, Sirivichayakul, Sunee, Tragonlugsana, Nipattra, Trichavaroj, Rapee, Ubolyam, Sasiwimol, Vasan, Sandhya, Wattanaboonyongcharoen, Phandee, Yamchuenpong, Thipvadee, Crowell, Trevor A, Colby, Donn J, Pinyakorn, Suteeraporn, Sacdalan, Carlo, Pagliuzza, Amélie, Intasan, Jintana, Benjapornpong, Khunthalee, Tangnaree, Kamonkan, Chomchey, Nitiya, Kroon, Eugène, de Souza, Mark S, Tovanabutra, Sodsai, Rolland, Morgane, Eller, Michael A, Paquin-Proulx, Dominic, Bolton, Diane L, Tokarev, Andrey, Thomas, Rasmi, Takata, Hiroshi, Trautmann, Lydie, Krebs, Shelly J, Modjarrad, Kayvon, McDermott, Adrian B, Bailer, Robert T, Doria-Rose, Nicole, Patel, Bijal, Gorelick, Robert J, Fullmer, Brandie A, Schuetz, Alexandra, Grandin, Pornsuk V, O'Connell, Robert J, Ledgerwood, Julie E, Graham, Barney S, Tressler, Randall, Mascola, John R, Chomont, Nicolas, Michael, Nelson L, Robb, Merlin L, Phanuphak, Nittaya, and Ananworanich, Jintanat

Published
2019
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5. Transmission dynamics among participants initiating anti-retroviral therapy upon diagnosis of early acute HIV-1 infection in Thailand

Author

Kroon, Eugène, Pham, Phuc T., Sirivichayakul, Sunee, Trichavaroj, Rapee, Colby, Donn J., Pinyakorn, Suteeraporn, Phanuphak, Nittaya, Sanders-Buell, Eric, Van Griensven, Frits, Kijak, Gustavo H., Kim, Jerome H., Michael, Nelson L., Robb, Merlin.L., Ananworanich, Jintanat, De Souza, Mark S., and Tovanabutra, Sodsai

Published
2018
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6. Acute HIV infection detection and immediate treatment estimated to reduce transmission by 89% among men who have sex with men in Bangkok

Author

Kroon, Eugene D.M.B., Phanuphak, Nittaya, Shattock, Andrew J., Fletcher, James L.K., Pinyakorn, Suteeraporn, Chomchey, Nitiya, Akapirat, Siriwat, de Souza, Mark S., Robb, Merlin L., Kim, Jerome H., van Griensven, Frits, Ananworanich, Jintanat, and Wilson, David P.

Subjects
HIV infections -- Development and progression -- Comparative analysis -- Health aspects -- Diagnosis -- Drug therapy -- Research, Disease transmission -- Development and progression -- Comparative analysis -- Health aspects -- Prevention -- Research, MSM (Men who have sex with men) -- Health aspects, Antiretroviral agents -- Dosage and administration, Health
Abstract

Introduction: Antiretroviral treatment (ART) reduces HIV transmission. Despite increased ART coverage, incidence remains high among men who have sex with men (MSM) in many places. Acute HIV infection (AHI) is characterized by high viral replication and increased infectiousness. We estimated the feasible reduction in transmission by targeting MSM with AHI for early ART. Methods: We recruited a cohort of 88 MSM with AHI in Bangkok, Thailand, who initiated ART immediately. A risk calculator based on viral load and reported behaviour, calibrated to Thai epidemiological data, was applied to estimate the number of onwards transmissions. This was compared with the expected number without early interventions. Results: Forty of the MSM were in 4th-generation AHI stages 1 and 2 (4thG stage 1, HIV nucleic acid testing (NAT)+/4thG immunoassay (IA)-/3rdG IA-; 4thG stage 2, NAT+/4thG IA+/3rdG IA-) while 48 tested positive on third-generation IA but had negative or indeterminate western blot (4thG stage 3). Mean plasma HIV RNA was 5.62 [log.sub.10] copies/ml. Any condomless sex in the four months preceding the study was reported by 83.7%, but decreased to 21.2% by 24 weeks on ART. After ART, 48/88 (54.6%) attained HIV RNA Conclusions: Disproportionate HIV transmission occurs during AHI. Diagnosis of AHI with early ART initiation can substantially reduce onwards transmission. Keywords: HIV; acute infection; men who have sex with men; models/projections; prevention of sexual transmission; behavioural interventions; antiretroviral therapy, Introduction Antiretroviral treatment (ART) reduces HIV viral load and HIV transmission in HIV-discordant heterosexual couples [1-6]. However, despite increased uptake of ART since 1996, HIV incidence continues to rise among [...]

Published
2017
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7. Transmission dynamics among participants initiating antiretroviral therapy upon diagnosis of early acute HIV-1 infection in Thailand

Author

Kroon, Eugène, Pham, Phuc T., Sirivichayakul, Sunee, Trichavaroj, Rapee, Colby, Donn J., Pinyakorn, Suteeraporn, Phanuphak, Nittaya, Sanders-Buell, Eric, van Griensven, Frits, Kijak, Gustavo H., Kim, Jerome H., Michael, Nelson L., Robb, Merlin L., Ananworanich, Jintanat, De Souza, Mark S., and Tovanabutra, Sodsai

Published
2018
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9. Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand

Author

Robb, Merlin L., Eller, Leigh A., Kibuuka, Hannah, Rono, Kathleen, Maganga, Lucas, Nitayaphan, Sorachai, Kroon, Eugene, Sawe, Fred K., Sinei, Samuel, Sriplienchan, Somchai, Jagodzinski, Linda L., Malia, Jennifer, Manak, Mark, de Souza, Mark S., Tovanabutra, Sodsai, Sanders-Buell, Eric, Rolland, Morgane, Dorsey-Spitz, Julie, Eller, Michael A., Milazzo, Mark, Li, Qun, Lewandowski, Andrew, Wu, Hao, Swann, Edith, OʼConnell, Robert J., Peel, Sheila, Dawson, Peter, Kim, Jerome H., and Michael, Nelson L.

Published
2016
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10. Extended Evaluation of the Virologic, Immunologic, and Clinical Course of Volunteers Who Acquired HIV-1 Infection in a Phase III Vaccine Trial of ALVAC-HIV and AIDSVAX B/E

Author

Rerks-Ngarm, Supachai, Paris, Robert M., Chunsutthiwat, Supamit, Premsri, Nakorn, Namwat, Chawetsan, Bowonwatanuwong, Chureeratana, Li, Shuying S., Kaewkungkal, Jaranit, Trichavaroj, Rapee, Churikanont, Nampueng, de Souza, Mark S., Andrews, Charla, Francis, Donald, Adams, Elizabeth, Flores, Jorge, Gurunathan, Sanjay, Tartaglia, Jim, O'Connell, Robert J., Eamsila, Chirapa, Nitayaphan, Sorachai, Ngauy, Viseth, Thongcharoen, Prasert, Kunasol, Prayura, Michael, Nelson L., Robb, Merlin L., Gilbert, Peter B., and Kim, Jerome H.

Published
2013
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11. Magnitude and Breadth of the Neutralizing Antibody Response in the RV144 and Vax003 HIV-1 Vaccine Efficacy Trials

Author

Montefiori, David C., Karnasuta, Chitraporn, Huang, Ying, Ahmed, Hasan, Gilbert, Peter, de Souza, Mark S., McLinden, Robert, Tovanabutra, Sodsai, Laurence-Chenine, Agnes, Sanders-Buell, Eric, Moody, M. Anthony, Bonsignori, Mattia, Ochsenbauer, Christina, Kappes, John, Tang, Haili, Greene, Kelli, Gao, Hongmei, LaBranche, Celia C., Andrews, Charla, Polonis, Victoria R., Rerks-Ngarm, Supachai, Pitisuttithum, Punnee, Nitayaphan, Sorachai, Kaewkungwal, Jaranit, Self, Steve G., Berman, Phillip W., Francis, Donald, Sinangil, Faruk, Lee, Carter, Tartaglia, Jim, Robb, Merlin L., Haynes, Barton F., Michael, Nelson L., and Kim, Jerome H.

Published
2012
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12. A Phase 1/2 Study of a Multiclade HIV-1 DNA Plasmid Prime and Recombinant Adenovirus Serotype 5 Boost Vaccine in HIV-Uninfected East Africans (RV 172)

Author

Kibuuka, Hannah, Kimutai, Robert, Maboko, Leonard, Sawe, Fred, Schunk, Mirjam S., Kroidl, Arne, Shaffer, Douglas, Eller, Leigh Anne, Kibaya, Rukia, Eller, Michael A., Schindler, Karin B., Schuetz, Alexandra, Millard, Monica, Kroll, Jason, Dally, Len, Hoelscher, Michael, Bailer, Robert, Cox, Josephine H., Marovich, Mary, Birx, Deborah L., Graham, Barney S., Michael, Nelson L., de Souza, Mark S., and Robb, Merlin L.

Published
2010

14. Immune Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

Author

Haynes, Barton F., Gilbert, Peter B., Juliana McElrath, M., Zolla-Pazner, Susan, Tomaras, Georgia D., Munir Alam, S., Evans, David, Montefiori, David, Karnasuta, Chitraporn, Sutthent, Ruengpueng, Liao, Hua-Xin, DeVico, Anthony, Lewis, George, Williams, Constance, Pinter, Abraham, Fong, Youyi, Janes, Holly, DeCamp, Allan, Huang, Yunda, Rao, Mangala, Billings, Erik, Karasavvas, Nicos, Robb, Merlin L., Ngauy, Viseth, de Souza, Mark S., Paris, Robert, Ferrari, Guido, Bailer, Robert T., Soderberg, Kelly A., Andrews, Charla, Berman, Phillip, Frahm, Nicole, De Rosa, Stephen C., Alpert, Michael D., Yates, Nicole L., Shen, Xiaoying, Koup, Richard A., Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Rerks-Ngarm, Supachai, Michael, Nelson L., and Kim, Jerome H.

Published
2012

15. Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok Thailand

Author

Ratto-Kim, Silvia, Chuenchitra, Thippawan, Pulliam, Lynn, Paris, Robert, Sukwit, Suchitra, Gongwon, Siriphan, Sithinamsuwan, Pasiri, Nidhinandana, Samart, Thitivichianlert, Sataporn, Shiramizu, Bruce T., de Souza, Mark S., Chitpatima, Suwicha T., Sun, Bing, Rempel, Hans, Nitayaphan, Sorachai, Williams, Kenneth, Kim, Jerome H., Shikuma, Cecilia M., and Valcour, Victor G.

Published
2008
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18. A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection

Author

Kroon, Eugène D.M.B., primary, Ananworanich, Jintanat, additional, Pagliuzza, Amélie, additional, Rhodes, Ajantha, additional, Phanuphak, Nittaya, additional, Trautmann, Lydie, additional, Mitchell, Julie L., additional, Chintanaphol, Michelle, additional, Intasan, Jintana, additional, Pinyakorn, Suteeraporn, additional, Benjapornpong, Khuntalee, additional, Chang, J. Judy, additional, Colby, Donn J., additional, Chomchey, Nitiya, additional, Fletcher, James L.K., additional, Eubanks, Keith, additional, Yang, Hua, additional, Kapson, John, additional, Dantanarayana, Ashanti, additional, Tennakoon, Surekha, additional, Gorelick, Robert J., additional, Maldarelli, Frank, additional, Robb, Merlin L., additional, Kim, Jerome H., additional, Spudich, Serena, additional, Chomont, Nicolas, additional, Phanuphak, Praphan, additional, Lewin, Sharon R., additional, and de Souza, Mark S., additional

Published
2020
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19. A phase 1/2 study of a multiclade HIV-1 DNA plasmid prime and recombinant adenovirus erotype 5 boost vaccine in HIV-uninfected east Africans (RV 172)

Author

Kibuuka, Hannah, Kimutai, Robert, Maboko, Leonard, Sawe, Fred, Schunk, Mirjam S., Kroidl, Arne, Shaffer, Douglas, Eller, Leigh Anne, Kibaya, Rukia, Eller, Michael A., Schindler, Karin B., Schuetz, Alexandra, Millard, Monica, Kroll, Jason, Dally, Len, Hoelscher, Michael, Bailer, Robert, Cox, Josephine H., Marovich, Mary, Birx, Deborah L., Graham, Barney S., Michael, Nelson L., de Souza, Mark S., and Robb, Merlin L.

Subjects
AIDS vaccines -- Dosage and administration, AIDS vaccines -- Research, DNA vaccines -- Dosage and administration, DNA vaccines -- Research, HIV infection -- Care and treatment, HIV infection -- Research, Health
Published
2010

21. Preferential and persistent impact of acute HIV-1 infection on CD4+ iNKT cells in colonic mucosa.

Author

Paquin-Proulx, Dominic, Lal, Kerri G., Phuang-Ngern, Yuwadee, Creegan, Matthew, Tokarev, Andrey, Suhkumvittaya, Suchada, Alrubayyi, Aljawharah, Kroon, Eugène, Pinyakorn, Suteeraporn, Slike, Bonnie M., Bolton, Diane L., Krebs, Shelly J., Eller, Leigh Anne, Sajjaweerawan, Chayada, Pagliuzza, Amélie, Chomont, Nicolas, Rerknimitr, Rungsun, Chomchey, Nitiya, Phanuphak, Nittaya, and de Souza, Mark S.

Subjects
HIV, CD4 antigen, MUCOUS membranes, VIRAL load, T cells, COMMERCIAL products, CURCUMIN
Abstract

Acute HIV-1 infection (AHI) results in the widespread depletion of CD4+ T cells in peripheral blood and gut mucosal tissue. However, the impact on the predominantly CD4+ immunoregulatory invariant natural killer T (iNKT) cells during AHI remains unknown. Here, iNKT cells from peripheral blood and colonic mucosa were investigated during treated and untreated AHI. iNKT cells in blood were activated and rapidly depleted in untreated AHI. At the time of peak HIV-1 viral load, these cells showed the elevated expression of cell death-associated transcripts compared to preinfection. Residual peripheral iNKT cells suffered a diminished responsiveness to in vitro stimulation early into chronic infection. Additionally, HIV-1 DNA, as well as spliced and unspliced viral RNA, were detected in iNKT cells isolated from blood, indicating the active infection of these cells in vivo. The loss of iNKT cells occurred from Fiebig stage III in the colonic mucosa, and these cells were not restored to normal levels after initiation of ART during AHI. CD4+ iNKT cells were depleted faster and more profoundly than conventional CD4+ T cells, and the preferential infection of CD4+ iNKT cells over conventional CD4+ T cells was confirmed by in vitro infection experiments. In vitro data also provided evidence of latent infection in iNKT cells. Strikingly, preinfection levels of peripheral blood CD4+ iNKT cells correlated directly with the peak HIV-1 load. These findings support a model in which iNKT cells are early targets for HIV-1 infection, driving their rapid loss from circulation and colonic mucosa. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Short Communication: Characterization of Cellular Immune Responses in Thai Individuals With and Without HIV-Associated Neurocognitive Disorders

Author

Ratto-Kim, Silvia, Schuetz, Alexandra, Sithinamsuwan, Pasiri, Barber, John, Hutchings, Nicholas, Lerdlum, Sukalaya, Fletcher, James L. K., Phuang-Ngern, Yuwadee, Chuenarom, Weerawan, Tipsuk, Somporn, Pothisri, Mantana, Jadwattanakul, Tanate, Jirajariyavej, Supunnee, Sajjaweerawan, Chayada, Akapirat, Siriwat, Chalermchai, Thep, Suttichom, Duanghathai, Kaewboon, Boot, Prueksakaew, Peeriya, Karnsomlap, Putthachard, Clifford, David, Paul, Robert H., de Souza, Mark S., Kim, Jerome H., Ananworanich, Jintanat, and Valcour, Victor

Subjects
Adult, Male, Immunity, Cellular, AIDS Dementia Complex, Immunology, HIV Infections, CD8-Positive T-Lymphocytes, Middle Aged, Viral Load, Lymphocyte Activation, Thailand, Plasma, Young Adult, Humans, Female
Abstract

HIV-associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating activated/HIV-infected M/M, T cell activation may play a role in the development of HAND. We sought to investigate the relationship between cognition and both CD8(+) T cell activation (HLA-DR(+)/CD38(+)) and HIV-specific CD8(+) T cell responses at the time of HIV diagnosis and 12 months postinitiation of ART. CD8(+) T cell activation was increased in HAND compared to cognitive normal (NL) individuals and correlated directly with plasma viral load and inversely with the cognitive status. In addition, Gag-specific cytolytic activity (CD107a/b(+)) was decreased in HAND compared with NL individuals and correlated with their neurological testing, suggesting a potential role of cytotoxic CD8(+) T cells in the mechanism of HAND development.

Published
2018

24. Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial

Author

Crowell, Trevor A, primary, Colby, Donn J, additional, Pinyakorn, Suteeraporn, additional, Sacdalan, Carlo, additional, Pagliuzza, Amélie, additional, Intasan, Jintana, additional, Benjapornpong, Khunthalee, additional, Tangnaree, Kamonkan, additional, Chomchey, Nitiya, additional, Kroon, Eugène, additional, de Souza, Mark S, additional, Tovanabutra, Sodsai, additional, Rolland, Morgane, additional, Eller, Michael A, additional, Paquin-Proulx, Dominic, additional, Bolton, Diane L, additional, Tokarev, Andrey, additional, Thomas, Rasmi, additional, Takata, Hiroshi, additional, Trautmann, Lydie, additional, Krebs, Shelly J, additional, Modjarrad, Kayvon, additional, McDermott, Adrian B, additional, Bailer, Robert T, additional, Doria-Rose, Nicole, additional, Patel, Bijal, additional, Gorelick, Robert J, additional, Fullmer, Brandie A, additional, Schuetz, Alexandra, additional, Grandin, Pornsuk V, additional, O'Connell, Robert J, additional, Ledgerwood, Julie E, additional, Graham, Barney S, additional, Tressler, Randall, additional, Mascola, John R, additional, Chomont, Nicolas, additional, Michael, Nelson L, additional, Robb, Merlin L, additional, Phanuphak, Nittaya, additional, Ananworanich, Jintanat, additional, Ake, Julie A., additional, Akapirat, Siriwat, additional, Bose, Meera, additional, Cale, Evan, additional, Chan, Phillip, additional, Chanthaburanun, Sararut, additional, Churikanont, Nampueng, additional, Dawson, Peter, additional, Dumrongpisutikul, Netsiri, additional, Getchalarat, Saowanit, additional, Jongrakthaitae, Surat, additional, Jongsakul, Krisada, additional, Lerdlum, Sukalaya, additional, Manasnayakorn, Sopark, additional, McCullough, Corinne, additional, Milazzo, Mark, additional, Nuntapinit, Bessara, additional, On, Kier, additional, Ouellette, Madelaine, additional, Phanuphak, Praphan, additional, Sanders-Buell, Eric, additional, Sangnoi, Nongluck, additional, Shangguan, Shida, additional, Sirivichayakul, Sunee, additional, Tragonlugsana, Nipattra, additional, Trichavaroj, Rapee, additional, Ubolyam, Sasiwimol, additional, Vasan, Sandhya, additional, Wattanaboonyongcharoen, Phandee, additional, and Yamchuenpong, Thipvadee, additional

Published
2019
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25. A flow cytometry based assay that simultaneously measures cytotoxicity and monocyte mediated antibody dependent effector activity

Author

Alrubayyi, Aljawharah, primary, Schuetz, Alexandra, additional, Lal, Kerri G., additional, Jongrakthaitae, Surat, additional, Paolino, Kristopher M., additional, Ake, Julie A., additional, Robb, Merlin L., additional, de Souza, Mark S., additional, Michael, Nelson L., additional, Paquin-Proulx, Dominic, additional, and Eller, Michael A., additional

Published
2018
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27. Comparison of Antibody Responses Induced by RV144, VAX003, and VAX004 Vaccination Regimens

Author

Karnasuta, Chitraporn, primary, Akapirat, Siriwat, additional, Madnote, Sirinan, additional, Savadsuk, Hathairat, additional, Puangkaew, Jiraporn, additional, Rittiroongrad, Surawach, additional, Rerks-Ngarm, Supachai, additional, Nitayaphan, Sorachai, additional, Pitisuttithum, Punnee, additional, Kaewkungwal, Jaranit, additional, Tartaglia, James, additional, Sinangil, Faruk, additional, Francis, Donald P., additional, Robb, Merlin L., additional, de Souza, Mark S., additional, Michael, Nelson L., additional, Excler, Jean-Louis, additional, Kim, Jerome H., additional, O'Connell, Robert J., additional, and Karasavvas, Nicos, additional

Published
2017
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28. Initiation of Antiretroviral Therapy During Acute HIV-1 Infection Leads to a High Rate of Nonreactive HIV Serology

Author

de Souza, Mark S., primary, Pinyakorn, Suteeraporn, additional, Akapirat, Siriwat, additional, Pattanachaiwit, Supanit, additional, Fletcher, James L. K., additional, Chomchey, Nitiya, additional, Kroon, Eugene D., additional, Ubolyam, Sasiwimol, additional, Michael, Nelson L., additional, Robb, Merlin L., additional, Phanuphak, Praphan, additional, Kim, Jerome H., additional, Phanuphak, Nittaya, additional, and Ananworanich, Jintanat, additional

Published
2016
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29. Sex and Urbanicity Contribute to Variation in Lymphocyte Distribution across Ugandan Populations

Author

Naluyima, Prossy, primary, Eller, Leigh Anne, additional, Ouma, Benson J., additional, Kyabaggu, Denis, additional, Kataaha, Peter, additional, Guwatudde, David, additional, Kibuuka, Hannah, additional, Wabwire-Mangen, Fred, additional, Robb, Merlin L., additional, Michael, Nelson L., additional, de Souza, Mark S., additional, Sandberg, Johan K., additional, and Eller, Michael A., additional

Published
2016
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30. Characterization of HIV-1 gp120 antibody specificities induced in anogenital secretions of RV144 vaccine recipients after late boost immunizations.

Author

Akapirat, Siriwat, Karnasuta, Chitraporn, Vasan, Sandhya, Rerks-Ngarm, Supachai, Pitisuttithum, Punnee, Madnote, Sirinan, Savadsuk, Hathairat, Rittiroongrad, Surawach, Puangkaew, Jiraporn, Phogat, Sanjay, Tartaglia, James, Sinangil, Faruk, de Souza, Mark S., Excler, Jean-Louis, Kim, Jerome H., Robb, Merlin L., Michael, Nelson L., Ngauy, Viseth, O'Connell, Robert J., and Karasavvas, Nicos

Subjects
ANTIBODY specificity, IMMUNOSPECIFICITY, IMMUNIZATION, VACCINATION, COMMUNICABLE diseases
Abstract

Sexual transmission is the principal driver of the human immunodeficiency virus (HIV) pandemic. Understanding HIV vaccine-induced immune responses at mucosal surfaces can generate hypotheses regarding mechanisms of protection, and may influence vaccine development. The RV144 (ClinicalTrials.gov NCT00223080) efficacy trial showed protection against HIV infections but mucosal samples were not collected, therefore, the contribution of mucosal antibodies to preventing HIV-1 acquisition is unknown. Here, we report the generation, magnitude and persistence of antibody responses to recombinant gp120 envelope and antigens including variable one and two loop scaffold antigens (gp70V1V2) previously shown to correlate with risk in RV144. We evaluated antibody responses to gp120 A244gD and gp70V1V2 92TH023 (both CRF01_AE) and Case A2 (subtype B) in cervico-vaginal mucus (CVM), seminal plasma (SP) and rectal secretions (RS) from HIV-uninfected RV144 vaccine recipients, who were randomized to receive two late boosts of ALVAC-HIV/AIDSVAX®B/E, AIDSVAX®B/E, or ALVAC-HIV alone at 0 and 6 months. Late vaccine boosting increased IgG geometric mean titers (GMT) to gp120 A244gD in AIDSVAX®B/E and ALVAC-HIV/AIDSVAX®B/E CVM (28 and 17 fold, respectively), followed by SP and RS. IgG to gp70V1V2 92TH023 increased in AIDSVAX®B/E and ALVAC-HIV/AIDSVAX®B/E CVM (11–17 fold) and SP (2 fold) two weeks post first boost. IgG to Case A2 was only detected in AIDSVAX®B/E and ALVAC-HIV/AIDSVAX®B/E CVM. Mucosal IgG to gp120 A244gD (CVM, SP, RS), gp70V1V2 92TH023 (CVM, SP), and Case A2 (CVM) correlated with plasma IgG levels (p<0.001). Although the magnitude of IgG responses declined after boosting, anti-gp120 A244gD IgG responses in CVM persisted for 12 months post final vaccination. Further studies in localization, persistence and magnitude of envelope specific antibodies (IgG and dimeric IgA) in anogenital secretions will help determine their role in preventing mucosal HIV acquisition. [ABSTRACT FROM AUTHOR]

Published
2018
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31. Identification of Immunodominant CD4-Restricted Epitopes Co-Located with Antibody Binding Sites in Individuals Vaccinated with ALVAC-HIV and AIDSVAX B/E

Author

Ratto-Kim, Silvia, primary, de Souza, Mark S., additional, Currier, Jeffrey R., additional, Karasavvas, Nicos, additional, Sidney, John, additional, Rolland, Morgane, additional, Valencia-Micolta, Anais, additional, Madnote, Sirinan, additional, Sette, Alessandro, additional, Nitayaphan, Sorachai, additional, Pitisuttuthum, Punnee, additional, Kaewkungwal, Jaranit, additional, Rerks-Ngarm, Supachai, additional, O’Connell, Robert, additional, Michael, Nelson, additional, Robb, Merlin L., additional, Marovich, Mary, additional, and Kim, Jerome H., additional

Published
2015
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32. Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines

Author

Chung, Amy W., primary, Ghebremichael, Musie, additional, Robinson, Hannah, additional, Brown, Eric, additional, Choi, Ickwon, additional, Lane, Sophie, additional, Dugast, Anne-Sophie, additional, Schoen, Matthew K., additional, Rolland, Morgane, additional, Suscovich, Todd J., additional, Mahan, Alison E., additional, Liao, Larry, additional, Streeck, Hendrik, additional, Andrews, Charla, additional, Rerks-Ngarm, Supachai, additional, Nitayaphan, Sorachai, additional, de Souza, Mark S., additional, Kaewkungwal, Jaranit, additional, Pitisuttithum, Punnee, additional, Francis, Donald, additional, Michael, Nelson L., additional, Kim, Jerome H., additional, Bailey-Kellogg, Chris, additional, Ackerman, Margaret E., additional, and Alter, Galit, additional

Published
2014
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33. Molecular Evolution of the HIV-1 Thai Epidemic between the Time of RV144 Immunogen Selection to the Execution of the Vaccine Efficacy Trial

Author

Kijak, Gustavo H., primary, Tovanabutra, Sodsai, additional, Rerks-Ngarm, Supachai, additional, Nitayaphan, Sorachai, additional, Eamsila, Chirapa, additional, Kunasol, Prayura, additional, Khamboonruang, Chirasak, additional, Thongcharoen, Prasert, additional, Namwat, Chawetsan, additional, Premsri, Nakorn, additional, Benenson, Michael, additional, Morgan, Patricia, additional, Bose, Meera, additional, Sanders-Buell, Eric, additional, Paris, Robert, additional, Robb, Merlin L., additional, Birx, Deborah L., additional, De Souza, Mark S., additional, McCutchan, Francine E., additional, Michael, Nelson L., additional, and Kim, Jerome H., additional

Published
2013
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34. IgG Antibody Responses to Recombinant gp120 Proteins, gp70V1/V2 Scaffolds, and a CyclicV2 Peptide in Thai Phase I/II Vaccine Trials Using Different Vaccine Regimens.

Author

Karasavvas, Nicos, Karnasuta, Chitraporn, Savadsuk, Hathairat, Madnote, Sirinan, Inthawong, Dutsadee, Chantakulkij, Somsak, Rittiroongrad, Surawach, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Thongcharoen, Prasert, Siriyanon, Vinai, Andrews, Charla A., Barnett, Susan W., Tartaglia, James, Sinangil, Faruk, Francis, Donald P., Robb, Merlin L., Michael, Nelson L., Ngauy, Viseth, and de Souza, Mark S.

Abstract

RV144 correlates of risk analysis showed that IgG antibodies to gp70V1V2 scaffolds inversely correlated with risk of HIV acquisition. We investigated IgG antibody responses in RV135 and RV132, two ALVAC-HIV prime-boost vaccine trials conducted in Thailand prior to RV144. Both trials used ALVAC-HIV (vCP1521) at 0, 1, 3, and 6 months and HIV-1 gp120MNgD and gp120A244gD in alum (RV135) or gp120SF2 and gp120CM235 in MF59 (RV132) at 3 and 6 months. We assessed ELISA binding antibodies to the envelope proteins (Env) 92TH023, A244gD and MNgD, cyclicV2, and gp70V1V2 CaseA2 (subtype B) and 92TH023 (subtype CRF01_AE), and Env-specific IgG1 and IgG3. Antibody responses to gp120 A244gD, MNgD, and gp70V1V2 92TH023 scaffold were significantly higher in RV135 than in RV132. Antibodies to gp70V1V2 CaseA2 were detected only in RV135 vaccine recipients and IgG1 and IgG3 antibody responses to A244gD were significantly higher in RV135. IgG binding to gp70V1V2 CaseA2 and CRF01_AE scaffolds was higher with the AIDSVAX®B/E boost but both trials showed similar rates of antibody decline post-vaccination. MF59 did not result in higher IgG antibody responses compared to alum with the antigens tested. However, notable differences in the structure of the recombinant proteins and dosage used for immunizations may have contributed to the magnitude and specificity of IgG induced by the two trials. [ABSTRACT FROM AUTHOR]

Published
2015
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36. Extended Evaluation of the Virologic, Immunologic, and Clinical Course of Volunteers Who Acquired HIV-1 Infection in a Phase III Vaccine Trial of ALVAC-HIV and AIDSVAX B/E

Author

Rerks-Ngarm, Supachai, primary, Paris, Robert M., additional, Chunsutthiwat, Supamit, additional, Premsri, Nakorn, additional, Namwat, Chawetsan, additional, Bowonwatanuwong, Chureeratana, additional, Li, Shuying S., additional, Kaewkungkal, Jaranit, additional, Trichavaroj, Rapee, additional, Churikanont, Nampueng, additional, de Souza, Mark S., additional, Andrews, Charla, additional, Francis, Donald, additional, Adams, Elizabeth, additional, Flores, Jorge, additional, Gurunathan, Sanjay, additional, Tartaglia, Jim, additional, O'Connell, Robert J., additional, Eamsila, Chirapa, additional, Nitayaphan, Sorachai, additional, Ngauy, Viseth, additional, Thongcharoen, Prasert, additional, Kunasol, Prayura, additional, Michael, Nelson L., additional, Robb, Merlin L., additional, Gilbert, Peter B., additional, and Kim, Jerome H., additional

Published
2012
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37. HLA class II restriction of HIV-1 clade-specific neutralizing antibody responses in ethnic Thai recipients of the RV144 prime-boost vaccine combination of ALVAC-HIV and AIDSVAX® B/E

Author

Paris, Robert, primary, Bejrachandra, Sasitorn, additional, Thongcharoen, Prasert, additional, Nitayaphan, Sorachai, additional, Pitisuttithum, Punnee, additional, Sambor, Anna, additional, Gurunathan, Sanjay, additional, Francis, Donald, additional, Ratto-Kim, Silvia, additional, Karnasuta, Chitraporn, additional, de Souza, Mark S., additional, Polonis, Victoria R., additional, Brown, Arthur E., additional, Kim, Jerome H., additional, and Stephens, Henry A., additional

Published
2012
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38. Human Immunodeficiency Virus Type 1 Infection Is Associated with Increased NK Cell Polyfunctionality and Higher Levels of KIR3DL1 + NK Cells in Ugandans Carrying the HLA-B Bw4 Motif

Author

Eller, Michael A., primary, Koehler, Rebecca N., additional, Kijak, Gustavo H., additional, Eller, Leigh Anne, additional, Guwatudde, David, additional, Marovich, Mary A., additional, Michael, Nelson L., additional, de Souza, Mark S., additional, Wabwire-Mangen, Fred, additional, Robb, Merlin L., additional, Currier, Jeffrey R., additional, and Sandberg, Johan K., additional

Published
2011
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39. Innate and Adaptive Immune Responses Both Contribute to Pathological CD4 T Cell Activation in HIV-1 Infected Ugandans

Author

Eller, Michael A., primary, Blom, Kim G., additional, Gonzalez, Veronica D., additional, Eller, Leigh Anne, additional, Naluyima, Prossy, additional, Laeyendecker, Oliver, additional, Quinn, Thomas C., additional, Kiwanuka, Noah, additional, Serwadda, David, additional, Sewankambo, Nelson K., additional, Tasseneetrithep, Boonrat, additional, Wawer, Maria J., additional, Gray, Ronald H., additional, Marovich, Mary A., additional, Michael, Nelson L., additional, de Souza, Mark S., additional, Wabwire-Mangen, Fred, additional, Robb, Merlin L., additional, Currier, Jeffrey R., additional, and Sandberg, Johan K., additional

Published
2011
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40. Phase I Safety and Immunogenicity Evaluation of MVA-CMDR, a Multigenic, Recombinant Modified Vaccinia Ankara-HIV-1 Vaccine Candidate

Author

Currier, Jeffrey R., primary, Ngauy, Viseth, additional, de Souza, Mark S., additional, Ratto-Kim, Silvia, additional, Cox, Josephine H., additional, Polonis, Victoria R., additional, Earl, Patricia, additional, Moss, Bernard, additional, Peel, Sheila, additional, Slike, Bonnie, additional, Sriplienchan, Somchai, additional, Thongcharoen, Prasert, additional, Paris, Robert M., additional, Robb, Merlin L., additional, Kim, Jerome, additional, Michael, Nelson L., additional, and Marovich, Mary A., additional

Published
2010
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41. Quality Monitoring of HIV-1-Infected and Uninfected Peripheral Blood Mononuclear Cell Samples in a Resource-Limited Setting

Author

Olemukan, Robert E., primary, Eller, Leigh Anne, additional, Ouma, Benson J., additional, Etonu, Ben, additional, Erima, Simon, additional, Naluyima, Prossy, additional, Kyabaggu, Denis, additional, Cox, Josephine H., additional, Sandberg, Johan K., additional, Wabwire-Mangen, Fred, additional, Michael, Nelson L., additional, Robb, Merlin L., additional, de Souza, Mark S., additional, and Eller, Michael A., additional

Published
2010
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42. Elevated Natural Killer Cell Activity Despite Altered Functional and Phenotypic Profile in Ugandans With HIV-1 Clade A or Clade D Infection

Author

Eller, Michael A, primary, Eller, Leigh Anne, additional, Ouma, Benson J, additional, Thelian, Doris, additional, Gonzalez, Veronica D, additional, Guwatudde, David, additional, McCutchan, Francine E, additional, Marovich, Mary A, additional, Michael, Nelson L, additional, de Souza, Mark S, additional, Wabwire-Mangen, Fred, additional, Robb, Merlin L, additional, Currier, Jeffrey R, additional, and Sandberg, Johan K, additional

Published
2009
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44. Reference Intervals in Healthy Adult Ugandan Blood Donors and Their Impact on Conducting International Vaccine Trials

Author

Eller, Leigh Anne, primary, Eller, Michael A., additional, Ouma, Benson, additional, Kataaha, Peter, additional, Kyabaggu, Denis, additional, Tumusiime, Richard, additional, Wandege, Joseph, additional, Sanya, Ronald, additional, Sateren, Warren B., additional, Wabwire-Mangen, Fred, additional, Kibuuka, Hannah, additional, Robb, Merlin L., additional, Michael, Nelson L., additional, and de Souza, Mark S., additional

Published
2008
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46. Large-Scale Human Immunodeficiency Virus Rapid Test Evaluation in a Low-Prevalence Ugandan Blood Bank Population

Author

Eller, Leigh A., primary, Eller, Michael A., additional, Ouma, Benson J., additional, Kataaha, Peter, additional, Bagaya, Bernard S., additional, Olemukan, Robert L., additional, Erima, Simon, additional, Kawala, Lilian, additional, de Souza, Mark S., additional, Kibuuka, Hannah, additional, Wabwire-Mangen, Fred, additional, Peel, Sheila A., additional, O'Connell, Robert J., additional, Robb, Merlin L., additional, and Michael, Nelson L., additional

Published
2007
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47. A Phase 1/2 Comparative Vaccine Trial of the Safety and Immunogenicity of a CRF01_AE (Subtype E) Candidate Vaccine

Author

Thongcharoen, Prasert, primary, Suriyanon, Vinai, additional, Paris, Robert M, additional, Khamboonruang, Chirasak, additional, de Souza, Mark S, additional, Ratto-Kim, Silvia, additional, Karnasuta, Chitraporn, additional, Polonis, Victoria R, additional, Baglyos, Lynn, additional, Habib, Raphaelle El, additional, Gurunathan, Sanjay, additional, Barnett, Susan, additional, Brown, Arthur E, additional, Birx, Deborah L, additional, McNeil, John G, additional, and Kim, Jerome H, additional

Published
2007
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48. Distinguishing molecular forms of HIV-1 in Asia with a high-throughput, fluorescent genotyping assay, MHAbce v.2

Author

Kijak, Gustavo H., primary, Tovanabutra, Sodsai, additional, Sanders-Buell, Eric, additional, Watanaveeradej, Veerachai, additional, de Souza, Mark S., additional, Nelson, Kenrad E., additional, Ketsararat, Vidhaya, additional, Gulgolgarn, Vilawan, additional, Wera-arpachai, Manu, additional, Sriplienchan, Somchai, additional, Khamboonrueng, Chirasak, additional, Birx, Deborah L., additional, Robb, Merlin L., additional, and McCutchan, Francine E., additional

Published
2007
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50. Biologic and Genetic Characterization of a Panel of 60 Human Immunodeficiency Virus Type 1 Isolates, Representing Clades A, B, C, D, CRF01_AE, and CRF02_AG, for the Development and Assessment of Candidate Vaccines

Author

Brown, Bruce K., primary, Darden, Janice M., additional, Tovanabutra, Sodsai, additional, Oblander, Tamara, additional, Frost, Julie, additional, Sanders-Buell, Eric, additional, de Souza, Mark S., additional, Birx, Deborah L., additional, McCutchan, Francine E., additional, and Polonis, Victoria R., additional

Published
2005
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